ATE417127T1 - Nukelinsäuresequenzbestimmung mittels elektronischem nachweis - Google Patents

Nukelinsäuresequenzbestimmung mittels elektronischem nachweis

Info

Publication number
ATE417127T1
ATE417127T1 AT00953701T AT00953701T ATE417127T1 AT E417127 T1 ATE417127 T1 AT E417127T1 AT 00953701 T AT00953701 T AT 00953701T AT 00953701 T AT00953701 T AT 00953701T AT E417127 T1 ATE417127 T1 AT E417127T1
Authority
AT
Austria
Prior art keywords
nukelic
acid sequence
sequence determination
electronic detection
snps
Prior art date
Application number
AT00953701T
Other languages
English (en)
Inventor
Robert Umek
Gary Blackburn
Bruce Irvine
Robert H Terbrueggen
Changjun Yu
Jost G Vielmetter
Original Assignee
Clinical Micro Sensors Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Micro Sensors Inc filed Critical Clinical Micro Sensors Inc
Application granted granted Critical
Publication of ATE417127T1 publication Critical patent/ATE417127T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Composite Materials (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Insulating Materials (AREA)
  • Materials For Medical Uses (AREA)
AT00953701T 1999-07-26 2000-07-26 Nukelinsäuresequenzbestimmung mittels elektronischem nachweis ATE417127T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14569599P 1999-07-26 1999-07-26
US19025900P 2000-03-17 2000-03-17

Publications (1)

Publication Number Publication Date
ATE417127T1 true ATE417127T1 (de) 2008-12-15

Family

ID=26843217

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00953701T ATE417127T1 (de) 1999-07-26 2000-07-26 Nukelinsäuresequenzbestimmung mittels elektronischem nachweis

Country Status (9)

Country Link
US (1) US7935481B1 (de)
EP (1) EP1218541B1 (de)
JP (1) JP3926625B2 (de)
AT (1) ATE417127T1 (de)
AU (1) AU779220B2 (de)
CA (1) CA2380258C (de)
DE (1) DE60041072D1 (de)
ES (1) ES2319380T3 (de)
WO (1) WO2001007665A2 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1241000A (en) 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
JP2004532026A (ja) 2001-03-30 2004-10-21 アメルシャム・バイオサイエンシーズ・アクチボラグ P450単一ヌクレオチド多型バイオチップ分析
WO2003085082A2 (en) * 2001-04-03 2003-10-16 Clinical Micro Sensors, Inc. Nucleic acid reactions using labels with different redox potentials
US20030143556A1 (en) * 2001-04-03 2003-07-31 Gary Blackburn Nucleic acid reactions using labels with different redox potentials
WO2003018834A2 (de) 2001-08-25 2003-03-06 Friz Biochem Gmbh Verdrängungsassay zur detektion von nukleinsäureoligomer-hybridisierungsereignissen
DE10141691A1 (de) * 2001-08-25 2003-03-13 Friz Biochem Gmbh Verdrängungsassay zur Detektion von Ligat-Ligand-Assoziationsereignissen
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
DE10261528B4 (de) * 2002-12-23 2006-10-05 Friz Biochem Gesellschaft Für Bioanalytik Mbh Elektrisches Substrat zum Einsatz als Träger von Biomolekülen
CA2524585A1 (en) 2003-05-02 2004-11-11 Centrum Mikrobiologii I Wirusologii Polskiej Akademii Nauk Nucleoside derivative, modified oligonucleotide, method for their synthesis and applications thereof
CA2594483C (en) * 2005-01-28 2014-08-26 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
EP2639578B1 (de) 2006-12-14 2016-09-14 Life Technologies Corporation Vorrichtung zur Messung von Analyten mithilfe großer FET-Arrays
AT505495A1 (de) * 2007-07-04 2009-01-15 Arc Austrian Res Centers Gmbh Verfahren zur identifizierung und quantifizierung von organischen und biochemischen substanzen
US8648605B2 (en) * 2007-09-28 2014-02-11 Hitachi Chemical Company, Ltd. Sensor, sensor system, portable sensor system, method of analyzing metal ions, mounting substrate, method of analyzing plating preventing chemical species, method of analyzing produced compound, and method of analyzing monovalent copper chemical species
KR100819059B1 (ko) * 2007-10-08 2008-04-03 한국전자통신연구원 비대칭 디설파이드 정착기를 가지는 분자 전자소자용화합물 및 그 제조 방법과 그 화합물로부터 얻어지는 분자활성층을 가지는 분자 전자소자
KR100799593B1 (ko) 2007-10-08 2008-01-30 한국전자통신연구원 비대칭 디설파이드 정착기를 가지는 분자 전자소자용화합물 및 그 제조 방법과 그 화합물로부터 얻어지는 분자활성층을 가지는 분자 전자소자
CA2740414A1 (en) * 2008-10-14 2010-04-22 Bioaccel System and method for inferring str allelic genotype from snps
CN102301228A (zh) * 2008-10-22 2011-12-28 生命技术公司 用于生物和化学分析的集成式传感器阵列
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
EP3427830B1 (de) 2012-10-24 2021-06-23 Genmark Diagnostics Inc. Integrierte multiplex-zielanalyse
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス, インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
ES3038141T3 (en) 2014-11-11 2025-10-09 Hoffmann La Roche Fluid sample processing cartridge
EP3234576B1 (de) 2014-12-18 2023-11-22 Life Technologies Corporation Integrierte schaltung mit hoher datenrate und mit transmitterkonfiguration
US11300578B2 (en) 2016-09-19 2022-04-12 Roche Molecular Systems, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US12209274B2 (en) * 2017-05-31 2025-01-28 Centrillion Technology Holdings Corporation Oligonucleotide probe array with electronic detection system
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
EP3673086B1 (de) 2017-08-24 2025-04-09 Roche Diagnostics GmbH Elektrochemischer nachweis von bakteriellen und / oder pilzinfektionen
JP7813728B2 (ja) 2020-06-12 2026-02-13 エフ. ホフマン-ラ ロシュ アーゲー 診断装置上のベイを評価するためのシステムおよび方法
AU2023282374A1 (en) * 2022-06-07 2024-11-21 F. Hoffmann-La Roche Ag Ferrocene labelled primers for electrochemical detection

Family Cites Families (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1219824A (en) 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US5241060A (en) 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US5509410A (en) 1983-06-06 1996-04-23 Medisense, Inc. Strip electrode including screen printing of a single layer
GB8328520D0 (en) 1983-10-25 1983-11-23 Serono Diagnostics Ltd Methods of assay
US4840893A (en) 1983-12-16 1989-06-20 Medisense, Inc. Electrochemical assay for nucleic acids and nucleic acid probes
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US4707352A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US5013831A (en) 1984-01-30 1991-05-07 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4952685A (en) 1984-01-30 1990-08-28 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US5002885A (en) 1984-01-30 1991-03-26 Enzo Biochem, Inc. Detectable molecules, method preparation and use
US4943523A (en) 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US5175269A (en) 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
CA1260372A (en) 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
GB8417301D0 (en) 1984-07-06 1984-08-08 Serono Diagnostics Ltd Assay
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US4713347A (en) 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US5112974A (en) 1985-01-18 1992-05-12 The Trustees Of Columbia University In The City Of New York Mixed ligand complexes and uses thereof as binding agents to DNA
GB8507706D0 (en) 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5595908A (en) 1985-09-26 1997-01-21 University Of Southern Mississipi Piezoelectric device for detection of polynucleotide hybridization
US4876187A (en) 1985-12-05 1989-10-24 Meiogenics, Inc. Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
CA1273552A (en) 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CA1254945A (en) 1986-02-27 1989-05-30 Marco F. Cardosi Application of tetrathiafulvalenes in bioelectrochemical processes
US4704193A (en) 1986-05-14 1987-11-03 Gte Laboratories Incorporated Covalently coupled cofactor modified electrodes and methods of synthesis and use
US4851331A (en) 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
US5175270A (en) 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
ZA877772B (en) 1986-10-23 1988-04-20 Amoco Corporation Target and background capture methods and apparatus for affinity assays
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US4787963A (en) 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
FI80476C (fi) 1987-10-09 1990-06-11 Orion Yhtymae Oy Foerbaettrat hybridisationsfoerfarande, vid foerfarandet anvaent redskap och reagensfoerpackning.
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US5308754A (en) 1988-03-21 1994-05-03 Kankare Jouko J Electrogenerated luminescence in solution
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
IL92474A (en) 1988-11-29 1994-04-12 Orion Yhtymae Oy Reaction method and combination for determining nucleotide sequences
US5089112A (en) 1989-03-20 1992-02-18 Associated Universities, Inc. Electrochemical biosensor based on immobilized enzymes and redox polymers
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5015569A (en) 1989-12-01 1991-05-14 Board Of Trustees Of Leland Stanford University Acceleration of nucleic acid hybridization
CA2033692A1 (en) 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
EP0478319B1 (de) 1990-09-28 1997-04-02 Kabushiki Kaisha Toshiba Verfahren zum Gennachweis
US5776672A (en) 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
DE4039677A1 (de) 1990-12-12 1992-06-17 Boehringer Mannheim Gmbh Universalbindefilm
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5180968A (en) 1991-03-01 1993-01-19 Research Foundation Of State University Of New York Method and apparatus for compensation of double layer charging current in electrochemical cells
US5888819A (en) 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
RU1794088C (ru) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
US5171853A (en) 1991-08-05 1992-12-15 North Carolina State University Process of cleaving nucleic acids with oxoruthenium(IV) complexes
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
JP3509859B2 (ja) 1991-11-07 2004-03-22 ナノトロニクス,インコーポレイテッド 供与体−供与体エネルギー転移系を創製するための発色団および蛍光団でコンジュゲート化されたポリヌクレオチドのハイブリダイゼーション
DK0567635T3 (da) 1991-11-15 2000-09-25 Igen Int Inc Hurtige assays for amplifikationsprodukter
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5391272A (en) 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
DK0566751T3 (da) 1992-03-23 1996-03-04 Hoffmann La Roche DNA-påvisningsmetode
GB9210176D0 (en) 1992-05-12 1992-06-24 Cemu Bioteknik Ab Chemical method
GB9212010D0 (en) 1992-06-05 1992-07-15 Medisense Inc Mediators to oxidoreductase enzymes
US5710028A (en) 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
IL102930A (en) 1992-08-25 1997-03-18 Yissum Res Dev Co Electrobiochemical analytical method and electrodes
US5633134A (en) * 1992-10-06 1997-05-27 Ig Laboratories, Inc. Method for simultaneously detecting multiple mutations in a DNA sample
US5312527A (en) 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
JPH06153997A (ja) 1992-11-27 1994-06-03 Canon Inc 検出信号増幅による標的核酸の検出方法
EP0599337B1 (de) 1992-11-27 2006-03-08 Canon Kabushiki Kaisha Verfahren und Sonde zum Nachweis von Nukleinsäuren
US5244560A (en) 1992-12-29 1993-09-14 The Regents Of The University Of California Method of fabrication for capillary electrophoresis and electrochemical detector for the same
WO1994020841A1 (en) 1993-03-05 1994-09-15 University Of Wollongong Pulsed electrochemical detection using polymer electroactive electrodes
FR2703359B1 (fr) 1993-03-31 1995-06-23 Cis Bio Int Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5616464A (en) 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
EP0708839A1 (de) 1993-06-17 1996-05-01 ID Biomedical Corporation Verbesserte nukleinsäurereaktionen
AU7208894A (en) 1993-06-17 1995-01-17 Research Foundation Of The State University Of New York, The Improved methods for detecting nucleic acid sequences
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5861242A (en) 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
RU2041261C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ изготовления матрицы для детектирования мисматчей
RU2041262C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель
RU2041263C1 (ru) 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
AU7487294A (en) 1993-08-18 1995-03-14 Id Biomedical Corporation Compositions and methods for detecting target nucleic acid sequences utilizing flanking sequence enzyme molecules
WO1995008626A1 (en) 1993-09-20 1995-03-30 The Regents Of The University Of Colorado Strategy for the production of rna from immobilized templates
WO1995014106A2 (en) 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
IL108726A (en) 1994-02-22 1999-12-31 Yissum Res Dev Co Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor
US5871918A (en) 1996-06-20 1999-02-16 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
FR2720832A1 (fr) 1994-04-22 1995-12-08 Francis Garnier Electrodes et membranes électroactives à base de peptides bioactifs, pour la reconnaissance, l'extraction ou le relargage d'espèces biologiquement actives.
SE9402116D0 (sv) 1994-06-15 1994-06-15 Pharmacia Biosensor Ab A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate
GB9417211D0 (en) 1994-08-25 1994-10-12 Solicitor For The Affairs Of H Nucleotide sequencing method
AU703344B2 (en) 1994-08-26 1999-03-25 Igen International, Inc. Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5601982A (en) 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
KR100449615B1 (ko) 1995-03-10 2004-12-08 메소 스케일 테크놀러지즈, 엘엘시 다-배열,다-특이적전기화학발광시험법
DE19515552A1 (de) 1995-04-27 1996-10-31 Europ Lab Molekularbiolog Simultane Sequenzierung von Nukleinsäuren
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
NZ311955A (en) 1995-06-27 1999-04-29 Univ North Carolina Electrochemical detection of nucleic acid hybridization
US5968745A (en) 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US5747255A (en) 1995-09-29 1998-05-05 Lynx Therapeutics, Inc. Polynucleotide detection by isothermal amplification using cleavable oligonucleotides
DE19536858C2 (de) 1995-10-03 2000-04-13 Danfoss As Verfahren und Vorrichtung zum Transport eines Fluids durch einen Kanal
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5830341A (en) 1996-01-23 1998-11-03 Gilmartin; Markas A. T. Electrodes and metallo isoindole ringed compounds
US5795453A (en) 1996-01-23 1998-08-18 Gilmartin; Markas A. T. Electrodes and metallo isoindole ringed compounds
US5861247A (en) 1996-01-26 1999-01-19 University Of Chicago Rapid method to detect duplex formation in sequencing by hybridization methods
US5851772A (en) 1996-01-29 1998-12-22 University Of Chicago Microchip method for the enrichment of specific DNA sequences
ATE234462T1 (de) 1996-04-25 2003-03-15 Pence Inc Biosensor-vorrichtung und verfahren
US6107080A (en) 1996-04-25 2000-08-22 Mcgill University Biosensor device and method
WO1998004740A1 (en) 1996-07-29 1998-02-05 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US5874046A (en) 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
AU739375B2 (en) * 1996-11-05 2001-10-11 Clinical Micro Sensors, Inc. Electrodes linked via conductive oligomers to nucleic acids
US5942397A (en) 1996-12-11 1999-08-24 Tarlov; Michael J. Surface immobilization of biopolymers
AU5716098A (en) 1996-12-23 1998-07-17 University Of Chicago, The Customized oligonucleotide microchips as multiple biosensors
US6306584B1 (en) 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
JP2002524021A (ja) 1997-02-06 2002-07-30 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 分子相互作用の検出および薬剤発見のための電気化学的プローブ
WO1998049344A1 (en) 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
US6060327A (en) 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
ATE335845T1 (de) 1997-05-16 2006-09-15 Exact Sciences Corp Elektrophoretische analyse von molekülen mit immobilisierten sonden
US6587082B1 (en) 1997-06-10 2003-07-01 Stacey Y. Moore Multiple access computer monitoring system
AU744503B2 (en) * 1997-06-12 2002-02-28 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes
WO1999013109A1 (en) 1997-09-11 1999-03-18 Seq, Ltd. Method for dna sequencing analysis
SE9703314D0 (sv) 1997-09-15 1997-09-15 Sangtec Medical Ab Capacity affinity sensor
DE19741716A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Adressierbares modulares Erkennungssystem, seine Herstellung und Verwendung
US5945286A (en) 1997-10-23 1999-08-31 Motorola, Inc. Electrochemical-based molecular detection apparatus and method
US6203758B1 (en) 1997-11-10 2001-03-20 Bio-Pixel Ltd. Micro-circuit system with array of functionalized micro-electrodes
US5922617A (en) 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
WO1999037819A2 (en) 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6686150B1 (en) * 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6060023A (en) 1998-03-31 2000-05-09 Motorola, Inc. Molecular sensing apparatus
WO1999057319A1 (en) * 1998-05-06 1999-11-11 Clinical Micro Sensors Electronic detection of nucleic acids using monolayers
US6290839B1 (en) * 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
AU1241000A (en) * 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6361671B1 (en) 1999-01-11 2002-03-26 The Regents Of The University Of California Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels

Also Published As

Publication number Publication date
EP1218541B1 (de) 2008-12-10
US7935481B1 (en) 2011-05-03
WO2001007665A9 (en) 2002-07-11
JP2004500033A (ja) 2004-01-08
JP3926625B2 (ja) 2007-06-06
EP1218541A2 (de) 2002-07-03
DE60041072D1 (de) 2009-01-22
WO2001007665A2 (en) 2001-02-01
AU6610400A (en) 2001-02-13
WO2001007665A3 (en) 2002-05-02
CA2380258A1 (en) 2001-02-01
CA2380258C (en) 2008-07-15
AU779220B2 (en) 2005-01-13
ES2319380T3 (es) 2009-05-07

Similar Documents

Publication Publication Date Title
DE60041072D1 (de) Em nachweis
EP1456409A4 (de) Paralleles scoring von polymorphismen mittels amplifikation und fehlerkorrektur
WO2005044836A3 (de) Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
WO2002038806A3 (de) Nachweis von nukleinsäure-polymorphismen
WO2004081186A3 (en) Single nucleotide polymorphisms associated with stenosis, methods of detection and uses thereof
DK1178999T3 (da) L-RIBO-LNA-analoger
ATE542922T1 (de) 2'-terminator-assoziierte pyrophosphorolyse- aktivierte polymerisierung
ATE396993T1 (de) Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität
ATE315666T1 (de) Methode zur amplifizierung und möglicher charakterisierung von nukleinsäuren
WO2004023092A3 (en) Genetic analysis and authentication
WO2004072238A3 (en) Terminal-phosphate-labeled nucleotides with new linkers
AU2003241311A8 (en) Simple catalytic dna biosensors for ions based on color changes
ATE299185T1 (de) Hemmung der expression von genen mittels dsrna
EP2500440A3 (de) Mit Myokardinfarkt assoziierte genetische Polymorphismen, Nachweisverfahren und deren Verwendungen
IL154689A0 (en) Compositions containing nucleic acid primers or constructs and methods for detecting nucleic acids using the same
WO2005035545A3 (en) Single nucleotide polymorphism analysis of highly polymorphic target sequences
DE50001509D1 (de) Carboxylfunktionelles additiv zur aufkondensierung von polyamiden
BR0109062A (pt) Inibidores de frutose-1,6-bisfosfatase de arila
DE60235005D1 (de) Nachweis der instabilität von mikrosatelliten und
DE60132471D1 (de) Modulation der immunostimulatorischen aktivität von immunostimulierenden oligonukleotidanaloga durch positionelle chemische veränderungen
BRPI0409048A (pt) composição curável, composição de revestimento, método de produção de revestimento sobre um substrato e método de produção de sistema de multiplos revestimentos
WO2004065570A3 (en) Methods of metallizing nucleic acid molecules and methods of attaching nucleic acid molecules to conductive surfaces
WO2002061121A3 (en) Methods of analysis of nucleic acids
HUP0203914A2 (en) High order nucleic acid based structures
CA2506797A1 (en) Detectable labeled nucleoside analogs and methods of use thereof

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties