ATE421996T1 - Verfahren zur herstellung optisch aktiver n- carbamat-geschützter beta-lactame durch optische auflösung unter verwendung einer candida antarctica lipase - Google Patents
Verfahren zur herstellung optisch aktiver n- carbamat-geschützter beta-lactame durch optische auflösung unter verwendung einer candida antarctica lipaseInfo
- Publication number
- ATE421996T1 ATE421996T1 AT05826088T AT05826088T ATE421996T1 AT E421996 T1 ATE421996 T1 AT E421996T1 AT 05826088 T AT05826088 T AT 05826088T AT 05826088 T AT05826088 T AT 05826088T AT E421996 T1 ATE421996 T1 AT E421996T1
- Authority
- AT
- Austria
- Prior art keywords
- candida antarctica
- lactame
- optically active
- protected beta
- producing optically
- Prior art date
Links
- 102000004882 Lipase Human genes 0.000 title abstract 2
- 108090001060 Lipase Proteins 0.000 title abstract 2
- 239000004367 Lipase Substances 0.000 title abstract 2
- 241001661345 Moesziomyces antarcticus Species 0.000 title abstract 2
- 235000019421 lipase Nutrition 0.000 title abstract 2
- 238000004090 dissolution Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000003287 optical effect Effects 0.000 title 1
- 150000003952 β-lactams Chemical class 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62840104P | 2004-11-15 | 2004-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE421996T1 true ATE421996T1 (de) | 2009-02-15 |
Family
ID=36190809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05826088T ATE421996T1 (de) | 2004-11-15 | 2005-11-15 | Verfahren zur herstellung optisch aktiver n- carbamat-geschützter beta-lactame durch optische auflösung unter verwendung einer candida antarctica lipase |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7459301B2 (de) |
| EP (1) | EP1812581B1 (de) |
| JP (1) | JP4738416B2 (de) |
| AT (1) | ATE421996T1 (de) |
| CA (1) | CA2580151C (de) |
| DE (1) | DE602005012597D1 (de) |
| DK (1) | DK1812581T3 (de) |
| ES (1) | ES2320364T3 (de) |
| PT (1) | PT1812581E (de) |
| WO (1) | WO2006055528A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4812763B2 (ja) * | 2004-05-18 | 2011-11-09 | ライジェル ファーマシューティカルズ， インコーポレイテッド | シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途 |
| GB2420559B (en) * | 2004-11-15 | 2008-08-06 | Rigel Pharmaceuticals Inc | Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses |
| WO2007070872A1 (en) | 2005-12-15 | 2007-06-21 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and their uses |
| HU227663B1 (en) * | 2007-07-09 | 2011-10-28 | Univ Szegedi | Resolution process |
| MX2011006725A (es) | 2008-12-22 | 2011-09-15 | Millennium Pharm Inc | Combinacion de inhibidores de aurora cinasa y anticuerpos anti-cd20. |
| EP2489663A1 (de) | 2011-02-16 | 2012-08-22 | Almirall, S.A. | Verbindungen als Syk-Kinasehemmer |
| US10335494B2 (en) | 2013-12-06 | 2019-07-02 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-CD30 antibodies |
| JP2018524292A (ja) | 2015-07-21 | 2018-08-30 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | オーロラキナーゼインヒビターと化学療法剤の投与 |
| US11874276B2 (en) | 2018-04-05 | 2024-01-16 | Dana-Farber Cancer Institute, Inc. | STING levels as a biomarker for cancer immunotherapy |
| WO2019201279A1 (zh) * | 2018-04-18 | 2019-10-24 | 广东东阳光药业有限公司 | 一种桥环化合物的制备方法 |
| US20220305048A1 (en) | 2019-08-26 | 2022-09-29 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1095160T3 (da) | 1998-07-09 | 2004-05-17 | Lonza Ag | Fremgangsmåde til fremstilling af (1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-on-derivater |
-
2005
- 2005-11-15 AT AT05826088T patent/ATE421996T1/de active
- 2005-11-15 US US11/281,186 patent/US7459301B2/en active Active
- 2005-11-15 DE DE602005012597T patent/DE602005012597D1/de not_active Expired - Lifetime
- 2005-11-15 DK DK05826088T patent/DK1812581T3/da active
- 2005-11-15 CA CA2580151A patent/CA2580151C/en not_active Expired - Fee Related
- 2005-11-15 EP EP05826088A patent/EP1812581B1/de not_active Expired - Lifetime
- 2005-11-15 WO PCT/US2005/041276 patent/WO2006055528A2/en not_active Ceased
- 2005-11-15 PT PT05826088T patent/PT1812581E/pt unknown
- 2005-11-15 ES ES05826088T patent/ES2320364T3/es not_active Expired - Lifetime
- 2005-11-15 JP JP2007541425A patent/JP4738416B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT1812581E (pt) | 2009-04-22 |
| EP1812581A2 (de) | 2007-08-01 |
| JP2008520206A (ja) | 2008-06-19 |
| EP1812581B1 (de) | 2009-01-28 |
| US20060166308A1 (en) | 2006-07-27 |
| DK1812581T3 (da) | 2009-05-11 |
| CA2580151A1 (en) | 2006-05-26 |
| JP4738416B2 (ja) | 2011-08-03 |
| ES2320364T3 (es) | 2009-05-21 |
| WO2006055528A3 (en) | 2006-08-31 |
| CA2580151C (en) | 2014-02-04 |
| US7459301B2 (en) | 2008-12-02 |
| WO2006055528A2 (en) | 2006-05-26 |
| DE602005012597D1 (de) | 2009-03-19 |
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| UEP | Publication of translation of european patent specification |
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