ATE423116T1 - Synthese von heteroaryl acetamiden - Google Patents
Synthese von heteroaryl acetamidenInfo
- Publication number
- ATE423116T1 ATE423116T1 AT03814010T AT03814010T ATE423116T1 AT E423116 T1 ATE423116 T1 AT E423116T1 AT 03814010 T AT03814010 T AT 03814010T AT 03814010 T AT03814010 T AT 03814010T AT E423116 T1 ATE423116 T1 AT E423116T1
- Authority
- AT
- Austria
- Prior art keywords
- heteroaryl
- alpha
- acetamids
- synthesis
- hydroxyacetamide
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- -1 heteroaryl acetamide Chemical compound 0.000 abstract 5
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical group N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 abstract 1
- 229960001475 zolpidem Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43576302P | 2002-12-18 | 2002-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE423116T1 true ATE423116T1 (de) | 2009-03-15 |
Family
ID=32682277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03814010T ATE423116T1 (de) | 2002-12-18 | 2003-12-16 | Synthese von heteroaryl acetamiden |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7385056B2 (de) |
| EP (1) | EP1575952B1 (de) |
| JP (1) | JP2006516139A (de) |
| CN (1) | CN100398539C (de) |
| AT (1) | ATE423116T1 (de) |
| AU (1) | AU2003297153B2 (de) |
| CA (1) | CA2509561A1 (de) |
| DE (1) | DE60326270D1 (de) |
| DK (1) | DK1575952T3 (de) |
| ES (1) | ES2320758T3 (de) |
| MX (1) | MXPA05006438A (de) |
| WO (1) | WO2004058758A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE451371T1 (de) * | 2004-06-22 | 2009-12-15 | Mallinckrodt Inc | Synthese von heteroarylacetamiden aus reaktionsmischungen mit reduziertem wassergehalt |
| WO2007109120A2 (en) | 2006-03-17 | 2007-09-27 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| EP1845098A1 (de) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazinen, deren Herstellungverfahren und ihre Verwendung als GABA Rezeptor Liganden |
| US20080145425A1 (en) * | 2006-12-15 | 2008-06-19 | Pliva Research & Development Limited | Pharmaceutical composition of zolpidem |
| ES2573292T3 (es) | 2007-09-19 | 2016-06-07 | Ambit Biosciences Corporation | Formas sólidas que comprenden N-(5-terc-butil-isoxazol-3-il)-N'-{4-[7-(2-morfolin-4-il-etoxi)imidazo[2,1-b][1,3]benzotiazol-2-il]fenil}urea, composiciones de las mismas y usos de las mismas |
| UA103918C2 (en) | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| CN103360387B (zh) * | 2012-03-28 | 2016-12-14 | 江苏豪森药业集团有限公司 | 一种制备化合物唑吡坦的方法 |
| CN114249723B (zh) * | 2020-09-25 | 2025-02-07 | 鲁南制药集团股份有限公司 | 一种唑吡坦及其关键中间体的制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2492382A1 (fr) * | 1980-10-22 | 1982-04-23 | Synthelabo | Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique |
| US4675323A (en) * | 1985-08-06 | 1987-06-23 | Synthelabo | Imidazo(1,2-a)quinoline derivatives useful as anxiolytic agents |
| FR2593179B1 (fr) | 1986-01-22 | 1988-04-01 | Synthelabo | Derives d'imidazo(1,2-a)quinoleines, leur preparation et leur application en therapeutique |
| FR2600650B1 (fr) * | 1986-06-27 | 1988-09-09 | Synthelabo | Procede de preparation d'imidazopyridines et composes intermediaires |
| FR2606410B1 (fr) * | 1986-11-07 | 1989-02-24 | Synthelabo | Imidazopyridines, leur preparation et leur application en therapeutique |
| DE3865073D1 (de) * | 1987-03-27 | 1991-10-31 | Synthelabo | Imidazopyridinderivate, ihre herstellung und therapeutische verwendung. |
| EP0524055A1 (de) * | 1991-07-19 | 1993-01-20 | Synthelabo | Imidazo(2,1-b)benzothiazolderivate, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung |
| EP0607076A1 (de) * | 1993-01-15 | 1994-07-20 | Synthelabo | 9H-Imidazo 1,2-a benzimidazolderivate mit GABA wirkung |
| FR2700546B1 (fr) | 1993-01-15 | 1995-02-17 | Synthelabo | Dérivés d'imidazo[2,1-b]benzoxazole-3-acétamide, leur préparation et leur application en thérapeutique. |
| FR2719843B1 (fr) * | 1994-05-10 | 1996-06-07 | Synthelabo | Dérivés de 5,6-dihydro-4h-imidazo [2',1':2,3] imidazo-[4,5,1-ij] quinoléine et de 4,5-dihydroimidazo [1,2-a] pyrrolo-[1,2,3-cd] benzimidazole, leur préparation et leur application en thérapeutique. |
| FR2741073B1 (fr) | 1995-11-09 | 1997-12-12 | Synthelabo | Derives de 4,5-dihydroimidazo(1,2-a)pyrrolo(1,2,3-cd) benzimidazole, leur preparation et leur application en therapeutique |
| ES2151834B1 (es) | 1998-08-06 | 2001-08-16 | Sint Quimica Sa | Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales. |
| EP1038875B1 (de) * | 1999-03-25 | 2003-06-04 | Synthon B.V. | Imidazopyridinderivate und Verfahren zu ihrer Herstellung |
| HRP20020471B1 (en) | 1999-11-22 | 2007-12-31 | Egis Gy�gyszergy�r RT | Process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(n,n-dimethyl-acetamide) and intermediates |
| PL358548A1 (en) | 2000-04-24 | 2004-08-09 | Teva Pharmaceutical Industries Ltd. | Zolpidem hemitartrate |
| IT1318624B1 (it) * | 2000-07-14 | 2003-08-27 | Dinamite Dipharma S P A In For | Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi. |
| WO2002014306A1 (en) | 2000-08-17 | 2002-02-21 | Cilag Ag | Process for the preparation of imidazopyridines |
| AU2001284322A1 (en) | 2000-08-29 | 2002-03-13 | Ranbaxy Laboratories Limited | Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem |
| WO2004007496A1 (en) * | 2002-07-15 | 2004-01-22 | Scinopharm Taiwan, Ltd. | Process for the preparation of imidazo(1,2-a)pyridine-3-acetamides |
| ATE451371T1 (de) * | 2004-06-22 | 2009-12-15 | Mallinckrodt Inc | Synthese von heteroarylacetamiden aus reaktionsmischungen mit reduziertem wassergehalt |
-
2003
- 2003-12-16 ES ES03814010T patent/ES2320758T3/es not_active Expired - Lifetime
- 2003-12-16 MX MXPA05006438A patent/MXPA05006438A/es active IP Right Grant
- 2003-12-16 US US10/537,604 patent/US7385056B2/en not_active Expired - Fee Related
- 2003-12-16 DE DE60326270T patent/DE60326270D1/de not_active Expired - Lifetime
- 2003-12-16 AU AU2003297153A patent/AU2003297153B2/en not_active Ceased
- 2003-12-16 WO PCT/US2003/039951 patent/WO2004058758A1/en not_active Ceased
- 2003-12-16 AT AT03814010T patent/ATE423116T1/de not_active IP Right Cessation
- 2003-12-16 JP JP2004563575A patent/JP2006516139A/ja not_active Ceased
- 2003-12-16 DK DK03814010T patent/DK1575952T3/da active
- 2003-12-16 CA CA002509561A patent/CA2509561A1/en not_active Abandoned
- 2003-12-16 CN CNB2003801069540A patent/CN100398539C/zh not_active Expired - Fee Related
- 2003-12-16 EP EP03814010A patent/EP1575952B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003297153A1 (en) | 2004-07-22 |
| MXPA05006438A (es) | 2005-09-08 |
| DE60326270D1 (de) | 2009-04-02 |
| CN100398539C (zh) | 2008-07-02 |
| CA2509561A1 (en) | 2004-07-15 |
| US20060025588A1 (en) | 2006-02-02 |
| AU2003297153B2 (en) | 2010-06-10 |
| WO2004058758A1 (en) | 2004-07-15 |
| CN1729188A (zh) | 2006-02-01 |
| JP2006516139A (ja) | 2006-06-22 |
| EP1575952A1 (de) | 2005-09-21 |
| ES2320758T3 (es) | 2009-05-28 |
| DK1575952T3 (da) | 2009-05-25 |
| EP1575952B1 (de) | 2009-02-18 |
| US7385056B2 (en) | 2008-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |