ATE419273T1 - Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3 - Google Patents
Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3Info
- Publication number
- ATE419273T1 ATE419273T1 AT99954212T AT99954212T ATE419273T1 AT E419273 T1 ATE419273 T1 AT E419273T1 AT 99954212 T AT99954212 T AT 99954212T AT 99954212 T AT99954212 T AT 99954212T AT E419273 T1 ATE419273 T1 AT E419273T1
- Authority
- AT
- Austria
- Prior art keywords
- vectors derived
- antennapedia homeodomain
- translocation
- helix
- homeodomain helix
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract 2
- 108700031308 Antennapedia Homeodomain Proteins 0.000 title 1
- 208000011616 HELIX syndrome Diseases 0.000 title 1
- 230000005945 translocation Effects 0.000 title 1
- 102000003939 Membrane transport proteins Human genes 0.000 abstract 1
- 108090000301 Membrane transport proteins Proteins 0.000 abstract 1
- 230000009061 membrane transport Effects 0.000 abstract 1
- 108010043655 penetratin Proteins 0.000 abstract 1
- MCYTYTUNNNZWOK-LCLOTLQISA-N penetratin Chemical compound C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=CC=C1 MCYTYTUNNNZWOK-LCLOTLQISA-N 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Details Of Aerials (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Surgical Instruments (AREA)
- Structure Of Belt Conveyors (AREA)
- Medicinal Preparation (AREA)
- Aerials With Secondary Devices (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9825001.2A GB9825001D0 (en) | 1998-11-13 | 1998-11-13 | A delivery vector |
| GBGB9825000.4A GB9825000D0 (en) | 1998-11-13 | 1998-11-13 | A delivery vector |
| GBGB9902522.3A GB9902522D0 (en) | 1999-02-04 | 1999-02-04 | Truncated vectors |
| GBGB9902525.6A GB9902525D0 (en) | 1999-02-04 | 1999-02-04 | Translocation vectors |
| GBGB9914578.1A GB9914578D0 (en) | 1999-06-22 | 1999-06-22 | Truncated vetors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419273T1 true ATE419273T1 (de) | 2009-01-15 |
Family
ID=27517480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99954212T ATE419273T1 (de) | 1998-11-13 | 1999-11-11 | Translokationsvektoren abgeleitet von der antennapedia homeodomain helix 3 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7153931B1 (de) |
| EP (2) | EP1958961A3 (de) |
| JP (1) | JP2002530059A (de) |
| AT (1) | ATE419273T1 (de) |
| AU (1) | AU766489B2 (de) |
| CA (1) | CA2350919A1 (de) |
| CZ (1) | CZ20011671A3 (de) |
| DE (1) | DE69940215D1 (de) |
| ES (1) | ES2318906T3 (de) |
| GB (1) | GB2346616B (de) |
| HU (1) | HUP0204199A3 (de) |
| IL (1) | IL142869A0 (de) |
| WO (1) | WO2000029427A2 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786397B1 (fr) * | 1998-11-30 | 2003-01-10 | Synt Em | Vecteurs peptidiques de substances a travers la barriere hematoencephalique pour etre utilises dans le diagnostic ou la therapie d'une affection du snc |
| US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| US6864355B1 (en) | 2000-05-02 | 2005-03-08 | Yale University | Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain |
| US8128922B2 (en) * | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
| US7049395B2 (en) | 2000-05-02 | 2006-05-23 | Yale University | Anti-inflammatory compounds and uses thereof |
| GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
| DE10027777A1 (de) * | 2000-06-07 | 2001-12-13 | Otogene Ag | Transfektionsverfahren |
| FR2816845B1 (fr) * | 2000-11-20 | 2006-10-20 | Centre Nat Rech Scient | Vecteurs de transport a travers un epithelium a jonctions serrees |
| EP1406573A4 (de) * | 2001-06-07 | 2005-03-30 | Skinmedica Inc | Konditionierte zellkulturmedien und ihre verwendungszwecke |
| DE10128832A1 (de) * | 2001-06-15 | 2003-02-06 | Jochen Reis | Vektor und dessen Verwendung in gentherapeutischen Verfahren |
| EP1432728A4 (de) * | 2001-08-30 | 2007-10-24 | Praecis Pharm Inc | Verfahren und zusammensetzungen zur behandlung entzündlicher erkrankungen |
| WO2003064614A2 (en) * | 2002-01-30 | 2003-08-07 | Yale University | Transport peptides and uses therefor |
| EP1354953A1 (de) * | 2002-04-17 | 2003-10-22 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Smac-Peptide zur Verwendung als therapeutische Mittel gegen Krebs und Autoimmunerkrankungen |
| EP1354952A1 (de) * | 2002-04-17 | 2003-10-22 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Smac-Peptide zur Verwendung als therapeutische Mittel gegen Krebs und Autoimmunerkrankungen |
| EP1495124A2 (de) * | 2002-04-17 | 2005-01-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Smac-peptide zur verwendung als therapeutische mittel gegen krebs und autoimmunerkrankungen |
| US20060178297A1 (en) * | 2003-01-28 | 2006-08-10 | Troy Carol M | Systems and methods for silencing expression of a gene in a cell and uses thereof |
| EP2857036B1 (de) | 2003-01-31 | 2016-12-21 | Mount Sinai School of Medicine of New York University | Kombinationstherapie zur behandlung von proteinmangelstörungen |
| EP1599213A4 (de) | 2003-02-24 | 2009-07-15 | Ira Sanders | Zellmembran-translokation von regulierten snare- inhibitoren, zusammensetzungen dafür und verfahren zur behandlung von erkrankungen |
| EP1618129A2 (de) * | 2003-04-30 | 2006-01-25 | Applied Research Systems ARS Holding N.V. | Inhibitoren von beta-amyloid und deren verwendung |
| US9701725B2 (en) | 2003-05-05 | 2017-07-11 | The Johns Hopkins University | Anti-cancer DNA vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
| GB0311576D0 (en) * | 2003-05-20 | 2003-06-25 | Inst Of Ophthalomology | Anti-inflammatory agents |
| US7737250B2 (en) | 2003-06-19 | 2010-06-15 | Mount Sinai School Of Medicine Of New York University | Peptides for treating axonal damage, inhibition of neurotransmitter release and pain transmission, and blocking calcium influx in neurons |
| US7342114B2 (en) * | 2003-07-01 | 2008-03-11 | California Pacific Medical Center | Podophyllotoxin derivatives |
| EP2228069A1 (de) * | 2003-09-16 | 2010-09-15 | Garvan Institute Of Medical Research | Antagonisten der Protein Kinase C-Epsilon (pkcepsilon) und deren Anwendungen für die Behandlung von damit im Zusammenhang stehenden aberranten Glukosestoffwechsel |
| US20050148534A1 (en) * | 2003-09-22 | 2005-07-07 | Castellino Angelo J. | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
| KR100897915B1 (ko) * | 2004-11-03 | 2009-05-18 | 포휴먼텍(주) | 경피전달을 위한 약제 조성물 |
| GB0803352D0 (en) | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
| CA2716565C (en) * | 2008-02-28 | 2017-09-12 | Toray Industries, Inc. | Pharmaceutical composition for transnasal administration |
| WO2009147368A1 (en) * | 2008-06-04 | 2009-12-10 | Medical Research Council | Peptides |
| WO2010033240A2 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| FR2941230B1 (fr) | 2009-01-19 | 2011-03-18 | Centre Nat Rech Scient | Polypeptides d'adressage specifique a des cellules-cibles d'otx2 |
| US20120165265A1 (en) * | 2009-02-26 | 2012-06-28 | Dolmetsch Ricardo E | Calcium Signaling Modulators Involving STIM and ORAI Proteins |
| RU2548807C2 (ru) * | 2009-05-20 | 2015-04-20 | Торэй Индастриз, Инк. | Пептиды, проникающие в клетку |
| US20100322957A1 (en) * | 2009-05-22 | 2010-12-23 | Aderem Alan A | Secretion-related bacterial proteins for nlrc4 stimulation |
| GB201001602D0 (en) | 2010-02-01 | 2010-03-17 | Cytovation As | Oligopeptidic compounds and uses therof |
| JP5757497B2 (ja) * | 2010-10-06 | 2015-07-29 | 公立大学法人大阪府立大学 | シガトキシン類ｃｔｘ１ｂおよび５４−デオキシ−ｃｔｘ１ｂを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット |
| AU2012249474A1 (en) | 2011-04-28 | 2013-11-07 | Stc.Unm | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same |
| CN103998458B (zh) | 2011-08-30 | 2018-10-09 | 医学研究理事会 | 具有中央疏水域的细胞穿透肽 |
| GB201318954D0 (en) | 2013-10-28 | 2013-12-11 | Cupid Peptide Company Ltd | Cell transport |
| GB201507722D0 (en) | 2015-05-06 | 2015-06-17 | Norwegian Univ Sci & Tech Ntnu | Anti-bacterial agents and their use in therapy |
| US10087194B2 (en) | 2015-10-27 | 2018-10-02 | California Pacific Medical Center | Podophyllotoxin derivatives and their use |
| CN106937529B (zh) | 2015-10-27 | 2021-02-05 | 加州太平洋医疗中心 | 鬼臼毒素衍生物及其应用 |
| WO2017120504A1 (en) | 2016-01-08 | 2017-07-13 | Durfee Paul N | Osteotropic nanoparticles for prevention or treatment of bone metastases |
| EP3497119A1 (de) | 2016-08-09 | 2019-06-19 | Aarhus Universitet | Modulation von ifi16 und sting-aktivität |
| WO2018045155A1 (en) * | 2016-09-02 | 2018-03-08 | The Board Of Trustees Of The University Of Illinois | Kif13b-derived peptide and method of inhibiting angiogenesis |
| US11344629B2 (en) | 2017-03-01 | 2022-05-31 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
| CN111201247A (zh) | 2017-04-28 | 2020-05-26 | 奥克兰联合服务有限公司 | 治疗方法和新颖构建体 |
| WO2020068798A1 (en) | 2018-09-24 | 2020-04-02 | Guo Jimin | Living mammalian cells modified with functional modular nanoparticles |
| US20220048953A1 (en) | 2018-09-26 | 2022-02-17 | Kaneka Corporation | Cell-penetrating peptide |
| US12208164B2 (en) | 2019-02-28 | 2025-01-28 | Unm Rainforest Innovations | Modular metal-organic polyhedra superassembly compositions |
| GB201915454D0 (en) | 2019-10-24 | 2019-12-11 | Norwegian Univ Sci & Tech Ntnu | Antibacterial bone cement and uses thereof |
| GB202006699D0 (en) | 2020-05-06 | 2020-06-17 | Therapim Pty Ltd | Dosage regimen |
| GB202008888D0 (en) | 2020-06-11 | 2020-07-29 | Norwegian Univ Of Science And Technology (Ntnu) | Peptides for sepsis treatment |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4847240A (en) | 1978-01-16 | 1989-07-11 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
| US5043329A (en) | 1987-02-17 | 1991-08-27 | Board Of Regents, University Of Texas System | Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract |
| DE3836971C1 (de) | 1988-10-31 | 1990-05-17 | Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De | |
| FR2662698A1 (fr) | 1990-06-05 | 1991-12-06 | Centre Nat Rech Scient | Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite. |
| US5888762A (en) | 1990-06-05 | 1999-03-30 | Centre National De La Recherche Scientifique (Cnrs) | Neurotropic growth factors comprising a homeobox peptide |
| EP0751225B1 (de) | 1990-10-15 | 2001-03-28 | Tecnogen S.C.P.A. | Verfahren zur Feststellung von proteolitischen Wirkungen und/oder deren Inhibitoren |
| WO1993022343A1 (en) | 1992-05-01 | 1993-11-11 | The Rockfeller University | Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom |
| US5674977A (en) | 1993-02-05 | 1997-10-07 | The Ontario Cancer Institute | Branched synthetic peptide conjugate |
| US5807746A (en) * | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
| FR2739621B1 (fr) | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
| US5843903A (en) | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
| US6344436B1 (en) * | 1996-01-08 | 2002-02-05 | Baylor College Of Medicine | Lipophilic peptides for macromolecule delivery |
| US5877282A (en) * | 1996-09-20 | 1999-03-02 | Bristol-Myers Squibb Company | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
| WO1998013059A1 (en) | 1996-09-27 | 1998-04-02 | Bristol-Myers Squibb Company | Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells |
| AU7737196A (en) * | 1996-11-14 | 1998-06-03 | Brigham And Women's Hospital | Polyphosphoinositide binding peptides for intracellular drug delivery |
| US5929042A (en) | 1997-03-03 | 1999-07-27 | The Trustees Of Columbia University In The City Of New York | Antisense compounds which prevent cell death and uses thereof |
| IT1291649B1 (it) * | 1997-04-24 | 1999-01-19 | Intercos Italiana | Polveri cosmetiche rivestite con ingredienti naturali |
| US6635623B1 (en) * | 1997-06-13 | 2003-10-21 | Baylor College Of Medicine | Lipoproteins as nucleic acid vectors |
| AU741546B2 (en) | 1997-07-24 | 2001-12-06 | Perseptive Biosystems, Inc. | Conjugates of transporter peptides and nucleic acid analogs, and their use |
| JP2001513987A (ja) * | 1997-08-22 | 2001-09-11 | ワシントン大学 | 誘導性制御システムおよびその使用 |
| GB9718609D0 (en) * | 1997-09-02 | 1997-11-05 | Imp College Innovations Ltd | Fusion protein |
| CN1357048A (zh) * | 1998-03-06 | 2002-07-03 | 牛津生物医学（英国）有限公司 | 增强前体药物活化 |
| WO1999064449A2 (en) * | 1998-06-10 | 1999-12-16 | The Queen's University Of Belfast | Cell-permeable peptide |
| GB9812675D0 (en) | 1998-06-11 | 1998-08-12 | Univ Edinburgh | Peptides |
| GB9814527D0 (en) | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
-
1999
- 1999-11-11 AU AU10630/00A patent/AU766489B2/en not_active Ceased
- 1999-11-11 WO PCT/GB1999/003750 patent/WO2000029427A2/en not_active Ceased
- 1999-11-11 EP EP07018932A patent/EP1958961A3/de not_active Withdrawn
- 1999-11-11 ES ES99954212T patent/ES2318906T3/es not_active Expired - Lifetime
- 1999-11-11 DE DE69940215T patent/DE69940215D1/de not_active Expired - Fee Related
- 1999-11-11 GB GB9926719A patent/GB2346616B/en not_active Expired - Fee Related
- 1999-11-11 EP EP99954212A patent/EP1135410B1/de not_active Expired - Lifetime
- 1999-11-11 CZ CZ20011671A patent/CZ20011671A3/cs unknown
- 1999-11-11 CA CA002350919A patent/CA2350919A1/en not_active Abandoned
- 1999-11-11 JP JP2000582414A patent/JP2002530059A/ja not_active Withdrawn
- 1999-11-11 HU HU0204199A patent/HUP0204199A3/hu unknown
- 1999-11-11 AT AT99954212T patent/ATE419273T1/de not_active IP Right Cessation
- 1999-11-11 IL IL14286999A patent/IL142869A0/xx unknown
- 1999-11-12 US US09/438,460 patent/US7153931B1/en not_active Expired - Fee Related
-
2001
- 2001-05-11 US US09/854,204 patent/US7101967B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002530059A (ja) | 2002-09-17 |
| US7153931B1 (en) | 2006-12-26 |
| WO2000029427A3 (en) | 2000-10-05 |
| CA2350919A1 (en) | 2000-05-25 |
| AU1063000A (en) | 2000-06-05 |
| AU766489B2 (en) | 2003-10-16 |
| GB9926719D0 (en) | 2000-01-12 |
| DE69940215D1 (de) | 2009-02-12 |
| CZ20011671A3 (cs) | 2001-10-17 |
| EP1135410A2 (de) | 2001-09-26 |
| US20020098236A1 (en) | 2002-07-25 |
| WO2000029427A2 (en) | 2000-05-25 |
| EP1135410B1 (de) | 2008-12-31 |
| US7101967B2 (en) | 2006-09-05 |
| ES2318906T3 (es) | 2009-05-01 |
| EP1958961A2 (de) | 2008-08-20 |
| HUP0204199A3 (en) | 2005-09-28 |
| IL142869A0 (en) | 2002-03-10 |
| EP1958961A3 (de) | 2008-09-03 |
| HUP0204199A2 (hu) | 2003-03-28 |
| GB2346616A (en) | 2000-08-16 |
| GB2346616B (en) | 2004-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1135410 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |