ATE423199T1 - Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik - Google Patents

Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik

Info

Publication number
ATE423199T1
ATE423199T1 AT02743820T AT02743820T ATE423199T1 AT E423199 T1 ATE423199 T1 AT E423199T1 AT 02743820 T AT02743820 T AT 02743820T AT 02743820 T AT02743820 T AT 02743820T AT E423199 T1 ATE423199 T1 AT E423199T1
Authority
AT
Austria
Prior art keywords
human thrombin
prethrombin
human
producing human
thrombin
Prior art date
Application number
AT02743820T
Other languages
English (en)
Inventor
Hiroshi Yonemura
Takayuki Imamura
Hiroshi Nakatake
Kenji Soejima
Chikateru Nozaki
Original Assignee
Chemo Sero Therapeut Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst
Application granted granted Critical
Publication of ATE423199T1 publication Critical patent/ATE423199T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT02743820T 2001-07-06 2002-07-04 Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik ATE423199T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001206919 2001-07-06

Publications (1)

Publication Number Publication Date
ATE423199T1 true ATE423199T1 (de) 2009-03-15

Family

ID=19042979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02743820T ATE423199T1 (de) 2001-07-06 2002-07-04 Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik

Country Status (9)

Country Link
US (1) US7635577B2 (de)
EP (1) EP1405910B1 (de)
JP (1) JP4227012B2 (de)
KR (2) KR100983878B1 (de)
CN (1) CN100347297C (de)
AT (1) ATE423199T1 (de)
CA (1) CA2452768C (de)
DE (1) DE60231210D1 (de)
WO (1) WO2003004641A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040219140A1 (en) * 2001-02-22 2004-11-04 Reiner Class Compositions and methods for preventing platelet aggregation
WO2005010178A1 (ja) 2003-07-29 2005-02-03 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 組換えフィブリノゲン高産生細胞の作製方法及び高産生細胞
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
EP2180045B1 (de) 2003-10-24 2015-12-23 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Neuartige rekombinante Tierzellen mit hoher Proteinproduktion, Herstellungsverfahren dafür und Verfahren zur Proteinmassenproduktion damit
JP2008504808A (ja) * 2004-05-24 2008-02-21 パナコス ファーマシューティカルズ インコーポレーティッド ウイルスキャプシドスペーサーペプチド１タンパク質のプロセシングの破壊によるｈｉｖ−１複製の阻害
KR101599062B1 (ko) 2005-04-13 2016-03-02 아스트라제네카 아베 감마 카르복실화를 필요로 하는 단백질 생산용 벡터를 포함하는 숙주 세포
AU2006298160A1 (en) 2005-09-30 2007-04-12 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for preparing recombinant human thrombin with culture cell
RU2008139428A (ru) * 2006-03-06 2010-05-20 Хьюмэджин, Инк. (Us) Способ получения рекомбинантного тромбина и фибриногена человека
US8206967B2 (en) * 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
WO2009128474A1 (ja) 2008-04-16 2009-10-22 財団法人化学及血清療法研究所 トロンビン固定化生体吸収性シート製剤の製造方法
WO2014103608A1 (ja) 2012-12-25 2014-07-03 一般財団法人化学及血清療法研究所 HPV/HBsキメラタンパク質を有効成分とするHPV感染症及び／又はＢ型肝炎用ワクチン
JP6216647B2 (ja) 2013-03-15 2017-10-18 シスメックス株式会社 組換え型プロトロンビンの製造方法およびその利用
WO2025208342A1 (zh) * 2024-04-02 2025-10-09 苏州泽璟生物制药股份有限公司 高纯度且低残留的重组人凝血酶制备方法及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2824434B2 (ja) 1989-11-28 1998-11-11 財団法人化学及血清療法研究所 新規発現ベクター
US5583107A (en) 1990-09-04 1996-12-10 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
US5278144A (en) 1990-09-04 1994-01-11 Cor Therapeutics, Inc. Antithrombosis agents
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex
JP3168087B2 (ja) * 1993-01-11 2001-05-21 株式会社ヤスヰ 洗車方法及びその装置
AT404357B (de) 1995-06-13 1998-11-25 Immuno Ag Prothrombin-derivate
EP1076698A2 (de) 1998-05-14 2001-02-21 Battelle Memorial Institute Menschliche blutgerinnungsfaktoren aus transgenen pflanzen
WO2001004146A2 (en) * 1999-07-09 2001-01-18 Cohesion Technologies, Inc. Ecarin polypeptides, polynucleotides encoding ecarin, and methods for use thereof
CN1298017A (zh) * 1999-11-29 2001-06-06 中国科学技术大学 一种快速活化凝血酶原的方法

Also Published As

Publication number Publication date
JPWO2003004641A1 (ja) 2004-10-28
KR20040032147A (ko) 2004-04-14
EP1405910A4 (de) 2005-02-02
CN100347297C (zh) 2007-11-07
EP1405910B1 (de) 2009-02-18
WO2003004641A1 (en) 2003-01-16
DE60231210D1 (de) 2009-04-02
KR100983878B1 (ko) 2010-09-27
KR20090087136A (ko) 2009-08-14
EP1405910A1 (de) 2004-04-07
CA2452768A1 (en) 2003-01-16
US20040197858A1 (en) 2004-10-07
JP4227012B2 (ja) 2009-02-18
CN1551917A (zh) 2004-12-01
CA2452768C (en) 2011-06-07
US7635577B2 (en) 2009-12-22

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