ATE420073T1 - Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidinstereoisomere - Google Patents

Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidinstereoisomere

Info

Publication number: ATE420073T1
Authority: AT; Austria
Prior art keywords: erythro; stereoisomers; carbon atoms; threo; reacting
Prior art date: 1997-01-31

Application number

AT05077084T

Other languages

English (en)

Inventor

Sowmianarayanan Ramaswamy

Vikram Khetani

Original Assignee

Celgene Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-31

Filing date

1998-05-26

Publication date

2009-01-15

1998-05-26 Application filed by Celgene Corp filed Critical Celgene Corp

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE420073T1 publication Critical patent/ATE420073T1/de

Links

DWKUKQRKVCMOLP-UHFFFAOYSA-N 1-piperideine Chemical class C1CCN=CC1 DWKUKQRKVCMOLP-UHFFFAOYSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 8
125000004432 carbon atom Chemical group C* 0.000 abstract 6
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 5
150000003839 salts Chemical class 0.000 abstract 5
239000002253 acid Substances 0.000 abstract 4
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
239000002585 base Substances 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal alkoxide Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000005233 alkylalcohol group Chemical group 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
150000003053 piperidines Chemical class 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT05077084T 1997-01-31 1998-05-26 Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidinstereoisomere ATE420073T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/792,661 US5965734A (en)	1997-01-31	1997-01-31	Processes and intermediates for preparing 2-substituted piperidine stereoisomers
PCT/US1998/010599 WO1999061425A1 (en)	1997-01-31	1998-05-26	Processes and intermediates for preparing 2-substituted piperidine stereoisomers
EP98923727A EP1082307B1 (de)	1997-01-31	1998-05-26	Verfahren und zwischenprodukte zur herstellung 2-substituierter piperidin-stereoisomere

Publications (1)

Publication Number	Publication Date
ATE420073T1 true ATE420073T1 (de)	2009-01-15

Family

ID=26794135

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT05077084T ATE420073T1 (de)	1997-01-31	1998-05-26	Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidinstereoisomere
AT98923727T ATE304531T1 (de)	1997-01-31	1998-05-26	Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidin-stereoisomere

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT98923727T ATE304531T1 (de)	1997-01-31	1998-05-26	Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidin-stereoisomere

Country Status (12)

Country	Link
US (1)	US5965734A (de)
EP (2)	EP1082307B1 (de)
JP (1)	JP4491135B2 (de)
AT (2)	ATE420073T1 (de)
AU (1)	AU765194B2 (de)
CA (1)	CA2333089C (de)
CY (1)	CY1108818T1 (de)
DE (2)	DE69840457D1 (de)
DK (2)	DK1612207T3 (de)
ES (2)	ES2320012T3 (de)
PT (1)	PT1612207E (de)
WO (1)	WO1999061425A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5922736A (en) *	1995-12-04	1999-07-13	Celegene Corporation	Chronic, bolus administration of D-threo methylphenidate
US6486177B2 (en) *	1995-12-04	2002-11-26	Celgene Corporation	Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5837284A (en) *	1995-12-04	1998-11-17	Mehta; Atul M.	Delivery of multiple doses of medications
US6962997B1 (en) *	1997-05-22	2005-11-08	Celgene Corporation	Process and intermediates for resolving piperidyl acetamide steroisomers
US6359139B1 (en) *	2000-11-07	2002-03-19	Celgene Corporation	Methods for production of piperidyl acetamide stereoisomers
US20020187192A1 (en) *	2001-04-30	2002-12-12	Yatindra Joshi	Pharmaceutical composition which reduces or eliminates drug abuse potential
US20030073681A1 (en) *	2001-08-21	2003-04-17	Hauske James R.	2-substituted piperidines that are ligands for monoamine receptors and transporters
US6638533B2 (en)	2002-01-03	2003-10-28	George Krsek	Pulse dosage formulations of methylphenidate and method to prepare same
US20050239830A1 (en) *	2004-04-26	2005-10-27	Vikram Khetani	Methods of diminishing co-abuse potential
NZ555842A (en) *	2004-12-09	2010-10-29	Celgene Corp	Treatment of various conditions of patients with Tourette syndrome, tics, or a family history thereof sing D-threo methylphenidate free from other isomers
ITMI20042415A1 (it) *	2004-12-17	2005-03-17	Clariant Lsm Italia Spa	Sintesi di alfa-aril-alfa-piperid-2-il-acetammidi e loro idrolisi acida
US9233924B2 (en)	2014-03-11	2016-01-12	Ampac Fine Chemicals Llc	Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2507631A (en) *	1944-01-19	1950-05-16	Ciba Pharm Prod Inc	Pyridine and piperidine compounds and process of making same
US2957880A (en) *	1953-12-23	1960-10-25	Ciba Pharm Prod Inc	Process for the conversion of stereoisomers
JPS5630978A (en) *	1979-08-24	1981-03-28	Kyowa Hakko Kogyo Co Ltd	Novel mitomycin and its preparation
US4978744A (en) *	1989-01-27	1990-12-18	Arizona Board Of Regents	Synthesis of dolastatin 10
US5075315A (en) *	1990-05-17	1991-12-24	Mcneilab, Inc.	Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives
US5597915A (en) *	1992-03-16	1997-01-28	Merck Sharp & Dohme Ltd.	Benzodiazepine derivatives, compositions containing them and their use in therapy
ES2162907T3 (es) *	1993-11-22	2002-01-16	Merck & Co Inc	3-acilaminobenzacepinas.
ATE189812T1 (de) *	1995-10-30	2000-03-15	Hoffmann La Roche	1-alpha, 26-dihydroxy-d-homo-vitamin d3
DE19615119A1 (de) *	1996-04-17	1997-10-23	Bayer Ag	Neue Arylessigsäureamide

1997
- 1997-01-31 US US08/792,661 patent/US5965734A/en not_active Expired - Lifetime
1998
- 1998-05-26 PT PT05077084T patent/PT1612207E/pt unknown
- 1998-05-26 AT AT05077084T patent/ATE420073T1/de active
- 1998-05-26 AT AT98923727T patent/ATE304531T1/de active
- 1998-05-26 DE DE69840457T patent/DE69840457D1/de not_active Expired - Lifetime
- 1998-05-26 ES ES05077084T patent/ES2320012T3/es not_active Expired - Lifetime
- 1998-05-26 DK DK05077084T patent/DK1612207T3/da active
- 1998-05-26 ES ES98923727T patent/ES2249830T3/es not_active Expired - Lifetime
- 1998-05-26 CA CA002333089A patent/CA2333089C/en not_active Expired - Lifetime
- 1998-05-26 DE DE69831611T patent/DE69831611T2/de not_active Expired - Lifetime
- 1998-05-26 AU AU75950/98A patent/AU765194B2/en not_active Expired
- 1998-05-26 JP JP2000550831A patent/JP4491135B2/ja not_active Expired - Fee Related
- 1998-05-26 DK DK98923727T patent/DK1082307T3/da active
- 1998-05-26 EP EP98923727A patent/EP1082307B1/de not_active Expired - Lifetime
- 1998-05-26 WO PCT/US1998/010599 patent/WO1999061425A1/en not_active Ceased
- 1998-05-26 EP EP05077084A patent/EP1612207B1/de not_active Expired - Lifetime
2009
- 2009-02-26 CY CY20091100223T patent/CY1108818T1/el unknown

Also Published As

Publication number	Publication date
DK1082307T3 (da)	2005-12-19
DE69831611T2 (de)	2006-06-14
JP2002516313A (ja)	2002-06-04
HK1090915A1 (en)	2007-01-05
DE69840457D1 (de)	2009-02-26
EP1612207B1 (de)	2009-01-07
DK1612207T3 (da)	2009-05-04
EP1082307A1 (de)	2001-03-14
EP1082307A4 (de)	2004-04-14
AU7595098A (en)	1999-12-13
CY1108818T1 (el)	2014-04-09
AU765194B2 (en)	2003-09-11
EP1612207A1 (de)	2006-01-04
CA2333089C (en)	2008-10-14
US5965734A (en)	1999-10-12
ES2320012T3 (es)	2009-05-18
EP1082307B1 (de)	2005-09-14
PT1612207E (pt)	2009-02-04
CA2333089A1 (en)	1999-12-02
WO1999061425A1 (en)	1999-12-02
JP4491135B2 (ja)	2010-06-30
ATE304531T1 (de)	2005-09-15
DE69831611D1 (de)	2005-10-20
ES2249830T3 (es)	2006-04-01

Legal Events

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Title

Description

2009-09-15

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