ATE418338T1 - Camptothecin-analoge und verfahren zu ihrer herstellung - Google Patents

Camptothecin-analoge und verfahren zu ihrer herstellung

Info

Publication number: ATE418338T1
Authority: AT; Austria
Prior art keywords: group; alkyl; hydrogen; together form; alkoxyl
Prior art date: 1997-08-29

Application number

AT98944535T

Other languages

English (en)

Inventor

Dennis Curran

Hubert Josien

David Bom

Original Assignee

Univ Pittsburgh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-29

Filing date

1998-08-26

Publication date

2009-01-15

1998-08-26 Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE418338T1 publication Critical patent/ATE418338T1/de

Links

238000000034 method Methods 0.000 title abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
125000006593 (C2-C3) alkynyl group Chemical group 0.000 abstract 1
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
102000003915 DNA Topoisomerases Human genes 0.000 abstract 1
108090000323 DNA Topoisomerases Proteins 0.000 abstract 1
230000007018 DNA scission Effects 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
-1 carbamoyloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/083—Syntheses without formation of a Si-C bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT98944535T 1997-08-29 1998-08-26 Camptothecin-analoge und verfahren zu ihrer herstellung ATE418338T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/921,102 US6150343A (en)	1993-06-30	1997-08-29	Camptothecin analogs and methods of preparation thereof

Publications (1)

Publication Number	Publication Date
ATE418338T1 true ATE418338T1 (de)	2009-01-15

Family

ID=25444921

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98944535T ATE418338T1 (de)	1997-08-29	1998-08-26	Camptothecin-analoge und verfahren zu ihrer herstellung

Country Status (9)

Country	Link
US (6)	US6150343A (de)
EP (1)	EP1017399B1 (de)
JP (1)	JP4903936B2 (de)
AT (1)	ATE418338T1 (de)
AU (1)	AU760543B2 (de)
CA (1)	CA2302226C (de)
DE (1)	DE69840388D1 (de)
ES (1)	ES2320183T3 (de)
WO (1)	WO1999009996A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6150343A (en) *	1993-06-30	2000-11-21	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
US6743917B2 (en)	1993-06-30	2004-06-01	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
US6136978A (en) *	1993-06-30	2000-10-24	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
FR2754179B1 (fr)	1996-10-08	1998-12-24	Theramex	Nouvelle composition hormononale et son utilisation
US6207832B1 (en) *	1999-04-09	2001-03-27	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
WO2002062340A1 (en) *	2001-02-07	2002-08-15	University Of Kentucky Research Foundation	Highly lipophilic camptothecin prodrugs, methods of preparation, and formulations thereof
US6372906B1 (en)	2001-04-12	2002-04-16	University Of Pittsburgh	Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en)	2001-08-27	2004-04-20	University Of Pittsburgh	Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
WO2003099825A1 (en) *	2002-05-22	2003-12-04	University Of Pittsburgh	Synthesis of polycyclic quinolines
JP4701185B2 (ja)	2003-12-17	2011-06-15	バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド	カンプトテシン誘導体の製造方法
US7346153B2 (en) *	2004-11-12	2008-03-18	International Business Machines Corporation	Dynamically alerting callers of changes to menu structures in a telephone prompting system
PE20080145A1 (es) *	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
US8410045B2 (en)	2006-03-30	2013-04-02	Drais Pharmaceuticals, Inc.	Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
WO2009051578A1 (en) *	2007-10-16	2009-04-23	Bionumerik Pharmaceuticals, Inc.	C10-substituted camptothecin analogs
WO2009051580A1 (en) *	2007-10-16	2009-04-23	Bionumerik Pharmaceuticals, Inc.	C7-substituted camptothecin analogs
WO2009078999A1 (en)	2007-12-17	2009-06-25	Janssen Pharmaceutica N.V.	Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
CN107428770B (zh) *	2014-10-22	2019-10-01	维瓦西塔斯肿瘤学公司	用于喜树碱类似物合成的方法和体系

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5405963A (en) *	1993-06-10	1995-04-11	Smithkline Beecham Corporation	Process for asymmetric total synthesis of camptothecin analogues
US6136978A (en) *	1993-06-30	2000-10-24	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
US6252079B1 (en)	1993-06-30	2001-06-26	University Of Pittsburgh	Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
US6211371B1 (en)	1993-06-30	2001-04-03	University Of Pittsburgh	Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
US6150343A (en) *	1993-06-30	2000-11-21	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
US6743917B2 (en) *	1993-06-30	2004-06-01	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
US5744605A (en)	1993-06-30	1998-04-28	University Of Pittsburgh	Intermediates in the synthesis of (+) camptothecin and related compounds and synthesis thereof
IL127800A (en) *	1996-08-19	2005-11-20	Bionumerik Pharmaceuticals Inc	Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them
US6169080B1 (en) *	1997-02-13	2001-01-02	Bionumerik Pharmaceuticals, Inc.	Highly lipophilic camptothecin derivatives
AU6272598A (en) *	1997-02-14	1998-09-08	Bionumerik Pharmaceuticals, Inc.	Highly lipophilic camptothecin derivatives
US6948279B1 (en)	1997-04-22	2005-09-27	Caldwell Manufacturing Company	Support system for laterally removable sash
US6057303A (en) *	1998-10-20	2000-05-02	Bionumerik Pharmaceuticals, Inc.	Highly lipophilic Camptothecin derivatives
US6403604B1 (en) *	2001-03-01	2002-06-11	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
US7687497B2 (en) *	2007-10-16	2010-03-30	Bionumerik Pharmaceuticals, Inc.	C10-substituted camptothecin analogs

1997
- 1997-08-29 US US08/921,102 patent/US6150343A/en not_active Expired - Lifetime
1998
- 1998-08-26 DE DE69840388T patent/DE69840388D1/de not_active Expired - Lifetime
- 1998-08-26 AT AT98944535T patent/ATE418338T1/de active
- 1998-08-26 EP EP98944535A patent/EP1017399B1/de not_active Expired - Lifetime
- 1998-08-26 WO PCT/US1998/017683 patent/WO1999009996A1/en not_active Ceased
- 1998-08-26 AU AU92056/98A patent/AU760543B2/en not_active Ceased
- 1998-08-26 JP JP2000507386A patent/JP4903936B2/ja not_active Expired - Fee Related
- 1998-08-26 CA CA2302226A patent/CA2302226C/en not_active Expired - Fee Related
- 1998-08-26 ES ES98944535T patent/ES2320183T3/es not_active Expired - Lifetime
2000
- 2000-08-07 US US09/633,561 patent/US6455699B1/en not_active Expired - Lifetime
2002
- 2002-09-20 US US10/251,153 patent/US20030105324A1/en not_active Abandoned
2003
- 2003-07-29 US US10/629,432 patent/US7271159B2/en not_active Expired - Fee Related
2007
- 2007-07-09 US US11/825,729 patent/US7514418B2/en not_active Expired - Fee Related
- 2007-10-31 US US11/981,059 patent/US7655640B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69840388D1 (de)	2009-02-05
CA2302226A1 (en)	1999-03-04
US20070259905A1 (en)	2007-11-08
US6150343A (en)	2000-11-21
JP2001513567A (ja)	2001-09-04
US20030105324A1 (en)	2003-06-05
AU9205698A (en)	1999-03-16
US7655640B2 (en)	2010-02-02
US7514418B2 (en)	2009-04-07
EP1017399A4 (de)	2002-11-13
CA2302226C (en)	2010-08-24
WO1999009996A1 (en)	1999-03-04
AU760543B2 (en)	2003-05-15
US7271159B2 (en)	2007-09-18
EP1017399B1 (de)	2008-12-24
ES2320183T3 (es)	2009-05-19
US6455699B1 (en)	2002-09-24
US20080269169A1 (en)	2008-10-30
US20040029835A1 (en)	2004-02-12
EP1017399A1 (de)	2000-07-12
JP4903936B2 (ja)	2012-03-28

Legal Events

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2009-09-15

UEP

Publication of translation of european patent specification

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Publication	Publication Date	Title
DE69840388D1 (de)	2009-02-05	Camptothecin-analoge und verfahren zu ihrer herstellung
ATE128975T1 (de)	1995-10-15	Harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente.
HU912143D0 (en)	1991-12-30	Plant protecting preparations containing o-benzyl-oxymeters and process for the production of the active agents
ATE127801T1 (de)	1995-09-15	Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung.
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MY112232A (en)	2001-05-31	Indole derivatives
ATE89559T1 (de)	1993-06-15	Camptothecin-derivate und verfahren zu ihrer herstellung.
ATE172731T1 (de)	1998-11-15	Pyrazolopyridinverbindung und verfahren zu ihrer herstellung
FI961914A0 (fi)	1996-05-06	Lyhytvaikutteiset dihydropyridiinit
JPS56115784A (en)	1981-09-11	Novel pyridinecarboxamide derivative and its preparation
DE58904143D1 (de)	1993-05-27	Arylalkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel.
GB8426200D0 (en)	1984-11-21	Chemical compounds
FR2679555B1 (fr)	1993-11-19	Nouveaux derives de l'uree, leur preparation et leur application en therapeutique.
AT389108B (de)	1989-10-25	Neue pyridazinonderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
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ATE41659T1 (de)	1989-04-15	Benzothiazepinderivate, verfahren zur herstellung und pharmazeutische zusammensetzungen.
EP0315434A3 (de)	1990-01-10	Pyridoxalhydrazon-Derivate, ihre Herstellung und Verwendung und diese enthaltende Arzneimittel
ES8603415A1 (es)	1985-12-16	Un procedimiento para preparar derivados de dihidropiridina
WO1998003540A3 (en)	1998-04-09	1,2-substituted cycloalkane derivatives as thrombine inhibitors, a process for the preparation thereof and the use thereof in pharmaceutical formulations
PT82550A (en)	1986-06-01	1,3 oxathiane derivatives
IE901104L (en)	1990-09-28	New bronchospasmolytic compounds and process for their¹preparation
EP0367671A3 (de)	1991-07-31	Beta-D-phenylthioxyloside, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel