ATE423571T1 - Verwendung von bispezifischen antikörpern gegen einen aktivierenden rezeptor fcepsilonri und gegen einen inhibierenden rezeptor ox2ra (cd200ra) zur regulierung der immunantworten - Google Patents
Verwendung von bispezifischen antikörpern gegen einen aktivierenden rezeptor fcepsilonri und gegen einen inhibierenden rezeptor ox2ra (cd200ra) zur regulierung der immunantwortenInfo
- Publication number
- ATE423571T1 ATE423571T1 AT02801055T AT02801055T ATE423571T1 AT E423571 T1 ATE423571 T1 AT E423571T1 AT 02801055 T AT02801055 T AT 02801055T AT 02801055 T AT02801055 T AT 02801055T AT E423571 T1 ATE423571 T1 AT E423571T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor
- bispecific antibodies
- ox2ra
- cd200ra
- activative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32918201P | 2001-10-12 | 2001-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE423571T1 true ATE423571T1 (de) | 2009-03-15 |
Family
ID=23284239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02801055T ATE423571T1 (de) | 2001-10-12 | 2002-10-11 | Verwendung von bispezifischen antikörpern gegen einen aktivierenden rezeptor fcepsilonri und gegen einen inhibierenden rezeptor ox2ra (cd200ra) zur regulierung der immunantworten |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20030077282A1 (de) |
| EP (3) | EP2316485A1 (de) |
| JP (2) | JP4381140B2 (de) |
| AT (1) | ATE423571T1 (de) |
| AU (1) | AU2002334997A1 (de) |
| CA (1) | CA2462883A1 (de) |
| DE (1) | DE60231316D1 (de) |
| ES (1) | ES2321701T3 (de) |
| MX (1) | MXPA04003291A (de) |
| WO (1) | WO2003030835A2 (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060084082A1 (en) * | 1997-03-07 | 2006-04-20 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| US6989248B2 (en) | 1999-05-06 | 2006-01-24 | The Trustees Of Columbia University In The City Of New York | Methods of use of compounds which inhibit the stem cell signaling pathway |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US8231878B2 (en) * | 2001-03-20 | 2012-07-31 | Cosmo Research & Development S.P.A. | Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
| US20090081199A1 (en) * | 2001-03-20 | 2009-03-26 | Bioxell S.P.A. | Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
| US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
| CA2342376C (en) * | 2001-03-20 | 2013-11-12 | Marco Colonna | A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof |
| US7265208B2 (en) * | 2001-05-01 | 2007-09-04 | The Regents Of The University Of California | Fusion molecules and treatment of IgE-mediated allergic diseases |
| CA2462883A1 (en) * | 2001-10-12 | 2003-04-17 | Schering Corporation | Use of bispecific antibodies to regulate immune responses |
| NZ553470A (en) * | 2002-03-15 | 2008-10-31 | Schering Corp | Methods of modulating CD200 receptors |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| US8187593B2 (en) * | 2002-08-14 | 2012-05-29 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8530627B2 (en) * | 2002-08-14 | 2013-09-10 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8968730B2 (en) | 2002-08-14 | 2015-03-03 | Macrogenics Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8193318B2 (en) * | 2002-08-14 | 2012-06-05 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8946387B2 (en) * | 2002-08-14 | 2015-02-03 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8044180B2 (en) * | 2002-08-14 | 2011-10-25 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| CA2512729C (en) | 2003-01-09 | 2014-09-16 | Macrogenics, Inc. | Identification and engineering of antibodies with variant fc regions and methods of using same |
| BG65715B1 (bg) * | 2003-09-04 | 2009-08-31 | Чавдар ВАСИЛЕВ | Средство за селективно подтискане на патологични днк - специфични в клетки |
| JP2007518827A (ja) * | 2004-02-02 | 2007-07-12 | シェーリング コーポレイション | Cd200およびcd200rを調節する方法 |
| WO2005077065A2 (en) * | 2004-02-09 | 2005-08-25 | The Regents Of The University Of California | Selective high-affinity polydentate ligands and methods of making such |
| ES2375481T3 (es) * | 2004-03-30 | 2012-03-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Anticuerpos biespecíficos para elegir como diana células que participan en reacciones de tipo alérgico, composiciones y usos de los mismos. |
| CA2565874C (en) * | 2004-05-10 | 2017-10-03 | Macrogenics, Inc. | Humanized fc.gamma.riib-specific antibodies and methods of use thereof |
| TW200607523A (en) | 2004-06-01 | 2006-03-01 | Domantis Ltd | Drug compositions, fusions and conjugates |
| US7655229B2 (en) * | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
| AU2005335714B2 (en) | 2004-11-10 | 2012-07-26 | Macrogenics, Inc. | Engineering Fc antibody regions to confer effector function |
| GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| EP1674479A1 (de) * | 2004-12-22 | 2006-06-28 | Memorial Sloan-Kettering Cancer Center | Modulierung von Fc-gamma-Rezeptoren zur Optimierung einer Immunotherapie |
| BG65954B1 (bg) * | 2005-01-05 | 2010-07-30 | Чавдар ВАСИЛЕВ | Средство за селективно подтискане активността на патологични автореактивни в-клетки |
| ES2971647T3 (es) | 2005-04-15 | 2024-06-06 | Macrogenics Inc | Diacuerpos covalentes y usos de los mismos |
| US11254748B2 (en) | 2005-04-15 | 2022-02-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| US9963510B2 (en) * | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| PL1874821T3 (pl) | 2005-04-26 | 2013-09-30 | Trion Pharma Gmbh | Kombinacja przeciwciał i glikokortykoidów do leczenia raka |
| GB0510790D0 (en) * | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
| RU2423381C2 (ru) | 2005-07-25 | 2011-07-10 | Трабьон Фармасьютикалз, Инк. | Снижение количества в-клеток с использованием cd37-специфических и cd20-специфических связывающих молекул |
| PL2573114T3 (pl) * | 2005-08-10 | 2016-10-31 | Identyfikacja i inżynieria przeciwciał z wariantami regionów FC oraz sposoby ich stosowania | |
| EP1999470A4 (de) * | 2006-03-10 | 2009-08-19 | Macrogenics Inc | Identifizierung und herstellung von antikörpern mit variierenden schweren ketten und anwendungsverfahren dafür |
| WO2008105886A2 (en) | 2006-05-26 | 2008-09-04 | Macrogenics, Inc. | HUMANIZED FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
| NZ573646A (en) | 2006-06-12 | 2012-04-27 | Wyeth Llc | Single-chain multivalent binding proteins with effector function |
| ES2599319T3 (es) | 2006-06-26 | 2017-02-01 | Macrogenics, Inc. | Anticuerpos específicos de Fc RIIB y métodos de uso de éstos |
| WO2008002933A2 (en) * | 2006-06-26 | 2008-01-03 | Macrogenics, Inc. | Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof |
| US20080112961A1 (en) * | 2006-10-09 | 2008-05-15 | Macrogenics, Inc. | Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same |
| US8652466B2 (en) * | 2006-12-08 | 2014-02-18 | Macrogenics, Inc. | Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting |
| US8795667B2 (en) * | 2007-12-19 | 2014-08-05 | Macrogenics, Inc. | Compositions for the prevention and treatment of smallpox |
| JP2011507882A (ja) | 2007-12-20 | 2011-03-10 | シェーリング コーポレイション | Fdf03抗体およびそれの使用 |
| WO2009123894A2 (en) * | 2008-04-02 | 2009-10-08 | Macrogenics, Inc. | Her2/neu-specific antibodies and methods of using same |
| ES2589912T3 (es) | 2008-04-02 | 2016-11-17 | Macrogenics, Inc. | Anticuerpos específicos para el complejo BCR y procedimientos de uso de los mismos |
| RU2531754C2 (ru) | 2008-04-11 | 2014-10-27 | ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ,ЭлЭлСи,US | Связывающееся с cd37 иммунотерапевтическое средство и его комбинация с бифункциональным химиотерапевтическим средством |
| CN102083850B (zh) | 2008-04-21 | 2015-08-12 | 加利福尼亚大学董事会 | 选择性高亲和力多齿配体及其制备方法 |
| US20110081347A1 (en) * | 2008-06-04 | 2011-04-07 | Macrogenics, Inc. | Antibodies with Altered Binding to FcRn and Methods of Using Same |
| CA2741489A1 (en) * | 2008-10-22 | 2010-04-29 | The Regents Of The University Of Michigan | Methods, compositions, and kits for diagnosing, monitoring, and treating disease |
| WO2010135183A1 (en) * | 2009-05-20 | 2010-11-25 | Schering Corporation | Modulation of pilr receptors to treat sepsis |
| JP5898082B2 (ja) | 2009-10-07 | 2016-04-06 | マクロジェニクス,インコーポレーテッド | フコシル化程度の変更により改良されたエフェクター機能を示すFc領域含有ポリペプチドおよびその使用法 |
| EP2542256B1 (de) | 2010-03-04 | 2019-05-22 | MacroGenics, Inc. | Mit b7-h3 reagierende antikörper, immunologisch wirkende fragmente davon und verwendungen davon |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| AU2011286024B2 (en) | 2010-08-02 | 2014-08-07 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| WO2012071042A1 (en) * | 2010-11-24 | 2012-05-31 | Government Of The U.S.A. Represented By The Secretary, Dept. Of Health & Human Services | Compositions and methods for treating or preventing lupus |
| US10017762B2 (en) | 2010-11-24 | 2018-07-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compositions and methods for treating or preventing lupus |
| BR112013029892A2 (pt) | 2011-05-21 | 2016-12-20 | Macrogenics Inc | polipeptídeo, molécula de ligação a antígeno, diacorpo e uso de uma porção polipeptídica de uma proteína de ligação a soro desimunizada |
| WO2013013029A1 (en) | 2011-07-19 | 2013-01-24 | The Board Of Trustees Of The University Of Illinois | Anti-clta4, anti-glut2 protein for the treatment of type 1 diabetes |
| JP6411218B2 (ja) | 2012-02-15 | 2018-10-24 | ノヴォ ノルディスク アー/エス | 骨髄細胞で発現されるトリガー受容体1(trem−1)に結合し、それを遮断する抗体 |
| US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
| CN104203977A (zh) | 2012-02-15 | 2014-12-10 | 诺和诺德A/S(股份有限公司) | 结合肽聚糖识别蛋白1的抗体 |
| EP2825553B1 (de) | 2012-03-14 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Multispezifische antigenbindungsmoleküle und verwendungen davon |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| SMT202100464T1 (it) | 2013-03-14 | 2021-11-12 | Macrogenics Inc | Molecole bispecifiche che sono immunoreattive con cellule effettrici immunitarie che esprimono un recettore di attivazione |
| WO2014188423A1 (en) | 2013-05-21 | 2014-11-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Treatment of mast cell related pathologies |
| US9879081B2 (en) | 2013-06-25 | 2018-01-30 | Samsung Electronics Co., Ltd. | Protein complex, bispecific antibody including the protein complex, and method of preparation thereof |
| UA116479C2 (uk) | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ |
| US11384149B2 (en) | 2013-08-09 | 2022-07-12 | Macrogenics, Inc. | Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof |
| EP2839842A1 (de) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bispezifische monovalente Diabodies mit Fähigkeit zur Bindung von CD123 und CD3 und Verwendungen davon |
| EP2840091A1 (de) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bispezifische Diabodies, die gpA33 und CD3 binden können und Anwendungen dieser |
| SG11201605784YA (en) | 2014-01-17 | 2016-08-30 | Minomic Internat Ltd | Cell surface prostate cancer antigen for diagnosis |
| EA037844B1 (ru) | 2014-07-17 | 2021-05-27 | Ново Нордиск А/С | Сайт-направленный мутагенез антител к trem-1 |
| MX386297B (es) | 2014-09-29 | 2025-03-18 | Univ Duke | Moleculas biespecificas que comprenden un brazo orientado a la envoltura vih-1. |
| IL296285A (en) | 2015-07-06 | 2022-11-01 | Regeneron Pharma | Multispecific antigen-binding molecules and uses thereof |
| WO2017053469A2 (en) | 2015-09-21 | 2017-03-30 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
| GEP20227398B (en) | 2016-04-15 | 2022-07-25 | Macrogenics Inc | Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof |
| EP3448891A1 (de) | 2016-04-28 | 2019-03-06 | Regeneron Pharmaceuticals, Inc. | Verfahren zur herstellung multispezifischer antigenbindender moleküle |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| DK3635009T3 (da) | 2017-06-07 | 2026-03-30 | Regeneron Pharma | Sammensætninger og fremgangsmåder til internalisering af enzymer |
| DK3601358T5 (da) | 2017-08-03 | 2024-09-02 | Alector Llc | Anti-trem2-antistoffer og fremgangsmåder til anvendelse deraf |
| WO2019195126A1 (en) | 2018-04-02 | 2019-10-10 | Bristol-Myers Squibb Company | Anti-trem-1 antibodies and uses thereof |
| KR102871690B1 (ko) | 2018-04-30 | 2025-10-16 | 리제너론 파마슈티칼스 인코포레이티드 | Her2 및/또는 aplp2에 결합하는 항체 및 이중특이적 항원-결합 분자 및 접합체 그리고 이들의 용도 |
| BR112020023145A2 (pt) | 2018-05-17 | 2021-02-02 | Regeneron Pharmaceuticals, Inc. | anticorpo anti-cd63 ou fragmento de ligação ao antígeno do mesmo, molécula de ligação ao antígeno biespecífica, proteína terapêutica de múltiplos domínios, polinucleotídeo composição farmacêutica, e, composto |
| CN110872356B (zh) * | 2018-09-03 | 2023-06-13 | 广西慧宝源健康产业有限公司 | 双特异性抗体及其使用方法 |
| UY38407A (es) | 2018-10-15 | 2020-05-29 | Novartis Ag | Anticuerpos estabilizadores de trem2 |
| CA3192204A1 (en) | 2020-08-19 | 2022-02-24 | Xencor, Inc. | Anti-cd28 and/or anti-b7h3 compositions |
| US12365743B2 (en) | 2022-02-23 | 2025-07-22 | Xencor, Inc. | Anti-CD28 x anti-PSMA antibodies |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2046920B1 (de) | 1969-06-19 | 1974-05-03 | Citizen Watch Co Ltd | |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| DE3382317D1 (de) | 1982-03-15 | 1991-07-25 | Schering Corp | Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer. |
| EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3483949D1 (de) | 1983-09-26 | 1991-02-21 | Udo Dr Med Ehrenfeld | Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr. |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| US4954617A (en) * | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| FI105320B (fi) * | 1988-04-04 | 2000-07-31 | Oncogen | Menetelmä vasta-aineheterokonjugaattien valmistamiseksi, joita käytetään imusoluaktiivisuuden säätelyssä ja diagnoosissa |
| DE3814079A1 (de) | 1988-04-26 | 1989-11-09 | Bayer Ag | Sinterformkoerper auf basis von aluminiumtitanat, verfahren zu ihrer herstellung sowie deren verwendung |
| US6197298B1 (en) * | 1991-04-19 | 2001-03-06 | Tanox, Inc. | Modified binding molecules specific for T lymphocytes and their use as in vivo immune modulators in animals |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| EP0861891A1 (de) * | 1996-12-31 | 1998-09-02 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Verbindungen zur Modulation zellnegativer Regulierungen und deren biologische Anwendungen |
| EP1032662B1 (de) | 1997-11-07 | 2006-03-08 | Trillium Therapeutics Inc. | Verfahren und zusammensetzungen zur immunomodulation |
| US7223729B2 (en) | 1997-11-07 | 2007-05-29 | Trillium Therapeutics Inc. | Methods of treating allergy by administering a CD200 protein |
| US6955811B2 (en) | 1997-11-07 | 2005-10-18 | Trillium Therapeutics Inc. | Methods of inhibiting immune response suppression by administering antibodies to OX-2 |
| KR20010034512A (ko) * | 1998-02-19 | 2001-04-25 | 베렌슨, 론 | 림프구 활성화 조절을 위한 조성물 및 그 방법 |
| EP1100869A4 (de) | 1998-07-30 | 2005-04-27 | Human Genome Sciences Inc | 98 menschliche sekretierte proteine |
| WO2000029431A1 (en) * | 1998-11-17 | 2000-05-25 | Tanox, Inc. | Bispecific molecules cross-linking itim and itam for therapy |
| US7118743B2 (en) * | 1998-11-17 | 2006-10-10 | Tanox, Inc. | Bispecific molecules cross-linking ITIM and ITAM for therapy |
| US20020192215A1 (en) | 1999-04-13 | 2002-12-19 | Schering Corporation, A New Jersey Corporation | Novel uses of mammalian OX2 protein and related reagents |
| AU4341300A (en) | 1999-04-13 | 2000-11-14 | Schering Corporation | Novel uses of mammalian ox2 protein and related reagents |
| MXPA01011519A (es) | 1999-05-13 | 2003-08-20 | Medical Res Council | Homologos del receptor ox2. |
| EP1240183A2 (de) | 1999-11-15 | 2002-09-18 | Schering Corporation | Gene die spezifisch in menschlichen dendritischen zellen exprimiert werden |
| ATE406385T1 (de) | 2000-11-22 | 2008-09-15 | Trillium Therapeutics Inc | Verkürztes cd200 |
| US9249229B2 (en) | 2000-12-08 | 2016-02-02 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US20040198661A1 (en) | 2000-12-08 | 2004-10-07 | Bowdish Katherine S. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| AU2001247543A1 (en) | 2001-03-16 | 2003-09-02 | Tanox, Inc. | Bispecific molecules cross-linking itim and itam for therapy of allergies |
| US7186818B2 (en) * | 2001-04-26 | 2007-03-06 | Immunex Corporation | DNA encoding soluble variants of human OX2 receptors |
| CA2448668A1 (en) | 2001-05-24 | 2002-11-28 | Trillium Therapeutics Inc. | Modulation of cd200 receptors |
| CA2462883A1 (en) | 2001-10-12 | 2003-04-17 | Schering Corporation | Use of bispecific antibodies to regulate immune responses |
| US20040126777A1 (en) * | 2002-01-28 | 2004-07-01 | Bhatt Ramesh Rajani | Lp mammalian proteins; related reagents |
| NZ553470A (en) * | 2002-03-15 | 2008-10-31 | Schering Corp | Methods of modulating CD200 receptors |
| CA2487428A1 (en) | 2002-06-07 | 2003-12-18 | Trillium Therapeutics Inc. | Cd200-receptor mediated modulation of bone development |
| AU2003299823A1 (en) | 2002-12-27 | 2004-07-29 | Schering Corporation | Methods of inducing and maintaining immune tolerance |
| US20070244052A1 (en) * | 2003-12-19 | 2007-10-18 | Schering Corporation | Methods for Identifying Agonists or Antagonists of CD200R Signaling Molecules and Methods of Using the Same |
| JP2007518827A (ja) * | 2004-02-02 | 2007-07-12 | シェーリング コーポレイション | Cd200およびcd200rを調節する方法 |
-
2002
- 2002-10-11 CA CA002462883A patent/CA2462883A1/en not_active Abandoned
- 2002-10-11 ES ES02801055T patent/ES2321701T3/es not_active Expired - Lifetime
- 2002-10-11 AT AT02801055T patent/ATE423571T1/de not_active IP Right Cessation
- 2002-10-11 US US10/270,084 patent/US20030077282A1/en not_active Abandoned
- 2002-10-11 AU AU2002334997A patent/AU2002334997A1/en not_active Abandoned
- 2002-10-11 EP EP10182926A patent/EP2316485A1/de not_active Withdrawn
- 2002-10-11 WO PCT/US2002/032711 patent/WO2003030835A2/en not_active Ceased
- 2002-10-11 MX MXPA04003291A patent/MXPA04003291A/es active IP Right Grant
- 2002-10-11 EP EP02801055A patent/EP1439857B1/de not_active Expired - Lifetime
- 2002-10-11 JP JP2003533869A patent/JP4381140B2/ja not_active Expired - Lifetime
- 2002-10-11 DE DE60231316T patent/DE60231316D1/de not_active Expired - Lifetime
- 2002-10-11 EP EP09151125A patent/EP2072059A1/de not_active Withdrawn
-
2009
- 2009-08-12 JP JP2009187524A patent/JP2009256389A/ja active Pending
-
2010
- 2010-05-25 US US12/787,044 patent/US8236309B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8236309B2 (en) | 2012-08-07 |
| MXPA04003291A (es) | 2004-07-23 |
| WO2003030835A2 (en) | 2003-04-17 |
| JP2009256389A (ja) | 2009-11-05 |
| EP1439857B1 (de) | 2009-02-25 |
| ES2321701T3 (es) | 2009-06-10 |
| WO2003030835A3 (en) | 2003-10-09 |
| JP4381140B2 (ja) | 2009-12-09 |
| CA2462883A1 (en) | 2003-04-17 |
| EP1439857A4 (de) | 2004-11-17 |
| US20030077282A1 (en) | 2003-04-24 |
| US20100330034A1 (en) | 2010-12-30 |
| EP1439857A2 (de) | 2004-07-28 |
| DE60231316D1 (de) | 2009-04-09 |
| EP2316485A1 (de) | 2011-05-04 |
| JP2006501130A (ja) | 2006-01-12 |
| EP2072059A1 (de) | 2009-06-24 |
| AU2002334997A1 (en) | 2003-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE423571T1 (de) | Verwendung von bispezifischen antikörpern gegen einen aktivierenden rezeptor fcepsilonri und gegen einen inhibierenden rezeptor ox2ra (cd200ra) zur regulierung der immunantworten | |
| DK1784426T3 (da) | Humaniserede anti-beta7-antagonister og anvendelser deraf | |
| DK1565489T3 (da) | Internaliserende antistoffer specifikke for RAAG10-celleoverflademålet | |
| NO20053435L (no) | Immunoglobulinvarianter og anvendelser derav | |
| CY1111622T1 (el) | Ανθρωποποιημενοι ανταγωνιστες anti-cmet | |
| ATE550352T1 (de) | Verfahren zur herstellung von hybridantikörper | |
| PL401886A1 (pl) | Neutralizujace o wysokim powinowactwie izolowane ludzkie przeciwcialo anty-TNF-alfa, zastosowanie tego przeciwciala, krysztal zawierajacy ludzkie przeciwcialo anty-TNF-alfa i preparat zawierajacy ten krysztal | |
| ATE530195T1 (de) | Bispezifische einzelketten-fv-antikörper-moleküle und anwendungsverfahren dafür | |
| DK1354034T3 (da) | Transgene transchromosomale gnavere til fremstilling af humane antistoffer | |
| DK1212422T3 (da) | Humane CTLA-4-antistoffer og anvendelserne deraf | |
| NO20054351L (no) | Monoklonalt antistoff og hybridom som produserer dette | |
| NI200500230A (es) | Anticuerpos contra interleucina 22 y sus usos de los mismos | |
| EP1885399A4 (de) | Humanisierte antikörper gegen cd40 und verfahren zu ihrer anwendung | |
| ATE554107T1 (de) | Als therapeutika geeignete monovalente antikörperfragmente | |
| PT1557462E (pt) | Células de indução da aceitação de um transplante de origem monocítica e a sua preparação e utilização | |
| TW200510459A (en) | RG1 antibodies and uses thereof | |
| ATE466031T1 (de) | Anti-hgf-r-antikörper und deren verwendung | |
| EP4223778A4 (de) | Anti-claudin18.2- und cd3-bispezifischer antikörper und verwendung davon | |
| EP3757122A4 (de) | Zur spezifischen bindung des humanen, mit plasmalemma-vesikel assoziierten protein pv-1 fähiger, monoklonaler antikörper sowie herstellungsverfahren und verwendung davon | |
| CY1110144T1 (el) | Αντισωματα για την ταυτοποιηση και/ή την απομονωση τουλαχιστον ενος κυτταρικου πληθυσμου ο οποιος επιλεγεται απο την ομαδα την περιλαμβανουσα αιμοποιητικα βλαστοκυτταρα, νευρικα βλαστοκυτταρα, νευρικα αρχεγονα κυτταρα, μεσεγχυματικα βλαστοκυτταρα και μεσεγχυματικα αρχεγονα κυτταρα | |
| DE60238987D1 (de) | Behandlung von bauchspeicheldrüsenkrebs mit einem monoklonalen antikörper | |
| EE200500012A (et) | Peptiid-pähine passiivne immunoteraapia ateroskleroosi raviks | |
| IL165088A0 (en) | Transgenic ungulates capable of human antibody production | |
| DK0840620T3 (da) | IL-8-antagonister til behandling af astma | |
| DK1263790T3 (da) | Monoklonale antistoffer for den humane LDL-receptor, deres produktionsmetode og anvendelse |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |