ATE421900T1 - Herstellung von kleinen kristallen - Google Patents
Herstellung von kleinen kristallenInfo
- Publication number
- ATE421900T1 ATE421900T1 AT03720684T AT03720684T ATE421900T1 AT E421900 T1 ATE421900 T1 AT E421900T1 AT 03720684 T AT03720684 T AT 03720684T AT 03720684 T AT03720684 T AT 03720684T AT E421900 T1 ATE421900 T1 AT E421900T1
- Authority
- AT
- Austria
- Prior art keywords
- small crystals
- crystal
- solution
- vortex mixer
- ultrasound
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 6
- 238000002604 ultrasonography Methods 0.000 abstract 2
- 238000005054 agglomeration Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 239000012296 anti-solvent Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
- F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
- F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
- B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
- B01D9/0054—Use of anti-solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0081—Use of vibrations, e.g. ultrasound
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10S117/901—Levitation, reduced gravity, microgravity, space
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Drying Of Solid Materials (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2002/002006 WO2002089942A1 (en) | 2001-05-05 | 2002-05-02 | Formation of small crystals |
| GBGB0219815.8A GB0219815D0 (en) | 2002-08-24 | 2002-08-24 | Preparation of small crystals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE421900T1 true ATE421900T1 (de) | 2009-02-15 |
Family
ID=9942964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03720684T ATE421900T1 (de) | 2002-05-02 | 2003-04-08 | Herstellung von kleinen kristallen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7326294B2 (de) |
| EP (1) | EP1499410B1 (de) |
| JP (1) | JP2005524519A (de) |
| AT (1) | ATE421900T1 (de) |
| AU (1) | AU2003224261A1 (de) |
| DE (1) | DE60326037D1 (de) |
| DK (1) | DK1499410T3 (de) |
| ES (1) | ES2321919T3 (de) |
| GB (1) | GB0219815D0 (de) |
| PT (1) | PT1499410E (de) |
| SI (1) | SI1499410T1 (de) |
| WO (1) | WO2003092851A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL224720B1 (pl) * | 2003-02-21 | 2017-01-31 | Univ Bath | Sposób wytwarzania cząstek krystalicznych, cząstki krystaliczne oraz kompozycja farmaceutyczna je zawierająca |
| JP2005177746A (ja) * | 2003-11-28 | 2005-07-07 | Mitsubishi Chemicals Corp | 有機化合物微粒子の製造方法 |
| EP1688169A4 (de) * | 2003-11-28 | 2008-10-01 | Mitsubishi Chem Corp | Verfahren zur herstellung von feinen teilchen einer organischen verbindung |
| GB0415237D0 (en) * | 2004-07-07 | 2004-08-11 | Accentus Plc | Formation of sugar coatings |
| JP4586581B2 (ja) * | 2005-03-07 | 2010-11-24 | 株式会社Ihi | 脱リン装置 |
| EP1782797A1 (de) * | 2005-11-02 | 2007-05-09 | Pharmatex Italia Srl | Verfahren zur Herstellung von sterilen pulverförmigen pharmazeutischen Verbindungen |
| JP2010503721A (ja) * | 2006-09-19 | 2010-02-04 | フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ | 微粒子の製造 |
| WO2008035962A1 (en) * | 2006-09-19 | 2008-03-27 | Fujifilm Manufacturing Europe B.V. | Process and device for the precipitation of an organic compound |
| WO2008053475A1 (en) * | 2006-11-02 | 2008-05-08 | Omrix Biopharmaceuticals Ltd. | Method of micronization |
| GB0705159D0 (en) | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
| GB0714223D0 (en) * | 2007-07-20 | 2007-08-29 | Fujifilm Mfg Europe Bv | Preparation of fine particles |
| US8771524B2 (en) * | 2008-02-08 | 2014-07-08 | Purac Biochem B.V. | Vortex mixer and method of obtaining a supersaturated solution or slurry |
| EP2321022B1 (de) | 2008-07-18 | 2016-11-02 | Prosonix Limited | Verfahren zur erhöhung der kristallinität |
| GB0900080D0 (en) | 2009-01-06 | 2009-02-11 | Prosonix Ltd | An apparatus and process for producing crystals |
| WO2011127255A1 (en) * | 2010-04-08 | 2011-10-13 | Merck Sharp & Dohme Corp. | Preparation of lipid nanoparticles |
| DE102010017490A1 (de) * | 2010-06-21 | 2011-12-22 | WME Gesellschaft für windkraftbetriebene Meerwasserentsalzung mbH | Verfahren zur Aufbereitung eines salzhaltigen Rohwassers zur Herstellung eines Prozesswassers, damit hergestelltes Prozesswasser und Vorrichtung zur Durchführung des Verfahrens |
| US8708159B2 (en) | 2011-02-16 | 2014-04-29 | Oakwood Laboratories, Llc | Manufacture of microspheres using a hydrocyclone |
| EP2500072A1 (de) | 2011-03-15 | 2012-09-19 | LEK Pharmaceuticals d.d. | Neuartiges Verfahren zum Entfernen von Restlösemittel |
| US20140031557A1 (en) * | 2011-04-18 | 2014-01-30 | Hefeibeinie Medical Technology Company, Ltd. | Method for purification of calcium channel blockers of dihydorpyridine type and preparation of nanoparticles thereof |
| US9855538B2 (en) | 2013-03-08 | 2018-01-02 | The Board Of Trustees Of The University Of Illinois | Ultrasonic method and apparatus for producing particles having a controlled size distribution |
| CN115160090B (zh) * | 2022-07-06 | 2023-05-12 | 西安近代化学研究所 | 一种基于微流控技术的hmx超细化制备方法及制备系统 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2396689A (en) * | 1942-12-10 | 1946-03-19 | American Cyanamid Co | Spray crystallizing apparatus |
| BE572854A (de) * | 1956-07-06 | |||
| US4489503A (en) * | 1980-11-28 | 1984-12-25 | Olin Corporation | Process for drying wet particles of available halogen compounds |
| JP2789751B2 (ja) | 1989-12-27 | 1998-08-20 | 住友化学工業株式会社 | ベルヌーイ法単結晶用原料アルミナの製造法 |
| GB9007027D0 (en) | 1990-03-29 | 1990-05-30 | Atomic Energy Authority Uk | Precipitation apparatus and method |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| GB2276567B (en) * | 1993-04-03 | 1996-11-27 | Atomic Energy Authority Uk | Processing vessel |
| IL105658A (en) * | 1993-05-11 | 1995-10-31 | Ultrasonic Dryer Ltd | Spray drying system |
| AUPO637197A0 (en) * | 1997-04-23 | 1997-05-15 | F.H. Faulding & Co. Limited | Taste-masked pharmaceutical compositions |
| GB2341120B (en) * | 1998-09-04 | 2002-04-17 | Aea Technology Plc | Controlling uniformity of crystalline precipitates |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| GB9825054D0 (en) | 1998-11-17 | 1999-01-13 | Aea Technology Plc | Method for performing cell culture |
| GB9828721D0 (en) * | 1998-12-24 | 1999-02-17 | Glaxo Group Ltd | Novel apparatus and process |
| DE19903125B4 (de) * | 1999-01-27 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga |
| DE10004860A1 (de) * | 1999-02-03 | 2000-10-05 | Max Delbrueck Centrum | Druckluftinhalator zur pulmonalen Applikation liposomalen Pulver-Aerosols sowie dafür geeignete Pulver-Aerosole |
| US6723346B1 (en) * | 1999-04-30 | 2004-04-20 | Roche Vitamins Inc. | Process for preparing spray granules containing riboflavin |
| US6223455B1 (en) * | 1999-05-03 | 2001-05-01 | Acusphere, Inc. | Spray drying apparatus and methods of use |
| US6601776B1 (en) * | 1999-09-22 | 2003-08-05 | Microcoating Technologies, Inc. | Liquid atomization methods and devices |
| JP4257717B2 (ja) | 2000-02-14 | 2009-04-22 | 日本碍子株式会社 | 単結晶育成用の原料粉末の製造方法および単結晶の製造方法 |
| EP1409101B1 (de) | 2001-05-05 | 2006-04-12 | Accentus plc | Bildung kleiner krsitalle |
| DE10137017A1 (de) * | 2001-07-30 | 2003-02-20 | Basf Ag | Kristallisationsverfahren zur Einstellung kleiner Partikel |
| US20030106488A1 (en) * | 2001-12-10 | 2003-06-12 | Wen-Chiang Huang | Manufacturing method for semiconductor quantum particles |
-
2002
- 2002-08-24 GB GBGB0219815.8A patent/GB0219815D0/en not_active Ceased
-
2003
- 2003-04-08 US US10/513,153 patent/US7326294B2/en not_active Expired - Fee Related
- 2003-04-08 DE DE60326037T patent/DE60326037D1/de not_active Expired - Lifetime
- 2003-04-08 EP EP03720684A patent/EP1499410B1/de not_active Expired - Lifetime
- 2003-04-08 AT AT03720684T patent/ATE421900T1/de active
- 2003-04-08 PT PT03720684T patent/PT1499410E/pt unknown
- 2003-04-08 ES ES03720684T patent/ES2321919T3/es not_active Expired - Lifetime
- 2003-04-08 DK DK03720684T patent/DK1499410T3/da active
- 2003-04-08 JP JP2004501028A patent/JP2005524519A/ja active Pending
- 2003-04-08 WO PCT/GB2003/001540 patent/WO2003092851A1/en not_active Ceased
- 2003-04-08 AU AU2003224261A patent/AU2003224261A1/en not_active Abandoned
- 2003-04-08 SI SI200331558T patent/SI1499410T1/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20050155541A1 (en) | 2005-07-21 |
| DK1499410T3 (da) | 2009-06-02 |
| GB0219815D0 (en) | 2002-10-02 |
| ES2321919T3 (es) | 2009-06-15 |
| US7326294B2 (en) | 2008-02-05 |
| DE60326037D1 (de) | 2009-03-19 |
| PT1499410E (pt) | 2009-04-08 |
| EP1499410A1 (de) | 2005-01-26 |
| WO2003092851A1 (en) | 2003-11-13 |
| SI1499410T1 (sl) | 2009-06-30 |
| EP1499410B1 (de) | 2009-01-28 |
| AU2003224261A1 (en) | 2003-11-17 |
| JP2005524519A (ja) | 2005-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1499410 Country of ref document: EP |
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| EEIH | Change in the person of patent owner |