DK0770065T3 - Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer - Google Patents

Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer

Info

Publication number: DK0770065T3
Authority: DK; Denmark
Prior art keywords: inhibitors; phenyl derivatives; pde; derivatives useful; group
Prior art date: 1994-06-21

Application number

DK95922633T

Other languages

English (en)

Inventor

Graham John Warrellow

Rikki Peter Alexander

Original Assignee

Celltech R&D Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-21

Filing date

1995-06-21

Publication date

2004-07-19

1994-06-21 Priority claimed from GB9412385A external-priority patent/GB9412385D0/en

1994-06-22 Priority claimed from GB9412492A external-priority patent/GB9412492D0/en

1995-06-21 Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd

2004-07-19 Application granted granted Critical

2004-07-19 Publication of DK0770065T3 publication Critical patent/DK0770065T3/da

Links

239000002587 phosphodiesterase IV inhibitor Substances 0.000 title abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000007101 Muscle Cramp Diseases 0.000 abstract 1
208000005392 Spasm Diseases 0.000 abstract 1
-1 Tri-substituted phenyl Chemical class 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000028709 inflammatory response Effects 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Lock And Its Accessories (AREA)

DK95922633T 1994-06-21 1995-06-21 Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer DK0770065T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9412385A GB9412385D0 (en)	1994-06-21	1994-06-21	Chemical compounds
GB9412492A GB9412492D0 (en)	1994-06-22	1994-06-22	Chemical compounds

Publications (1)

Publication Number	Publication Date
DK0770065T3 true DK0770065T3 (da)	2004-07-19

Family

ID=26305090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95922633T DK0770065T3 (da)	1994-06-21	1995-06-21	Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer

Country Status (18)

Country	Link
US (2)	US5786354A (da)
EP (1)	EP0770065B1 (da)
JP (1)	JP3856465B2 (da)
CN (1)	CN1304372C (da)
AT (1)	ATE263153T1 (da)
AU (1)	AU707472B2 (da)
CZ (1)	CZ293311B6 (da)
DE (1)	DE69532808T2 (da)
DK (1)	DK0770065T3 (da)
ES (1)	ES2218548T3 (da)
FI (1)	FI115302B (da)
HU (1)	HUT76803A (da)
NO (1)	NO312672B1 (da)
NZ (1)	NZ288294A (da)
PT (1)	PT770065E (da)
RU (1)	RU2201921C2 (da)
SK (1)	SK282661B6 (da)
WO (1)	WO1995035281A1 (da)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9222253D0 (en) *	1992-10-23	1992-12-09	Celltech Ltd	Chemical compounds
GB9304919D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
GB9304920D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
DE69433594T2 (de) *	1993-12-22	2004-08-05	Celltech R&D Ltd., Slough	Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
US6245774B1 (en)	1994-06-21	2001-06-12	Celltech Therapeutics Limited	Tri-substituted phenyl or pyridine derivatives
US5786354A (en) *	1994-06-21	1998-07-28	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives and processes for their preparation
GB9412573D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9412571D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9523675D0 (en)	1995-11-20	1996-01-24	Celltech Therapeutics Ltd	Chemical compounds
US5710170A (en) *	1995-12-15	1998-01-20	Merck Frosst Canada, Inc.	Tri-aryl ethane derivatives as PDE IV inhibitors
CA2238875C (en) *	1995-12-15	2003-09-16	Merck Frosst Canada Inc.	Tri-aryl ethane derivatives as pde iv inhibitors
GB9526246D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526245D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526243D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
DE19605766A1 (de) *	1996-02-16	1997-08-21	Basf Ag	Substituierte 2-Phenylpyridine
GB9608435D0 (en) *	1996-04-24	1996-06-26	Celltech Therapeutics Ltd	Chemical compounds
GB9619284D0 (en) *	1996-09-16	1996-10-30	Celltech Therapeutics Ltd	Chemical compounds
GB9622363D0 (en) *	1996-10-28	1997-01-08	Celltech Therapeutics Ltd	Chemical compounds
GB9625184D0 (en) *	1996-12-04	1997-01-22	Celltech Therapeutics Ltd	Chemical compounds
US6057329A (en) *	1996-12-23	2000-05-02	Celltech Therapeutics Limited	Fused polycyclic 2-aminopyrimidine derivatives
GB9705361D0 (en)	1997-03-14	1997-04-30	Celltech Therapeutics Ltd	Chemical compounds
GB9713087D0 (en) *	1997-06-20	1997-08-27	Celltech Therapeutics Ltd	Chemical compounds
US6180650B1 (en) *	1999-04-23	2001-01-30	Merck Frosst Canada & Co.	Heterosubstituted pyridine derivatives as PDE 4 inhibitors
GB9914258D0 (en)	1999-06-18	1999-08-18	Celltech Therapeutics Ltd	Chemical compounds
EP1212089B1 (en)	1999-08-21	2006-03-22	ALTANA Pharma AG	Synergistic combination of roflumilast and salmeterol
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
GB9924862D0 (en)	1999-10-20	1999-12-22	Celltech Therapeutics Ltd	Chemical compounds
US6410563B1 (en)	1999-12-22	2002-06-25	Merck Frosst Canada & Co.	Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
MY123585A (en) *	2000-03-23	2006-05-31	Merck Canada Inc	Tri-aryl-substituted-ethane pde4 inhibitors.
US6639077B2 (en)	2000-03-23	2003-10-28	Merck Frosst Canada & Co.	Tri-aryl-substituted-ethane PDE4 inhibitors
AU2001261962B2 (en)	2000-05-25	2005-04-21	Merck Frosst Canada Ltd	Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
US6740666B2 (en)	2000-12-20	2004-05-25	Merck & Co., Inc.	Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
US6699890B2 (en)	2000-12-22	2004-03-02	Memory Pharmaceuticals Corp.	Phosphodiesterase 4 inhibitors
DE10064997A1 (de)	2000-12-23	2002-06-27	Merck Patent Gmbh	Benzoylpyridazine
US7205320B2 (en) *	2001-01-22	2007-04-17	Memory Pharmaceuticals Corp.	Phosphodiesterase 4 inhibitors
US7153871B2 (en) *	2001-01-22	2006-12-26	Memory Pharmaceuticals Corporation	Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
JP4460221B2 (ja)	2001-05-24	2010-05-12	メルクフロストカナダリミテツド	１−ビアリール−１，８−ナフチリジン−４−オン系ホスホジエステラーゼ−４阻害薬
KR100874791B1 (ko) *	2001-05-29	2008-12-18	바이엘 쉐링 파마 악티엔게젤샤프트	Ｃｄｋ-억제 피리미딘, 그의 제조방법 및 약제로서의 용도
JO2311B1 (en)	2001-08-29	2005-09-12	ميرك فروست كندا ليمتد	Alkyl inhibitors Ariel phosphodiesterase-4
DE10150517A1 (de) *	2001-10-12	2003-04-17	Merck Patent Gmbh	Verwendung von Phosphodiesterase IV-Inhibitoren
EP1539697A1 (en)	2002-07-19	2005-06-15	Memory Pharmaceutical Corporation	Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
RU2354648C2 (ru)	2002-07-19	2009-05-10	Мемори Фармасьютиклз Корпорейшн	Соединения 6-амино-1н-индазола и 4-аминобензофурана в качестве ингибиторов фосфодиэстеразы 4
AU2003295656B2 (en) *	2002-11-19	2010-11-11	Memory Pharmaceuticals Corporation	Pyridine N-oxide compounds as phosphodiesterase 4 inhibitors
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
MXPA05010373A (es)	2003-04-01	2005-12-05	Applied Research Systems	Inhibidores de fosfodiesterasas en infertilidad.
DE10344742A1 (de)	2003-09-25	2005-04-14	Endress + Hauser Flowtec Ag, Reinach	Verfahren zum Einstellen einer mechanischen Resonanzfrequenz
MY141255A (en) *	2003-12-11	2010-03-31	Memory Pharm Corp	Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
MX2007004488A (es) *	2004-10-13	2007-09-11	Wyeth Corp	Analogos de anilino-pirimidina n-bencenosulfonilo sustituidos.
EP2258358A3 (en)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en)	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
DE602007012105D1 (de) *	2006-07-14	2011-03-03	Chiesi Farma Spa	Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren
EP2068872A1 (en)	2006-09-08	2009-06-17	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (en)	2007-06-04	2015-10-28	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2022783A1 (en)	2007-08-08	2009-02-11	CHIESI FARMACEUTICI S.p.A.	"Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors"
EP2070913A1 (en)	2007-12-14	2009-06-17	CHIESI FARMACEUTICI S.p.A.	Ester derivatives as phosphodiesterase inhibitors
EP2810951B1 (en)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010003084A2 (en) *	2008-07-02	2010-01-07	Memory Pharmaceuticals Corporation	Phosphodiesterase 4 inhibitors
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2196465A1 (en)	2008-12-15	2010-06-16	Almirall, S.A.	(3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (en)	2009-02-27	2010-09-08	Almirall, S.A.	New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
EP2380890A1 (en)	2010-04-23	2011-10-26	Almirall, S.A.	New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en)	2010-05-31	2011-12-14	Almirall, S.A.	3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es)	2011-03-01	2018-04-23	Synergy Pharmaceuticals Inc.	Proceso de preparación de agonistas de guanilato ciclasa C
CA2838435A1 (en)	2011-06-06	2012-12-13	Chiesi Farmaceutici S.P.A.	Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
CN103827088B (zh)	2011-09-26	2017-10-13	奇斯药制品公司	作为磷酸二酯酶抑制剂的1‑苯基‑2‑吡啶基烷基醇的衍生物
EP2768822B1 (en)	2011-10-21	2017-12-06	Chiesi Farmaceutici S.p.A.	Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
RU2637945C2 (ru)	2012-06-04	2017-12-08	КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.	Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы
KR102192739B1 (ko)	2012-12-05	2020-12-18	키에시 파르마슈티시 엣스. 피. 에이.	포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체
US9545446B2 (en)	2013-02-25	2017-01-17	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
CA2905435A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
SI3004138T1 (sl)	2013-06-05	2024-07-31	Bausch Health Ireland Limited	Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
KR102456567B1 (ko)	2013-08-09	2022-10-19	알데릭스, 인코포레이티드	인산염 수송을 억제하기 위한 화합물 및 방법
WO2020237096A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Combination for lowering serum phosphate in a patient

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1285932A (fr) *	1960-12-26	1962-03-02	Nord Aviation	Charge creuse
US3947467A (en) *	1973-08-02	1976-03-30	Eli Lilly And Company	3-(5-Nitro-2-imidazolyl) pyrazoles
FR2257272B1 (da) *	1974-01-15	1978-08-25	Pharmascience Labo
DE2413935A1 (de) *	1974-03-20	1975-10-16	Schering Ag	4-(polyalkoxy-phenyl)-2-pyrrolidone
US4193926A (en) *	1974-03-20	1980-03-18	Schering Aktiengesellschaft	4-(Polyalkoxy phenyl)-2-pyrrolidones
DE2541855A1 (de) *	1975-09-18	1977-03-31	Schering Ag	4-(polyalkoxy-phenyl)-2-pyrrolidone ii
FR2313422A2 (fr) *	1975-06-02	1976-12-31	Labaz	Nouveaux stabilisants des polymeres et copolymeres du chlorure de vinyle
SU888821A3 (ru) *	1976-12-03	1981-12-07	Шеринг Аг (Инофирма)	Способ получени 5-(замещенный фенил)-оксазолидинонов или их серусодержащих аналогов
EP0006298B1 (en) *	1978-06-15	1982-03-31	Imperial Chemical Industries Plc	Anti-inflammatory 1-phenyl-2-aminoethanol derivatives, pharmaceutical compositions thereof for topical use, and processes for their manufacture
DE3374313D1 (de) *	1982-12-23	1987-12-10	Smith Kline French Lab	Aminopyrimidinone derivatives as histamine h1-antagonists
IT1161221B (it) *	1983-04-21	1987-03-18	Ripharm Srl	Composto per il trattamento della psoriasi
DE3581570D1 (de) *	1984-06-25	1991-03-07	Ciba Geigy Ag	Pyrimidinderivate wirksam als schaedlingsbekaempfungsmittel.
DE3751742T3 (de) *	1986-01-13	2002-11-21	American Cyanamid Co., Wayne	4,5,6-Substituierte 2-Pyrimidinamine
US4788195A (en) *	1986-01-13	1988-11-29	American Cyanamid Company	4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
US4876252A (en) *	1986-01-13	1989-10-24	American Cyanamid Company	4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
WO1987006576A1 (en) *	1986-04-29	1987-11-05	Pfizer Inc.	Calcium independent camp phosphodiesterase inhibitor antidepressant
US5128358A (en) *	1988-01-19	1992-07-07	Pfizer Inc.	Aryl substituted nitrogen heterocyclic antidepressants
US4792561A (en) *	1986-05-29	1988-12-20	Syntex (U.S.A.) Inc.	Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
US4921862A (en) *	1986-05-29	1990-05-01	Syntex (U.S.A.) Inc.	Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors
CN1030415A (zh) *	1987-02-20	1989-01-18	山之内制药株式会社	饱和的杂环碳酰胺衍生物和它的制备方法
US4971959A (en) *	1987-04-14	1990-11-20	Warner-Lambert Company	Trisubstituted phenyl analogs having activity for congestive heart failure
US5274002A (en) *	1987-04-14	1993-12-28	Warner-Lambert Company	Trisubstituted phenyl analogs having activity for congestive heart failure
DE3882821D1 (de) *	1987-06-11	1993-09-09	Ciba Geigy Ag	Mikrobizide.
US4966622A (en) *	1988-04-12	1990-10-30	Ciba-Geigy Corporation	N-phenyl-N-pyrimidin-2-ylureas
US4897396A (en) *	1988-06-03	1990-01-30	Ciba-Geigy Corporation	2-phenylamino pyrimidine derivatives and their uses as microbicides
DK0469013T3 (da) *	1989-04-17	1995-10-02	Byk Gulden Lomberg Chem Fab	Hidtil ukendte arylpyridaziner, fremstilling deraf, anvendelse deraf og lægemidler indeholdende disse
US5164372A (en) *	1989-04-28	1992-11-17	Fujisawa Pharmaceutical Company, Ltd.	Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
JPH0377923A (ja) *	1989-08-18	1991-04-03	Sekisui Chem Co Ltd	有機非線形光学材料
JPH075572B2 (ja) *	1989-08-18	1995-01-25	積水化学工業株式会社	２―［２―（２―ヒドロキシフェニル）ビニルピラジンおよびその製造法
DE4003919A1 (de) *	1990-02-09	1991-08-14	Basf Ag	Heteroarylalkene, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung
GB9007762D0 (en) *	1990-04-05	1990-06-06	Beecham Group Plc	Novel compounds
WO1991016892A1 (en) *	1990-04-27	1991-11-14	Rorer International (Holdings), Inc.	Styryl compounds which inhibit egf receptor protein tyrosine kinase
US5393788A (en) *	1990-07-10	1995-02-28	Smithkline Beecham Corporation	Phenylalkyl oxamides
US5124455A (en) *	1990-08-08	1992-06-23	American Home Products Corporation	Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
NZ239946A (en) *	1990-09-28	1994-09-27	Smith Kline French Lab	3-(tetrazol-5-yl)-6-(substituted phenyl)pyridine derivatives and medicaments
JPH06501941A (ja) *	1990-10-16	1994-03-03	ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング	アリールピリダジノン
AU9030691A (en) *	1990-11-06	1992-05-26	Smithkline Beecham Corporation	Imidazolidinone compounds
SE470395B (sv) *	1990-12-05	1994-02-14	Erik Lindgren Produktide Ab	Ryggstödjande anordning
GB9027055D0 (en) *	1990-12-13	1991-02-06	Sandoz Ltd	Organic compounds
US5698711A (en) *	1991-01-28	1997-12-16	Rhone-Poulenc Rorer Limited	Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group
IE71647B1 (en) *	1991-01-28	1997-02-26	Rhone Poulenc Rorer Ltd	Benzamide derivatives
US5449676A (en) *	1991-04-26	1995-09-12	Byk Gulden Lomberg Chemische Fabrik Gmbh	Pyridazines
US5191084A (en) *	1991-05-01	1993-03-02	American Home Products Corporation	Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents
PT100441A (pt) *	1991-05-02	1993-09-30	Smithkline Beecham Corp	Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
EP0540165A1 (en) *	1991-10-03	1993-05-05	Zeneca Limited	Alkanoic acid derivatives
CA2080554A1 (en) *	1991-10-15	1993-04-16	Mitsubishi Chemical Corporation	Styrene derivatives
DE4136921A1 (de) *	1991-11-11	1993-05-13	Knoll Ag	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
US5326898A (en) *	1992-02-11	1994-07-05	Allergan, Inc.	Substituted phenylethenyl compounds having retinoid-like biological activity
WO1993019748A1 (en) *	1992-04-02	1993-10-14	Smithkline Beecham Corporation	Compounds useful for treating inflammatory diseases and for inhibiting production of tumor necrosis factor
TW225528B (da) *	1992-04-03	1994-06-21	Ciba Geigy Ag
US5521184A (en) *	1992-04-03	1996-05-28	Ciba-Geigy Corporation	Pyrimidine derivatives and processes for the preparation thereof
GB9212673D0 (en) *	1992-06-15	1992-07-29	Celltech Ltd	Chemical compounds
GB9212693D0 (en) *	1992-06-15	1992-07-29	Celltech Ltd	Chemical compounds
CZ14795A3 (en) *	1992-07-28	1996-07-17	Rhone Poulenc Rorer Ltd	Benzene derivative containing phenyl group bound to aryl or heteroaryl fraction through an aliphatic or hetero atom containing group, process of its preparation and pharmaceutical composition containing thereof
GB9222253D0 (en) *	1992-10-23	1992-12-09	Celltech Ltd	Chemical compounds
AU673569B2 (en) *	1992-12-02	1996-11-14	Pfizer Inc.	Catechol diethers as selective PDE-IV inhibitors
KR100190730B1 (ko) *	1992-12-17	1999-06-01	디. 제이. 우드, 스피겔 알렌 제이	부신피질 호르몬 유리인자(crf) 길항물질로서 치환된 피라졸
TW263495B (da) *	1992-12-23	1995-11-21	Celltech Ltd
GB9226830D0 (en) *	1992-12-23	1993-02-17	Celltech Ltd	Chemical compounds
US5622977A (en) *	1992-12-23	1997-04-22	Celltech Therapeutics Limited	Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
GB9304919D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
GB9304920D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
GB9315595D0 (en) *	1993-07-28	1993-09-08	Res Inst Medicine Chem	New compounds
KR100330553B1 (ko) *	1993-10-01	2002-11-27	노파르티스 아게	약물학적활성피리딘유도체및그의제조방법
JPH08503971A (ja) *	1993-10-01	1996-04-30	チバ−ガイギーアクチェンゲゼルシャフト	ピリミジンアミン誘導体及びその調製のための方法
WO1995009851A1 (en) *	1993-10-01	1995-04-13	Ciba-Geigy Ag	Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof
US5543520A (en) *	1993-10-01	1996-08-06	Ciba-Geigy Corporation	Pyrimidine derivatives
ATE154932T1 (de) *	1993-11-26	1997-07-15	Pfizer	Isoxazolinverbindungen als entzündungshemmende mittel
GB9326699D0 (en) *	1993-12-22	1994-03-02	Celltech Ltd	Chemical compounds
GB9326173D0 (en) *	1993-12-22	1994-02-23	Celltech Ltd	Chemical compounds and process
DE69433594T2 (de) *	1993-12-22	2004-08-05	Celltech R&D Ltd., Slough	Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
US5691376A (en) *	1994-02-17	1997-11-25	American Home Products Corporation	Substituted biphenyl derivatives
US5559137A (en) *	1994-05-16	1996-09-24	Smithkline Beecham Corp.	Compounds
AU2265495A (en) *	1994-06-06	1996-01-04	Pfizer Inc.	Substituted pyrazoles having corticotropin-releasing factor (crf) antagonist activity
US5786354A (en) *	1994-06-21	1998-07-28	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives and processes for their preparation
US6245774B1 (en) *	1994-06-21	2001-06-12	Celltech Therapeutics Limited	Tri-substituted phenyl or pyridine derivatives
GB9412571D0 (en) *	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9412573D0 (en) *	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9412672D0 (en) *	1994-06-23	1994-08-10	Celltech Ltd	Chemical compounds
GB2301363B (en) *	1994-12-23	1998-12-30	Celltech Therapeutics Ltd	Human phosphodiesterase type ivc and its production and use
US5593997A (en) *	1995-05-23	1997-01-14	Pfizer Inc.	4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
BR9610823A (pt) *	1995-10-02	1999-07-13	Hoffmann La Roche	Derivados de pirimidina como antagonistas do receptor
GB9526243D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526245D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526246D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9608435D0 (en) *	1996-04-24	1996-06-26	Celltech Therapeutics Ltd	Chemical compounds
GB9625184D0 (en) *	1996-12-04	1997-01-22	Celltech Therapeutics Ltd	Chemical compounds

1995
- 1995-06-20 US US08/492,639 patent/US5786354A/en not_active Expired - Fee Related
- 1995-06-21 PT PT95922633T patent/PT770065E/pt unknown
- 1995-06-21 SK SK1630-96A patent/SK282661B6/sk unknown
- 1995-06-21 AT AT95922633T patent/ATE263153T1/de not_active IP Right Cessation
- 1995-06-21 DK DK95922633T patent/DK0770065T3/da active
- 1995-06-21 CN CNB951937405A patent/CN1304372C/zh not_active Expired - Fee Related
- 1995-06-21 EP EP95922633A patent/EP0770065B1/en not_active Expired - Lifetime
- 1995-06-21 ES ES95922633T patent/ES2218548T3/es not_active Expired - Lifetime
- 1995-06-21 JP JP50184396A patent/JP3856465B2/ja not_active Expired - Fee Related
- 1995-06-21 HU HU9603578A patent/HUT76803A/hu unknown
- 1995-06-21 DE DE1995632808 patent/DE69532808T2/de not_active Expired - Fee Related
- 1995-06-21 AU AU27461/95A patent/AU707472B2/en not_active Ceased
- 1995-06-21 NZ NZ288294A patent/NZ288294A/xx unknown
- 1995-06-21 RU RU97100794/04A patent/RU2201921C2/ru not_active IP Right Cessation
- 1995-06-21 WO PCT/GB1995/001459 patent/WO1995035281A1/en not_active Ceased
- 1995-06-21 CZ CZ19963730A patent/CZ293311B6/cs not_active IP Right Cessation
1996
- 1996-12-19 FI FI965126A patent/FI115302B/fi active IP Right Grant
- 1996-12-20 NO NO19965524A patent/NO312672B1/no unknown
1998
- 1998-03-26 US US09/048,592 patent/US6077854A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI115302B (fi)	2005-04-15
DE69532808T2 (de)	2005-01-13
JP3856465B2 (ja)	2006-12-13
US6077854A (en)	2000-06-20
CZ293311B6 (cs)	2004-03-17
HU9603578D0 (en)	1997-02-28
ES2218548T3 (es)	2004-11-16
EP0770065B1 (en)	2004-03-31
CN1151732A (zh)	1997-06-11
CN1304372C (zh)	2007-03-14
NO965524D0 (no)	1996-12-20
RU2201921C2 (ru)	2003-04-10
ATE263153T1 (de)	2004-04-15
HUT76803A (en)	1997-11-28
AU707472B2 (en)	1999-07-08
PT770065E (pt)	2004-08-31
WO1995035281A1 (en)	1995-12-28
AU2746195A (en)	1996-01-15
NZ288294A (en)	1999-01-28
EP0770065A1 (en)	1997-05-02
JPH10503173A (ja)	1998-03-24
SK282661B6 (sk)	2002-11-06
SK163096A3 (en)	1997-10-08
NO965524L (no)	1996-12-20
NO312672B1 (no)	2002-06-17
FI965126A7 (fi)	1996-12-19
DE69532808D1 (de)	2004-05-06
US5786354A (en)	1998-07-28
CZ373096A3 (en)	1997-08-13
FI965126A0 (fi)	1996-12-19

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DK0874824T3 (da)	2003-10-13	Trisubstituerede phenylderivater nyttige som PDE IV inhibitorer
FI982436A0 (fi)	1998-11-10	Kondensoituneet heterosykliset yhdisteet
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DK0766670T3 (da)	2002-04-22	Tri-substituerede phenylderivater anvendelige som PDE IV inhibitorer
ATE273955T1 (de)	2004-09-15	Triarylethanderivate als pde iv hemmer
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NO20020570D0 (no)	2002-02-05	Substituerte aromatiske ringforbindelser, fremgangsmåte for fremstilling av samme, og anvendelse
RO91141B (ro)	1987-07-03	Procedeu pentru prepararea unor derivati de 2-oxindol-1-carboxamida
MY111226A (en)	1999-09-30	Tri-substituted phenyl derivatives as phosphodiesterase inhibitors