ATE396993T1 - Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität - Google Patents

Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität

Info

Publication number
ATE396993T1
ATE396993T1 AT03724241T AT03724241T ATE396993T1 AT E396993 T1 ATE396993 T1 AT E396993T1 AT 03724241 T AT03724241 T AT 03724241T AT 03724241 T AT03724241 T AT 03724241T AT E396993 T1 ATE396993 T1 AT E396993T1
Authority
AT
Austria
Prior art keywords
chemokine receptor
tetrahydropyranyl
cyclopentyl
receptor activity
modulators
Prior art date
Application number
AT03724241T
Other languages
English (en)
Inventor
Richard Jiao
Gregori Morriello
Lihu Yang
Stephen Goble
Sander Mills
Alexander Pasternak
Changyou Zhou
Gabor Butora
Shankaran Kothandaraman
Deodialsingh Guiadeen
Cheng Tang
Christopher Moyes
Original Assignee
Merck & Co Inc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Sharp & Dohme filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE396993T1 publication Critical patent/ATE396993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03724241T 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität ATE396993T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37618002P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
ATE396993T1 true ATE396993T1 (de) 2008-06-15

Family

ID=29401316

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03724241T ATE396993T1 (de) 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität

Country Status (15)

Country Link
US (1) US6812234B2 (de)
EP (1) EP1501507B1 (de)
JP (1) JP3780291B2 (de)
AT (1) ATE396993T1 (de)
AU (1) AU2003231114B8 (de)
CA (1) CA2483752C (de)
CY (1) CY1110399T1 (de)
DE (1) DE60321333D1 (de)
DK (1) DK1501507T3 (de)
ES (1) ES2306867T3 (de)
NZ (1) NZ536477A (de)
PT (1) PT1501507E (de)
SI (1) SI1501507T1 (de)
WO (1) WO2003092586A2 (de)
ZA (1) ZA200407940B (de)

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AU2004287416C1 (en) * 2003-10-27 2010-09-09 Merck Sharp & Dohme Corp. CCR-2 antagonist salt
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CA2551869A1 (en) * 2004-01-02 2005-07-28 Merck & Co., Inc. Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
JP2007519734A (ja) * 2004-01-28 2007-07-19 メルク　エンド　カムパニー　インコーポレーテッド アミノシクロペンチルピリドピラジノン系ケモカイン受容体活性調節剤
EP1742915A4 (de) 2004-04-26 2009-12-02 Merck & Co Inc Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokinrezeptoraktivität
EP1742919A4 (de) * 2004-04-26 2010-04-28 Merck Sharp & Dohme Tetrahydropyranyl-cyclopentyl-1-substituierte und 1,1-disubstituierte tetrahydroisochinoline-modulatoren der chemokinrezeptoraktivität
CN101103027A (zh) * 2004-04-28 2008-01-09 默克公司 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂
JP2007537264A (ja) * 2004-05-11 2007-12-20 インサイト コーポレイション ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド
GEP20094843B (en) 2004-06-28 2009-11-25 Incyte Corp 3-aminocyclopentane carboxamides as modulators of chemokine receptors
EP1763347A4 (de) 2004-06-28 2009-05-20 Incyte Corp 3-aminocyclopentanecarboxamide als chemokinrezeptor-modulatoren
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
US20080194548A1 (en) * 2005-01-06 2008-08-14 Forrest Michael J Drug Combination Therapy and Pharmaceutical Compositions for Treating Inflammatory Disorders
CA2599897A1 (en) * 2005-03-11 2006-09-21 Merck & Co., Inc. Process for the preparation of (r)-4,4-dialkoxy-pyran-3-ols such as (r)-4,4-dimethoxy-pyran-3-ol
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
CA2743030C (en) * 2008-11-26 2013-10-22 Pfizer Inc. 3-aminocyclopentanecarboxamides as chemokine receptor modulators
DK2379525T3 (en) 2008-12-19 2015-10-19 Boehringer Ingelheim Int Cyclic pyrimidin-4-carboxamides, as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
WO2011073154A1 (en) 2009-12-17 2011-06-23 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists and uses thereof
ES2539382T3 (es) 2009-12-22 2015-06-30 Cephalon, Inc. Derivados tricíclicos y su uso farmacéutico y composiciones
EP2534158B1 (de) * 2010-02-09 2014-01-08 Bristol-Myers Squibb Company Benzylpyrrolidinonderivate als modulatoren der chemokin-rezeptoraktivität
US9018212B2 (en) * 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
US20130345254A1 (en) * 2011-03-17 2013-12-26 Anilkumar G. Nair Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
HK1216233A1 (zh) 2013-02-28 2016-10-28 参天制药株式会社 含有四氢吡喃基氨基环戊基羰基四氢吡啶并吡啶衍生物作为有效成分的眼後段疾病的预防或治疗剂
PT3297438T (pt) 2015-05-21 2022-01-25 Chemocentryx Inc Moduladores de ccr2
WO2017004537A1 (en) 2015-07-02 2017-01-05 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
WO2018134731A1 (en) 2017-01-17 2018-07-26 Glaxosmithkline Intellectual Property Development Limited Non peptidic heterobivalent molecules for treating inflammatory diseases
MA50665A (fr) 2017-09-25 2020-08-05 Chemocentryx Inc Polythérapie utilisant un antagoniste du récepteur 2 de la chimiokine (ccr2) et un inhibiteur pd-1/pd-l1
IL275898B2 (en) 2018-01-08 2025-05-01 Chemocentryx Inc Methods for treating solid tumors with CCR2 antagonists
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
CN119925562B (zh) * 2023-11-03 2025-11-28 中国科学院上海药物研究所 趋化因子受体2拮抗剂在制备治疗糖尿病并发焦虑症的应用

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US3647804A (en) * 1970-02-27 1972-03-07 Upjohn Co Cycloalkanecarboxamides
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JP2004506013A (ja) * 2000-08-17 2004-02-26 メルク　エンド　カムパニー　インコーポレーテッド シクロペンチル系ケモカイン受容体活性調節剤
MXPA03008109A (es) 2001-03-07 2003-12-12 Pfizer Prod Inc Moduladores de la actividad de receptores de quimiocinas.
JO2479B1 (en) * 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine

Also Published As

Publication number Publication date
PT1501507E (pt) 2008-08-12
DE60321333D1 (de) 2008-07-10
CA2483752A1 (en) 2003-11-13
EP1501507A2 (de) 2005-02-02
US20040167156A1 (en) 2004-08-26
WO2003092586A3 (en) 2004-09-16
EP1501507A4 (de) 2006-05-17
NZ536477A (en) 2005-05-27
CA2483752C (en) 2011-03-29
US6812234B2 (en) 2004-11-02
AU2003231114B2 (en) 2008-07-24
ZA200407940B (en) 2006-06-28
AU2003231114B8 (en) 2008-08-14
ES2306867T3 (es) 2008-11-16
JP3780291B2 (ja) 2006-05-31
AU2003231114A1 (en) 2003-11-17
DK1501507T3 (da) 2008-09-29
JP2005523929A (ja) 2005-08-11
EP1501507B1 (de) 2008-05-28
SI1501507T1 (sl) 2008-12-31
WO2003092586A2 (en) 2003-11-13
CY1110399T1 (el) 2014-04-09

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