DK0770065T3 - Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer - Google Patents

Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer

Info

Publication number: DK0770065T3
Authority: DK; Denmark
Prior art keywords: inhibitors; phenyl derivatives; pde; derivatives useful; group
Prior art date: 1994-06-21

Application number

DK95922633T

Other languages

English (en)

Inventor

Graham John Warrellow

Rikki Peter Alexander

Original Assignee

Celltech R&D Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-21

Filing date

1995-06-21

Publication date

2004-07-19

1994-06-21 Priority claimed from GB9412385A external-priority patent/GB9412385D0/en

1994-06-22 Priority claimed from GB9412492A external-priority patent/GB9412492D0/en

1995-06-21 Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd

2004-07-19 Application granted granted Critical

2004-07-19 Publication of DK0770065T3 publication Critical patent/DK0770065T3/da

Links

239000002587 phosphodiesterase IV inhibitor Substances 0.000 title abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000007101 Muscle Cramp Diseases 0.000 abstract 1
208000005392 Spasm Diseases 0.000 abstract 1
-1 Tri-substituted phenyl Chemical class 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000028709 inflammatory response Effects 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Lock And Its Accessories (AREA)

DK95922633T 1994-06-21 1995-06-21 Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer DK0770065T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9412385A GB9412385D0 (en)	1994-06-21	1994-06-21	Chemical compounds
GB9412492A GB9412492D0 (en)	1994-06-22	1994-06-22	Chemical compounds

Publications (1)

Publication Number	Publication Date
DK0770065T3 true DK0770065T3 (da)	2004-07-19

Family

ID=26305090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95922633T DK0770065T3 (da)	1994-06-21	1995-06-21	Trisubstituerede phenylderivater nyttige som PDE IV-inhibitorer

Country Status (18)

Country	Link
US (2)	US5786354A (da)
EP (1)	EP0770065B1 (da)
JP (1)	JP3856465B2 (da)
CN (1)	CN1304372C (da)
AT (1)	ATE263153T1 (da)
AU (1)	AU707472B2 (da)
CZ (1)	CZ293311B6 (da)
DE (1)	DE69532808T2 (da)
DK (1)	DK0770065T3 (da)
ES (1)	ES2218548T3 (da)
FI (1)	FI115302B (da)
HU (1)	HUT76803A (da)
NO (1)	NO312672B1 (da)
NZ (1)	NZ288294A (da)
PT (1)	PT770065E (da)
RU (1)	RU2201921C2 (da)
SK (1)	SK282661B6 (da)
WO (1)	WO1995035281A1 (da)

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1995
- 1995-06-20 US US08/492,639 patent/US5786354A/en not_active Expired - Fee Related
- 1995-06-21 CZ CZ19963730A patent/CZ293311B6/cs not_active IP Right Cessation
- 1995-06-21 SK SK1630-96A patent/SK282661B6/sk unknown
- 1995-06-21 ES ES95922633T patent/ES2218548T3/es not_active Expired - Lifetime
- 1995-06-21 RU RU97100794/04A patent/RU2201921C2/ru not_active IP Right Cessation
- 1995-06-21 DK DK95922633T patent/DK0770065T3/da active
- 1995-06-21 WO PCT/GB1995/001459 patent/WO1995035281A1/en not_active Ceased
- 1995-06-21 EP EP95922633A patent/EP0770065B1/en not_active Expired - Lifetime
- 1995-06-21 HU HU9603578A patent/HUT76803A/hu unknown
- 1995-06-21 AT AT95922633T patent/ATE263153T1/de not_active IP Right Cessation
- 1995-06-21 CN CNB951937405A patent/CN1304372C/zh not_active Expired - Fee Related
- 1995-06-21 PT PT95922633T patent/PT770065E/pt unknown
- 1995-06-21 AU AU27461/95A patent/AU707472B2/en not_active Ceased
- 1995-06-21 JP JP50184396A patent/JP3856465B2/ja not_active Expired - Fee Related
- 1995-06-21 NZ NZ288294A patent/NZ288294A/xx unknown
- 1995-06-21 DE DE1995632808 patent/DE69532808T2/de not_active Expired - Fee Related
1996
- 1996-12-19 FI FI965126A patent/FI115302B/fi active IP Right Grant
- 1996-12-20 NO NO19965524A patent/NO312672B1/no unknown
1998
- 1998-03-26 US US09/048,592 patent/US6077854A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP3856465B2 (ja)	2006-12-13
HU9603578D0 (en)	1997-02-28
WO1995035281A1 (en)	1995-12-28
NO965524D0 (no)	1996-12-20
CN1151732A (zh)	1997-06-11
CZ293311B6 (cs)	2004-03-17
DE69532808D1 (de)	2004-05-06
FI965126A0 (fi)	1996-12-19
JPH10503173A (ja)	1998-03-24
RU2201921C2 (ru)	2003-04-10
US6077854A (en)	2000-06-20
EP0770065B1 (en)	2004-03-31
NO312672B1 (no)	2002-06-17
NO965524L (no)	1996-12-20
SK163096A3 (en)	1997-10-08
AU707472B2 (en)	1999-07-08
DE69532808T2 (de)	2005-01-13
US5786354A (en)	1998-07-28
EP0770065A1 (en)	1997-05-02
AU2746195A (en)	1996-01-15
HUT76803A (en)	1997-11-28
ATE263153T1 (de)	2004-04-15
FI965126A7 (fi)	1996-12-19
CZ373096A3 (en)	1997-08-13
FI115302B (fi)	2005-04-15
SK282661B6 (sk)	2002-11-06
NZ288294A (en)	1999-01-28
PT770065E (pt)	2004-08-31
CN1304372C (zh)	2007-03-14
ES2218548T3 (es)	2004-11-16

Publication	Publication Date	Title
NO965524L (no)	1996-12-20	Tri-substituerte fenylderivater anvendelige som PDE IV inhibitorer
DK0874824T3 (da)	2003-10-13	Trisubstituerede phenylderivater nyttige som PDE IV inhibitorer
FI982436A0 (fi)	1998-11-10	Kondensoituneet heterosykliset yhdisteet
PT640065E (pt)	2002-04-29	Derivados de fenilo trissubstituido como inibidores de fosfodiestereases e processos para a sua preparacao
DK0766670T3 (da)	2002-04-22	Tri-substituerede phenylderivater anvendelige som PDE IV inhibitorer
DE69730345D1 (de)	2004-09-23	Triarylethanderivate als pde iv hemmer
NO980154L (no)	1998-03-10	Sykliske GMP-spesifikke fosfodiesteraseinhibitorer
DK534381A (da)	1982-06-06	Fremgangsmaade til fremstilling af 2-oxoazetidinderivater
NO20020570D0 (no)	2002-02-05	Substituerte aromatiske ringforbindelser, fremgangsmåte for fremstilling av samme, og anvendelse
MY111226A (en)	1999-09-30	Tri-substituted phenyl derivatives as phosphodiesterase inhibitors