CR20240246A - Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden - Google Patents

Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden

Info

Publication number
CR20240246A
CR20240246A CR20240246A CR20240246A CR20240246A CR 20240246 A CR20240246 A CR 20240246A CR 20240246 A CR20240246 A CR 20240246A CR 20240246 A CR20240246 A CR 20240246A CR 20240246 A CR20240246 A CR 20240246A
Authority
CR
Costa Rica
Prior art keywords
antibodies
ltbr
agonist anti
bispecific
methods
Prior art date
Application number
CR20240246A
Other languages
English (en)
Inventor
Stefan Dengl
Guy Georges
Felix Bormann
Michelle Victoria Brydon
Monika Heidrich
Fanny Mende
Ralf Hosse
Leo Frederik Kunz
Stephane Leclair
Miroslav Nikolov
Pablo Umaña
Desirée Leisibach
Olaf Mundigl
Harald Duerr
Roberta Bianchi
Lydia Jasmin Hanisch
Cornelia Wagner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20240246A publication Critical patent/CR20240246A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La invención se refiere a novedosos anticuerpos que se unen al receptor de linfotoxina beta (LTBR) y a moléculas de unión a antígeno biespecíficas que comprenden estos novedosos anticuerpos anti-LTBR y un dominio de unión a antígeno que se une a un antígeno asociado a un tumor, en particular a la proteína de activación de fibroblastos (FAP), a procedimientos de producción de estas moléculas y a procedimientos de uso de las mismas
CR20240246A 2021-12-20 2022-12-09 Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden CR20240246A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21215804 2021-12-20
EP22208828 2022-11-22
PCT/EP2022/086540 WO2023117834A1 (en) 2021-12-20 2022-12-19 Agonistic ltbr antibodies and bispecific antibodies comprising them

Publications (1)

Publication Number Publication Date
CR20240246A true CR20240246A (es) 2024-07-19

Family

ID=84901289

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20240246A CR20240246A (es) 2021-12-20 2022-12-09 Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden

Country Status (15)

Country Link
US (1) US20250034269A1 (es)
EP (1) EP4453031A1 (es)
KR (1) KR20240122864A (es)
CN (1) CN119143873A (es)
AR (1) AR128031A1 (es)
AU (1) AU2022423749A1 (es)
CA (1) CA3243043A1 (es)
CL (1) CL2024001878A1 (es)
CO (1) CO2024008179A2 (es)
CR (1) CR20240246A (es)
IL (1) IL313258A (es)
MX (1) MX2024007314A (es)
PE (1) PE20241754A1 (es)
TW (1) TW202340248A (es)
WO (1) WO2023117834A1 (es)

Families Citing this family (7)

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WO2023218320A1 (en) * 2022-05-11 2023-11-16 Pfizer Inc. Anti-lymphotoxin beta receptor antibodies and methods of use thereof
WO2025012620A1 (en) * 2023-07-07 2025-01-16 Mestag Therapeutics Ltd Binding constructs
EP4527851A1 (en) 2023-09-22 2025-03-26 Bayer Aktiengesellschaft Bispecific antibodies binding ltbr and lrrc15
TW202540200A (zh) 2023-12-01 2025-10-16 美商基利科學股份有限公司 抗ｆａｐ－ｌｉｇｈｔ融合蛋白及其用途
WO2025172588A1 (en) 2024-02-16 2025-08-21 Mestag Therapeutics Ltd Bispecific constructs directed against fap and ltbr
WO2025172587A1 (en) 2024-02-16 2025-08-21 Mestag Therapeutics Ltd Binding constructs
WO2025221736A2 (en) * 2024-04-15 2025-10-23 Janssen Biotech, Inc. Ltbr binding molecules and uses thereof

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Also Published As

Publication number Publication date
CN119143873A (zh) 2024-12-17
AU2022423749A1 (en) 2024-06-13
IL313258A (en) 2024-08-01
CO2024008179A2 (es) 2024-07-29
PE20241754A1 (es) 2024-08-28
AR128031A1 (es) 2024-03-20
WO2023117834A1 (en) 2023-06-29
CL2024001878A1 (es) 2024-10-04
KR20240122864A (ko) 2024-08-13
MX2024007314A (es) 2024-06-26
TW202340248A (zh) 2023-10-16
EP4453031A1 (en) 2024-10-30
US20250034269A1 (en) 2025-01-30
CA3243043A1 (en) 2025-02-26
JP2025500949A (ja) 2025-01-15

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