ATE420869T1 - Promotoren zur proliferation und differenzierung von stammzellen und/oder vorstufen von neuronenzellen - Google Patents

Promotoren zur proliferation und differenzierung von stammzellen und/oder vorstufen von neuronenzellen

Info

Publication number: ATE420869T1
Authority: AT; Austria
Prior art keywords: group; ring; proliferation; differentiation; acyl
Prior art date: 2000-10-05

Application number

AT01972687T

Other languages

English (en)

Inventor

Shigenori Okawa

Masaomi Miyamoto

Masahiro Okura

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-05

Filing date

2001-10-04

Publication date

2009-01-15

2001-10-04 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE420869T1 publication Critical patent/ATE420869T1/de

Links

230000004069 differentiation Effects 0.000 title abstract 2
230000035755 proliferation Effects 0.000 title abstract 2
210000000130 stem cell Anatomy 0.000 title abstract 2
210000002569 neuron Anatomy 0.000 title 1
125000002252 acyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000001931 aliphatic group Chemical group 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
210000005155 neural progenitor cell Anatomy 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT01972687T 2000-10-05 2001-10-04 Promotoren zur proliferation und differenzierung von stammzellen und/oder vorstufen von neuronenzellen ATE420869T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2000306801		2000-10-05

Publications (1)

Publication Number	Publication Date
ATE420869T1 true ATE420869T1 (de)	2009-01-15

Family

ID=18787424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01972687T ATE420869T1 (de)	2000-10-05	2001-10-04	Promotoren zur proliferation und differenzierung von stammzellen und/oder vorstufen von neuronenzellen

Country Status (9)

Country	Link
US (2)	US20040034049A1 (de)
EP (1)	EP1323716B1 (de)
AT (1)	ATE420869T1 (de)
AU (1)	AU2001292350A1 (de)
CA (1)	CA2424870A1 (de)
DE (1)	DE60137437D1 (de)
ES (1)	ES2317935T3 (de)
PT (1)	PT1323716E (de)
WO (1)	WO2002028850A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0988289A2 (de) *	1997-06-05	2000-03-29	Takeda Pharmaceutical Company Limited	Benzofurane und benzothiophene als unterdrücker der neurodegeneration
DE60228577D1 (de)	2001-07-13	2008-10-09	Takeda Pharmaceutical	Verfahren zur herstellung von benzofuranderivaten
AU2003202988A1 (en) *	2002-01-14	2003-07-30	The Board Of Trustees Of The University Of Illinois	Use of modified pyrimidine compounds to promote stem cell migration and proliferation
PL371366A1 (en) *	2002-03-01	2005-06-13	Takeda Pharmaceutical Company Limited	Antidepressant
US7465815B2 (en) *	2003-06-26	2008-12-16	Takeda Pharmaceutical Company Limited	Cannabinoid receptor modulator
EP1783121A4 (de) *	2004-08-27	2009-08-05	Takeda Pharmaceutical	Azoverbindungen und verfahren zu deren herstellung
CA2658764A1 (en) *	2006-07-20	2008-01-24	Mehmet Kahraman	Benzothiophene inhibitors of rho kinase
TW201000099A (en)	2008-06-20	2010-01-01	Amgen Inc	S1P1 receptor agonists and use thereof
WO2010104194A1 (en)	2009-03-10	2010-09-16	Takeda Pharmaceutical Company Limited	Benzofuran derivatives
WO2011062194A1 (ja)	2009-11-18	2011-05-26	武田薬品工業株式会社	アミノピリジン誘導体
WO2011133661A2 (en) *	2010-04-21	2011-10-27	Research Development Foundation	Methods and compositions related to dopaminergic neuronal cells
MX2024000313A (es)	2021-07-09	2024-03-06	Plexium Inc	Compuestos de arilo y composiciones farmaceuticas que modulan la ikzf2.
WO2025140655A1 (en) *	2023-12-30	2025-07-03	Fujian Haixi Pharmaceuticals Co., Ltd.	Heteroaryl compounds as multi-target protein kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175103A (en) *	1991-10-21	1992-12-29	Trustees Of University Of Pennsylvania	Preparation of pure cultures of post-mitotic human neurons
WO1996015226A1 (en) *	1994-11-14	1996-05-23	Neurospheres Holdings Ltd.	Regulation of neural stem cell proliferation
US5523309A (en) *	1995-03-10	1996-06-04	Eli Lilly And Company	Benzofuran pharmaceutical compounds
US6428977B1 (en) *	1995-12-20	2002-08-06	Curis, Inc.	Signalin family of TGFβ signal transduction proteins, and uses related thereto
JPH1149765A (ja) *	1997-06-05	1999-02-23	Takeda Chem Ind Ltd	複素環化合物、その製造法および剤
JP3553442B2 (ja) *	1998-12-04	2004-08-11	武田薬品工業株式会社	ベンゾフラン誘導体、その製造法および用途
WO2000034262A1 (en) *	1998-12-04	2000-06-15	Takeda Chemical Industries, Ltd.	Benzofuran derivatives, process for the preparation of the same and uses thereof

2001
- 2001-10-04 WO PCT/JP2001/008739 patent/WO2002028850A1/ja not_active Ceased
- 2001-10-04 CA CA002424870A patent/CA2424870A1/en not_active Abandoned
- 2001-10-04 EP EP01972687A patent/EP1323716B1/de not_active Expired - Lifetime
- 2001-10-04 AT AT01972687T patent/ATE420869T1/de active
- 2001-10-04 AU AU2001292350A patent/AU2001292350A1/en not_active Abandoned
- 2001-10-04 DE DE60137437T patent/DE60137437D1/de not_active Expired - Lifetime
- 2001-10-04 PT PT01972687T patent/PT1323716E/pt unknown
- 2001-10-04 ES ES01972687T patent/ES2317935T3/es not_active Expired - Lifetime
- 2001-10-04 US US10/398,278 patent/US20040034049A1/en not_active Abandoned
2007
- 2007-12-14 US US12/002,273 patent/US20090012081A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2002028850A1 (en)	2002-04-11
PT1323716E (pt)	2009-02-09
EP1323716A4 (de)	2005-02-09
EP1323716A1 (de)	2003-07-02
CA2424870A1 (en)	2003-04-04
US20090012081A1 (en)	2009-01-08
DE60137437D1 (de)	2009-03-05
EP1323716B1 (de)	2009-01-14
US20040034049A1 (en)	2004-02-19
AU2001292350A1 (en)	2002-04-15
ES2317935T3 (es)	2009-05-01

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GB9910577D0 (en)	1999-07-07	Chemical compounds
DE60137437D1 (de)	2009-03-05	Promotoren zur proliferation und differenzierung von stammzellen und/oder vorstufen von neuronenzellen
DE69915508D1 (de)	2004-04-15	Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen
DK0770065T3 (da)	2004-07-19	Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer
DK0562439T3 (da)	1999-11-15	Triazolopyridazinforbindelser, deres fremstilling og anvendelse
EP0257102A4 (en)	1991-11-13	Agents for treating neurophathy
ATE160341T1 (de)	1997-12-15	Benzolsulfonamid-derivate und verfahren zur herstellung
NZ330656A (en)	1999-06-29	Tricyclic compounds, their production and use
ES2164164T3 (es)	2002-02-16	Derivados de aminotetrazol utiles como inhibidores de oxido nitrico sintasa.
EP1123918A4 (de)	2002-08-07	Aromatische aminderivate, verfahren zu ihrer herstellung und mittel, die diese enthalten
PT1717229E (pt)	2011-09-12	Novo composto cíclico tendo um grupo 4-piridilalquiltio tendo um amino (não) substituído introduzido no mesmo
WO2003074046A1 (en)	2003-09-12	Antidepressant
DE69411616D1 (de)	1998-08-20	Triazolopyridazin-Derivate, ihre Herstellung und Verwendung
ATE110064T1 (de)	1994-09-15	Azacyclische carbonsäurederivate,ihre herstellung und verwendung.
ATE279191T1 (de)	2004-10-15	Trizyklische dihydrobenzofurane, verfahren zu deren herstellung und mittel
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ATE375343T1 (de)	2007-10-15	Neue beta-lactamverbindungen und verfahren zu deren herstellung
DE69120221D1 (de)	1996-07-18	Pyrimidin-verbindung und ihr pharmazeutisch annehmbares salz
DE60019619D1 (de)	2005-05-25	Dihydrobenzofuranderivate, verfahren zu ihrer herstellung und mittel
ATE170516T1 (de)	1998-09-15	Alkylendiaminderivate
ATE120741T1 (de)	1995-04-15	N-hydroxy-dibenz(b,e>oxepin-alkylamine und - alkanoische säureamide, verwandte heterocyclische analoge, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von medikamenten.
ATE364039T1 (de)	2007-06-15	Bis-dicarbonsäuresalze von benazepril und herstellung von benazepril über diese salze
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