ATE396993T1 - Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität - Google Patents
Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivitätInfo
- Publication number
- ATE396993T1 ATE396993T1 AT03724241T AT03724241T ATE396993T1 AT E396993 T1 ATE396993 T1 AT E396993T1 AT 03724241 T AT03724241 T AT 03724241T AT 03724241 T AT03724241 T AT 03724241T AT E396993 T1 ATE396993 T1 AT E396993T1
- Authority
- AT
- Austria
- Prior art keywords
- chemokine receptor
- tetrahydropyranyl
- cyclopentyl
- receptor activity
- modulators
- Prior art date
Links
- 102000009410 Chemokine receptor Human genes 0.000 title abstract 2
- 108050000299 Chemokine receptor Proteins 0.000 title abstract 2
- WBUHGSNIYBJEDA-UHFFFAOYSA-N 1-cyclopentyl-2-(oxan-2-yl)-3,4-dihydro-2h-1,5-naphthyridine Chemical compound C1CCCC1N1C2=CC=CN=C2CCC1C1OCCCC1 WBUHGSNIYBJEDA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 abstract 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37618002P | 2002-04-29 | 2002-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE396993T1 true ATE396993T1 (de) | 2008-06-15 |
Family
ID=29401316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03724241T ATE396993T1 (de) | 2002-04-29 | 2003-04-25 | Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6812234B2 (de) |
| EP (1) | EP1501507B1 (de) |
| JP (1) | JP3780291B2 (de) |
| AT (1) | ATE396993T1 (de) |
| AU (1) | AU2003231114B8 (de) |
| CA (1) | CA2483752C (de) |
| CY (1) | CY1110399T1 (de) |
| DE (1) | DE60321333D1 (de) |
| DK (1) | DK1501507T3 (de) |
| ES (1) | ES2306867T3 (de) |
| NZ (1) | NZ536477A (de) |
| PT (1) | PT1501507E (de) |
| SI (1) | SI1501507T1 (de) |
| WO (1) | WO2003092586A2 (de) |
| ZA (1) | ZA200407940B (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| MY129850A (en) | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| MXPA05005660A (es) | 2002-11-27 | 2005-10-18 | Incyte Corp | Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina. |
| US7393844B2 (en) * | 2003-03-18 | 2008-07-01 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity |
| KR20060003353A (ko) * | 2003-04-15 | 2006-01-10 | 머크 앤드 캄파니 인코포레이티드 | 케모킨 수용체의벤족사지닐-아미도사이클로펜틸-헤테로사이클릭 조절제 |
| CA2521625A1 (en) * | 2003-04-17 | 2004-11-04 | Merck & Co., Inc. | Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity |
| US20060205761A1 (en) * | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
| AR045875A1 (es) | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
| ATE517622T1 (de) * | 2003-10-27 | 2011-08-15 | Merck Sharp & Dohme | Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten |
| BRPI0417605B8 (pt) | 2003-12-18 | 2021-05-25 | Incyte Corp | n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende. |
| EP1701724A4 (de) * | 2004-01-02 | 2007-11-14 | Merck & Co Inc | Alkylamino-, arylamino- und sulfonamidocyclopentylamidmodulatoren der aktivität von chemokinrezeptoren |
| CA2554387A1 (en) * | 2004-01-28 | 2005-08-11 | Merck & Co., Inc. | Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity |
| JP2007534758A (ja) * | 2004-04-26 | 2007-11-29 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性調節物質であるテトラヒドロピラニルシクロペンチル１−置換及び１，１−二置換テトラヒドロイソキノリン |
| CN1972913A (zh) * | 2004-04-26 | 2007-05-30 | 默克公司 | 四氢吡喃基环戊基四氢吡啶并吡啶趋化因子受体活性调节剂 |
| WO2005105092A2 (en) * | 2004-04-28 | 2005-11-10 | Merck & Co., Inc. | 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity |
| JP2007537264A (ja) * | 2004-05-11 | 2007-12-20 | インサイト コーポレイション | ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド |
| JP4116670B2 (ja) | 2004-06-28 | 2008-07-09 | インサイト コーポレイション | ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド |
| WO2006004741A2 (en) | 2004-06-28 | 2006-01-12 | Incyte Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| US20070238723A1 (en) * | 2004-10-15 | 2007-10-11 | Goble Stephen D | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| CN101098700A (zh) * | 2005-01-06 | 2008-01-02 | 默克公司 | 治疗炎性疾病的药物组合疗法和药用组合物 |
| EP1861386A1 (de) * | 2005-03-11 | 2007-12-05 | Merck & Co., Inc. | Verfahren für die zubereitung von (r)-4,4-dialkoxy-pyran-3-olen wie (r)-4,4-dimethoxy-pyran-3-ol |
| WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| WO2007053499A2 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| PT2370442E (pt) * | 2008-11-26 | 2013-06-27 | Pfizer | 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina |
| HUE025547T2 (en) | 2008-12-19 | 2016-02-29 | Boehringer Ingelheim Int | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| WO2011087712A2 (en) | 2009-12-22 | 2011-07-21 | Cephalon, Inc. | Tricyclic derivatives and their pharmaceutical use and compositions |
| US9040526B2 (en) | 2010-02-09 | 2015-05-26 | Bristol-Myers Squibb Company | Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity |
| EP2576542B1 (de) * | 2010-05-25 | 2015-04-22 | Boehringer Ingelheim International GmbH | Zur Behandlung von Atemwegs-, Schmerz,- Immun- und cardoivaskulären Erkrankungen geeignete cyclische Amidderivate von Pyridazin-3-carbonsäuren |
| WO2012125663A2 (en) * | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists |
| US8822460B2 (en) * | 2012-04-06 | 2014-09-02 | Janssen Pharmaceutica Nv | Fused cyclopentyl antagonists of CCR2 |
| EP2962691A4 (de) | 2013-02-28 | 2016-08-31 | Santen Pharmaceutical Co Ltd | Mittel zur prävention oder behandlung von erkrankungen der hinteren teile des auges mit einem tetrahydropyranyl-amino-cyclopentylcarbonyl-tetrahydropyridopyridin-derivat als wirkstoff |
| ES2904252T3 (es) | 2015-05-21 | 2022-04-04 | Chemocentryx Inc | Moduladores de CCR2 |
| MX383744B (es) | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
| EP3570893A1 (de) | 2017-01-17 | 2019-11-27 | GlaxoSmithKline Intellectual Property Development Ltd | Nicht-peptidische heterobivalente moleküle zur behandlung von entzündlichen erkrankungen |
| CN118267479A (zh) | 2017-09-25 | 2024-07-02 | 凯莫森特里克斯股份有限公司 | 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗 |
| IL275898B2 (en) | 2018-01-08 | 2025-05-01 | Chemocentryx Inc | Methods for treating solid tumors with CCR2 antagonists |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| CN119925562B (zh) * | 2023-11-03 | 2025-11-28 | 中国科学院上海药物研究所 | 趋化因子受体2拮抗剂在制备治疗糖尿病并发焦虑症的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
| US3647804A (en) * | 1970-02-27 | 1972-03-07 | Upjohn Co | Cycloalkanecarboxamides |
| US3772308A (en) * | 1972-06-02 | 1973-11-13 | Lilly Co Eli | Cyclopentanecetamides and cyclopentaneacetonitriles |
| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| JPH09291034A (ja) * | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
| GB9812037D0 (en) | 1998-06-04 | 1998-07-29 | Pfizer Ltd | Piperidones |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| AU5473400A (en) * | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| EP1318811B1 (de) * | 2000-08-17 | 2006-08-30 | Merck & Co., Inc. | Cyclopentylmodulatoren der chemokin-rezeptor-aktivität |
| CA2440803A1 (en) | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| MY129850A (en) * | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
-
2003
- 2003-04-25 EP EP03724241A patent/EP1501507B1/de not_active Expired - Lifetime
- 2003-04-25 WO PCT/US2003/012929 patent/WO2003092586A2/en not_active Ceased
- 2003-04-25 DE DE60321333T patent/DE60321333D1/de not_active Expired - Lifetime
- 2003-04-25 DK DK03724241T patent/DK1501507T3/da active
- 2003-04-25 JP JP2004500771A patent/JP3780291B2/ja not_active Expired - Fee Related
- 2003-04-25 SI SI200331285T patent/SI1501507T1/sl unknown
- 2003-04-25 NZ NZ536477A patent/NZ536477A/en not_active IP Right Cessation
- 2003-04-25 CA CA2483752A patent/CA2483752C/en not_active Expired - Lifetime
- 2003-04-25 AU AU2003231114A patent/AU2003231114B8/en not_active Ceased
- 2003-04-25 PT PT03724241T patent/PT1501507E/pt unknown
- 2003-04-25 ES ES03724241T patent/ES2306867T3/es not_active Expired - Lifetime
- 2003-04-25 AT AT03724241T patent/ATE396993T1/de active
- 2003-04-29 US US10/425,167 patent/US6812234B2/en not_active Expired - Lifetime
-
2004
- 2004-10-01 ZA ZA200407940A patent/ZA200407940B/en unknown
-
2008
- 2008-08-26 CY CY20081100915T patent/CY1110399T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2306867T3 (es) | 2008-11-16 |
| DK1501507T3 (da) | 2008-09-29 |
| WO2003092586A3 (en) | 2004-09-16 |
| DE60321333D1 (de) | 2008-07-10 |
| CA2483752A1 (en) | 2003-11-13 |
| CY1110399T1 (el) | 2014-04-09 |
| ZA200407940B (en) | 2006-06-28 |
| WO2003092586A2 (en) | 2003-11-13 |
| PT1501507E (pt) | 2008-08-12 |
| SI1501507T1 (sl) | 2008-12-31 |
| JP3780291B2 (ja) | 2006-05-31 |
| AU2003231114B2 (en) | 2008-07-24 |
| AU2003231114B8 (en) | 2008-08-14 |
| EP1501507B1 (de) | 2008-05-28 |
| JP2005523929A (ja) | 2005-08-11 |
| US20040167156A1 (en) | 2004-08-26 |
| EP1501507A2 (de) | 2005-02-02 |
| US6812234B2 (en) | 2004-11-02 |
| AU2003231114A1 (en) | 2003-11-17 |
| NZ536477A (en) | 2005-05-27 |
| EP1501507A4 (de) | 2006-05-17 |
| CA2483752C (en) | 2011-03-29 |
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Legal Events
| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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