ATE416375T1 - Mikrofluidische analysesysteme und -verfahren mit extrem hohem durchsatz - Google Patents

Mikrofluidische analysesysteme und -verfahren mit extrem hohem durchsatz

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Publication number
ATE416375T1
ATE416375T1 AT01922529T AT01922529T ATE416375T1 AT E416375 T1 ATE416375 T1 AT E416375T1 AT 01922529 T AT01922529 T AT 01922529T AT 01922529 T AT01922529 T AT 01922529T AT E416375 T1 ATE416375 T1 AT E416375T1
Authority
AT
Austria
Prior art keywords
analytical
methods
interface
extremely high
analysis systems
Prior art date
Application number
AT01922529T
Other languages
English (en)
Inventor
Anne Kopf-Sill
Andrea Chow
Peter Jann
Morten Jensen
Michael Spaid
Colin Kennedy
Michael Kennedy
Original Assignee
Caliper Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24137844&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE416375(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Caliper Life Sciences Inc filed Critical Caliper Life Sciences Inc
Application granted granted Critical
Publication of ATE416375T1 publication Critical patent/ATE416375T1/de

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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT01922529T 2000-03-27 2001-03-22 Mikrofluidische analysesysteme und -verfahren mit extrem hohem durchsatz ATE416375T1 (de)

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Families Citing this family (250)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
EP0999443A3 (de) * 1998-11-02 2002-09-18 The Institute of Physical and Chemical Research Kapillarelektroforesesvorrichtung, Probenplatte, und Probeneinspritzverfahren
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6692697B1 (en) * 1999-07-30 2004-02-17 Texas Instruments Incorporated Versatile flow cell front-end for optically-based integrated sensors
US6824663B1 (en) * 1999-08-27 2004-11-30 Aclara Biosciences, Inc. Efficient compound distribution in microfluidic devices
US6824664B1 (en) * 1999-11-04 2004-11-30 Princeton University Electrode-less dielectrophorises for polarizable particles
US6589729B2 (en) * 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US6358387B1 (en) * 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
JP3893849B2 (ja) * 2000-05-15 2007-03-14 株式会社日立製作所 キャピラリアレイ電気泳動装置及び電気泳動方法
US6635487B1 (en) 2000-05-17 2003-10-21 Caliper Technologies Corp. Fluorescence standard for use in microfluidic instruments
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
DE60117556T2 (de) 2000-06-21 2006-11-02 Bioarray Solutions Ltd. Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US7062418B2 (en) * 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
CN1232343C (zh) * 2000-07-03 2005-12-21 艾克索特罗恩公司 利用光生反应物进行化学反应的设备及方法
US7027683B2 (en) * 2000-08-15 2006-04-11 Nanostream, Inc. Optical devices with fluidic systems
WO2002023163A1 (en) 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
US6827095B2 (en) * 2000-10-12 2004-12-07 Nanostream, Inc. Modular microfluidic systems
EP1336097A4 (de) * 2000-10-13 2006-02-01 Fluidigm Corp Probeninjektionssystem auf der basis einer mikrofluidischen einrichtung für analytische einrichtungen
US7232109B2 (en) * 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
US20090118139A1 (en) 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US8900811B2 (en) 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7118917B2 (en) * 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
US6706163B2 (en) * 2001-03-21 2004-03-16 Michael Seul On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
EP1384022A4 (de) 2001-04-06 2004-08-04 California Inst Of Techn Nukleinsäure-amplifikation verwendende mikrofluidvorrichtungen
CA2440785A1 (en) * 2001-04-10 2002-10-24 Bioprocessors Corporation Microfermentor device and cell based screening method
US20040058407A1 (en) * 2001-04-10 2004-03-25 Miller Scott E. Reactor systems having a light-interacting component
US20040132166A1 (en) * 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US7641780B2 (en) * 2001-05-01 2010-01-05 Calibrant Biosystems, Inc. Two-dimensional microfluidics for protein separations and gene analysis
US6974526B2 (en) * 2001-05-01 2005-12-13 Calibrant Biosystems, Inc. Plastic microfluidics enabling two-dimensional protein separations in proteome analysis
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7075162B2 (en) * 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
US20030087198A1 (en) * 2001-09-19 2003-05-08 Dharmatilleke Saman Mangala Three-dimensional polymer nano/micro molding by sacrificial layer technique
US7192629B2 (en) 2001-10-11 2007-03-20 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
CA2497740C (en) 2001-10-15 2011-06-21 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
US20030082632A1 (en) * 2001-10-25 2003-05-01 Cytoprint, Inc. Assay method and apparatus
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US7691333B2 (en) * 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US7223371B2 (en) * 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
AU2003224817B2 (en) * 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US20030219754A1 (en) * 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
US20060086309A1 (en) * 2002-06-24 2006-04-27 Fluiding Corporation Recirculating fluidic network and methods for using the same
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
JP2004069395A (ja) * 2002-08-02 2004-03-04 Nec Corp マイクロチップ、マイクロチップの製造方法および成分検出方法
BR0313618A (pt) 2002-08-21 2005-06-21 Shell Int Research Método para análise quìmica de fluidos de poço
WO2004021526A2 (en) * 2002-08-30 2004-03-11 Spectra-Physics, Inc. Method and apparatus for polarization and wavelength insensitive pumping of solid state lasers
US7003011B2 (en) * 2002-08-30 2006-02-21 Spectra Physics, Inc. Thin disk laser with large numerical aperture pumping
JP2006501056A (ja) 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
WO2004040295A1 (en) * 2002-10-31 2004-05-13 Nanostream, Inc. Parallel detection chromatography systems
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US6987263B2 (en) * 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US20060076482A1 (en) * 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
US7087444B2 (en) 2002-12-16 2006-08-08 Palo Alto Research Center Incorporated Method for integration of microelectronic components with microfluidic devices
DE60330045D1 (de) * 2002-12-20 2009-12-24 Corning Inc Kapillarenassayvorrichtung und -verfahren
US6832787B1 (en) 2003-01-24 2004-12-21 Sandia National Laboratories Edge compression manifold apparatus
US6966336B1 (en) 2003-01-24 2005-11-22 Sandia National Laboratories Fluid injection microvalve
US7311882B1 (en) 2003-01-24 2007-12-25 Sandia National Laboratories Capillary interconnect device
US6918573B1 (en) 2003-01-27 2005-07-19 Sandia National Laboratories Microvalve
US20040163961A1 (en) * 2003-02-21 2004-08-26 West Virginia University Research Corporation Apparatus and method for using bi-directional capillary electrophoresis
US20040179972A1 (en) * 2003-03-14 2004-09-16 Nanostream, Inc. Systems and methods for detecting manufacturing defects in microfluidic devices
US7553455B1 (en) 2003-04-02 2009-06-30 Sandia Corporation Micromanifold assembly
US6926313B1 (en) 2003-04-02 2005-08-09 Sandia National Laboratories High pressure capillary connector
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
CA2521171C (en) * 2003-04-03 2013-05-28 Fluidigm Corp. Microfluidic devices and methods of using same
US7604965B2 (en) * 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US8828663B2 (en) * 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US7161334B1 (en) 2003-04-16 2007-01-09 Sandia National Laboratories Modular high voltage power supply for chemical analysis
WO2004094986A2 (en) * 2003-04-16 2004-11-04 Handylab, Inc. System and method for electrochemical detection of biological compounds
US7011793B2 (en) * 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
AU2004240944A1 (en) 2003-05-20 2004-12-02 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP1694731B1 (de) 2003-09-23 2012-03-28 University Of North Carolina At Chapel Hill Photohärtbare perfluorpolyether zur verwendung als neue werkstoffe in mikrofluidischen vorrichtungen
CA2544041C (en) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
CA2544202C (en) 2003-10-29 2012-07-24 Bioarray Solutions Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US7396677B2 (en) * 2003-11-07 2008-07-08 Nanosphere, Inc. Method of preparing nucleic acids for detection
KR100703889B1 (ko) 2003-12-29 2007-04-05 전자부품연구원 용액 성분 분석을 위한 소자 및 그의 제조 방법
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
ES2572382T3 (es) 2004-05-03 2016-05-31 Handylab Inc Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos
EP1758674A2 (de) * 2004-06-07 2007-03-07 Bioprocessors Corporation Schuberzeugung in einem reaktor
US20050271560A1 (en) * 2004-06-07 2005-12-08 Bioprocessors Corp. Gas control in a reactor
EP1765487A1 (de) * 2004-06-07 2007-03-28 Bioprocessors Corporation Mischen im reaktor
US7394542B2 (en) * 2004-08-18 2008-07-01 Chemimage Corporation Method and apparatus for chemical imaging in a microfluidic circuit
US7258776B2 (en) * 2004-07-08 2007-08-21 Applera Corporation Capillary array assembly for loading samples from a device, and method
WO2006015308A2 (en) * 2004-07-29 2006-02-09 California Institute Of Technology Modular microfluidic packaging system
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060204699A1 (en) * 2004-12-08 2006-09-14 George Maltezos Parylene coated microfluidic components and methods for fabrication thereof
US8695355B2 (en) 2004-12-08 2014-04-15 California Institute Of Technology Thermal management techniques, apparatus and methods for use in microfluidic devices
US7582263B2 (en) * 2005-01-27 2009-09-01 Octrolix Bv Universal interface for a micro-fluidic chip
DE102005049365A1 (de) * 2005-03-18 2006-09-21 BAM Bundesanstalt für Materialforschung und -prüfung Kalibriereinrichtung und Farbstoffkit sowie ihre Verwendung zur Charakterisierung von Lumineszenzmesssystemen
US8021629B2 (en) * 2005-03-24 2011-09-20 Konica Minolta Medical & Graphic, Inc. Analyzer
US9097723B2 (en) * 2005-04-01 2015-08-04 Caliper Life Sciences, Inc. Method and apparatus for performing peptide digestion on a microfluidic device
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
US8501416B2 (en) * 2005-04-19 2013-08-06 President And Fellows Of Harvard College Fluidic structures including meandering and wide channels
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007016931A1 (en) * 2005-07-25 2007-02-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Chip-holder for a micro-fluidic chip
EP2537657A3 (de) 2005-08-09 2016-05-04 The University of North Carolina At Chapel Hill Verfahren und Materialien zur Herstellung mikrofluidischer Vorrichtungen
US8480053B2 (en) 2005-09-02 2013-07-09 California Institute Of Technology Method and apparatus for the mechanical actuation of valves in fluidic devices
ES2379921T3 (es) 2005-09-29 2012-05-07 Siemens Medical Solutions Usa, Inc. Chip microfluídico que puede sintetizar moléculas marcadas radiactivamente en una escala adecuada para la obtención de imágenes en seres humanos con tomografía por emisión de positrones
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
WO2007056561A2 (en) * 2005-11-09 2007-05-18 Liquidia Technologies, Inc. Medical device, materials, and methods
US8152477B2 (en) * 2005-11-23 2012-04-10 Eksigent Technologies, Llc Electrokinetic pump designs and drug delivery systems
EP1801573A1 (de) * 2005-12-21 2007-06-27 Boehringer Mannheim Gmbh Vorrichtung und Verfahren für Parallele Zweidimensional-Elektrophorese
US20110040160A1 (en) * 2006-01-22 2011-02-17 Arkray, Inc. Analysis device having a discarding mechanism
US7862000B2 (en) 2006-02-03 2011-01-04 California Institute Of Technology Microfluidic method and structure with an elastomeric gas-permeable gasket
KR100735528B1 (ko) * 2006-02-07 2007-07-04 삼성전자주식회사 반도체 소자 제조용 장비, 반도체 소자의 제조 방법,웨이퍼
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US20090233378A1 (en) * 2006-03-29 2009-09-17 Konica Minolta Medical & Graphic, Inc. Method of Reaction in Flow Channel of Microchip and Analysis Device
US7439014B2 (en) * 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US7848848B2 (en) * 2006-04-28 2010-12-07 Freeslate, Inc. Robotic station for capturing both image and weight of a sample
US8137626B2 (en) * 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
US7629124B2 (en) * 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
WO2008012724A2 (en) * 2006-07-20 2008-01-31 Koninklijke Philips Electronics N.V. Optical tracking and position determination for detection methods and systems
US8187541B2 (en) * 2006-09-18 2012-05-29 California Institute Of Technology Apparatus for detecting target molecules and related methods
US20080131327A1 (en) * 2006-09-28 2008-06-05 California Institute Of Technology System and method for interfacing with a microfluidic chip
US7814928B2 (en) * 2006-10-10 2010-10-19 California Institute Of Technology Microfluidic devices and related methods and systems
US8518479B2 (en) * 2006-10-12 2013-08-27 Affymetrix, Inc. Fabrication of fluidic features within a plastic substrate
ATE544522T1 (de) * 2006-10-25 2012-02-15 Fraunhofer Ges Forschung Chiphalter, fluidsystem und chiphaltersystem
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
WO2008066869A2 (en) 2006-11-30 2008-06-05 Canon U.S. Life Sciences, Inc. Systems and methods for monitoring the amplification and dissociation behavior of dna molecules
EP2100138B1 (de) * 2006-12-28 2012-06-20 Wako Pure Chemical Industries, Ltd. Verfahren für interne teststandardisierung
US20080160629A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for off-line multidimensional concentration and separation of biomolecules
US20080156080A1 (en) * 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for multidimensional concentration and separation of biomolecules using capillary isotachophoresis
US7829032B2 (en) 2007-01-23 2010-11-09 Siemens Medical Solutions Usa, Inc. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
WO2008101124A1 (en) * 2007-02-15 2008-08-21 Broadley-James Corporation Sterile bioreactor bag with integrated drive unit
WO2008101127A2 (en) * 2007-02-15 2008-08-21 Broadley-James Corporation Bioreactor jacket
CA2682761C (en) 2007-04-04 2015-10-13 Network Biosystems, Inc. Methods for rapid multiplexed amplification of target nucleic acids
US8071035B2 (en) 2007-04-12 2011-12-06 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
JP5305361B2 (ja) 2007-05-04 2013-10-02 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニー 流体コネクタおよびマイクロ流体システム
US9458451B2 (en) 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
US8380457B2 (en) * 2007-08-29 2013-02-19 Canon U.S. Life Sciences, Inc. Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes
US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US8517990B2 (en) 2007-12-18 2013-08-27 Hospira, Inc. User interface improvements for medical devices
JP5072688B2 (ja) 2008-04-02 2012-11-14 キヤノン株式会社 走査型撮像装置
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
EP2153892A1 (de) * 2008-07-23 2010-02-17 ETH Zurich Mikroreaktorsystem und Verfahren zum Betrieb eines solchen Mikroreaktorsystems
WO2010036287A1 (en) 2008-09-24 2010-04-01 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
WO2010068670A1 (en) 2008-12-09 2010-06-17 Advanced Analytical Technologies, Inc. Capillary electrophoresis fluorescent detection system
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
FI20095063A0 (fi) 2009-01-26 2009-01-26 Wallac Oy Optinen mittauslaite
DK2391451T3 (en) 2009-02-02 2018-10-15 Opko Diagnostics Llc STRUCTURES FOR MANAGING LIGHT INTERACTION WITH MICROFLUIDIC DEVICES
US8449842B2 (en) * 2009-03-19 2013-05-28 Thermo Scientific Portable Analytical Instruments Inc. Molecular reader
DE112010002222B4 (de) 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
EP2443254A2 (de) * 2009-06-15 2012-04-25 NetBio, Inc. Verbesserte verfahren für forensische dna-quantifizierung
CN102782115A (zh) 2009-07-20 2012-11-14 西罗亚生物科技有限公司 微流控分析平台
CN102762289B (zh) 2009-12-18 2016-08-03 艾博特健康公司 生物流体分析卡盒
AU2011220873B2 (en) 2010-02-23 2014-07-10 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
US9199233B2 (en) 2010-03-31 2015-12-01 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with deflecting top panel
US9638632B2 (en) * 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
US9873118B2 (en) 2010-12-30 2018-01-23 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
ES2769028T3 (es) 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
CN104023834B (zh) 2011-05-04 2016-09-28 卢米耐克斯公司 用于集成的样品制备、反应和检测的设备与方法
JP2014519570A (ja) 2011-05-05 2014-08-14 エクシジェント テクノロジーズ， エルエルシー 動電学的送出システム用のゲル結合部
CA3106132C (en) 2011-05-12 2023-08-29 Ande Corporation Methods and compositions for rapid multiplex amplification of str loci
CA2844807C (en) 2011-08-19 2022-07-26 Hospira, Inc. Systems and methods for a graphical interface including a graphical representation of medical data
CN103890590B (zh) 2011-08-24 2016-03-09 艾博特健康公司 生物流体样品分析盒
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
ES2645966T3 (es) 2011-09-30 2017-12-11 Becton, Dickinson And Company Tira reactiva unificada
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
US11092977B1 (en) 2017-10-30 2021-08-17 Zane Coleman Fluid transfer component comprising a film with fluid channels
WO2013090709A1 (en) 2011-12-16 2013-06-20 Hospira, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
WO2013101741A1 (en) 2011-12-30 2013-07-04 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
MY193914A (en) 2012-03-05 2022-11-01 Oy Arctic Partners Ab Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume
JP6306566B2 (ja) 2012-03-30 2018-04-04 アイシーユー・メディカル・インコーポレーテッド 注入システムのポンプ内の空気を検出するための空気検出システムおよび方法
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
EP3586891B1 (de) 2012-07-31 2025-04-09 ICU Medical, Inc. Patientenbehandlungssystem für kritische medikamente
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
AU2013334189B2 (en) 2012-10-24 2018-08-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
AU2014268355B2 (en) 2013-05-24 2018-06-14 Icu Medical, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
ES2845748T3 (es) 2013-05-29 2021-07-27 Icu Medical Inc Sistema de infusión y método de uso que impiden la sobresaturación de un convertidor analógico-digital
CA2913915C (en) 2013-05-29 2022-03-29 Hospira, Inc. Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
WO2015131108A2 (en) * 2014-02-28 2015-09-03 Hospira, Inc. Infusion system and method which utilizes dual wavelength optical air-in-line detection
US11344673B2 (en) 2014-05-29 2022-05-31 Icu Medical, Inc. Infusion system and pump with configurable closed loop delivery rate catch-up
US11344668B2 (en) 2014-12-19 2022-05-31 Icu Medical, Inc. Infusion system with concurrent TPN/insulin infusion
EP3247988A4 (de) 2015-01-23 2018-12-19 Vanderbilt University Robustes interferometer und verfahren zur verwendung davon
US10850024B2 (en) 2015-03-02 2020-12-01 Icu Medical, Inc. Infusion system, device, and method having advanced infusion features
US10488321B2 (en) * 2015-03-19 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip
JP2017123813A (ja) * 2016-01-14 2017-07-20 東洋紡株式会社 検査装置
EP3408649B1 (de) 2016-01-29 2023-06-14 Vanderbilt University Interferometrie mit antwortfunktion in freier lösung
DE112016006197B4 (de) * 2016-02-22 2020-12-03 Hitachi High-Tech Corporation Lichtemittierende Detektionsvorrichtung
DE112016007594B3 (de) * 2016-02-22 2021-06-10 Hitachi High-Tech Corporation Lichtemittierende detektionsvorrichtung
WO2017167575A1 (en) * 2016-03-29 2017-10-05 Ge Healthcare Bio-Sciences Corp. Self-contained slide processing unit for biological specimens
CA3023658C (en) 2016-05-13 2023-03-07 Icu Medical, Inc. Infusion pump system and method with common line auto flush
AU2017277804B2 (en) 2016-06-10 2022-05-26 Icu Medical, Inc. Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion
DE102016124059B4 (de) * 2016-07-25 2019-12-19 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Vorrichtung für die mikrofluidik
US11085039B2 (en) 2016-12-12 2021-08-10 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
US11473081B2 (en) 2016-12-12 2022-10-18 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
JP7208902B2 (ja) 2016-12-30 2023-01-19 エクセラ・バイオサイエンシーズ・インコーポレイテッド マルチステージサンプル回収システム
EP3401014B1 (de) * 2017-05-10 2020-07-22 MiCareo Taiwan Co., Ltd. Mikrofluidischer chip, vorrichtung zur anreicherung von zellen und methode zur anreicherung von zellen in einem mikrofluidischen chip
US11067526B2 (en) 2017-08-17 2021-07-20 Abbott Point Of Care Inc. Devices, systems, and methods for performing optical and electrochemical assays
US11253852B2 (en) 2017-08-17 2022-02-22 Abbott Point Of Care Inc. Devices, systems, and methods for performing optical assays
CN110869746B (zh) 2017-08-17 2023-08-11 雅培医护站股份有限公司 利用通用电路系统执行光学和电化学测定的技术
JP7043220B2 (ja) 2017-10-30 2022-03-29 アークレイ株式会社 分析装置及び位置決め方法
US10089055B1 (en) 2017-12-27 2018-10-02 Icu Medical, Inc. Synchronized display of screen content on networked devices
WO2019130060A2 (en) * 2017-12-29 2019-07-04 Casela Technologies Fiber optic photon engine
EP3890876B1 (de) 2018-12-06 2024-05-01 Xcella Biosciences, Inc. Laterale belastung von mikrokapillaranordnungen
US11278671B2 (en) 2019-12-04 2022-03-22 Icu Medical, Inc. Infusion pump with safety sequence keypad
US12510461B2 (en) 2020-04-16 2025-12-30 Becton, Dickinson And Company Systems for light detection array multiplexing and methods for same
AU2021311443A1 (en) 2020-07-21 2023-03-09 Icu Medical, Inc. Fluid transfer devices and methods of use
DE102020128003A1 (de) 2020-10-23 2020-12-31 Bmg Labtech Gmbh Mikroplatten-Lesegerät
US11135360B1 (en) 2020-12-07 2021-10-05 Icu Medical, Inc. Concurrent infusion with common line auto flush
CN115244169B (zh) * 2021-01-29 2024-09-17 京东方科技集团股份有限公司 用于驱动微流控芯片的设备和驱动方法
KR102704928B1 (ko) * 2021-08-25 2024-09-10 한국기계연구원 순차적 유동 개시가 가능한 미세유로소자
US12599716B2 (en) 2021-10-12 2026-04-14 Icu Medical, Inc. Intravenous infusion pump with cassette insertion and pump control user interface
USD1091564S1 (en) 2021-10-13 2025-09-02 Icu Medical, Inc. Display screen or portion thereof with graphical user interface for a medical device
CA3241894A1 (en) 2021-12-10 2023-06-15 Icu Medical, Inc. Medical fluid compounding systems with coordinated flow control
WO2024247217A1 (ja) * 2023-06-01 2024-12-05 三菱電機株式会社 生体成分測定装置

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3486805A (en) 1965-02-20 1969-12-30 Asahi Optical Co Ltd Ultra-achromatic fluorite silica triplet lens system
US5274240A (en) 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US6309601B1 (en) * 1993-11-01 2001-10-30 Nanogen, Inc. Scanning optical detection system
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
CN1329729C (zh) * 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 微流体系统
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US6447727B1 (en) * 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
US6159739A (en) * 1997-03-26 2000-12-12 University Of Washington Device and method for 3-dimensional alignment of particles in microfabricated flow channels
WO1998049548A1 (en) * 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
US6001231A (en) * 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US5965410A (en) * 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6086740A (en) * 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
DE19916749B4 (de) * 1999-04-14 2004-02-12 Carl Zeiss Jena Gmbh Verfahren zur Untersuchung von Proben
JP2003502655A (ja) * 1999-06-22 2003-01-21 アジレント・テクノロジーズ・インコーポレーテッド 微小流体デバイスの操作用装置
US6156178A (en) * 1999-07-13 2000-12-05 Molecular Dynamics, Inc. Increased throughput analysis of small compounds using multiple temporally spaced injections
FR2797054A1 (fr) * 1999-07-27 2001-02-02 Commissariat Energie Atomique Dispositif de lecture de puce biologique
US6358387B1 (en) * 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods

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EP1277046A4 (de) 2003-09-03
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US6358387B1 (en) 2002-03-19
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US20010045358A1 (en) 2001-11-29
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AU2001249320B2 (en) 2005-10-06
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WO2001073417A9 (en) 2004-05-27
AU2006200021A1 (en) 2006-02-02
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US6881312B2 (en) 2005-04-19

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