ATE318324T1 - Verfahren zur herstellung von oligosaccharide - Google Patents

Verfahren zur herstellung von oligosaccharide

Info

Publication number
ATE318324T1
ATE318324T1 AT00949678T AT00949678T ATE318324T1 AT E318324 T1 ATE318324 T1 AT E318324T1 AT 00949678 T AT00949678 T AT 00949678T AT 00949678 T AT00949678 T AT 00949678T AT E318324 T1 ATE318324 T1 AT E318324T1
Authority
AT
Austria
Prior art keywords
cell
intermediates
degrading
culturing
modification
Prior art date
Application number
AT00949678T
Other languages
English (en)
Inventor
Eric Samain
Bernard Priem
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9547804&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE318324(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE318324T1 publication Critical patent/ATE318324T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
AT00949678T 1999-07-07 2000-07-07 Verfahren zur herstellung von oligosaccharide ATE318324T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9908772A FR2796082B1 (fr) 1999-07-07 1999-07-07 Procede de production d'oligosaccharides

Publications (1)

Publication Number Publication Date
ATE318324T1 true ATE318324T1 (de) 2006-03-15

Family

ID=9547804

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05111263T ATE466094T1 (de) 1999-07-07 2000-07-07 Verfahren zur herstellung von oligosacchariden
AT00949678T ATE318324T1 (de) 1999-07-07 2000-07-07 Verfahren zur herstellung von oligosaccharide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05111263T ATE466094T1 (de) 1999-07-07 2000-07-07 Verfahren zur herstellung von oligosacchariden

Country Status (11)

Country Link
US (2) US7521212B1 (de)
EP (2) EP1637611B1 (de)
JP (1) JP5058420B2 (de)
AT (2) ATE466094T1 (de)
AU (1) AU780290B2 (de)
CA (1) CA2378562C (de)
DE (2) DE60026142T2 (de)
FR (1) FR2796082B1 (de)
MX (1) MXPA02000240A (de)
NZ (1) NZ516808A (de)
WO (1) WO2001004341A1 (de)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1384786B1 (de) * 2001-04-02 2010-01-27 Glycomedics, Inc. Verfahren zur herstellung von oligosaccharidketten
FI20021989A0 (fi) * 2002-11-06 2002-11-06 Halina Miller-Podraza Korkean affiniteetin Helicobacter pylori-reseptorit ja niiden käyttö
US7820422B2 (en) 2005-06-16 2010-10-26 Centre National De La Recherche Scientifique (Cnrs) Efficient production of oligosaccharides using metabolically engineered microorganisms
WO2008002230A1 (en) * 2006-03-04 2008-01-03 Nilsson Kurt G I Production of glycoside oligosaccharides
WO2007101862A1 (en) 2006-03-09 2007-09-13 Centre National De La Recherche Scientifique (Cnrs) Method of producing sialylated oligosaccharides
EP1911850A1 (de) * 2006-10-09 2008-04-16 Centre National De La Recherche Scientifique (Cnrs) Verfahren zur Herstellung von 6-thio-sialierten Glykoproteinen und Glycokonjugaten
WO2010111530A1 (en) 2009-03-25 2010-09-30 Seneb Biosciences, Inc. Glycolipids as treatment for disease
WO2011100979A1 (en) 2010-02-19 2011-08-25 Glycom A/S Production of 6'-o-sialyllactose and intermediates
SG10201504733XA (en) 2010-07-12 2015-07-30 Univ Gent Metabolically engineered organisms for the production of added value bio-products
RU2460800C2 (ru) * 2010-08-04 2012-09-10 Государственное научное учреждение Всероссийский научно-исследовательский институт сельскохозяйственной микробиологии Российской академии сельскохозяйственных наук (ГНУ ВНИИСХМ Россельхозакадемии) Способ ферментативного получения пента-n-ацетилхитопентаозы
DE12746649T1 (de) 2011-02-16 2016-09-29 Glycosyn LLC Biosynthese menschlicher milcholigosaccaride in manipulierten Bakterien
WO2012158517A1 (en) 2011-05-13 2012-11-22 Glycosyn LLC The use of purified 2'-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics
DK2722394T3 (en) 2011-06-07 2018-06-18 Hero Ag OBJECTIVES OF OLIGOSACCHARIDES BY A BIOTECHNOLOGICAL PROCEDURE
NL2007268C2 (en) 2011-08-16 2013-02-19 Friesland Brands Bv Nutritional compositions comprising human milk oligosaccharides and uses thereof.
CA2847569C (en) 2011-09-08 2020-05-19 Novozymes Bioag A/S Seed treatment methods and compositions comprising lipo-chitooligosaccharides
UA116193C2 (uk) 2011-09-14 2018-02-26 Новозаймс Біоаг А/С Композиція для обробки рослини або насінини рослини та спосіб стимулювання росту рослин
CN107258790A (zh) 2011-09-23 2017-10-20 诺维信生物农业公司 用于增强植物生长的壳寡糖和方法
EP2747568B1 (de) 2011-09-23 2019-05-22 Novozymes Bioag A/S Kombinationen aus lipo-chitooligosacchariden und verfahren dafür zur anwendung bei der pflanzenwachstumsförderung
CN105746517A (zh) 2011-09-23 2016-07-13 诺维信生物农业公司 用于增强大豆生长的壳寡糖和方法
CA2849901A1 (en) 2011-09-23 2013-03-28 Novozymes Bioag A/S Chitooligosaccharides and methods for use in enhancing corn growth
US20150225758A1 (en) * 2011-11-08 2015-08-13 University Of Georgia Research Foundation, Inc. Genetically modified cells and methods for making activated sugar-nucleotides
CN103155816A (zh) * 2011-12-09 2013-06-19 青岛天力建筑加固工程有限公司 一种使单体树木便于靠接成整棵大树的模具
RU2517620C2 (ru) * 2012-02-17 2014-05-27 Государственное научное учреждение Всероссийский научно-исследовательский институт сельскохозяйственной микробиологии Российской академии сельскохозяйственных наук (ГНУ ВНИИСХМ Россельхозакадемии) Способ ферментативного получения пента-n-ацетилхитопентаозы и гекса-n-ацетилхитогексаозы
EP2859112A4 (de) 2012-06-08 2015-10-28 Glycom As Verfahren zur herstellung von oligosacchariden und oligosaccharidglykosiden durch fermentation
WO2014048439A1 (en) * 2012-09-25 2014-04-03 Glycom A/S Glycoconjugate synthesis
EP2728009B1 (de) 2012-10-31 2017-07-26 Jennewein Biotechnologie GmbH Verfahren zur Herstellung von Monosacchariden
WO2014086373A1 (en) 2012-12-07 2014-06-12 Glycom A/S Crystallisation of human milk oligosaccharides (hmo)
DE14769797T1 (de) 2013-03-14 2016-06-23 Glycosyn LLC Mikroorganismen und Verfahren zur Herstellung sialylierter und N-acetylglucosamin-haltiger Oligosaccharide
DK2999358T3 (en) 2013-05-22 2021-10-11 Glycom As Synthetic mixture of oligosaccharides for the treating a microbiota of a mammal
WO2015032413A1 (en) 2013-09-06 2015-03-12 Glycom A/S Fermentative production of oligosaccharides
DK3041946T4 (en) 2013-09-06 2025-11-03 Glycom As Fermentative production of oligosaccharides
EP2896628B1 (de) 2014-01-20 2018-09-19 Jennewein Biotechnologie GmbH Verfahren zur effizienten Reinigung von neutralen humanen Milch-Oligosacchariden (HMOs) aus mikrobieller Fermentation
PL2927316T3 (pl) 2014-03-31 2019-05-31 Jennewein Biotechnologie Gmbh Całkowita fermentacja oligosacharydów
ES2962258T3 (es) * 2014-05-15 2024-03-18 Glycosyn LLC Singenes de alfa(1,2) fucosiltransferasa para su utilización en la producción de oligosacáridos fucosilados
WO2015188834A1 (en) 2014-06-11 2015-12-17 Glycom A/S Separation of 2'-o-fucosyllactose from fermentation broth
US11926858B2 (en) 2014-06-27 2024-03-12 Glycom A/S Oligosaccharide production
ES3002778T3 (en) 2014-06-27 2025-03-07 Glycom As Oligosaccharide production
AU2015291487A1 (en) 2014-07-14 2017-02-16 Basf Se Biotechnological production of LNT, LNnT and the fucosylated derivatives thereof
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
PL3209673T5 (pl) 2014-10-24 2023-10-23 Glycom A/S Mieszaniny hmo
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
EP3212197A4 (de) 2014-10-29 2018-07-11 Glycom A/S Synthetische zusammensetzung und verfahren zur behandlung von reizdarmsyndrom
EP3212198B1 (de) 2014-10-29 2020-12-23 Glycom A/S Synthetische zusammensetzung und verfahren zur förderung von schleimhautwundheilung
US10500221B2 (en) 2014-12-05 2019-12-10 Glycom A/S Crystalline difucosyllactose
EP3229812A4 (de) 2014-12-08 2018-10-03 Glycom A/S Synthetische zusammensetzung zur behandlung von stoffwechselerkrankungen
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
DK3233875T3 (en) 2014-12-16 2022-12-19 Glycom As Separation of 2'-fl from a fermentation broth
WO2016157108A1 (en) 2015-03-31 2016-10-06 Glycom A/S Mixtures of human milk oligosaccharides comprising 3 '-o-sialyllactose
FR3035794B1 (fr) 2015-05-06 2017-05-05 Elicityl Procede pour la purification du sang total ou d'un produit issu du sang
FR3035799B1 (fr) 2015-05-06 2017-05-05 Elicityl Support pour la purification de liquides biologiques
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN107614511B (zh) 2015-06-09 2020-10-23 格礼卡姆股份公司 6’-SL、LNnT和LST c的三元混合物
EP3141610A1 (de) * 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Herstellung von menschlichen milch-oligosacchariden in mikrobiellen wirten mit gentechnisch verändertem import/export-system
ES2886951T3 (es) 2015-09-14 2021-12-21 Glycom As Composición para su uso en la modulación de la microbiota
US10780103B2 (en) 2015-10-28 2020-09-22 Glycom A/S Synthetic composition and method for modulating emotion and mood disorders
PL3368046T3 (pl) 2015-10-28 2022-11-28 Glycom A/S Syntetyczna kompozycja i sposób modulowania funkcji mózgu i zachowania
EP3377071B1 (de) 2015-11-17 2024-01-10 Glycom A/S Humane milch-oligosaccharide zur behandlung von komplikationen im zusammenhang mit antibiotika
EP3389668A4 (de) 2015-12-15 2019-08-21 Glycom A/S Mischung aus hmos
ES3011213T3 (en) 2015-12-18 2025-04-07 Glycom As Fermentative production of oligosaccharides
WO2017144062A1 (en) 2016-02-24 2017-08-31 Glycom A/S Synthetic composition for microbiota modulation
ES2991621T3 (es) 2016-03-07 2024-12-04 Glycom As Separación de oligosacáridos de caldo de fermentación
DK3445770T3 (da) 2016-04-19 2026-02-23 Glycom As Separering af oligosaccharider fra fermenteringssuppe
DK3452050T3 (da) 2016-05-05 2023-02-20 Glycom As Composition comprising hmos for the treatment of noninfectious diarrhoea
ES2924137T3 (es) 2016-05-05 2022-10-04 Glycom As Composición que comprende HMOS para uso en el tratamiento de la hipersensibilidad y/o dolor visceral mediados por mastocitos
US11224605B2 (en) 2016-05-19 2022-01-18 Glycom A/S Synthetic composition
EP3474861A4 (de) 2016-06-24 2020-04-15 Glycom A/S Zusammensetzungen mit hmos, deren herstellung und verwendung zur prävention und/oder behandlung von viralen und/oder bakteriellen infektionen
ES2856749T3 (es) * 2016-10-29 2021-09-28 Chr Hansen Hmo Gmbh Proceso para la producción de oligosacáridos fucosilados
US10407516B2 (en) 2016-10-31 2019-09-10 Glycom A/S Crystalline HMO
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2018157900A1 (en) 2017-03-01 2018-09-07 Glycom A/S Synthetic composition for microbiota modulation
EP3634429A4 (de) 2017-05-09 2020-11-04 Glycom A/S Synthetische zusammensetzung zur mikrobiotamodulation
WO2018215961A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising oligosaccharides and its use in medical treatment.
WO2018215960A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising one or more human milk oligosaccharides (hmos)
WO2019003135A1 (en) * 2017-06-30 2019-01-03 Glycom A/S PURIFICATION OF OLIGOSACCHARIDES
CN110914284B (zh) 2017-07-12 2025-01-07 格礼卡姆股份公司 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物
EP3438122A1 (de) 2017-08-01 2019-02-06 OligoScience Biotechnology GmbH Mikroorganismus zur herstellung menschlicher milcholigosaccharide
US11524019B2 (en) 2017-08-21 2022-12-13 Glycom A/S Synthetic composition for reducing allergy symptoms
EP3450443A1 (de) 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Verfahren zur reinigung sialylierter oligosaccharide
EP3456836A1 (de) 2017-09-13 2019-03-20 Glycom A/S Abtrennung von sialylierten oligosacchariden aus der fermentationsbrühe
CN111356461A (zh) 2017-10-04 2020-06-30 加利福尼亚大学董事会 免疫调节性低聚糖
GB201717555D0 (en) 2017-10-25 2017-12-06 Nonwovens Innovation & Res Institute Ltd Blood filter
CN111526879A (zh) 2017-11-02 2020-08-11 格礼卡姆股份公司 用于减少或预防疲劳和/或改善注意力或专注力的一种或多种hmo
EP3716984B1 (de) 2017-11-30 2024-03-20 Glycom A/S Gemisch von hmos zur behandlung von weizensensitivität
US11602545B2 (en) 2017-12-05 2023-03-14 Glycom A/S Human milk oligosaccharides for treating migraine
WO2019123316A1 (en) 2017-12-22 2019-06-27 Glycom A/S Composition comprising hmos for preventing or reducing nociception
CN108504678A (zh) * 2018-04-12 2018-09-07 江南大学 一种提高重组枯草芽孢杆菌几丁寡糖产量的方法
JP7492458B2 (ja) 2018-05-07 2024-05-29 クリスチャン・ハンセン・ハーエムオー・ゲーエムベーハー 微生物発酵によって得られた炭水化物からラクト－Ｎ－ネオテトラオース（ＬＮｎＴ）を精製するための簡素な方法
US11554131B2 (en) 2018-05-31 2023-01-17 Glycom A/S Mixture of HMOs for treating autoimmune diseases
PL3620510T3 (pl) 2018-09-06 2024-02-19 Chr. Hansen HMO GmbH Fermentacyjne wytwarzanie oligosacharydów przez całkowitą fermentację z wykorzystaniem mieszanego surowca
JP7591501B2 (ja) * 2018-12-04 2024-11-28 グリコム・アクティーゼルスカブ フコシル化オリゴ糖の合成
WO2020128945A1 (en) 2018-12-19 2020-06-25 Glycom A/S Separation of oligosaccharides
CN113194960A (zh) 2018-12-19 2021-07-30 格礼卡姆股份公司 用于治疗使用低fodmap饮食的人的组合物和方法
EP3702468A1 (de) 2019-03-01 2020-09-02 Jennewein Biotechnologie GmbH Fermentative produktion von kohlenhydraten durch mikrobielle zellen, die ein gemischtes ausgangsmaterial verwenden
EP3741770A1 (de) 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Reinigung von oligosacchariden aus einem fermentationsmedium mittels filtration
WO2021094133A2 (en) 2019-11-13 2021-05-20 Basf Se Enzymatic hydrolysis of 2',3-difucosyllactose
EP4065128A4 (de) 2019-11-29 2023-12-20 Glycom A/S Mischung von hmos zur verbesserung der mikrobiota von schwangeren frauen
CN114901825A (zh) 2019-12-18 2022-08-12 因比奥斯公司 在宿主细胞中产生唾液酸化寡糖
CN114829619A (zh) * 2019-12-19 2022-07-29 格礼卡姆股份公司 从发酵液中分离唾液酸化寡糖
EP4077699A1 (de) 2019-12-19 2022-10-26 Basf Se Erhöhung der raum-zeit-ausbeute, der kohlenstoffkonversionseffizienz und kohlenstoffsubstratflexibilität bei der herstellung von feinchemikalien
CN115175915A (zh) * 2020-02-24 2022-10-11 碳码股份公司 糖基氟化物的合成
CN115279778B (zh) 2020-03-12 2025-06-24 格礼卡姆股份公司 2’-fl的结晶
FR3110176B1 (fr) 2020-05-12 2022-05-13 Institut Nat Des Sciences Appliquees De Toulouse Souche et procédé de production d’oligosaccharides
WO2022013143A1 (en) 2020-07-13 2022-01-20 Glycom A/S Oligosaccharide production
CA3188909A1 (en) * 2020-08-10 2022-02-17 Sofie AESAERT Production of an oligosaccharide mixture by a cell
ES2966260T3 (es) 2020-08-10 2024-04-19 Inbiose Nv Producción de una mezcla de oligosacáridos neutros no fucosilados por una célula
WO2022034078A1 (en) * 2020-08-10 2022-02-17 Inbiose N.V. Method to produce a purified mixture of different oligosaccharides produced by cell cultivation or microbial fermentation
EP4255444A4 (de) 2020-12-04 2024-10-16 Glycom A/S Muttermilcholigosaccharide zur verwendung bei der unterstützung der reifung oder verbesserung von schlafmustern
US20240050582A1 (en) 2021-03-08 2024-02-15 Universiteit Gent Conjugates including multiple saccharidic chains on a linear protein and uses in mammals feed
DK181061B1 (en) 2021-03-12 2022-10-31 Glycom As Purification of sialooligosaccharides
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
US20250320535A1 (en) 2021-05-17 2025-10-16 Dsm Ip Assets B.V. Novel technology to enable sucrose utilization in strains for biosynthetic production
WO2022263425A1 (en) 2021-06-15 2022-12-22 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
US20250128210A1 (en) 2021-06-15 2025-04-24 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
US20240286081A1 (en) 2021-06-15 2024-08-29 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
EP4355465A1 (de) 2021-06-15 2024-04-24 DSM IP Assets B.V. Trennung von menschlichen milcholigosacchariden aus einer fermentationsbrühe
CN115873051B (zh) * 2022-05-17 2024-06-25 山东恒鲁生物科技有限公司 三糖的新晶型
US20250361256A1 (en) 2022-06-14 2025-11-27 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
DK202200588A1 (en) 2022-06-20 2024-02-23 Dsm Ip Assets Bv Mixture of fucosylated HMOs
CN121794370A (zh) 2023-08-25 2026-04-03 科·汉森有限公司 具有改变的底物特异性的n-乙酰葡糖胺基转移酶及其在发酵低聚糖生产中的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI883076A7 (fi) * 1987-10-29 1989-04-30 Soc Gen Pour Les Techniques Valmistusmenetelmä, jossa yhdistetään hyvin fruktoosipitoisia oligosidejä ja glukonihappoa käymisen avulla.
US5079353A (en) * 1987-12-02 1992-01-07 Chembiomed, Ltd. Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
JPH02273192A (ja) * 1989-04-13 1990-11-07 Meito Sangyo Kk イソマルチユロースの製造方法
CN1129953A (zh) * 1993-07-15 1996-08-28 尼奥斯药品公司 糖组分的合成方法
WO1995032279A1 (en) * 1994-05-19 1995-11-30 Bio-Polymer Research Co., Ltd. Cellulose-producing bacterium transformed with gene coding for enzyme related to sucrose metabolism
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
KR100555161B1 (ko) 1996-09-17 2006-11-30 교와 핫꼬 고교 가부시끼가이샤 당뉴클레오티드류및복합당질의제조법
US5945314A (en) * 1997-03-31 1999-08-31 Abbott Laboratories Process for synthesizing oligosaccharides
DE19735994A1 (de) * 1997-08-19 1999-02-25 Piepersberg Wolfgang Prof Dr Verfahren zur enzymatischen Synthese von Guanosindiphosphat-6-desoxyhexosen und deren Verwendung zur Herstellung von Oligosacchariden
CA2351022A1 (en) * 1998-11-18 2000-05-25 Neose Technologies, Inc. Low cost manufacture of oligosaccharides
WO2000070060A1 (en) * 1999-05-18 2000-11-23 University Of Iowa Research Foundation Production of complex carbohydrates
JP2001546898A (en) 1999-12-21 2003-06-10 Kyowa Hakko Kogyo Kk MODIFIED alpha -1,2-FUCOSYLTRANSFERASE GENE AND PROCESS FOR PRODUCING alpha -1,2-FUCOSYLTRANSFERASE AND FUCOSE-CONTAINING SUGAR CHAIN
AU2001246894A1 (en) 2000-04-11 2001-10-23 Kyowa Hakko Kogyo Co. Ltd. Alpha1,2-fucosyltransferase and process for producing fucose-containing complex carbohydrate

Also Published As

Publication number Publication date
DE60044310D1 (de) 2010-06-10
DE60026142D1 (de) 2006-04-27
CA2378562C (fr) 2013-11-26
US7521212B1 (en) 2009-04-21
ATE466094T1 (de) 2010-05-15
EP1637611B1 (de) 2010-04-28
WO2001004341A1 (fr) 2001-01-18
AU780290B2 (en) 2005-03-17
JP2003504072A (ja) 2003-02-04
EP1194584B1 (de) 2006-02-22
JP5058420B2 (ja) 2012-10-24
FR2796082A1 (fr) 2001-01-12
US8586332B2 (en) 2013-11-19
DE60026142T2 (de) 2006-11-23
FR2796082B1 (fr) 2003-06-27
AU6296100A (en) 2001-01-30
EP1637611A1 (de) 2006-03-22
CA2378562A1 (fr) 2001-01-18
MXPA02000240A (es) 2002-06-21
US20090082307A1 (en) 2009-03-26
EP1194584A1 (de) 2002-04-10
NZ516808A (en) 2004-07-30

Similar Documents

Publication Publication Date Title
ATE318324T1 (de) Verfahren zur herstellung von oligosaccharide
ATE527367T1 (de) Herstellung von oligosacchariden in transgenen pflanzen
Mayer et al. Enzyme-initiated domino (cascade) reactions
WO2002101019A3 (en) Methods of culturing animal cells and polypeptide production in animal cells
BR0012712B1 (pt) métodos de produção de l-aminoácidos aumentando-se o nadph celular.
CA2065839A1 (en) Method for Producing Secretable Glycosyltransferases and Other Golgi Processing Enzymes
PL1704230T3 (pl) Drobnoustrój przekształcony do wytwarzania 1,2-propanodiolu
YU83101A (sh) Postupci i materijali za sinteze organskih proizvoda
WO1998014602A3 (en) Preparation of d-amino acids by direct fermentative means
AU5102899A (en) Process and materials for production of glucosamine
ATE452201T1 (de) Produktion modifizierter glykoproteine mit mehrfach verzweigten strukturen
ATE207969T1 (de) Verfahren zur herstellung von zucker durch starke,saure hydrolyse von zellulose-und hemizellulose enthaltende materialien
DE502004000547D1 (de) Verfahren zur fermentativen Herstellung von L-Methionin
MY162745A (en) Process for the direct production of fermentation products from biomasses in a biofilm reactor
PH12022550956A1 (en) Method for enzymatically producing high-activity biological organic fertilizer
WO2003023024A1 (en) Starch synthases
ATE423199T1 (de) Verfahren zur herstelllung von menschlichem thrombin mittels genmodifikationstechnik
BRPI0606117A2 (pt) método de geração de ácido l-ascórbico, levedura recombinante e método para aumentar a produção, a produtividade, ou o rendimento de um produto produzido por um microorganismo durante a fermentação
DE602005024776D1 (de) Verfahren zur herstellung optisch aktiver aminosäuren unter verwendung eines ganzzellenkatalysators
WO2024141710A3 (en) An aquaculture system and methods for removing glycerol from the aquaculture system
ATE199170T1 (de) Verfahren zur herstellung von ethanol
TW200516151A (en) Biocatalytic preparation of 1-cyanocyclohexaneacetic acid
NZ515762A (en) Method of producing a heparin-binding protein by expressing it in a mammalian cell that can be cultured in anaerobic conditions
CA2392463A1 (en) Novel use of uridine diphosphate glucose 4-epimerase
NO985041L (no) FremgangsmÕte for fremstilling av modent benmorfogenetisk protein

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties