ATE421900T1 - Herstellung von kleinen kristallen - Google Patents

Herstellung von kleinen kristallen

Info

Publication number
ATE421900T1
ATE421900T1 AT03720684T AT03720684T ATE421900T1 AT E421900 T1 ATE421900 T1 AT E421900T1 AT 03720684 T AT03720684 T AT 03720684T AT 03720684 T AT03720684 T AT 03720684T AT E421900 T1 ATE421900 T1 AT E421900T1
Authority
AT
Austria
Prior art keywords
small crystals
crystal
solution
vortex mixer
ultrasound
Prior art date
Application number
AT03720684T
Other languages
English (en)
Inventor
Linda Jane Mccausland
David Reay
Original Assignee
Accentus Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2002/002006 external-priority patent/WO2002089942A1/en
Application filed by Accentus Plc filed Critical Accentus Plc
Application granted granted Critical
Publication of ATE421900T1 publication Critical patent/ATE421900T1/de

Links

Classifications

    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00Drying solid materials or objects by processes involving the application of heat
    • F26B3/02Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/10Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
    • F26B3/12Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1688Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D1/00Evaporating
    • B01D1/16Evaporating by spraying
    • B01D1/18Evaporating by spraying to obtain dry solids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/0018Evaporation of components of the mixture to be separated
    • B01D9/0027Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/005Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/005Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054Use of anti-solvent
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/0059General arrangements of crystallisation plant, e.g. flow sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/0081Use of vibrations, e.g. ultrasound
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S117/00Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
    • Y10S117/901Levitation, reduced gravity, microgravity, space

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Drying Of Solid Materials (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
AT03720684T 2002-05-02 2003-04-08 Herstellung von kleinen kristallen ATE421900T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2002/002006 WO2002089942A1 (en) 2001-05-05 2002-05-02 Formation of small crystals
GBGB0219815.8A GB0219815D0 (en) 2002-08-24 2002-08-24 Preparation of small crystals

Publications (1)

Publication Number Publication Date
ATE421900T1 true ATE421900T1 (de) 2009-02-15

Family

ID=9942964

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03720684T ATE421900T1 (de) 2002-05-02 2003-04-08 Herstellung von kleinen kristallen

Country Status (12)

Country Link
US (1) US7326294B2 (de)
EP (1) EP1499410B1 (de)
JP (1) JP2005524519A (de)
AT (1) ATE421900T1 (de)
AU (1) AU2003224261A1 (de)
DE (1) DE60326037D1 (de)
DK (1) DK1499410T3 (de)
ES (1) ES2321919T3 (de)
GB (1) GB0219815D0 (de)
PT (1) PT1499410E (de)
SI (1) SI1499410T1 (de)
WO (1) WO2003092851A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL224720B1 (pl) * 2003-02-21 2017-01-31 Univ Bath Sposób wytwarzania cząstek krystalicznych, cząstki krystaliczne oraz kompozycja farmaceutyczna je zawierająca
JP2005177746A (ja) * 2003-11-28 2005-07-07 Mitsubishi Chemicals Corp 有機化合物微粒子の製造方法
EP1688169A4 (de) * 2003-11-28 2008-10-01 Mitsubishi Chem Corp Verfahren zur herstellung von feinen teilchen einer organischen verbindung
GB0415237D0 (en) * 2004-07-07 2004-08-11 Accentus Plc Formation of sugar coatings
JP4586581B2 (ja) * 2005-03-07 2010-11-24 株式会社Ihi 脱リン装置
EP1782797A1 (de) * 2005-11-02 2007-05-09 Pharmatex Italia Srl Verfahren zur Herstellung von sterilen pulverförmigen pharmazeutischen Verbindungen
JP2010503721A (ja) * 2006-09-19 2010-02-04 フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ 微粒子の製造
WO2008035962A1 (en) * 2006-09-19 2008-03-27 Fujifilm Manufacturing Europe B.V. Process and device for the precipitation of an organic compound
WO2008053475A1 (en) * 2006-11-02 2008-05-08 Omrix Biopharmaceuticals Ltd. Method of micronization
GB0705159D0 (en) 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0714223D0 (en) * 2007-07-20 2007-08-29 Fujifilm Mfg Europe Bv Preparation of fine particles
US8771524B2 (en) * 2008-02-08 2014-07-08 Purac Biochem B.V. Vortex mixer and method of obtaining a supersaturated solution or slurry
EP2321022B1 (de) 2008-07-18 2016-11-02 Prosonix Limited Verfahren zur erhöhung der kristallinität
GB0900080D0 (en) 2009-01-06 2009-02-11 Prosonix Ltd An apparatus and process for producing crystals
WO2011127255A1 (en) * 2010-04-08 2011-10-13 Merck Sharp & Dohme Corp. Preparation of lipid nanoparticles
DE102010017490A1 (de) * 2010-06-21 2011-12-22 WME Gesellschaft für windkraftbetriebene Meerwasserentsalzung mbH Verfahren zur Aufbereitung eines salzhaltigen Rohwassers zur Herstellung eines Prozesswassers, damit hergestelltes Prozesswasser und Vorrichtung zur Durchführung des Verfahrens
US8708159B2 (en) 2011-02-16 2014-04-29 Oakwood Laboratories, Llc Manufacture of microspheres using a hydrocyclone
EP2500072A1 (de) 2011-03-15 2012-09-19 LEK Pharmaceuticals d.d. Neuartiges Verfahren zum Entfernen von Restlösemittel
US20140031557A1 (en) * 2011-04-18 2014-01-30 Hefeibeinie Medical Technology Company, Ltd. Method for purification of calcium channel blockers of dihydorpyridine type and preparation of nanoparticles thereof
US9855538B2 (en) 2013-03-08 2018-01-02 The Board Of Trustees Of The University Of Illinois Ultrasonic method and apparatus for producing particles having a controlled size distribution
CN115160090B (zh) * 2022-07-06 2023-05-12 西安近代化学研究所 一种基于微流控技术的hmx超细化制备方法及制备系统

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2396689A (en) * 1942-12-10 1946-03-19 American Cyanamid Co Spray crystallizing apparatus
BE572854A (de) * 1956-07-06
US4489503A (en) * 1980-11-28 1984-12-25 Olin Corporation Process for drying wet particles of available halogen compounds
JP2789751B2 (ja) 1989-12-27 1998-08-20 住友化学工業株式会社 ベルヌーイ法単結晶用原料アルミナの製造法
GB9007027D0 (en) 1990-03-29 1990-05-30 Atomic Energy Authority Uk Precipitation apparatus and method
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
GB2276567B (en) * 1993-04-03 1996-11-27 Atomic Energy Authority Uk Processing vessel
IL105658A (en) * 1993-05-11 1995-10-31 Ultrasonic Dryer Ltd Spray drying system
AUPO637197A0 (en) * 1997-04-23 1997-05-15 F.H. Faulding & Co. Limited Taste-masked pharmaceutical compositions
GB2341120B (en) * 1998-09-04 2002-04-17 Aea Technology Plc Controlling uniformity of crystalline precipitates
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
GB9825054D0 (en) 1998-11-17 1999-01-13 Aea Technology Plc Method for performing cell culture
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
DE19903125B4 (de) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga
DE10004860A1 (de) * 1999-02-03 2000-10-05 Max Delbrueck Centrum Druckluftinhalator zur pulmonalen Applikation liposomalen Pulver-Aerosols sowie dafür geeignete Pulver-Aerosole
US6723346B1 (en) * 1999-04-30 2004-04-20 Roche Vitamins Inc. Process for preparing spray granules containing riboflavin
US6223455B1 (en) * 1999-05-03 2001-05-01 Acusphere, Inc. Spray drying apparatus and methods of use
US6601776B1 (en) * 1999-09-22 2003-08-05 Microcoating Technologies, Inc. Liquid atomization methods and devices
JP4257717B2 (ja) 2000-02-14 2009-04-22 日本碍子株式会社 単結晶育成用の原料粉末の製造方法および単結晶の製造方法
EP1409101B1 (de) 2001-05-05 2006-04-12 Accentus plc Bildung kleiner krsitalle
DE10137017A1 (de) * 2001-07-30 2003-02-20 Basf Ag Kristallisationsverfahren zur Einstellung kleiner Partikel
US20030106488A1 (en) * 2001-12-10 2003-06-12 Wen-Chiang Huang Manufacturing method for semiconductor quantum particles

Also Published As

Publication number Publication date
US20050155541A1 (en) 2005-07-21
DK1499410T3 (da) 2009-06-02
GB0219815D0 (en) 2002-10-02
ES2321919T3 (es) 2009-06-15
US7326294B2 (en) 2008-02-05
DE60326037D1 (de) 2009-03-19
PT1499410E (pt) 2009-04-08
EP1499410A1 (de) 2005-01-26
WO2003092851A1 (en) 2003-11-13
SI1499410T1 (sl) 2009-06-30
EP1499410B1 (de) 2009-01-28
AU2003224261A1 (en) 2003-11-17
JP2005524519A (ja) 2005-08-18

Similar Documents

Publication Publication Date Title
ATE421900T1 (de) Herstellung von kleinen kristallen
NO20034848D0 (no) Dannelse av små krystaller
CA2015256A1 (en) Process for making acid activated bleaching earth using high susceptibility source clay and novel bleaching earth product
DE69635249D1 (de) Herstellung von Mikrosphären
ATE218390T1 (de) Mischer zum mischen von flüssigkeiten oder suspensionen und mischverfahren
CA2015257A1 (en) Process for making acid activated bleaching earth using high susceptibility source clay and novel bleaching earth product
DE59006185D1 (de) Herstellung kugelförmiger Dispersionen durch Kristallisation von Emulsionen.
DE69306128D1 (de) Herstellung von granulaten
ATE311244T1 (de) Vorrichtung zum mischen und anschliessendem versprühen von flüssigkeiten
BR0207921A (pt) Processo para produzir produtos de hidrocarbonetos sintéticos, e, método para separar lìquido a partir de uma mistura lìquido/sólido
GB1353215A (en) Method and apparatus for purifying water
BR0309625A (pt) Sistema de cristalização que utiliza atomização
ES2198691T3 (es) Procedimiento y dispositivo para la obtencion de productos granulados.
PT1011838E (pt) Processo de separacao
EP0248362A3 (en) Process for the production of an active protein from a biologically inactive form
EP0693516B1 (de) Verfahren zur Herstellung von Polysuccinimid oder Maleinamidsäure
DE60206805D1 (de) Vorrichtung zur chlorierung von wasser
DE69631602D1 (de) Wässrige dispersionen von polyamiden
DE69416883D1 (de) Elektrooptisches Material auf Basis von polymerdispersiertem Flüssigkristall, Verfahren zur Herstellung durch chemische Modifizierung der Grenzfläche, und Vorrichtung auf Basis von diesem Material
ATE435059T1 (de) Verfahren zur kristallisation unter verwendung von hydrodynamischer kavitation
SU856529A1 (ru) Акустический разбрызгиватель
TH53570A (th) การเตรียมของคาโพรแลคแทม
JPS57204285A (en) Removal of volatile organic component from water
Lillie Randomness and directiveness in the evolution and activity of living organisms
ATE14118T1 (de) Verfahren zum herstellen von n-methoxy-n-methyl- urethanen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1499410

Country of ref document: EP

EEIH Change in the person of patent owner