ATE419232T1 - Thiolalkylbezoesäurederivate - Google Patents

Thiolalkylbezoesäurederivate

Info

Publication number: ATE419232T1
Authority: AT; Austria
Prior art keywords: activity; compounds; thiolalkylbezoic; acid derivatives; effecting
Prior art date: 2001-05-30

Application number

AT02737263T

Other languages

English (en)

Inventor

Takashi Tsukamoto

Doris Stoermer

Dilrukshi Vitharana

Original Assignee

Guilford Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-30

Filing date

2002-05-30

Publication date

2009-01-15

2002-05-30 Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE419232T1 publication Critical patent/ATE419232T1/de

Links

239000002253 acid Substances 0.000 title 1
102000003958 Glutamate Carboxypeptidase II Human genes 0.000 abstract 2
108090000369 Glutamate Carboxypeptidase II Proteins 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
238000009007 Diagnostic Kit Methods 0.000 abstract 1
208000010412 Glaucoma Diseases 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000017442 Retinal disease Diseases 0.000 abstract 1
208000016624 Retinal neoplasm Diseases 0.000 abstract 1
230000005856 abnormality Effects 0.000 abstract 1
230000033115 angiogenesis Effects 0.000 abstract 1
235000010233 benzoic acid Nutrition 0.000 abstract 1
150000001559 benzoic acids Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
229930195712 glutamate Natural products 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001537 neural effect Effects 0.000 abstract 1
201000001119 neuropathy Diseases 0.000 abstract 1
230000007823 neuropathy Effects 0.000 abstract 1
230000036407 pain Effects 0.000 abstract 1
208000033808 peripheral neuropathy Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000017497 prostate disease Diseases 0.000 abstract 1
201000008933 retinal cancer Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Psychology (AREA)
Pregnancy & Childbirth (AREA)
Oncology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
Gynecology & Obstetrics (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)

AT02737263T 2001-05-30 2002-05-30 Thiolalkylbezoesäurederivate ATE419232T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29403601P	2001-05-30	2001-05-30
US34274601P	2001-12-28	2001-12-28

Publications (1)

Publication Number	Publication Date
ATE419232T1 true ATE419232T1 (de)	2009-01-15

Family

ID=26968313

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02737263T ATE419232T1 (de)	2001-05-30	2002-05-30	Thiolalkylbezoesäurederivate

Country Status (13)

Country	Link
US (2)	US6740777B2 (de)
EP (2)	EP2025666A3 (de)
JP (2)	JP4292471B2 (de)
AT (1)	ATE419232T1 (de)
AU (1)	AU2002310202B2 (de)
CA (1)	CA2448089C (de)
CY (1)	CY1108893T1 (de)
DE (1)	DE60230624D1 (de)
DK (1)	DK1406867T3 (de)
ES (1)	ES2319509T3 (de)
MX (1)	MXPA03010859A (de)
PT (1)	PT1406867E (de)
WO (1)	WO2002096866A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001265111A1 (en) *	2000-05-30	2001-12-11	Guilford Pharmaceuticals Inc.	Benzenedicarboxylic acid derivatives
MXPA03010859A (es) *	2001-05-30	2004-02-17	Guilford Pharm Inc	Derivados de acido tioalquilbenzoico.
US7148250B2 (en) *	2001-12-28	2006-12-12	Guilford Pharmaceuticals Inc.	Indoles as NAALADase inhibitors
DE602004021476D1 (de) *	2003-03-03	2009-07-23	Eisai Corp North America	THIOLACTONE ALS NAALADase INHIBITOREN
US20040186081A1 (en) *	2003-03-03	2004-09-23	Guilford Pharmaceuticals Inc.	Naaladase inhibitors for treating opioid tolerance
WO2004101483A1 (ja) *	2003-05-14	2004-11-25	Riken	新規３置換ベンゼン誘導体、その製造方法、およびそれを含む医薬組成物
US8198328B2 (en) *	2004-01-21	2012-06-12	New York University	Treatment of cancer using benzoic acid derivatives
US7282590B2 (en)	2004-02-12	2007-10-16	The Research Foundation Of State University Of New York	Drug conjugates
EP2299999B1 (de) *	2008-06-04	2017-08-16	Baylor College Of Medicine	Stat3-inhibitoren

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US3053890A (en) *	1960-03-31	1962-09-11	California Research Corp	Reaction products of formaldehyde and o-mercaptomethylbenzoic acid
US4318846A (en) *	1979-09-07	1982-03-09	Syva Company	Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US5089388A (en)	1983-04-19	1992-02-18	Syntex (U.S.A.) Inc.	Antibodies for salicylate and their preparation
US5314918A (en)	1987-06-24	1994-05-24	Smithkline Beecham Corporation	Leukotriene antagonists
US5204358A (en)	1987-11-25	1993-04-20	Merck Frosst Canada, Inc.	Hetaryl styryl quinolines as leukotriene inhibitors
US5258551A (en)	1991-12-18	1993-11-02	Shionogi & Co., Ltd.	Process for producing α-ketoamide derivative
US5409780A (en)	1992-02-13	1995-04-25	Chemtrak, Inc.	Aniline analogs for hydrogen peroxide detection
US5316887A (en)	1992-07-31	1994-05-31	Polaroid Corporation	Thermally developable photosensitive material
US5453502A (en)	1994-03-16	1995-09-26	Eli Lilly And Company	1,3,4 substituted and bicyclic derivatives of 2-azetidinones and processes for preparation thereof
AR006793A1 (es)	1996-04-26	1999-09-29	Ishihara Sangyo Kaisha	Compuestos pirazol o sus sales y herbicidas conteniendo los mismos
US6025344A (en) *	1996-06-17	2000-02-15	Guilford Pharmaceuticals Inc.	Certain dioic acid derivatives useful as NAALADase inhibitors
IL120531A (en)	1997-03-26	2006-12-31	Yissum Res Dev Co	Nitric oxide donors and pharmaceutical compositions containing them
MXPA01000144A (es) *	1998-07-06	2002-10-17	Guilford Pharm Inc	Inhibidores de naaladasa utiles como composiciones y compuestos farmaceuticos.
US6265609B1 (en)	1998-07-06	2001-07-24	Guilford Pharmaceuticals Inc.	Thio-substituted pentanedioic acid derivatives
JP5095050B2 (ja) *	1999-04-28	2012-12-12	ジョージタウンユニバーシティー	代謝調節型グルタミン酸受容体のリガンド、及び、ＮＡＡＬＡＤａｓｅの阻害剤
WO2001092274A2 (en) *	2000-05-30	2001-12-06	Guilford Pharmaceuticals Inc.	Naaladase inhibitors for treating retinal disorders and glaucoma
US20020013295A1 (en)	2000-05-30	2002-01-31	Slusher Barbara S.	Naaladase inhibitors for treating amyotrophic lateral sclerosis
AU2001265111A1 (en)	2000-05-30	2001-12-11	Guilford Pharmaceuticals Inc.	Benzenedicarboxylic acid derivatives
MXPA03010859A (es) *	2001-05-30	2004-02-17	Guilford Pharm Inc	Derivados de acido tioalquilbenzoico.

2002
- 2002-05-30 MX MXPA03010859A patent/MXPA03010859A/es active IP Right Grant
- 2002-05-30 US US10/156,880 patent/US6740777B2/en not_active Expired - Lifetime
- 2002-05-30 WO PCT/US2002/016971 patent/WO2002096866A2/en not_active Ceased
- 2002-05-30 CA CA2448089A patent/CA2448089C/en not_active Expired - Lifetime
- 2002-05-30 EP EP08019550A patent/EP2025666A3/de not_active Withdrawn
- 2002-05-30 ES ES02737263T patent/ES2319509T3/es not_active Expired - Lifetime
- 2002-05-30 AT AT02737263T patent/ATE419232T1/de active
- 2002-05-30 DK DK02737263T patent/DK1406867T3/da active
- 2002-05-30 JP JP2003500046A patent/JP4292471B2/ja not_active Expired - Lifetime
- 2002-05-30 AU AU2002310202A patent/AU2002310202B2/en not_active Expired
- 2002-05-30 PT PT02737263T patent/PT1406867E/pt unknown
- 2002-05-30 EP EP02737263A patent/EP1406867B1/de not_active Expired - Lifetime
- 2002-05-30 DE DE60230624T patent/DE60230624D1/de not_active Expired - Lifetime
2004
- 2004-04-07 US US10/819,146 patent/US7138543B2/en not_active Expired - Lifetime
2009
- 2009-01-22 JP JP2009011782A patent/JP2009149657A/ja active Pending
- 2009-03-20 CY CY20091100316T patent/CY1108893T1/el unknown

Also Published As

Publication number	Publication date
US20030100607A1 (en)	2003-05-29
WO2002096866A3 (en)	2004-01-15
MXPA03010859A (es)	2004-02-17
US6740777B2 (en)	2004-05-25
JP2009149657A (ja)	2009-07-09
AU2002310202B2 (en)	2008-05-15
EP1406867A2 (de)	2004-04-14
EP2025666A3 (de)	2010-03-31
CA2448089C (en)	2010-10-19
EP1406867B1 (de)	2008-12-31
EP2025666A2 (de)	2009-02-18
WO2002096866A2 (en)	2002-12-05
US7138543B2 (en)	2006-11-21
JP2005503353A (ja)	2005-02-03
CY1108893T1 (el)	2014-07-02
CA2448089A1 (en)	2002-12-05
PT1406867E (pt)	2009-02-25
JP4292471B2 (ja)	2009-07-08
ES2319509T3 (es)	2009-05-08
US20040198824A1 (en)	2004-10-07
DE60230624D1 (en)	2009-02-12
DK1406867T3 (da)	2009-04-06

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2009-09-15

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2011-05-15

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Publication	Publication Date	Title
CY1108893T1 (el)	2014-07-02	Παραγωγα θειοαλκυλ βενζοϊκου οξεος
WO2001092273A3 (en)	2002-07-25	Benzenedicarboxylic acid derivatives
WO2003057670A3 (en)	2003-11-06	Indoles as naaladase inhibitors
WO2002057222A3 (en)	2002-12-19	Thiol-based naaladase inhibitors
ATE440087T1 (de)	2009-09-15	2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
ATE501722T1 (de)	2011-04-15	Therapeutische behandlung androgenrezeptorbedingter leiden
NO20012765D0 (no)	2001-06-05	Karboksylsyrer og karboksylsyreisosterer av N-heterosykliske forbindelser
ATE380029T1 (de)	2007-12-15	Prodrugs von gaba-analoga, zusammensetzungen und ihre verwendungszwecke
EP1565581A4 (de)	2008-01-02	Zusammensetzungen, kits und verfahren zur identifizierung, beurteilung, vorbeugung und therapie von gebärmutterhalskrebs
MXPA03010328A (es)	2004-02-17	Acidos hidroxinamicos y acil hidroxaminasas como inhibidores de naaladasa.
DE60219614D1 (de)	2007-05-31	3, 7 thiaprostansäurederivate als mittel zur verminderung des augeninnendruckes
CA2337797A1 (en)	2000-01-13	Naaladase inhibitors useful as pharmaceutical compounds and compositions
WO2001034596A3 (en)	2002-03-07	Pyrrolecarbonylimino derivatives as naaladase inhibitors
WO2004063340A3 (en)	2005-07-14	Methods and compositions for treating cardiovascular disease using 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061,17662,1468,12282, 6350, 9035,1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123,12788,17729, 65552,1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 4
CY1109356T1 (el)	2014-07-02	Θειολακτονες ως αναστολεις της νααladασης
DE60108130D1 (de)	2005-02-03	Pharmazeutische zusammensetzungen zur behandlung von neurologischen krankheiten
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