ATE421900T1 - Herstellung von kleinen kristallen - Google Patents

Herstellung von kleinen kristallen

Info

Publication number
ATE421900T1
ATE421900T1 AT03720684T AT03720684T ATE421900T1 AT E421900 T1 ATE421900 T1 AT E421900T1 AT 03720684 T AT03720684 T AT 03720684T AT 03720684 T AT03720684 T AT 03720684T AT E421900 T1 ATE421900 T1 AT E421900T1
Authority
AT
Austria
Prior art keywords
small crystals
crystal
solution
vortex mixer
ultrasound
Prior art date
Application number
AT03720684T
Other languages
English (en)
Inventor
Linda Jane Mccausland
David Reay
Original Assignee
Accentus Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2002/002006 external-priority patent/WO2002089942A1/en
Application filed by Accentus Plc filed Critical Accentus Plc
Application granted granted Critical
Publication of ATE421900T1 publication Critical patent/ATE421900T1/de

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
    • F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
    • Y10S117/901—Levitation, reduced gravity, microgravity, space

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Drying Of Solid Materials (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
AT03720684T 2002-05-02 2003-04-08 Herstellung von kleinen kristallen ATE421900T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2002/002006 WO2002089942A1 (en) 2001-05-05 2002-05-02 Formation of small crystals
GBGB0219815.8A GB0219815D0 (en) 2002-08-24 2002-08-24 Preparation of small crystals

Publications (1)

Publication Number Publication Date
ATE421900T1 true ATE421900T1 (de) 2009-02-15

Family

ID=9942964

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03720684T ATE421900T1 (de) 2002-05-02 2003-04-08 Herstellung von kleinen kristallen

Country Status (12)

Country Link
US (1) US7326294B2 (de)
EP (1) EP1499410B1 (de)
JP (1) JP2005524519A (de)
AT (1) ATE421900T1 (de)
AU (1) AU2003224261A1 (de)
DE (1) DE60326037D1 (de)
DK (1) DK1499410T3 (de)
ES (1) ES2321919T3 (de)
GB (1) GB0219815D0 (de)
PT (1) PT1499410E (de)
SI (1) SI1499410T1 (de)
WO (1) WO2003092851A1 (de)

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EP1610878B1 (de) * 2003-02-21 2014-09-03 University Of Bath Verfahren zur herstellung von teilchen
JP2005177746A (ja) * 2003-11-28 2005-07-07 Mitsubishi Chemicals Corp 有機化合物微粒子の製造方法
WO2005051511A1 (ja) * 2003-11-28 2005-06-09 Mitsubishi Chemical Corporation 有機化合物微粒子の製造方法
GB0415237D0 (en) * 2004-07-07 2004-08-11 Accentus Plc Formation of sugar coatings
JP4586581B2 (ja) * 2005-03-07 2010-11-24 株式会社Ihi 脱リン装置
EP1782797A1 (de) * 2005-11-02 2007-05-09 Pharmatex Italia Srl Verfahren zur Herstellung von sterilen pulverförmigen pharmazeutischen Verbindungen
WO2008035962A1 (en) * 2006-09-19 2008-03-27 Fujifilm Manufacturing Europe B.V. Process and device for the precipitation of an organic compound
EP2063970A1 (de) * 2006-09-19 2009-06-03 FUJIFILM Manufacturing Europe B.V. Herstellung von feinen teilchen
TWI411450B (zh) * 2006-11-02 2013-10-11 Omrix Biopharmaceuticals Ltd 微粒化方法
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0714223D0 (en) * 2007-07-20 2007-08-29 Fujifilm Mfg Europe Bv Preparation of fine particles
US8771524B2 (en) * 2008-02-08 2014-07-08 Purac Biochem B.V. Vortex mixer and method of obtaining a supersaturated solution or slurry
WO2010007447A1 (en) * 2008-07-18 2010-01-21 Prosonix Limited Process for improving crystallinity
GB0900080D0 (en) 2009-01-06 2009-02-11 Prosonix Ltd An apparatus and process for producing crystals
EP3391877A1 (de) * 2010-04-08 2018-10-24 The Trustees of Princeton University Herstellung von lipidnanopartikeln
DE102010017490A1 (de) * 2010-06-21 2011-12-22 WME Gesellschaft für windkraftbetriebene Meerwasserentsalzung mbH Verfahren zur Aufbereitung eines salzhaltigen Rohwassers zur Herstellung eines Prozesswassers, damit hergestelltes Prozesswasser und Vorrichtung zur Durchführung des Verfahrens
US8708159B2 (en) * 2011-02-16 2014-04-29 Oakwood Laboratories, Llc Manufacture of microspheres using a hydrocyclone
EP2500072A1 (de) 2011-03-15 2012-09-19 LEK Pharmaceuticals d.d. Neuartiges Verfahren zum Entfernen von Restlösemittel
US20140031557A1 (en) * 2011-04-18 2014-01-30 Hefeibeinie Medical Technology Company, Ltd. Method for purification of calcium channel blockers of dihydorpyridine type and preparation of nanoparticles thereof
US9855538B2 (en) 2013-03-08 2018-01-02 The Board Of Trustees Of The University Of Illinois Ultrasonic method and apparatus for producing particles having a controlled size distribution
CN115160090B (zh) * 2022-07-06 2023-05-12 西安近代化学研究所 一种基于微流控技术的hmx超细化制备方法及制备系统

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US2396689A (en) * 1942-12-10 1946-03-19 American Cyanamid Co Spray crystallizing apparatus
BE572854A (de) * 1956-07-06
US4489503A (en) * 1980-11-28 1984-12-25 Olin Corporation Process for drying wet particles of available halogen compounds
JP2789751B2 (ja) 1989-12-27 1998-08-20 住友化学工業株式会社 ベルヌーイ法単結晶用原料アルミナの製造法
GB9007027D0 (en) 1990-03-29 1990-05-30 Atomic Energy Authority Uk Precipitation apparatus and method
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
GB2276567B (en) * 1993-04-03 1996-11-27 Atomic Energy Authority Uk Processing vessel
IL105658A (en) * 1993-05-11 1995-10-31 Ultrasonic Dryer Ltd Spray drying system
AUPO637197A0 (en) 1997-04-23 1997-05-15 F.H. Faulding & Co. Limited Taste-masked pharmaceutical compositions
GB2341120B (en) 1998-09-04 2002-04-17 Aea Technology Plc Controlling uniformity of crystalline precipitates
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GB9825054D0 (en) 1998-11-17 1999-01-13 Aea Technology Plc Method for performing cell culture
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
DE19903125B4 (de) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga
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JP4257717B2 (ja) 2000-02-14 2009-04-22 日本碍子株式会社 単結晶育成用の原料粉末の製造方法および単結晶の製造方法
CA2445146A1 (en) 2001-05-05 2002-11-14 Accentus Plc Formation of small crystals
DE10137017A1 (de) * 2001-07-30 2003-02-20 Basf Ag Kristallisationsverfahren zur Einstellung kleiner Partikel
US20030106488A1 (en) * 2001-12-10 2003-06-12 Wen-Chiang Huang Manufacturing method for semiconductor quantum particles

Also Published As

Publication number Publication date
DE60326037D1 (de) 2009-03-19
US7326294B2 (en) 2008-02-05
ES2321919T3 (es) 2009-06-15
SI1499410T1 (sl) 2009-06-30
PT1499410E (pt) 2009-04-08
US20050155541A1 (en) 2005-07-21
DK1499410T3 (da) 2009-06-02
WO2003092851A1 (en) 2003-11-13
EP1499410A1 (de) 2005-01-26
AU2003224261A1 (en) 2003-11-17
EP1499410B1 (de) 2009-01-28
JP2005524519A (ja) 2005-08-18
GB0219815D0 (en) 2002-10-02

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