ATE42304T1 - 4-amino-3-halo-2-pyridinone nukleosid- und nukleotid-verbindungen. - Google Patents

4-amino-3-halo-2-pyridinone nukleosid- und nukleotid-verbindungen.

Info

Publication number: ATE42304T1
Authority: AT; Austria
Prior art keywords: pyridinone; nucleoside; halo; amino; nucleotide compounds
Prior art date: 1985-07-29

Application number

AT86110427T

Other languages

English (en)

Inventor

Dennis J Mcnamara

Phillip Dan Cook

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-29

Filing date

1986-07-29

Publication date

1989-05-15

1986-07-29 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1989-05-15 Application granted granted Critical

1989-05-15 Publication of ATE42304T1 publication Critical patent/ATE42304T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000002777 nucleoside Substances 0.000 title 1
239000002773 nucleotide Substances 0.000 title 1
-1 4-methylbenzoyl Chemical group 0.000 abstract 2
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
125000001589 carboacyl group Chemical group 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
241001529936 Murinae Species 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Chemical group 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Chemical group 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Hematology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT86110427T 1985-07-29 1986-07-29 4-amino-3-halo-2-pyridinone nukleosid- und nukleotid-verbindungen. ATE42304T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/759,816 US4681873A (en)	1985-07-29	1985-07-29	4-amino-3-halo-2-pyridinone nucleoside and nucleotide compounds
EP86110427A EP0210639B1 (de)	1985-07-29	1986-07-29	4-Amino-3-halo-2-pyridinone Nukleosid- und Nukleotid-Verbindungen

Publications (1)

Publication Number	Publication Date
ATE42304T1 true ATE42304T1 (de)	1989-05-15

Family

ID=25057063

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86110427T ATE42304T1 (de)	1985-07-29	1986-07-29	4-amino-3-halo-2-pyridinone nukleosid- und nukleotid-verbindungen.

Country Status (5)

Country	Link
US (1)	US4681873A (de)
EP (1)	EP0210639B1 (de)
JP (1)	JPS6270387A (de)
AT (1)	ATE42304T1 (de)
DE (1)	DE3662895D1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5644043A (en) *	1988-02-16	1997-07-01	Eli Lilly And Company	2',3'-dideoxy-2',2'-difluoronucleosides and intermediates
EP0389723A1 (de) *	1989-03-29	1990-10-03	Merrell Dow Pharmaceuticals Inc.	Alpha-glukosidase-Inhibitoren
US5134066A (en) *	1989-08-29	1992-07-28	Monsanto Company	Improved probes using nucleosides containing 3-dezauracil analogs
CN101318923A (zh) *	2003-09-17	2008-12-10	沃尼尔·朗伯有限责任公司	[R－(R,R)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯基氨基)羰基]－1H－吡咯－1－庚酸的结晶形式

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2802005A (en) *		1957-08-06		S-eluorourace
US2885396A (en) *	1957-03-21	1959-05-05	Heidelberger Charles	N-glycosides of 5-fluorouracil
US3355278A (en) *	1961-03-13	1967-11-28	Hooker Chemical Corp	Herbicidal composition and method
US3201389A (en) *	1962-09-24	1965-08-17	Kyowa Hakko Kogyo Kk	Method for preparing ribonucleoside-5'-phosphates or their salts from ribonucleosides
GB1100824A (en) *	1964-05-11	1968-01-24	Robert Neville Haszeldine	Polyfluoropyridines
NL6816241A (de) *	1967-12-01	1969-06-03
US3705147A (en) *	1969-08-22	1972-12-05	Univ Utah	3-deazapyrimidine nucleosides and method of preparation thereof
BE758759A (fr) *	1969-11-12	1971-05-10	Merck & Co Inc	Pyridones anti-inflammatoires
US3721676A (en) *	1969-11-12	1973-03-20	Merck & Co Inc	Certain 3-amino-2(1h)pyridones
US3853897A (en) *	1971-07-16	1974-12-10	Merck & Co Inc	Certain 1-substituted-3-amino-1(2h)pyridones
US3836645A (en) *	1972-06-23	1974-09-17	Icn Pharmaceuticals	Anti-viral compositions containing 3-deaza nucleosides
EP0015584A3 (de) *	1979-03-12	1980-12-10	Kailash Kumar Dr. Prof. Gauri	Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
US4526988A (en) *	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor

1985
- 1985-07-29 US US06/759,816 patent/US4681873A/en not_active Expired - Fee Related
1986
- 1986-07-28 JP JP61175846A patent/JPS6270387A/ja active Pending
- 1986-07-29 AT AT86110427T patent/ATE42304T1/de not_active IP Right Cessation
- 1986-07-29 DE DE8686110427T patent/DE3662895D1/de not_active Expired
- 1986-07-29 EP EP86110427A patent/EP0210639B1/de not_active Expired

Also Published As

Publication number	Publication date
DE3662895D1 (en)	1989-05-24
EP0210639B1 (de)	1989-04-19
EP0210639A3 (en)	1988-02-03
JPS6270387A (ja)	1987-03-31
US4681873A (en)	1987-07-21
EP0210639A2 (de)	1987-02-04

Legal Events

Date	Code	Title	Description
1989-10-15	UEP	Publication of translation of european patent specification
1994-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE108452T1 (de)	1994-07-15	Puringruppen enthaltende cyclobutane.
UA6343A1 (uk)	1994-12-29	Спосіб одержання похідних 2-оксоінділ-1-карбоксаміда
GB9813535D0 (en)	1998-08-19	Chemical compounds
ES8802517A1 (es)	1988-07-01	Un procedimiento para preparar fenoxialquil (substituido con heterocido)-isoxazoles y furanos.
ATE55390T1 (de)	1990-08-15	Senfgas-derivate der c-6-aminogalaktose und ihre verwendung.
ATE110382T1 (de)	1994-09-15	Oxetanocin.
ATE53588T1 (de)	1990-06-15	Herstellung von cytosin-nukleosiden.
ES8802363A1 (es)	1988-06-01	Procedimiento para la fabricacion de derivados nucleosidos
ATE42304T1 (de)	1989-05-15	4-amino-3-halo-2-pyridinone nukleosid- und nukleotid-verbindungen.
DK426185D0 (da)	1985-09-19	Nucleosid- og purinderivater
GB2043636B (en)	1983-05-11	Pyrimido benzazepine derivatives
MX9303990A (es)	1994-01-31	Tetrazolil (fenoxi y fenoxialquil) piperidinil piridazinas como agentes antivirales.
GB2129425B (en)	1987-02-11	5-halovinyl-2'-deoxyuridine derivatives
SE8500307D0 (sv)	1985-01-23	Nya, antiviruella medel
IE811349L (en)	1981-12-23	Adenine nucleosides
ES8307801A1 (es)	1983-08-16	Procedimiento para la preparacion de derivados ergoticos.
FI956246A0 (fi)	1995-12-22	Hiili-asykliset nukleosidijohdannaiset antiviraalisina ja antineoplastisina aineina
IT1274023B (it)	1997-07-14	Derivati della purina ad attivita' farmacologica, loro uso e composizioni farmaceutiche che li contengono
JPS532478A (en)	1978-01-11	Synthesis of 1-(2-tetrahydrofuryl)-5-fluorouracil
TH9308A (th)	1991-08-01	พิริมิดีนคลีโอไซด์ที่ใช้ต้านไวรัส
TH5978A (th)	1989-05-01	อนุพันธ์ไดแซ็กคาไรด์