ATE419837T1 - Feuchtgranulierungsmethode zur herstellung pharmazeutischer aripiprazolzusammensetzungen - Google Patents

Feuchtgranulierungsmethode zur herstellung pharmazeutischer aripiprazolzusammensetzungen

Info

Publication number: ATE419837T1
Authority: AT; Austria
Prior art keywords: granulation method; producing pharmaceutical; moist granulation; aripiprazole compositions; aripiprazole
Prior art date: 2006-01-05

Application number

AT06251324T

Other languages

English (en)

Inventor

Julia Hrakovsky

Ruth Tenengauzer

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-01-05

Filing date

2006-03-14

Publication date

2009-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36637023&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE419837(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-03-14 Application filed by Teva Pharma filed Critical Teva Pharma

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE419837T1 publication Critical patent/ATE419837T1/de

Links

CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title abstract 2
229960004372 aripiprazole Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
238000009481 moist granulation Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT06251324T 2006-01-05 2006-03-14 Feuchtgranulierungsmethode zur herstellung pharmazeutischer aripiprazolzusammensetzungen ATE419837T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US75670806P	2006-01-05	2006-01-05

Publications (1)

Publication Number	Publication Date
ATE419837T1 true ATE419837T1 (de)	2009-01-15

Family

ID=36637023

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06251324T ATE419837T1 (de)	2006-01-05	2006-03-14	Feuchtgranulierungsmethode zur herstellung pharmazeutischer aripiprazolzusammensetzungen

Country Status (13)

Country	Link
US (1)	US8865722B2 (de)
EP (2)	EP1808164B2 (de)
JP (1)	JP4875001B2 (de)
CN (1)	CN101351192A (de)
AT (1)	ATE419837T1 (de)
CA (1)	CA2627693A1 (de)
DE (1)	DE602006004694D1 (de)
DK (1)	DK1808164T3 (de)
ES (1)	ES2318693T5 (de)
IL (1)	IL190916A0 (de)
PL (1)	PL1808164T3 (de)
PT (1)	PT1808164E (de)
WO (1)	WO2007081366A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI320783B (en)	2005-04-14	2010-02-21	Otsuka Pharma Co Ltd	Heterocyclic compound
TR200604349A2 (tr) *	2006-08-15	2008-03-21	NOBEL İLAÇ SANAYii VE TiCARET A.Ş.	Aripiprazol içeren farmasötik bileşimler
GB0618879D0 (en)	2006-09-26	2006-11-01	Zysis Ltd	Pharmaceutical compositions
WO2010079506A2 (en)	2008-06-23	2010-07-15	Torrent Pharmaceuticals Ltd.	Pharmaceutical composition of aripiprazole
EA201200485A1 (ru)	2009-09-15	2012-10-30	Рациофарм Гмбх	Перорально распадающаяся фармацевтическая лекарственная форма, содержащая арипипразол
CN102106826B (zh) *	2009-12-29	2013-06-05	上海中西制药有限公司	一种阿立哌唑固体制剂及其制备方法
SG184891A1 (en) *	2010-04-30	2012-11-29	Bristol Myers Squibb Co	Pharmaceutical compositions comprising n-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-l-(4-fluorophenyl)-2-oxo- 1,2-dihydropyridine-3 -carboxamide
CN102850268B (zh) *	2011-06-27	2015-07-15	上海中西制药有限公司	阿立哌唑ⅰ型微晶、阿立哌唑固体制剂及制备方法
JO3753B1 (ar)	2011-10-14	2021-01-31	Otsuka Pharma Co Ltd	قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه
WO2013083674A1 (de) *	2011-12-08	2013-06-13	Hexal Ag	Neue pharmazeutische statin-zusammensetzung
WO2014104989A1 (en) *	2011-12-27	2014-07-03	Mahmut Bilgic	Pharmaceutical compositions comprising aripiprazole
WO2013100878A1 (en) *	2011-12-27	2013-07-04	Mahmut Bilgic	Pharmaceutical formulations comprising aripiprazole
WO2013175508A2 (en)	2012-05-24	2013-11-28	Medreich Limited	Stable pharmaceutical composition of aripiprazole
JP6007169B2 (ja) *	2012-11-30	2016-10-12	大原薬品工業株式会社	アリピプラゾール無水物を含有する固形製剤の製造方法
KR101759017B1 (ko) *	2013-04-30	2017-07-17	오쓰까 세이야꾸 가부시키가이샤	아리피프라졸을 포함하는 경구 고형 제제 및 아리피프라졸을 포함하는 경구 고형 제제의 제조방법
US9051268B2 (en)	2013-04-30	2015-06-09	Otsuka Pharmaceutical Co., Ltd.	Oral solid preparation comprising aripiprazole and method for producing oral solid preparation comprising aripiprazole
GR1008442B (el) *	2014-01-16	2015-03-05	"Φαρματεν Α.Β.Ε.Ε.",	Φαρμακευτικο σκευασμα περιεχον αριπιπραζολη ή αλας αυτης
EP3002005A1 (de) *	2014-09-30	2016-04-06	Molkerei Meggle Wasserburg GmbH & Co. Kg	Direktkomprimierter Hilfsstoff auf Basis von Lactose, Cellulose und Stärke
WO2016189504A1 (en) *	2015-05-28	2016-12-01	Leiutis Pharmaceuticals Pvt Ltd	Non-lyophilized compositions of aripiprazole and methods of preparation thereof
US11672761B2 (en)	2020-11-16	2023-06-13	Orcosa Inc.	Rapidly infusing platform and compositions for therapeutic treatment in humans
WO2022103639A1 (en)	2020-11-16	2022-05-19	Orcosa Inc.	Methods of treating autoimmune or inflammatory conditions with cannabidiol or its derivatives/analogs

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA71629C2 (en)	1999-08-03	2004-12-15	Lilli Icos Llc	Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction
WO2003030868A1 (en) *	2001-10-09	2003-04-17	Bristol-Myers Squibb Company	Flashmelt oral dosage formulation
CA2311734C (en)	2000-04-12	2011-03-08	Bristol-Myers Squibb Company	Flash-melt oral dosage formulation
MY129350A (en) *	2001-04-25	2007-03-30	Bristol Myers Squibb Co	Aripiprazole oral solution
AR033485A1 (es) *	2001-09-25	2003-12-26	Otsuka Pharma Co Ltd	Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
TWI324074B (en) *	2001-10-09	2010-05-01	Bristol Myers Squibb Co	Flashmelt oral dosage formulation
JP2003238393A (ja) *	2002-02-15	2003-08-27	Otsuka Pharmaceut Co Ltd	施錠性が改善された錠剤及びその製造方法
DE10224170A1 (de) *	2002-05-31	2003-12-11	Desitin Arzneimittel Gmbh	Pharmazeutische Zusammensetzung mit verzögerter Wirkstofffreisetzung
WO2004083183A1 (en) *	2003-03-21	2004-09-30	Hetero Drugs Limited	Novel crystalline forms of aripiprazole
WO2004106322A2 (en) *	2003-04-25	2004-12-09	Cadila Healthcare Limited	Polymorphs of aripiprazole
JP2007509155A (ja)	2003-10-21	2007-04-12	アルファーマインコーポレイテッド	クエチアピンを含有する薬剤
UA82561C2 (uk)	2003-10-23	2008-04-25	Оцука Фармасьютикалз Ко., Лтд.	Стерильна ін'єкційна композиція арипіпразолу з контрольованим вивільненням, спосіб її виготовлення та спосіб лікування шизофренії
ES2374922T3 (es) *	2003-12-16	2012-02-23	Teva Pharmaceutical Industries Ltd.	Procedimientos de preparación de formas cristalinas de aripiprazol.
RU2766487C2 (ru) *	2004-01-20	2022-03-15	Новартис Аг	Композиция и способ прямого прессования
US7507823B2 (en) *	2004-05-06	2009-03-24	Bristol-Myers Squibb Company	Process of making aripiprazole particles
CN101087760B (zh) *	2004-11-18	2011-09-28	斯索恩有限公司	结晶的阿立哌唑溶剂化物
CN102627603A (zh) *	2004-11-18	2012-08-08	斯索恩有限公司	制备结晶阿立哌唑的方法
EP1686117A1 (de) *	2005-01-27	2006-08-02	Sandoz AG	Polymorph und Solvate von Aripiprazol
EP2783688A1 (de) *	2005-03-17	2014-10-01	Synhton B.V.	Pharmazeutische Tabletten von kristallinem Aripiprazol Typ II
EP1879865A1 (de)	2005-04-15	2008-01-23	Medichem S.A.	Synthesen und herstellungen von polymorphen aus kristallinem aripiprazol
JP2008540644A (ja)	2005-07-15	2008-11-20	テバファーマシューティカルインダストリーズリミティド	新規粒質化方法及びそれから生成される粒質物
US20070014864A1 (en) *	2005-07-15	2007-01-18	Teva Pharmaceutical Industries, Ltd.	Novel pharmaceutical granulate
US20070014854A1 (en) *	2005-07-15	2007-01-18	Ilan Zalit	Novel granulation process
US20070014853A1 (en) *	2005-07-15	2007-01-18	Ilan Zalit	Pharmaceutical dosage form containing novel pharmaceutical granulate
CA2622758A1 (en) *	2005-09-15	2007-03-29	Elan Pharma International, Limited	Nanoparticulate aripiprazole formulations
TW200800202A (en) *	2005-12-22	2008-01-01	Teva Pharma	Processes for reducing particle size of aripiprazole
US20070148245A1 (en) *	2005-12-22	2007-06-28	Ilan Zalit	Compressed solid dosage forms with drugs of low solubility and process for making the same
CN101340896A (zh)	2005-12-22	2009-01-07	特瓦制药工业有限公司	含有低溶解性药物的压缩的固体剂型和其制备方法
WO2007092779A2 (en)	2006-02-03	2007-08-16	Dr. Reddy's Laboratories Ltd.	Aripiprazole co-crystals
EP1880714A1 (de) *	2006-07-20	2008-01-23	Helm AG	Amorphes Aripiprazol und Verfahren zu dessen Herstellung

2006
- 2006-03-14 DE DE602006004694T patent/DE602006004694D1/de not_active Expired - Lifetime
- 2006-03-14 ES ES06251324.7T patent/ES2318693T5/es not_active Expired - Lifetime
- 2006-03-14 EP EP06251324.7A patent/EP1808164B2/de not_active Expired - Lifetime
- 2006-03-14 CA CA002627693A patent/CA2627693A1/en not_active Abandoned
- 2006-03-14 PT PT06251324T patent/PT1808164E/pt unknown
- 2006-03-14 AT AT06251324T patent/ATE419837T1/de not_active IP Right Cessation
- 2006-03-14 EP EP08018220A patent/EP2036545A1/de not_active Withdrawn
- 2006-03-14 WO PCT/US2006/009279 patent/WO2007081366A1/en not_active Ceased
- 2006-03-14 DK DK06251324T patent/DK1808164T3/da active
- 2006-03-14 PL PL06251324T patent/PL1808164T3/pl unknown
- 2006-03-14 CN CNA2006800498824A patent/CN101351192A/zh active Pending
- 2006-03-14 US US11/376,029 patent/US8865722B2/en active Active
- 2006-03-14 JP JP2007558352A patent/JP4875001B2/ja not_active Expired - Fee Related
2008
- 2008-04-16 IL IL190916A patent/IL190916A0/en unknown

Also Published As

Publication number	Publication date
DE602006004694D1 (de)	2009-02-26
JP4875001B2 (ja)	2012-02-15
IL190916A0 (en)	2008-11-03
EP2036545A1 (de)	2009-03-18
EP1808164B2 (de)	2018-07-04
PT1808164E (pt)	2009-03-17
EP1808164A1 (de)	2007-07-18
US20070154544A1 (en)	2007-07-05
ES2318693T3 (es)	2009-05-01
WO2007081366A1 (en)	2007-07-19
EP1808164B1 (de)	2009-01-07
ES2318693T5 (es)	2018-10-04
CA2627693A1 (en)	2007-07-19
JP2008531737A (ja)	2008-08-14
PL1808164T3 (pl)	2009-06-30
US8865722B2 (en)	2014-10-21
CN101351192A (zh)	2009-01-21
DK1808164T3 (da)	2009-04-20

Legal Events

Date	Code	Title	Description
2009-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE419837T1 (de)	2009-01-15	Feuchtgranulierungsmethode zur herstellung pharmazeutischer aripiprazolzusammensetzungen
EP1885415A4 (de)	2012-02-22	Vorrichtung zur medikamentverabreichung
NL2000690A1 (nl)	2007-12-11	Gestabiliseerde farmaceutische samenstellingen omvattende fesoterodine.
DE502007004540D1 (de)	2010-09-09	Fertigungslinie zur Herstellung wurstförmiger Produkte
HUS1200023I1 (hu)	2021-03-29	Eljárás vakcinák elõállítására
BRPI0913379A2 (pt)	2015-11-24	formulações farmacêuticas sólidas compreendendo bibw 2992
LTC1781298I2 (lt)	2018-09-25	Farmacinės kompozicijos, turinčios benzoksazino, skirtos respiracinių ligų gydymui
HUE049177T2 (hu)	2020-09-28	Dohánytartalmú elszívható termék
DK2474321T3 (da)	2019-06-03	Sammensætninger til behandling af collagenmedierede sygdomme
BRPI0820997A2 (pt)	2014-12-23	Comprimidos de desintegração oral compreendendo difenidramina.
DK1962873T3 (da)	2013-08-26	Farmaceutiske sammensætninger omfattende oxalat-reducerende bakterier
SMT201200014B (it)	2012-07-10	Nalmefene cloridrato diidrato.
IL190915A0 (en)	2008-11-03	Dry formulations of aripiprazole
DE112008000701A5 (de)	2010-08-12	Zusammensetzung zur Herstellung von Speisern
IL194961A0 (en)	2009-08-03	Compounds a-r-x for the manufacture of pharmaceutical preparations
IL192415A0 (en)	2008-12-29	Pharmaceutical composition for the treatment of nail diseases
DE602006009764D1 (de)	2009-11-26	Terphenylderivate zur Alzheimerbehandlung
AT503967A3 (de)	2010-06-15	Vorrichtung zur herstellung von formteilen
ATE501717T1 (de)	2011-04-15	Einsatz von agomelatin zur herstellung von medikamenten zur behandlung des smith-magenis- syndroms (sms)
DE602006019979D1 (de)	2011-03-17	Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen
SMAP200900029A (it)	2009-11-06	Stampo assemblabile per produzione di calzature
DK2216039T3 (da)	2012-10-22	Farmaceutiske sammensætninger til behandling af angst
ZA200805656B (en)	2009-11-25	Prodrug ER²-selective substances, methods for the production thereof and pharmaceutical compositions containing said compounds
DE602005007319D1 (de)	2008-07-17	Zubereitung zur kontinuierlichen Arzneimittelfreisetzung Chitosan enthaltend
DE602007011337D1 (de)	2011-02-03	Maschine zur Herstellung von Zigarettenfiltern