DK1877070T3 - Terapeutisk anvendelse af TGF-beta2 antisense-oligonucleotider - Google Patents

Terapeutisk anvendelse af TGF-beta2 antisense-oligonucleotider

Info

Publication number: DK1877070T3
Authority: DK; Denmark
Prior art keywords: tgf; antisense oligonucleotides; therapeutic use; oligonucleotide; beta3
Prior art date: 2005-05-05

Application number

DK06755024T

Other languages

Danish (da)

English (en)

Inventor

Karl-Hermann Schlingensiepen

Reimar Schlingensiepen

Original Assignee

Antisense Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-05

Filing date

2006-05-04

Publication date

2009-03-02

2006-05-04 Application filed by Antisense Pharma Gmbh filed Critical Antisense Pharma Gmbh

2009-03-02 Application granted granted Critical

2009-03-02 Publication of DK1877070T3 publication Critical patent/DK1877070T3/da

Links

108020000948 Antisense Oligonucleotides Proteins 0.000 title 1
102000011117 Transforming Growth Factor beta2 Human genes 0.000 title 1
101800000304 Transforming growth factor beta-2 Proteins 0.000 title 1
239000000074 antisense oligonucleotide Substances 0.000 title 1
238000012230 antisense oligonucleotides Methods 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 abstract 3
101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 abstract 2
102000003814 Interleukin-10 Human genes 0.000 abstract 2
108090000174 Interleukin-10 Proteins 0.000 abstract 2
102100027584 Protein c-Fos Human genes 0.000 abstract 2
108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 abstract 2
102100023132 Transcription factor Jun Human genes 0.000 abstract 2
102000046299 Transforming Growth Factor beta1 Human genes 0.000 abstract 2
101800002279 Transforming growth factor beta-1 Proteins 0.000 abstract 2
102000056172 Transforming growth factor beta-3 Human genes 0.000 abstract 2
108090000097 Transforming growth factor beta-3 Proteins 0.000 abstract 2
102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 2
108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 2
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 2
229960002986 dinoprostone Drugs 0.000 abstract 2
229940076144 interleukin-10 Drugs 0.000 abstract 2
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 2
101150082674 E2 gene Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
108020004999 messenger RNA Proteins 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Oncology (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK06755024T 2005-05-05 2006-05-04 Terapeutisk anvendelse af TGF-beta2 antisense-oligonucleotider DK1877070T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05009802		2005-05-05
US68049305P	2005-05-13	2005-05-13
PCT/EP2006/062067 WO2006117400A2 (en)	2005-05-05	2006-05-04	Use of low doses of oligonucleotides antisense to tgf-beta, vegf, interleukin-10, c-jun, c-fos or prostaglandin e2 genes in the treatment of tumors

Publications (1)

Publication Number	Publication Date
DK1877070T3 true DK1877070T3 (da)	2009-03-02

Family

ID=36370983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06755024T DK1877070T3 (da)	2005-05-05	2006-05-04	Terapeutisk anvendelse af TGF-beta2 antisense-oligonucleotider

Country Status (19)

Country	Link
US (1)	US8097597B2 (de)
EP (2)	EP2062586B1 (de)
JP (2)	JP4977035B2 (de)
AT (1)	ATE418992T1 (de)
AU (2)	AU2006243218B2 (de)
BR (1)	BRPI0611452A2 (de)
CA (1)	CA2591586A1 (de)
CY (1)	CY1108944T1 (de)
DE (1)	DE602006004578D1 (de)
DK (1)	DK1877070T3 (de)
ES (1)	ES2319332T3 (de)
MX (1)	MX2007007184A (de)
NZ (1)	NZ562954A (de)
PL (1)	PL1877070T3 (de)
PT (1)	PT1877070E (de)
RU (1)	RU2427377C2 (de)
SI (1)	SI1877070T1 (de)
WO (1)	WO2006117400A2 (de)
ZA (2)	ZA200709237B (de)

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DK1877070T3 (da)	2005-05-05	2009-03-02	Antisense Pharma Gmbh	Terapeutisk anvendelse af TGF-beta2 antisense-oligonucleotider
EP1935428A1 (de) *	2006-12-22	2008-06-25	Antisense Pharma GmbH	Oligonukleotid-Polymer Konjugate
JP2012508779A (ja) *	2008-11-14	2012-04-12	アンチセンス・ファーマ・ゲーエムベーハー	腫瘍の治療に適するオリゴヌクレオチドの用法
US8822425B2 (en)	2008-11-14	2014-09-02	Antisense Pharma Gmbh	Dosage of oligonucleotides suitable for the treatment of tumors
RU2572826C2 (ru)	2008-12-02	2016-01-20	Чиралджен, Лтд.	Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
CA2767253A1 (en)	2009-07-06	2011-01-13	Ontorii, Inc.	Novel nucleic acid prodrugs and methods of use thereof
JP5868324B2 (ja)	2010-09-24	2016-02-24	株式会社Wave Life Sciences Japan	不斉補助基
EP2453017A1 (de) *	2010-11-12	2012-05-16	Antisense Pharma GmbH	Oligonucleotide zur Verwendung bei der Prophilaxe und/oder Behandlung von TGF-beta1- und TGF-beta2-, TGF-beta2- und TGF-beta3-, TGF-beta1- und TGF-beta3- oder TGF-beta1-, TGF-beta2- und TGF-beta3-mRNA-Überexpressionskrankheiten
AU2012284265B2 (en)	2011-07-19	2017-08-17	Wave Life Sciences Ltd.	Methods for the synthesis of functionalized nucleic acids
JP6453212B2 (ja)	2012-07-13	2019-01-16	ウェイブライフサイエンシズリミテッドＷａｖｅＬｉｆｅＳｃｉｅｎｃｅｓＬｔｄ．	キラル制御
CN104684923B (zh)	2012-07-13	2018-09-28	株式会社新日本科学	手性核酸佐剂
SG11201500239VA (en)	2012-07-13	2015-03-30	Wave Life Sciences Japan	Asymmetric auxiliary group
JP6618910B2 (ja) *	2013-09-05	2019-12-11	サレプタセラピューティクス，インコーポレイテッド	酸性α−グルコシダーゼにおけるアンチセンス誘導エクソン２包含
WO2015108047A1 (ja)	2014-01-15	2015-07-23	株式会社新日本科学	免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108046A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
WO2015108048A1 (ja)	2014-01-15	2015-07-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
ES2917473T3 (es)	2014-01-16	2022-07-08	Wave Life Sciences Ltd	Diseño quiral
US9758786B2 (en)	2016-02-09	2017-09-12	Autotelic, Llc	Compositions and methods for treating pancreatic cancer
DE102019000490A1 (de) *	2019-01-23	2020-07-23	HAEMES Verwaltungsgesellschaft mbH	Verwendung von Oligonukleotiden für die Behandlung von Tumoren
KR102680316B1 (ko) *	2021-11-01	2024-07-01	오토텔릭바이오 주식회사	안티센스 올리고뉴클레오타이드

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DK1877070T3 (da)	2005-05-05	2009-03-02	Antisense Pharma Gmbh	Terapeutisk anvendelse af TGF-beta2 antisense-oligonucleotider

2006
- 2006-05-04 DK DK06755024T patent/DK1877070T3/da active
- 2006-05-04 ES ES06755024T patent/ES2319332T3/es active Active
- 2006-05-04 CA CA002591586A patent/CA2591586A1/en not_active Abandoned
- 2006-05-04 US US11/792,041 patent/US8097597B2/en not_active Expired - Fee Related
- 2006-05-04 MX MX2007007184A patent/MX2007007184A/es active IP Right Grant
- 2006-05-04 AU AU2006243218A patent/AU2006243218B2/en not_active Ceased
- 2006-05-04 EP EP08173070.7A patent/EP2062586B1/de active Active
- 2006-05-04 NZ NZ562954A patent/NZ562954A/en not_active IP Right Cessation
- 2006-05-04 DE DE602006004578T patent/DE602006004578D1/de active Active
- 2006-05-04 JP JP2007551691A patent/JP4977035B2/ja not_active Expired - Fee Related
- 2006-05-04 WO PCT/EP2006/062067 patent/WO2006117400A2/en not_active Ceased
- 2006-05-04 BR BRPI0611452-0A patent/BRPI0611452A2/pt not_active Application Discontinuation
- 2006-05-04 AT AT06755024T patent/ATE418992T1/de active
- 2006-05-04 SI SI200630221T patent/SI1877070T1/sl unknown
- 2006-05-04 PL PL06755024T patent/PL1877070T3/pl unknown
- 2006-05-04 PT PT06755024T patent/PT1877070E/pt unknown
- 2006-05-04 RU RU2007145046/15A patent/RU2427377C2/ru not_active IP Right Cessation
- 2006-05-04 ZA ZA200709237A patent/ZA200709237B/xx unknown
- 2006-05-04 EP EP06755024A patent/EP1877070B1/de active Active
2008
- 2008-10-31 ZA ZA2008/09354A patent/ZA200809354B/en unknown
2009
- 2009-03-27 CY CY20091100366T patent/CY1108944T1/el unknown
- 2009-12-10 JP JP2009280553A patent/JP2010090159A/ja active Pending
- 2009-12-17 AU AU2009251023A patent/AU2009251023B2/en not_active Ceased

Also Published As

Publication number	Publication date
CA2591586A1 (en)	2006-11-09
EP2062586B1 (de)	2017-03-15
ZA200709237B (en)	2009-04-29
PL1877070T3 (pl)	2009-06-30
RU2427377C2 (ru)	2011-08-27
AU2009251023A1 (en)	2010-01-14
BRPI0611452A2 (pt)	2010-09-08
ES2319332T3 (es)	2009-05-06
PT1877070E (pt)	2009-03-13
DE602006004578D1 (de)	2009-02-12
WO2006117400A2 (en)	2006-11-09
AU2006243218A1 (en)	2006-11-09
JP2010090159A (ja)	2010-04-22
WO2006117400A3 (en)	2007-01-25
NZ562954A (en)	2009-10-30
EP2062586A2 (de)	2009-05-27
CY1108944T1 (el)	2014-07-02
MX2007007184A (es)	2008-01-14
US20090306176A1 (en)	2009-12-10
SI1877070T1 (sl)	2009-06-30
JP4977035B2 (ja)	2012-07-18
ZA200809354B (en)	2010-02-24
EP2062586A3 (de)	2009-08-12
JP2008528460A (ja)	2008-07-31
RU2007145046A (ru)	2009-06-10
EP1877070A2 (de)	2008-01-16
US8097597B2 (en)	2012-01-17
AU2009251023B2 (en)	2012-02-02
ATE418992T1 (de)	2009-01-15
AU2006243218B2 (en)	2009-09-17
EP1877070B1 (de)	2008-12-31

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JP2007517498A5 (de)	2007-11-22
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