ATE417276T1 - Proteinphosphorylierung in t-zellrezeptor- signalwegen - Google Patents

Proteinphosphorylierung in t-zellrezeptor- signalwegen

Info

Publication number
ATE417276T1
ATE417276T1 AT04794025T AT04794025T ATE417276T1 AT E417276 T1 ATE417276 T1 AT E417276T1 AT 04794025 T AT04794025 T AT 04794025T AT 04794025 T AT04794025 T AT 04794025T AT E417276 T1 ATE417276 T1 AT E417276T1
Authority
AT
Austria
Prior art keywords
modified peptide
specific antibody
modification
preparation
modified
Prior art date
Application number
AT04794025T
Other languages
English (en)
Inventor
Albrecht Moritz
Kimberly Lee
John Rush
Roberto Polakiewicz
Original Assignee
Cell Signaling Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Signaling Technology Inc filed Critical Cell Signaling Technology Inc
Application granted granted Critical
Publication of ATE417276T1 publication Critical patent/ATE417276T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT04794025T 2004-02-12 2004-10-04 Proteinphosphorylierung in t-zellrezeptor- signalwegen ATE417276T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/777,893 US7300753B2 (en) 1998-09-04 2004-02-12 Immunoaffinity isolation of modified peptides from complex mixtures

Publications (1)

Publication Number Publication Date
ATE417276T1 true ATE417276T1 (de) 2008-12-15

Family

ID=34911345

Family Applications (3)

Application Number Title Priority Date Filing Date
AT04777654T ATE417273T1 (de) 2004-02-12 2004-07-07 Proteinphosphorylierung bei grosszellig- anaplastischem lymphom
AT04780956T ATE419379T1 (de) 2004-02-12 2004-08-12 Proteinphosphorylierung in c-src-signalwegen
AT04794025T ATE417276T1 (de) 2004-02-12 2004-10-04 Proteinphosphorylierung in t-zellrezeptor- signalwegen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT04777654T ATE417273T1 (de) 2004-02-12 2004-07-07 Proteinphosphorylierung bei grosszellig- anaplastischem lymphom
AT04780956T ATE419379T1 (de) 2004-02-12 2004-08-12 Proteinphosphorylierung in c-src-signalwegen

Country Status (8)

Country Link
US (1) US7300753B2 (de)
EP (3) EP1718976B1 (de)
JP (2) JP2005225858A (de)
AT (3) ATE417273T1 (de)
CA (3) CA2556021A1 (de)
DE (3) DE602004018388D1 (de)
ES (3) ES2317044T3 (de)
WO (3) WO2005083439A1 (de)

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US9085609B2 (en) * 1998-09-04 2015-07-21 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US20110111424A1 (en) * 2001-06-21 2011-05-12 Cell Signaling Technology, Inc. Analysis of ubiquitinated polypeptides
US7563584B2 (en) 2001-07-10 2009-07-21 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting the activation state of multiple proteins in single cells
US7393656B2 (en) * 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7381535B2 (en) 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
US7973134B2 (en) * 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
US7935790B2 (en) * 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
US20060172429A1 (en) * 2005-01-31 2006-08-03 Nilsson Erik J Methods of identification of biomarkers with mass spectrometry techniques
US20090099340A1 (en) * 2007-10-12 2009-04-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
PL1891446T3 (pl) * 2005-06-14 2013-08-30 Cellzome Gmbh Sposób identyfikacji nowych związków oddziałujących z enzymami
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WO2007027906A2 (en) * 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
WO2007027957A2 (en) * 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
US20100151495A9 (en) * 2005-08-31 2010-06-17 Cell Signaling Technolgy, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
CN101321782A (zh) 2005-12-01 2008-12-10 纽约血库公司 Abl激酶的肽抑制剂
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WO2008127248A1 (en) * 2007-04-13 2008-10-23 Cell Signaling Technology, Inc. Gene defects and mutant alk kinase in human solid tumors
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WO2007127335A2 (en) * 2006-04-27 2007-11-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in atm and atr kinase signaling pathways
US20090203034A1 (en) * 2006-05-12 2009-08-13 Ailan Guo Reagents for the detection of tyrosine phosphorylation in brain ischemia signaling pathways
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US7939636B2 (en) * 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
US20090258442A1 (en) * 2006-08-31 2009-10-15 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
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EP1975184A3 (de) * 2007-03-26 2008-11-26 Cell Signaling Technology, Inc. Serin- oder Threonin-Phosphorylationsorte
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US20090220991A1 (en) * 2008-02-29 2009-09-03 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
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Also Published As

Publication number Publication date
US20050003450A1 (en) 2005-01-06
EP1718977B1 (de) 2008-12-10
ES2321197T3 (es) 2009-06-03
JP2007308506A (ja) 2007-11-29
CA2556019A1 (en) 2005-09-09
DE602004018836D1 (de) 2009-02-12
EP1718760B1 (de) 2008-12-31
DE602004018390D1 (de) 2009-01-22
WO2005083113A1 (en) 2005-09-09
DE602004018388D1 (de) 2009-01-22
JP2005225858A (ja) 2005-08-25
EP1718760A1 (de) 2006-11-08
ES2321520T3 (es) 2009-06-08
WO2005083444A1 (en) 2005-09-09
ATE417273T1 (de) 2008-12-15
ES2317044T3 (es) 2009-04-16
EP1718977A1 (de) 2006-11-08
CA2556022A1 (en) 2005-09-09
EP1718976B1 (de) 2008-12-10
US7300753B2 (en) 2007-11-27
EP1718976A1 (de) 2006-11-08
WO2005083439A1 (en) 2005-09-09
CA2556021A1 (en) 2005-09-09
ATE419379T1 (de) 2009-01-15

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