ATE419537T1 - Verwendung eines polypeptids zur auffindung von multipler sklerose - Google Patents
Verwendung eines polypeptids zur auffindung von multipler skleroseInfo
- Publication number
- ATE419537T1 ATE419537T1 AT00953247T AT00953247T ATE419537T1 AT E419537 T1 ATE419537 T1 AT E419537T1 AT 00953247 T AT00953247 T AT 00953247T AT 00953247 T AT00953247 T AT 00953247T AT E419537 T1 ATE419537 T1 AT E419537T1
- Authority
- AT
- Austria
- Prior art keywords
- detecting
- degenerative
- neurological
- treating
- polypeptide
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 201000006417 multiple sclerosis Diseases 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 3
- 208000012902 Nervous system disease Diseases 0.000 abstract 3
- 208000025966 Neurological disease Diseases 0.000 abstract 3
- 230000003412 degenerative effect Effects 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 3
- 230000000926 neurological effect Effects 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract 1
- 102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 abstract 1
- 102000004506 Blood Proteins Human genes 0.000 abstract 1
- 108010017384 Blood Proteins Proteins 0.000 abstract 1
- 102000018755 Calgranulin B Human genes 0.000 abstract 1
- 108010052495 Calgranulin B Proteins 0.000 abstract 1
- 102100023364 Ganglioside GM2 activator Human genes 0.000 abstract 1
- 101710201362 Ganglioside GM2 activator Proteins 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 102000017852 Saposin Human genes 0.000 abstract 1
- 108050007079 Saposin Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- XGVJWXAYKUHDOO-UHFFFAOYSA-N galanthidine Natural products C1CN2CC3=CC=4OCOC=4C=C3C3C2C1=CC(O)C3O XGVJWXAYKUHDOO-UHFFFAOYSA-N 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- CKAXXGPMLYVWQI-UHFFFAOYSA-N lycorin Chemical compound C1C2=CC=3OCOC=3C=C2C2C(O)C(O)=CC3C2N1CC3 CKAXXGPMLYVWQI-UHFFFAOYSA-N 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 108010049224 perlecan Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960003471 retinol Drugs 0.000 abstract 1
- 235000020944 retinol Nutrition 0.000 abstract 1
- 239000011607 retinol Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Rehabilitation Therapy (AREA)
- Toxicology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9909372A FR2797402B1 (fr) | 1999-07-15 | 1999-07-15 | Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419537T1 true ATE419537T1 (de) | 2009-01-15 |
Family
ID=9548286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00953247T ATE419537T1 (de) | 1999-07-15 | 2000-07-17 | Verwendung eines polypeptids zur auffindung von multipler sklerose |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7081345B1 (de) |
| EP (2) | EP2081028A1 (de) |
| JP (1) | JP2003509340A (de) |
| AT (1) | ATE419537T1 (de) |
| AU (1) | AU6576800A (de) |
| CA (1) | CA2379336A1 (de) |
| DE (1) | DE60041265D1 (de) |
| ES (1) | ES2317845T3 (de) |
| FR (1) | FR2797402B1 (de) |
| WO (1) | WO2001005422A2 (de) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6902890B1 (en) | 1999-11-04 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing monitoring, staging, imaging and treating cancer |
| AU2001233715A1 (en) * | 2000-01-26 | 2001-08-07 | Memorec Medical Molecular Research Cologne Stoffel Gmbh | Dermo- and gastro-specific sphingolipid activator |
| WO2002018423A1 (en) * | 2000-08-31 | 2002-03-07 | University Of Delaware | Bioactive peptide for cell adhesion |
| CA2434677A1 (en) * | 2001-01-12 | 2002-10-10 | Incyte Genomics, Inc. | Molecules for diagnostics and therapeutics |
| US20020160434A1 (en) * | 2001-04-30 | 2002-10-31 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1777 daltons |
| US7008800B2 (en) * | 2001-04-30 | 2006-03-07 | Artemis Proteomics, Ltd. | Biopolymer marker indicative of disease state having a molecular weight of 1077 daltons |
| US6593298B2 (en) | 2001-04-30 | 2003-07-15 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1690 daltons |
| US20020160532A1 (en) * | 2001-04-30 | 2002-10-31 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1998 daltons |
| US6627608B2 (en) | 2001-04-30 | 2003-09-30 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1206 daltons |
| US20020160417A1 (en) * | 2001-04-30 | 2002-10-31 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1424 daltons |
| US20040198950A1 (en) * | 2001-04-30 | 2004-10-07 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1518 daltons |
| US6998243B2 (en) * | 2001-04-30 | 2006-02-14 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1793 daltons |
| US7087435B2 (en) * | 2001-04-30 | 2006-08-08 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 2753 daltons |
| US6620786B2 (en) | 2001-04-30 | 2003-09-16 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having molecular weight of 2937 daltons |
| US20040224423A1 (en) * | 2001-04-30 | 2004-11-11 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 2056 daltons |
| US6620787B2 (en) | 2001-04-30 | 2003-09-16 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 2267 daltons |
| US6599877B2 (en) | 2001-04-30 | 2003-07-29 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1020 daltons |
| US6756476B2 (en) * | 2001-04-30 | 2004-06-29 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 2021 daltons |
| US7049397B2 (en) * | 2001-04-30 | 2006-05-23 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1211 daltons |
| US6890763B2 (en) | 2001-04-30 | 2005-05-10 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1350 daltons |
| US6677303B2 (en) * | 2001-04-30 | 2004-01-13 | Syn X Pharma | Biopolymer marker indicative of disease state having a molecular weight of 1097 daltons |
| US6602855B2 (en) * | 2001-04-30 | 2003-08-05 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1449 daltons |
| US6703366B2 (en) | 2001-04-30 | 2004-03-09 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1,896 daltons |
| US20020160423A1 (en) * | 2001-04-30 | 2002-10-31 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1536 daltons |
| US20020160421A1 (en) * | 2001-04-30 | 2002-10-31 | George Jackowski | Method for monitoring and validating stress induction of disease state |
| US20020160418A1 (en) * | 2001-04-30 | 2002-10-31 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1949 daltons |
| US7314717B2 (en) | 2001-04-30 | 2008-01-01 | Nanogen Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1562 daltons |
| US6617308B2 (en) | 2001-04-30 | 2003-09-09 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons |
| US6627607B2 (en) | 2001-04-30 | 2003-09-30 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1845 daltons |
| US20030040602A1 (en) * | 2001-04-30 | 2003-02-27 | George Jackowski | Biopolymer marker indicative of disease state having a molecular weight of 1406 daltons |
| US7294688B2 (en) * | 2001-04-30 | 2007-11-13 | Nanogen Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons |
| US6693080B2 (en) | 2001-04-30 | 2004-02-17 | Syn X Pharma | Biopolymer marker indicative of disease state having a molecular weight of 1521 daltons |
| US20020160533A1 (en) | 2001-04-30 | 2002-10-31 | George Jackowski | Biopolymer marker indicative of disease state having a molecular of weight of 1525 daltons |
| US6627606B2 (en) | 2001-04-30 | 2003-09-30 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1465 daltons |
| GB0112626D0 (en) | 2001-05-23 | 2001-07-18 | Osteometer Biotech As | Assay of isomerised and/or optically inverted proteins and protein fragments |
| AU2002335965A1 (en) * | 2001-11-23 | 2003-06-10 | Syn.X Pharma, Inc. | Pedf biopolymer markers predictive of alzheimers disease |
| AU2002335967A1 (en) * | 2001-11-23 | 2003-06-10 | Syn. X Pharma, Inc. | Protein biopolymer markers predictive of alzheimers disease |
| AU2002335963A1 (en) * | 2001-11-23 | 2003-06-10 | Syn.X Pharma, Inc. | Protein biopolymer markers predictive of alzheimers disease |
| US20070003974A1 (en) * | 2001-11-23 | 2007-01-04 | George Jackowski | Cene-E biopolymer marker indicative of age matched control |
| US20030100016A1 (en) * | 2001-11-23 | 2003-05-29 | George Jackowski | Complement C3 precursor biopolymer markers predictive of Alzheimers disease |
| US7026129B2 (en) * | 2001-11-23 | 2006-04-11 | Syn X Pharma, Inc. | IG lambda biopolymer markers predictive of Alzheimers disease |
| US20030100012A1 (en) * | 2001-11-23 | 2003-05-29 | George Jackowski | Plasma protease C1 biopolymer markers predictive of alzheimers disease |
| US7179606B2 (en) * | 2001-11-23 | 2007-02-20 | Syn X Pharma, Inc. | IG heavy chain, IG kappa, IG lambda biopolymer markers predictive of Alzheimer's disease |
| JP2005510727A (ja) * | 2001-11-23 | 2005-04-21 | シン.クス ファーマ、インコーポレイテッド | アルツハイマー病を予測するhpおよびアポリポタンパク質バイオポリマーマーカー |
| US20030113808A1 (en) * | 2001-12-13 | 2003-06-19 | George Jackowski | Apolipoprotein biopolymer markers predictive of alzheimers disease |
| US20030119074A1 (en) * | 2001-12-20 | 2003-06-26 | George Jackowski | Diagnosis and treatment of dementia utilizing thrombospondin |
| EP2500438A3 (de) * | 2002-09-25 | 2012-11-28 | Genentech, Inc. | Neue Zusammensetzungen und Verfahren zur Behandlung von Psoriasis |
| US20070123455A1 (en) * | 2003-04-04 | 2007-05-31 | Joel Palefsky | Immunomodulatory agents for treatment of inflammatory diseases |
| FR2841787A1 (fr) * | 2003-06-13 | 2004-01-09 | Biomerieux Stelhys | Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune |
| FR2841786A1 (fr) * | 2003-06-13 | 2004-01-09 | Biomerieux Stelhys | Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune |
| FR2864086A1 (fr) * | 2003-12-23 | 2005-06-24 | Biomerieux Sa | Facteur cytotoxique isole associe a la sclerose en plaques et procede de detection dudit facteur cytotoxique |
| CN1993378A (zh) | 2004-08-03 | 2007-07-04 | 转化技术制药公司 | Rage融合蛋白及使用方法 |
| JP2008537143A (ja) | 2005-04-19 | 2008-09-11 | バーミリオン, インコーポレイテッド | アルツハイマー病のためのバイオマーカーであるサポシンd及びfam3c |
| PT1928438E (pt) | 2005-09-26 | 2013-04-03 | Avigen Inc | Método para tratamento de dependências de drogas e comportamentos |
| BRPI0711193A2 (pt) | 2006-05-05 | 2013-06-18 | Transtech Pharma Inc | proteÍnas de fusço rage, formulaÇÕes e mÉtodos de uso dos mesmos |
| WO2007142924A1 (en) | 2006-05-31 | 2007-12-13 | Avigen, Inc. | Ibudilast for inhibiting macrophage migration inhibitory factor (mif) activity |
| EP2158210B1 (de) | 2007-06-14 | 2015-12-09 | Galactica Pharmaceuticals, Inc. | Rage-fusionsproteine |
| US8163203B2 (en) * | 2008-02-27 | 2012-04-24 | The Regents Of The University Of California | Yellow emitting phosphors based on Ce3+-doped aluminate and via solid solution for solid-state lighting applications |
| US8173598B2 (en) * | 2008-08-29 | 2012-05-08 | The Board Of Trustees Of The University Of Illinois | Myeloid protein activation of anti-inflammatory and anti-hypoxic pathway |
| AU2009297425A1 (en) * | 2008-09-25 | 2010-04-01 | Sumitomo Chemical Company, Limited | Biomarker for microdomain disorder |
| CN102803292A (zh) | 2009-04-20 | 2012-11-28 | 辉瑞公司 | 蛋白质糖基化的控制及其相关组合物和方法 |
| WO2011085136A2 (en) | 2010-01-06 | 2011-07-14 | Elan Pharmaceuticals, Inc. | Use of perlecan domain v in treating amyloidogenic disease |
| CA2804154C (en) * | 2010-07-01 | 2021-06-01 | The Texas A&M University System | Perlecan domain v protects, repairs and restores ischemic brain stroke injury and motor function |
| EP2601532B1 (de) * | 2010-08-06 | 2016-01-27 | Mycartis N.V. | Perlecan als biomarker für niereninsuffizienz |
| JP5959114B2 (ja) * | 2011-05-19 | 2016-08-02 | 学校法人 明治薬科大学 | リン酸化糖鎖を含有する組換えヒトサポシンbタンパク質及びその用途 |
| KR102119985B1 (ko) | 2013-01-11 | 2020-06-05 | 마크 씨 허즈버그 | mRNA 트랜스펙션을 수반하는 치료 조성물 및 방법 |
| AU2016349703A1 (en) | 2015-11-06 | 2018-11-01 | Vetica Labs, Inc. | Methods of detecting inflammatory markers and treating inflammatory conditions in companion animals |
| US11253570B2 (en) | 2016-11-07 | 2022-02-22 | Medizinische Hochschule Hannover (Mhh) | S100A8/S100A9-induced immunotolerance in newborn subjects |
| US11185539B2 (en) * | 2017-01-31 | 2021-11-30 | Medizinische Hochschule Hannover (Mhh) | Natural compounds and fibrosis |
| US11020464B2 (en) * | 2017-02-21 | 2021-06-01 | Osaka University | Immunogenic composition targeting S100A9 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP4150337A1 (de) * | 2020-05-13 | 2023-03-22 | Nordic Bioscience A/S | Calprotectin-assay |
| CN113336837B (zh) * | 2021-07-21 | 2022-12-23 | 中国药科大学 | 多肽及其在制备抗神经退行性疾病药物方面的应用 |
| US11780917B2 (en) | 2021-08-16 | 2023-10-10 | Taiwan Innovative Integration Services Co., Ltd. | Anti-GM2AP antibody and applications thereof |
| TWI795872B (zh) * | 2021-08-16 | 2023-03-11 | 微體生物醫學股份有限公司 | 抗gm2ap抗體及其應用 |
| WO2024012583A1 (zh) * | 2022-07-14 | 2024-01-18 | 浩峰生物科技股份有限公司 | 人源化岩藻糖基化gm2ap抗体 |
| US20240218078A1 (en) * | 2022-12-07 | 2024-07-04 | Vitae Biomedical Co., Ltd. | Anti-GM2AP ANTIBODY AND APPLICATIONS THEREOF |
| WO2024168151A2 (en) * | 2023-02-09 | 2024-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Capped peptides and methods for using the same |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| WO1990007712A1 (de) * | 1988-12-23 | 1990-07-12 | Bissendorf Peptide Gmbh | Antigen, assoziiert mit degenerativen erscheinungen des zentralen nervensystems (zns), dagegen gerichtete antikörper sowie verfahren zur diagnose von dysfunktionen des zns |
| EP0737750B1 (de) | 1989-03-21 | 2003-05-14 | Vical, Inc. | Expression von exogenen Polynukleotidsequenzen in Wirbeltieren |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| EP0710288B1 (de) | 1993-06-10 | 2006-04-05 | Genetic Therapy, Inc. | Adenovirale vektoren für die behandlung der hämophilie |
| NZ277614A (en) | 1993-11-24 | 1998-05-27 | Megabios Corp | Piperazine-containing amphiphiles and their use in liposomes for delivering genetic material intracellularly |
| FR2716198B1 (fr) * | 1994-02-15 | 1996-04-19 | Bio Merieux | Facteur cytotoxique tel qu'associé à la sclérose en plaques, sa détection et sa quantification. |
| ATE277640T1 (de) | 1994-03-07 | 2004-10-15 | Dow Chemical Co | Bioaktive und/oder gezielte dendrimere-konjugate enthaltend genetisches material |
| FR2719316B1 (fr) | 1994-04-28 | 1996-05-31 | Idm | Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules. |
| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| JPH08308582A (ja) * | 1995-05-23 | 1996-11-26 | Kao Corp | ラットgm2アクチベータ蛋白質遺伝子 |
| AU705035B2 (en) | 1995-06-07 | 1999-05-13 | Baylor College Of Medicine | Nucleic acid transporters for delivery of nucleic acids into a cell |
| FR2745974B1 (fr) * | 1996-03-14 | 1998-04-17 | Animal modifie, utilisations et procede pour mesurer l'efficacite d'un procede therapeutique | |
| WO1998011439A1 (fr) * | 1996-09-12 | 1998-03-19 | Bio Merieux | Procede de detection et/ou de quantification d'un facteur gliotoxique |
| CA2214843A1 (en) * | 1997-10-31 | 1999-04-30 | Brigitte Rigat | A novel inhibitor of platelet activating factor |
-
1999
- 1999-07-15 FR FR9909372A patent/FR2797402B1/fr not_active Expired - Fee Related
-
2000
- 2000-07-17 WO PCT/FR2000/002057 patent/WO2001005422A2/fr not_active Ceased
- 2000-07-17 US US10/030,937 patent/US7081345B1/en not_active Expired - Fee Related
- 2000-07-17 CA CA002379336A patent/CA2379336A1/fr not_active Abandoned
- 2000-07-17 JP JP2001510476A patent/JP2003509340A/ja active Pending
- 2000-07-17 DE DE60041265T patent/DE60041265D1/de not_active Expired - Lifetime
- 2000-07-17 ES ES00953247T patent/ES2317845T3/es not_active Expired - Lifetime
- 2000-07-17 EP EP08172758A patent/EP2081028A1/de not_active Withdrawn
- 2000-07-17 AT AT00953247T patent/ATE419537T1/de not_active IP Right Cessation
- 2000-07-17 EP EP00953247A patent/EP1203239B1/de not_active Expired - Lifetime
- 2000-07-17 AU AU65768/00A patent/AU6576800A/en not_active Abandoned
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2006
- 2006-06-12 US US11/450,360 patent/US7510843B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2797402A1 (fr) | 2001-02-16 |
| US20060223121A1 (en) | 2006-10-05 |
| JP2003509340A (ja) | 2003-03-11 |
| EP1203239B1 (de) | 2008-12-31 |
| EP2081028A1 (de) | 2009-07-22 |
| US7081345B1 (en) | 2006-07-25 |
| AU6576800A (en) | 2001-02-05 |
| WO2001005422A3 (fr) | 2002-02-28 |
| CA2379336A1 (fr) | 2001-01-25 |
| EP1203239A2 (de) | 2002-05-08 |
| US7510843B2 (en) | 2009-03-31 |
| ES2317845T3 (es) | 2009-05-01 |
| WO2001005422A2 (fr) | 2001-01-25 |
| DE60041265D1 (de) | 2009-02-12 |
| FR2797402B1 (fr) | 2004-03-12 |
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