DZ3268A1 - Synthese asymetrique de pregabaline - Google Patents

Synthese asymetrique de pregabaline

Info

Publication number: DZ3268A1
Authority: DZ; Algeria
Prior art keywords: pregabaline; asymmetric synthesis; asymmetric; synthesis
Prior art date: 2000-01-27

Application number

DZ013268A

Other languages

English (en)

Inventor

Mark Joseph Burk

Om Prakash Goel

Marvin Simon Hoekstra

Thomas Frederick Mich

Thomas Arthur Mulhern

James Andrew Ramsden

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-27

Filing date

2001-01-11

Publication date

2001-08-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DZ3268(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-01-11 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2001-08-02 Application granted granted Critical

2001-08-02 Publication of DZ3268A1 publication Critical patent/DZ3268A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DZ013268A 2000-01-27 2001-01-11 Synthese asymetrique de pregabaline DZ3268A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17835900P	2000-01-27	2000-01-27
US19042700P	2000-03-17	2000-03-17
PCT/IB2001/000024 WO2001055090A1 (fr)	2000-01-27	2001-01-11	Synthese asymetrique de pregabaline

Publications (1)

Publication Number	Publication Date
DZ3268A1 true DZ3268A1 (fr)	2001-08-02

Family

ID=26874236

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DZ013268A DZ3268A1 (fr)	2000-01-27	2001-01-11	Synthese asymetrique de pregabaline

Country Status (50)

Country	Link
US (1)	US6891059B2 (fr)
EP (1)	EP1250311B1 (fr)
JP (2)	JP4235384B2 (fr)
KR (1)	KR100549748B1 (fr)
CN (1)	CN1210253C (fr)
AP (1)	AP1438A (fr)
AR (1)	AR028499A1 (fr)
AT (1)	ATE261930T1 (fr)
AU (1)	AU777046B2 (fr)
BG (1)	BG65560B1 (fr)
BR (1)	BRPI0107863B8 (fr)
CA (1)	CA2396090C (fr)
CO (1)	CO5251411A1 (fr)
CR (1)	CR6703A (fr)
CU (1)	CU23221A3 (fr)
CY (1)	CY2004011I1 (fr)
CZ (1)	CZ302838B6 (fr)
DE (1)	DE60102356T2 (fr)
DK (1)	DK1250311T3 (fr)
DZ (1)	DZ3268A1 (fr)
EA (1)	EA004934B1 (fr)
EE (1)	EE05216B1 (fr)
EG (1)	EG24138A (fr)
ES (1)	ES2219493T3 (fr)
GE (1)	GEP20043236B (fr)
HN (1)	HN2001000010A (fr)
HR (1)	HRP20020627B1 (fr)
HU (1)	HU228815B1 (fr)
IL (2)	IL150633A0 (fr)
IS (1)	IS2038B (fr)
MA (1)	MA26869A1 (fr)
ME (1)	ME00921B (fr)
MX (1)	MXPA02007307A (fr)
MY (1)	MY127152A (fr)
NO (1)	NO327958B1 (fr)
NZ (1)	NZ519551A (fr)
OA (1)	OA12167A (fr)
PA (1)	PA8510501A1 (fr)
PE (1)	PE20011063A1 (fr)
PL (1)	PL203985B1 (fr)
PT (1)	PT1250311E (fr)
RS (1)	RS50257B (fr)
SI (1)	SI1250311T1 (fr)
SK (1)	SK287303B6 (fr)
SV (1)	SV2002000295A (fr)
TN (1)	TNSN01016A1 (fr)
TR (1)	TR200400953T4 (fr)
TW (1)	TWI288128B (fr)
UA (1)	UA75584C2 (fr)
WO (1)	WO2001055090A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6001876A (en)	1996-07-24	1999-12-14	Warner-Lambert Company	Isobutylgaba and its derivatives for the treatment of pain
SI1250311T1 (en) *	2000-01-27	2004-10-31	Warner-Lambert Company	Asymmetric synthesis of pregabalin
US6687187B2 (en) *	2000-08-11	2004-02-03	Phonak Ag	Method for directional location and locating system
EP1543831A1 (fr) *	2003-12-18	2005-06-22	Pfizer GmbH Arzneimittelwerk Gödecke	Composition de pregabaline
DE602005002253T2 (de) *	2004-03-12	2008-05-29	Warner-Lambert Company Llc	C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
UA82292C2 (uk) *	2004-04-14	2008-03-25	Пфайзер Продактс Инк.	Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
AP2466A (en) *	2004-06-21	2012-09-17	Warner Lambert Co	Preparation of pregabalin and related compounds
US7417165B2 (en) *	2005-04-06	2008-08-26	Teva Pharmaceutical Industries Ltd.	Crystalline forms of pregabalin
US7488846B2 (en)	2005-04-11	2009-02-10	Teva Pharmaceuical Industries Ltd.	Pregabalin free of lactam and a process for preparation thereof
WO2006110783A2 (fr) *	2005-04-11	2006-10-19	Teva Pharmaceutical Industries Ltd.	Procede de fabrication de (s)-pregabaline
KR20070067077A (ko)	2005-05-10	2007-06-27	테바 파마슈티컬 인더스트리즈 리미티드	이소부틸글루타르산을 함유하지 않는 프레가발린 및 이의제조 방법
KR100893312B1 (ko)	2005-05-10	2009-04-15	테바 파마슈티컬 인더스트리즈 리미티드	프레가발린 및 이의 염의 제조 방법
WO2006122259A1 (fr) *	2005-05-10	2006-11-16	Teva Pharmaceutical Industries Ltd.	Resolution optique de l'acide 3-carbamoylmethyl-5-methyl hexanoique
US20060270871A1 (en) *	2005-05-30	2006-11-30	Khanduri Chandra H	Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) *	2005-06-23	2008-08-13	江苏恩华药业股份有限公司	普瑞巴林中间体及其制备方法
WO2007035890A1 (fr)	2005-09-19	2007-03-29	Teva Pharmaceutical Industries Ltd.	Synthese asymetrique de l'acide (s)-(+)-3-(aminomethyl)-5-methylhexanoique
NL2000281C2 (nl) *	2005-11-02	2007-08-07	Pfizer Prod Inc	Vaste farmaceutische samenstellingen die pregabaline bevatten.
WO2007127309A2 (fr) *	2006-04-24	2007-11-08	Teva Pharmaceutical Industries Ltd.	Procede de synthese d'acide 3-isobutylglutarique
WO2007139933A2 (fr)	2006-05-24	2007-12-06	Teva Pharmaceutical Industries Ltd.	Procédés pour la préparation d'acide r-(+)-3-(carbamoyl méthyl)-5-méthylhexanoïque et de sels de celui-ci
EP2071032A3 (fr) *	2006-05-31	2009-07-08	Teva Pharmaceutical Industries Ltd	Utilisation d'une résolution enzymatique pour la préparation d'intermédiaires de la prégabaline
US20080015385A1 (en) *	2006-05-31	2008-01-17	Lilach Hedvati	Preparation of (S)-pregabalin-nitrile
EP1903027A1 (fr) *	2006-09-13	2008-03-26	Novartis AG	Procédé de préparation de l' acide amino-4 butyrique ou de ses derivés et leur utilisation pour la préparation des inhibiteurs NEP
WO2008118427A2 (fr) *	2007-03-22	2008-10-02	Teva Pharmaceutical Industries Ltd.	Synthèse de l'acide (s)-(+)-3-(aminométhyl)-5-méthylhexanoïque
WO2009001372A2 (fr)	2007-06-25	2008-12-31	Manne Satyanarayana Reddy	Nouveau procédé pour la préparation de la prégabaline
KR100846419B1 (ko) *	2007-08-10	2008-07-15	한국과학기술원	프레가발린의 신규한 제조 방법
KR20090101462A (ko) *	2007-10-03	2009-09-28	테바 파마슈티컬 인더스트리즈 리미티드	프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
EP2053040A1 (fr) *	2007-10-26	2009-04-29	Chemo Ibérica, S.A.	Intermédiaires de la Prégabaline et leurs procédés de préparation et Prégabaline
WO2009087674A2 (fr) *	2007-12-18	2009-07-16	Watson Pharma Private Limited	Procédé perfectionné pour la préparation de (s)-prégabaline
CA2710152A1 (fr) *	2007-12-26	2009-07-02	Generics (Uk) Limited	Procedes de preparation de la pregabaline
CN101910120B (zh) *	2008-01-10	2014-04-23	住友化学株式会社	用于制备环丙烷羧酸化合物的方法及用于此的中间体
EP2110372A1 (fr)	2008-04-16	2009-10-21	Chemo Ibérica, S.A.	Intermédiaires pour la préparation de prégabaline et leur procédé de préparation
SG176464A1 (en)	2008-05-09	2011-12-29	Agency Science Tech & Res	Diagnosis and treatment of kawasaki disease
KR20110025917A (ko)	2008-05-21	2011-03-14	산도즈 아게	５－메틸－３－니트로메틸－헥산산 에스테르의 입체선택적 효소 가수분해 방법
US20100087525A1 (en) *	2008-06-23	2010-04-08	Lilach Hedvati	Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (fr)	2008-12-19	2010-06-24	Pfizer Ireland Pharmaceuticals	Esters de malonate
CN101987826A (zh) *	2009-08-04	2011-03-23	铜陵凯顺生物科技有限公司	一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (fr)	2010-05-14	2011-11-17	Lupin Limited	Synthèse améliorée d'un ester alkylique optiquement pur de l'acide (s) - 3-cyano-5-méthyl-hexanoïque, intermédiaire de la (s)-prégabaline
US8212072B2 (en)	2010-08-13	2012-07-03	Divi's Laboratories, Ltd.	Process for the preparation of pregabalin
WO2012025861A1 (fr) *	2010-08-23	2012-03-01	Pfizer Manufacturing Ireland	Procédé de préparation de dérivés d'acide (s)-3-cyano-5-méthylhexanoïque et de prégabaline
CN102464594B (zh) *	2010-11-17	2014-06-25	凯瑞斯德生化(苏州)有限公司	普瑞巴林的中间体化合物的制备方法
WO2014181359A1 (fr)	2013-05-09	2014-11-13	Council Of Scientific & Industrial Research	Procédé pour la préparation d'un agent anticonvulsivant : le chlorhydrate de prégabaline
WO2016075082A1 (fr)	2014-11-10	2016-05-19	Sandoz Ag	Amination réductrice stéréosélective d'aldéhydes alpha-chiraux au moyen d'ω-transaminases pour la synthèse de précurseurs de la prégabaline et du brivaracétam
WO2017019791A1 (fr)	2015-07-27	2017-02-02	Teva Pharmaceuticals International Gmbh	Synthèse de (s)-prégabaline

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS588390B2 (ja) *	1978-05-23	1983-02-15	住友化学工業株式会社	光学活性ω↓−シアノ↓−α↓−アシルアミノ酸誘導体の製造法
US4939288A (en) *	1989-01-23	1990-07-03	Monsanto Company	Method of preparing (R)-succinic acid derivatives
US6197819B1 (en) *	1990-11-27	2001-03-06	Northwestern University	Gamma amino butyric acid analogs and optical isomers
US5171892A (en) *	1991-07-02	1992-12-15	E. I. Du Pont De Nemours And Company	Chiral phospholanes via chiral 1,4-diol cyclic sulfates
US5616793A (en)	1995-06-02	1997-04-01	Warner-Lambert Company	Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) *	1995-06-07	1997-06-10	Warner-Lambert Company	Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5840965A (en) *	1996-06-24	1998-11-24	E. I. Du Pont De Nemours And Company	Process for the production of purified telephthalic acid
US6001876A (en) *	1996-07-24	1999-12-14	Warner-Lambert Company	Isobutylgaba and its derivatives for the treatment of pain
US6127418A (en) *	1997-08-20	2000-10-03	Warner-Lambert Company	GABA analogs to prevent and treat gastrointestinal damage
ATE236869T1 (de)	1997-12-17	2003-04-15	Chirotech Technology Ltd	Asymmetrische hydrierung
AU3433199A (en)	1998-04-09	1999-11-01	Chirotech Technology Limited	Asymmetric hydrogenation
SI1250311T1 (en) *	2000-01-27	2004-10-31	Warner-Lambert Company	Asymmetric synthesis of pregabalin

2001
- 2001-01-11 SI SI200130109T patent/SI1250311T1/xx unknown
- 2001-01-11 KR KR1020027009629A patent/KR100549748B1/ko not_active Expired - Fee Related
- 2001-01-11 WO PCT/IB2001/000024 patent/WO2001055090A1/fr not_active Ceased
- 2001-01-11 EE EEP200200403A patent/EE05216B1/xx not_active IP Right Cessation
- 2001-01-11 RS YU56202A patent/RS50257B/sr unknown
- 2001-01-11 HU HU0204307A patent/HU228815B1/hu not_active IP Right Cessation
- 2001-01-11 TR TR2004/00953T patent/TR200400953T4/xx unknown
- 2001-01-11 HR HR20020627A patent/HRP20020627B1/xx not_active IP Right Cessation
- 2001-01-11 AT AT01900035T patent/ATE261930T1/de active
- 2001-01-11 CZ CZ20022520A patent/CZ302838B6/cs not_active IP Right Cessation
- 2001-01-11 PT PT01900035T patent/PT1250311E/pt unknown
- 2001-01-11 OA OA1200200227A patent/OA12167A/en unknown
- 2001-01-11 DZ DZ013268A patent/DZ3268A1/fr active
- 2001-01-11 PL PL357077A patent/PL203985B1/pl unknown
- 2001-01-11 CN CNB018041701A patent/CN1210253C/zh not_active Expired - Fee Related
- 2001-01-11 AU AU22138/01A patent/AU777046B2/en not_active Ceased
- 2001-01-11 IL IL15063301A patent/IL150633A0/xx unknown
- 2001-01-11 ME MEP-2008-447A patent/ME00921B/me unknown
- 2001-01-11 JP JP2001555033A patent/JP4235384B2/ja not_active Expired - Fee Related
- 2001-01-11 SK SK1078-2002A patent/SK287303B6/sk not_active IP Right Cessation
- 2001-01-11 BR BRPI0107863A patent/BRPI0107863B8/pt not_active IP Right Cessation
- 2001-01-11 CA CA002396090A patent/CA2396090C/fr not_active Expired - Fee Related
- 2001-01-11 EA EA200200642A patent/EA004934B1/ru not_active IP Right Cessation
- 2001-01-11 US US10/182,656 patent/US6891059B2/en not_active Expired - Lifetime
- 2001-01-11 MX MXPA02007307A patent/MXPA02007307A/es active IP Right Grant
- 2001-01-11 ES ES01900035T patent/ES2219493T3/es not_active Expired - Lifetime
- 2001-01-11 AP APAP/P/2002/002588A patent/AP1438A/en active
- 2001-01-11 DK DK01900035T patent/DK1250311T3/da active
- 2001-01-11 DE DE60102356T patent/DE60102356T2/de not_active Expired - Lifetime
- 2001-01-11 GE GEAP20016551A patent/GEP20043236B/en unknown
- 2001-01-11 NZ NZ519551A patent/NZ519551A/en not_active IP Right Cessation
- 2001-01-11 EP EP01900035A patent/EP1250311B1/fr not_active Expired - Lifetime
- 2001-01-19 TW TW090101221A patent/TWI288128B/zh not_active IP Right Cessation
- 2001-01-23 MY MYPI20010329A patent/MY127152A/en unknown
- 2001-01-23 PA PA20018510501A patent/PA8510501A1/es unknown
- 2001-01-24 CO CO01005266A patent/CO5251411A1/es active IP Right Grant
- 2001-01-24 HN HN2001000010A patent/HN2001000010A/es unknown
- 2001-01-24 EG EG20010073A patent/EG24138A/xx active
- 2001-01-24 PE PE2001000078A patent/PE20011063A1/es not_active Application Discontinuation
- 2001-01-25 AR ARP010100316A patent/AR028499A1/es not_active Application Discontinuation
- 2001-01-26 TN TNTNSN01016A patent/TNSN01016A1/fr unknown
- 2001-01-26 SV SV2001000295A patent/SV2002000295A/es active IP Right Grant
- 2001-11-01 UA UA2002065143A patent/UA75584C2/uk unknown
2002
- 2002-06-19 CU CU20020122A patent/CU23221A3/es unknown
- 2002-06-19 IS IS6430A patent/IS2038B/is unknown
- 2002-06-20 BG BG106849A patent/BG65560B1/bg unknown
- 2002-07-08 IL IL150633A patent/IL150633A/en not_active IP Right Cessation
- 2002-07-16 CR CR6703A patent/CR6703A/es unknown
- 2002-07-23 MA MA26738A patent/MA26869A1/fr unknown
- 2002-07-26 NO NO20023582A patent/NO327958B1/no not_active IP Right Cessation
2004
- 2004-12-20 CY CY2004011C patent/CY2004011I1/el unknown
2008
- 2008-09-30 JP JP2008254068A patent/JP4886753B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4235384B2 (ja)	2009-03-11
ES2219493T3 (es)	2004-12-01
UA75584C2 (uk)	2006-05-15
BG65560B1 (bg)	2008-12-30
NO20023582L (no)	2002-09-02
SI1250311T1 (en)	2004-10-31
EP1250311A1 (fr)	2002-10-23
AU2213801A (en)	2001-08-07
CN1396905A (zh)	2003-02-12
HUP0204307A3 (en)	2003-07-28
KR100549748B1 (ko)	2006-02-08
AP2002002588A0 (en)	2002-09-30
CA2396090C (fr)	2006-01-10
CN1210253C (zh)	2005-07-13
JP4886753B2 (ja)	2012-02-29
CZ302838B6 (cs)	2011-12-07
RS50257B (sr)	2009-07-15
CZ20022520A3 (cs)	2002-10-16
ATE261930T1 (de)	2004-04-15
MXPA02007307A (es)	2002-11-29
SV2002000295A (es)	2002-06-07
YU56202A (sh)	2006-01-16
EP1250311B1 (fr)	2004-03-17
AU777046B2 (en)	2004-09-30
AP1438A (en)	2005-05-23
IS6430A (is)	2002-06-19
TR200400953T4 (tr)	2004-07-21
TNSN01016A1 (fr)	2005-11-10
EG24138A (en)	2008-08-06
HN2001000010A (es)	2001-06-13
EA200200642A1 (ru)	2002-12-26
EE200200403A (et)	2003-10-15
TWI288128B (en)	2007-10-11
US6891059B2 (en)	2005-05-10
HU228815B1 (en)	2013-05-28
PE20011063A1 (es)	2001-10-18
HUP0204307A2 (hu)	2003-06-28
MA26869A1 (fr)	2004-12-20
SK287303B6 (sk)	2010-06-07
EA004934B1 (ru)	2004-10-28
IS2038B (is)	2005-08-15
NO327958B1 (no)	2009-10-26
PA8510501A1 (es)	2002-02-21
HRP20020627B1 (hr)	2011-01-31
DE60102356D1 (de)	2004-04-22
PT1250311E (pt)	2004-07-30
CR6703A (es)	2003-06-24
CY2004011I1 (el)	2010-07-28
DK1250311T3 (da)	2004-08-16
JP2003520841A (ja)	2003-07-08
IL150633A (en)	2009-08-03
KR20020073187A (ko)	2002-09-19
MY127152A (en)	2006-11-30
CA2396090A1 (fr)	2001-08-02
AR028499A1 (es)	2003-05-14
BRPI0107863B8 (pt)	2017-04-25
ME00921B (me)	2012-06-20
PL357077A1 (en)	2004-07-12
CO5251411A1 (es)	2003-02-28
BR0107863A (pt)	2002-11-05
BR0107863B1 (pt)	2013-06-18
GEP20043236B (en)	2004-05-25
JP2009073841A (ja)	2009-04-09
PL203985B1 (pl)	2009-11-30
NZ519551A (en)	2004-02-27
BG106849A (en)	2003-03-31
CU23221A3 (es)	2007-07-20
NO20023582D0 (no)	2002-07-26
WO2001055090A1 (fr)	2001-08-02
SK10782002A3 (sk)	2002-11-06
OA12167A (en)	2006-05-08
IL150633A0 (en)	2003-02-12
EE05216B1 (et)	2009-10-15
HRP20020627A2 (en)	2004-08-31
US20030212290A1 (en)	2003-11-13
DE60102356T2 (de)	2005-02-17

Publication	Publication Date	Title
PT1250311E (pt)	2004-07-30	Sintese assimetrica de pregabalina
FI20001572L (fi)	2001-12-31	Puhesynteesi
PT1315485E (pt)	2008-01-23	Composição catártica
PT1253932E (pt)	2005-07-29	Composicoes farmaceuticas de toxina botulinica
AR028567A1 (es)	2003-05-14	Nuevos derivados de fenil-propargileter
MXPA03000059A (es)	2003-10-15	Derivados de pirazol.
AR028596A1 (es)	2003-05-14	Nuevos derivados de fenilglicina
ID30187A (id)	2001-11-15	Dongkrak jenis pantagraf
PT1250321E (pt)	2006-09-29	Composicao de gliburida
DE60127311D1 (de)	2007-04-26	Verbesserung von luftbleichkatalysatoren
EP1169466A4 (fr)	2005-02-23	Synthese de 1,2,3,4-tetrahydroxybenzenes et de 1,2,3-trihydroxybenzenes au moyen de myo-inositol-1phosphate synthase et de myo-inositol 2-dehydrogenase
EE200300294A (et)	2003-10-15	Sulfoonamiid-asendatud imidasotriasinoonide valmistamismeetod
FR2803856B1 (fr)	2002-07-05	Synthese de l'hydroxyde de tetramethylammonium
ITMI20001112A0 (it)	2000-05-19	Catalizzatori solidi basici
AR028070A1 (es)	2003-04-23	Sintesis de compuestos de ciclohexendimetanol o ciclohexandimetanol
DE60031450D1 (de)	2006-11-30	Polymorph v von torasemid
EP1339391A4 (fr)	2009-09-02	Synthese de petites particules
EP1366056A4 (fr)	2003-12-03	Preparation de desoxynucleosides
AR028007A1 (es)	2003-04-23	Procedimiento para preparar eteres de oxima
DE50014381D1 (de)	2007-07-19	Stereoselektive Synthese von 2-Hydroxyketonen
DE60135223D1 (de)	2008-09-18	Shampoozusammensetzungen
SE0000713D0 (sv)	2000-03-03	Methods of synthesis
SE0004003D0 (sv)	2000-11-02	Synthesis of FLG
FR2810531B1 (fr)	2003-05-23	Trocart de coelio-chirurgie
UA4579S (uk)	2001-02-15	Дозиметр-радіометр гамма-бета-випромінювань