ATE418992T1 - Verwendung von tgf-beta2 antisense oligonukleotiden - Google Patents

Verwendung von tgf-beta2 antisense oligonukleotiden

Info

Publication number: ATE418992T1
Authority: AT; Austria
Prior art keywords: tgf; antisense oligonucleotides; oligonucleotide; beta3; beta1
Prior art date: 2005-05-05

Application number

AT06755024T

Other languages

English (en)

Inventor

Karl-Hermann Schlingensiepen

Reimar Schlingensiepen

Original Assignee

Antisense Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-05

Filing date

2006-05-04

Publication date

2009-01-15

2006-05-04 Application filed by Antisense Pharma Gmbh filed Critical Antisense Pharma Gmbh

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE418992T1 publication Critical patent/ATE418992T1/de

Links

108020000948 Antisense Oligonucleotides Proteins 0.000 title 1
239000000074 antisense oligonucleotide Substances 0.000 title 1
238000012230 antisense oligonucleotides Methods 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 abstract 3
101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 abstract 2
102000003814 Interleukin-10 Human genes 0.000 abstract 2
108090000174 Interleukin-10 Proteins 0.000 abstract 2
102100027584 Protein c-Fos Human genes 0.000 abstract 2
108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 abstract 2
102100023132 Transcription factor Jun Human genes 0.000 abstract 2
102000046299 Transforming Growth Factor beta1 Human genes 0.000 abstract 2
101800002279 Transforming growth factor beta-1 Proteins 0.000 abstract 2
102000056172 Transforming growth factor beta-3 Human genes 0.000 abstract 2
108090000097 Transforming growth factor beta-3 Proteins 0.000 abstract 2
102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 2
108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 2
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 2
229960002986 dinoprostone Drugs 0.000 abstract 2
229940076144 interleukin-10 Drugs 0.000 abstract 2
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 2
101150082674 E2 gene Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
108020004999 messenger RNA Proteins 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Oncology (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT06755024T 2005-05-05 2006-05-04 Verwendung von tgf-beta2 antisense oligonukleotiden ATE418992T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05009802		2005-05-05
US68049305P	2005-05-13	2005-05-13

Publications (1)

Publication Number	Publication Date
ATE418992T1 true ATE418992T1 (de)	2009-01-15

Family

ID=36370983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06755024T ATE418992T1 (de)	2005-05-05	2006-05-04	Verwendung von tgf-beta2 antisense oligonukleotiden

Country Status (19)

Country	Link
US (1)	US8097597B2 (de)
EP (2)	EP2062586B1 (de)
JP (2)	JP4977035B2 (de)
AT (1)	ATE418992T1 (de)
AU (2)	AU2006243218B2 (de)
BR (1)	BRPI0611452A2 (de)
CA (1)	CA2591586A1 (de)
CY (1)	CY1108944T1 (de)
DE (1)	DE602006004578D1 (de)
DK (1)	DK1877070T3 (de)
ES (1)	ES2319332T3 (de)
MX (1)	MX2007007184A (de)
NZ (1)	NZ562954A (de)
PL (1)	PL1877070T3 (de)
PT (1)	PT1877070E (de)
RU (1)	RU2427377C2 (de)
SI (1)	SI1877070T1 (de)
WO (1)	WO2006117400A2 (de)
ZA (2)	ZA200709237B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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NZ562954A (en)	2005-05-05	2009-10-30	Antisense Pharma Gmbh	Use of low doses of oligonucleotides antisense to TGF-beta, VEGF, interleukin-10, C-JUN, C-FOS or prostaglandin E2 genes in the treatment of tumors
EP1935428A1 (de) *	2006-12-22	2008-06-25	Antisense Pharma GmbH	Oligonukleotid-Polymer Konjugate
US8822425B2 (en)	2008-11-14	2014-09-02	Antisense Pharma Gmbh	Dosage of oligonucleotides suitable for the treatment of tumors
EP2356234B1 (de) *	2008-11-14	2017-08-16	Autotelic LLC	Dosierung von oligonucleotiden zur behandlung von tumoren
CN102282155B (zh)	2008-12-02	2017-06-09	日本波涛生命科学公司	磷原子修饰的核酸的合成方法
RU2612521C2 (ru)	2009-07-06	2017-03-09	Онтории, Инк.	Новые пролекарства нуклеиновых кислот и способы их применения
JP5868324B2 (ja)	2010-09-24	2016-02-24	株式会社Wave Life Sciences Japan	不斉補助基
EP2453017A1 (de) *	2010-11-12	2012-05-16	Antisense Pharma GmbH	Oligonucleotide zur Verwendung bei der Prophilaxe und/oder Behandlung von TGF-beta1- und TGF-beta2-, TGF-beta2- und TGF-beta3-, TGF-beta1- und TGF-beta3- oder TGF-beta1-, TGF-beta2- und TGF-beta3-mRNA-Überexpressionskrankheiten
CN103796657B (zh)	2011-07-19	2017-07-11	波涛生命科学有限公司	合成官能化核酸的方法
PL2872485T3 (pl)	2012-07-13	2021-05-31	Wave Life Sciences Ltd.	Asymetryczna grupa pomocnicza
CA2879066C (en)	2012-07-13	2019-08-13	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant
KR102213609B1 (ko)	2012-07-13	2021-02-08	웨이브 라이프 사이언시스 리미티드	키랄 제어
US11236338B2 (en) *	2013-09-05	2022-02-01	Sarepta Therapeutics, Inc.	Antisense-induced exon2 inclusion in acid alpha-glucosidase
JPWO2015108047A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
US10322173B2 (en)	2014-01-15	2019-06-18	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108048A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
BR112016016400A2 (pt)	2014-01-16	2017-10-03	Wave Life Sciences Ltd	Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos
US9758786B2 (en)	2016-02-09	2017-09-12	Autotelic, Llc	Compositions and methods for treating pancreatic cancer
DE102019000490A1 (de) *	2019-01-23	2020-07-23	HAEMES Verwaltungsgesellschaft mbH	Verwendung von Oligonukleotiden für die Behandlung von Tumoren
KR102680316B1 (ko) *	2021-11-01	2024-07-01	오토텔릭바이오 주식회사	안티센스 올리고뉴클레오타이드

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NZ562954A (en)	2005-05-05	2009-10-30	Antisense Pharma Gmbh	Use of low doses of oligonucleotides antisense to TGF-beta, VEGF, interleukin-10, C-JUN, C-FOS or prostaglandin E2 genes in the treatment of tumors

2006
- 2006-05-04 NZ NZ562954A patent/NZ562954A/en not_active IP Right Cessation
- 2006-05-04 AU AU2006243218A patent/AU2006243218B2/en not_active Ceased
- 2006-05-04 WO PCT/EP2006/062067 patent/WO2006117400A2/en not_active Ceased
- 2006-05-04 PT PT06755024T patent/PT1877070E/pt unknown
- 2006-05-04 EP EP08173070.7A patent/EP2062586B1/de not_active Expired - Lifetime
- 2006-05-04 PL PL06755024T patent/PL1877070T3/pl unknown
- 2006-05-04 RU RU2007145046/15A patent/RU2427377C2/ru not_active IP Right Cessation
- 2006-05-04 EP EP06755024A patent/EP1877070B1/de not_active Expired - Lifetime
- 2006-05-04 SI SI200630221T patent/SI1877070T1/sl unknown
- 2006-05-04 ZA ZA200709237A patent/ZA200709237B/xx unknown
- 2006-05-04 AT AT06755024T patent/ATE418992T1/de active
- 2006-05-04 JP JP2007551691A patent/JP4977035B2/ja not_active Expired - Fee Related
- 2006-05-04 ES ES06755024T patent/ES2319332T3/es not_active Expired - Lifetime
- 2006-05-04 MX MX2007007184A patent/MX2007007184A/es active IP Right Grant
- 2006-05-04 DK DK06755024T patent/DK1877070T3/da active
- 2006-05-04 DE DE602006004578T patent/DE602006004578D1/de not_active Expired - Lifetime
- 2006-05-04 US US11/792,041 patent/US8097597B2/en not_active Expired - Fee Related
- 2006-05-04 BR BRPI0611452-0A patent/BRPI0611452A2/pt not_active Application Discontinuation
- 2006-05-04 CA CA002591586A patent/CA2591586A1/en not_active Abandoned
2008
- 2008-10-31 ZA ZA2008/09354A patent/ZA200809354B/en unknown
2009
- 2009-03-27 CY CY20091100366T patent/CY1108944T1/el unknown
- 2009-12-10 JP JP2009280553A patent/JP2010090159A/ja active Pending
- 2009-12-17 AU AU2009251023A patent/AU2009251023B2/en not_active Ceased

Also Published As

Publication number	Publication date
ZA200709237B (en)	2009-04-29
JP4977035B2 (ja)	2012-07-18
BRPI0611452A2 (pt)	2010-09-08
SI1877070T1 (sl)	2009-06-30
DE602006004578D1 (de)	2009-02-12
WO2006117400A2 (en)	2006-11-09
AU2009251023A1 (en)	2010-01-14
AU2006243218B2 (en)	2009-09-17
EP1877070B1 (de)	2008-12-31
AU2006243218A1 (en)	2006-11-09
DK1877070T3 (da)	2009-03-02
EP2062586A3 (de)	2009-08-12
EP2062586B1 (de)	2017-03-15
RU2007145046A (ru)	2009-06-10
ZA200809354B (en)	2010-02-24
ES2319332T3 (es)	2009-05-06
CA2591586A1 (en)	2006-11-09
RU2427377C2 (ru)	2011-08-27
WO2006117400A3 (en)	2007-01-25
PL1877070T3 (pl)	2009-06-30
JP2010090159A (ja)	2010-04-22
NZ562954A (en)	2009-10-30
JP2008528460A (ja)	2008-07-31
MX2007007184A (es)	2008-01-14
US20090306176A1 (en)	2009-12-10
EP1877070A2 (de)	2008-01-16
PT1877070E (pt)	2009-03-13
EP2062586A2 (de)	2009-05-27
CY1108944T1 (el)	2014-07-02
AU2009251023B2 (en)	2012-02-02
US8097597B2 (en)	2012-01-17

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Publication	Publication Date	Title
ATE418992T1 (de)	2009-01-15	Verwendung von tgf-beta2 antisense oligonukleotiden
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