ATE423599T1 - Verwendung von histaminrezeptorantagonisten für die senkung des intrakranialen druckes - Google Patents

Verwendung von histaminrezeptorantagonisten für die senkung des intrakranialen druckes

Info

Publication number: ATE423599T1
Authority: AT; Austria
Prior art keywords: intracranial pressure; histamine receptor; brain injury; traumatic; histamine
Prior art date: 2001-11-23

Application number

AT07107669T

Other languages

English (en)

Inventor

Frank Tegtmeier

Frans Janssens

Joseph Leenaerts

Rossem Koenraad Van

Manuel Alcazar-Vaca

Pedro Martinez-Jimenez

Jose Manuel Bartolome-Nebreda

Antonio Gomez-Sanchez

Francisco Fernandez-Gadea

Reempts Jozef Van

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-23

Filing date

2002-11-22

Publication date

2009-03-15

2002-11-22 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2009-03-15 Application granted granted Critical

2009-03-15 Publication of ATE423599T1 publication Critical patent/ATE423599T1/de

Links

229940122236 Histamine receptor antagonist Drugs 0.000 title abstract 2
238000007917 intracranial administration Methods 0.000 title abstract 2
ZZHLYYDVIOPZBE-UHFFFAOYSA-N Trimeprazine Chemical compound C1=CC=C2N(CC(CN(C)C)C)C3=CC=CC=C3SC2=C1 ZZHLYYDVIOPZBE-UHFFFAOYSA-N 0.000 abstract 4
229960003790 alimemazine Drugs 0.000 abstract 2
239000000739 antihistaminic agent Substances 0.000 abstract 2
QTQPVLDZQVPLGV-UHFFFAOYSA-N oxomemazine Chemical compound C1=CC=C2N(CC(CN(C)C)C)C3=CC=CC=C3S(=O)(=O)C2=C1 QTQPVLDZQVPLGV-UHFFFAOYSA-N 0.000 abstract 2
WFNAKBGANONZEQ-UHFFFAOYSA-N 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine Chemical compound C1CN(C)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 WFNAKBGANONZEQ-UHFFFAOYSA-N 0.000 abstract 1
SFOVDSLXFUGAIV-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]-n-piperidin-4-ylbenzimidazol-2-amine Chemical compound C1=CC(F)=CC=C1CN1C2=CC=CC=C2N=C1NC1CCNCC1 SFOVDSLXFUGAIV-UHFFFAOYSA-N 0.000 abstract 1
YDDXVAXDYKBWDX-UHFFFAOYSA-N 1-cyano-3-[2-[[2-(diaminomethylideneamino)-4-thiazolyl]methylthio]ethyl]-2-methylguanidine Chemical compound N#CNC(=NC)NCCSCC1=CSC(N=C(N)N)=N1 YDDXVAXDYKBWDX-UHFFFAOYSA-N 0.000 abstract 1
BAWMMJAUVBLLEE-UHFFFAOYSA-N 2-[2-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 BAWMMJAUVBLLEE-UHFFFAOYSA-N 0.000 abstract 1
VNIOQSAWKLOGLY-UHFFFAOYSA-N 3-[(5-methylfuran-2-yl)methyl]-n-piperidin-4-ylimidazo[4,5-b]pyridin-2-amine Chemical compound O1C(C)=CC=C1CN1C2=NC=CC=C2N=C1NC1CCNCC1 VNIOQSAWKLOGLY-UHFFFAOYSA-N 0.000 abstract 1
USCSJAIWXWYTEH-UHFFFAOYSA-N 7-[3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]propoxy]-3,4-dimethylchromen-2-one Chemical compound C1=CC=2C(C)=C(C)C(=O)OC=2C=C1OCCCN(CC1)CCN1CC1=CC=C(Cl)C=C1 USCSJAIWXWYTEH-UHFFFAOYSA-N 0.000 abstract 1
MBUVEWMHONZEQD-UHFFFAOYSA-N Azeptin Chemical compound C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 MBUVEWMHONZEQD-UHFFFAOYSA-N 0.000 abstract 1
ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 abstract 1
GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 abstract 1
PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 abstract 1
ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 abstract 1
OCJYIGYOJCODJL-UHFFFAOYSA-N Meclizine Chemical compound CC1=CC=CC(CN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=C1 OCJYIGYOJCODJL-UHFFFAOYSA-N 0.000 abstract 1
HOKDBMAJZXIPGC-UHFFFAOYSA-N Mequitazine Chemical compound C12=CC=CC=C2SC2=CC=CC=C2N1CC1C(CC2)CCN2C1 HOKDBMAJZXIPGC-UHFFFAOYSA-N 0.000 abstract 1
UEQUQVLFIPOEMF-UHFFFAOYSA-N Mianserin Chemical compound C1C2=CC=CC=C2N2CCN(C)CC2C2=CC=CC=C21 UEQUQVLFIPOEMF-UHFFFAOYSA-N 0.000 abstract 1
PVLJETXTTWAYEW-UHFFFAOYSA-N Mizolastine Chemical compound N=1C=CC(=O)NC=1N(C)C(CC1)CCN1C1=NC2=CC=CC=C2N1CC1=CC=C(F)C=C1 PVLJETXTTWAYEW-UHFFFAOYSA-N 0.000 abstract 1
IJHNSHDBIRRJRN-UHFFFAOYSA-N N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=CC=C1 IJHNSHDBIRRJRN-UHFFFAOYSA-N 0.000 abstract 1
KUBONGDXTUOOLM-UHFFFAOYSA-N N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,3-benzothiazol-2-amine Chemical compound N=1C2=CC=CC=C2SC=1NCCCOC(C=1)=CC=CC=1CN1CCCCC1 KUBONGDXTUOOLM-UHFFFAOYSA-N 0.000 abstract 1
JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 abstract 1
OGEAASSLWZDQBM-UHFFFAOYSA-N Temelastine Chemical compound C1=NC(C)=CC=C1CC(C(N1)=O)=CN=C1NCCCCC1=NC=C(Br)C=C1C OGEAASSLWZDQBM-UHFFFAOYSA-N 0.000 abstract 1
GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
UFLGIAIHIAPJJC-UHFFFAOYSA-N Tripelennamine Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CC=C1 UFLGIAIHIAPJJC-UHFFFAOYSA-N 0.000 abstract 1
229960003792 acrivastine Drugs 0.000 abstract 1
PWACSDKDOHSSQD-IUTFFREVSA-N acrivastine Chemical compound C1=CC(C)=CC=C1C(\C=1N=C(\C=C\C(O)=O)C=CC=1)=C/CN1CCCC1 PWACSDKDOHSSQD-IUTFFREVSA-N 0.000 abstract 1
229960002469 antazoline Drugs 0.000 abstract 1
REYFJDPCWQRWAA-UHFFFAOYSA-N antazoline Chemical compound N=1CCNC=1CN(C=1C=CC=CC=1)CC1=CC=CC=C1 REYFJDPCWQRWAA-UHFFFAOYSA-N 0.000 abstract 1
GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical compound C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 abstract 1
229960000383 azatadine Drugs 0.000 abstract 1
SEBMTIQKRHYNIT-UHFFFAOYSA-N azatadine Chemical compound C1CN(C)CCC1=C1C2=NC=CC=C2CCC2=CC=CC=C21 SEBMTIQKRHYNIT-UHFFFAOYSA-N 0.000 abstract 1
229960004574 azelastine Drugs 0.000 abstract 1
208000029028 brain injury Diseases 0.000 abstract 1
ZDIGNSYAACHWNL-UHFFFAOYSA-N brompheniramine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 ZDIGNSYAACHWNL-UHFFFAOYSA-N 0.000 abstract 1
229960000725 brompheniramine Drugs 0.000 abstract 1
229960001705 buclizine Drugs 0.000 abstract 1
MOYGZHXDRJNJEP-UHFFFAOYSA-N buclizine Chemical compound C1=CC(C(C)(C)C)=CC=C1CN1CCN(C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)CC1 MOYGZHXDRJNJEP-UHFFFAOYSA-N 0.000 abstract 1
OJFSXZCBGQGRNV-UHFFFAOYSA-N carbinoxamine Chemical compound C=1C=CC=NC=1C(OCCN(C)C)C1=CC=C(Cl)C=C1 OJFSXZCBGQGRNV-UHFFFAOYSA-N 0.000 abstract 1
229960000428 carbinoxamine Drugs 0.000 abstract 1
XGHOVGYJHWQGCC-UHFFFAOYSA-N carebastine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(=O)CCCN1CCC(OC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 XGHOVGYJHWQGCC-UHFFFAOYSA-N 0.000 abstract 1
229950010123 carebastine Drugs 0.000 abstract 1
229960001803 cetirizine Drugs 0.000 abstract 1
229960004831 chlorcyclizine Drugs 0.000 abstract 1
229960003291 chlorphenamine Drugs 0.000 abstract 1
SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 abstract 1
229960001380 cimetidine Drugs 0.000 abstract 1
CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 abstract 1
DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 abstract 1
229960000876 cinnarizine Drugs 0.000 abstract 1
229960002881 clemastine Drugs 0.000 abstract 1
YNNUSGIPVFPVBX-NHCUHLMSSA-N clemastine Chemical compound CN1CCC[C@@H]1CCO[C@@](C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 YNNUSGIPVFPVBX-NHCUHLMSSA-N 0.000 abstract 1
CJXAEXPPLWQRFR-UHFFFAOYSA-N clemizole Chemical compound C1=CC(Cl)=CC=C1CN1C2=CC=CC=C2N=C1CN1CCCC1 CJXAEXPPLWQRFR-UHFFFAOYSA-N 0.000 abstract 1
229950002020 clemizole Drugs 0.000 abstract 1
ZSQANMZWGKYDER-JXMROGBWSA-N clocinizine Chemical compound C1=CC(Cl)=CC=C1C(C=1C=CC=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 ZSQANMZWGKYDER-JXMROGBWSA-N 0.000 abstract 1
229960003826 clocinizine Drugs 0.000 abstract 1
229960002896 clonidine Drugs 0.000 abstract 1
229960003564 cyclizine Drugs 0.000 abstract 1
UVKZSORBKUEBAZ-UHFFFAOYSA-N cyclizine Chemical compound C1CN(C)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 UVKZSORBKUEBAZ-UHFFFAOYSA-N 0.000 abstract 1
229960001140 cyproheptadine Drugs 0.000 abstract 1
JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 abstract 1
229960001271 desloratadine Drugs 0.000 abstract 1
229960001882 dexchlorpheniramine Drugs 0.000 abstract 1
SOYKEARSMXGVTM-HNNXBMFYSA-N dexchlorpheniramine Chemical compound C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Cl)C=C1 SOYKEARSMXGVTM-HNNXBMFYSA-N 0.000 abstract 1
229960004993 dimenhydrinate Drugs 0.000 abstract 1
MZDOIJOUFRQXHC-UHFFFAOYSA-N dimenhydrinate Chemical compound O=C1N(C)C(=O)N(C)C2=NC(Cl)=N[C]21.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 MZDOIJOUFRQXHC-UHFFFAOYSA-N 0.000 abstract 1
229960001992 dimetindene Drugs 0.000 abstract 1
MVMQESMQSYOVGV-UHFFFAOYSA-N dimetindene Chemical compound CN(C)CCC=1CC2=CC=CC=C2C=1C(C)C1=CC=CC=N1 MVMQESMQSYOVGV-UHFFFAOYSA-N 0.000 abstract 1
229960001640 dimetotiazine Drugs 0.000 abstract 1
VWNWVCJGUMZDIU-UHFFFAOYSA-N dimetotiazine Chemical compound C1=C(S(=O)(=O)N(C)C)C=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 VWNWVCJGUMZDIU-UHFFFAOYSA-N 0.000 abstract 1
229960000520 diphenhydramine Drugs 0.000 abstract 1
ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
OWQUZNMMYNAXSL-UHFFFAOYSA-N diphenylpyraline Chemical compound C1CN(C)CCC1OC(C=1C=CC=CC=1)C1=CC=CC=C1 OWQUZNMMYNAXSL-UHFFFAOYSA-N 0.000 abstract 1
229960000879 diphenylpyraline Drugs 0.000 abstract 1
HCFDWZZGGLSKEP-UHFFFAOYSA-N doxylamine Chemical compound C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 HCFDWZZGGLSKEP-UHFFFAOYSA-N 0.000 abstract 1
229960005178 doxylamine Drugs 0.000 abstract 1
229960001971 ebastine Drugs 0.000 abstract 1
MJJALKDDGIKVBE-UHFFFAOYSA-N ebastine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)CCCN1CCC(OC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 MJJALKDDGIKVBE-UHFFFAOYSA-N 0.000 abstract 1
229950003420 efletirizine Drugs 0.000 abstract 1
229960003449 epinastine Drugs 0.000 abstract 1
WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 abstract 1
XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 abstract 1
229960001596 famotidine Drugs 0.000 abstract 1
229960003592 fexofenadine Drugs 0.000 abstract 1
RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 abstract 1
229960000930 hydroxyzine Drugs 0.000 abstract 1
ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 abstract 1
201000009941 intracranial hypertension Diseases 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
229960004958 ketotifen Drugs 0.000 abstract 1
229960001120 levocabastine Drugs 0.000 abstract 1
ZCGOMHNNNFPNMX-KYTRFIICSA-N levocabastine Chemical compound C1([C@@]2(C(O)=O)CCN(C[C@H]2C)[C@@H]2CC[C@@](CC2)(C#N)C=2C=CC(F)=CC=2)=CC=CC=C1 ZCGOMHNNNFPNMX-KYTRFIICSA-N 0.000 abstract 1
229960003088 loratadine Drugs 0.000 abstract 1
JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 abstract 1
229960001474 meclozine Drugs 0.000 abstract 1
229960000582 mepyramine Drugs 0.000 abstract 1
YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 abstract 1
229960005042 mequitazine Drugs 0.000 abstract 1
HTMIBDQKFHUPSX-UHFFFAOYSA-N methdilazine Chemical compound C1N(C)CCC1CN1C2=CC=CC=C2SC2=CC=CC=C21 HTMIBDQKFHUPSX-UHFFFAOYSA-N 0.000 abstract 1
229960004056 methdilazine Drugs 0.000 abstract 1
229960003955 mianserin Drugs 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229960001144 mizolastine Drugs 0.000 abstract 1
RSKQGBFMNPDPLR-UHFFFAOYSA-N niaprazine Chemical compound C=1C=CN=CC=1C(=O)NC(C)CCN(CC1)CCN1C1=CC=C(F)C=C1 RSKQGBFMNPDPLR-UHFFFAOYSA-N 0.000 abstract 1
229960002686 niaprazine Drugs 0.000 abstract 1
229960004872 nizatidine Drugs 0.000 abstract 1
SGXXNSQHWDMGGP-IZZDOVSWSA-N nizatidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CSC(CN(C)C)=N1 SGXXNSQHWDMGGP-IZZDOVSWSA-N 0.000 abstract 1
229950009470 noberastine Drugs 0.000 abstract 1
229960002698 oxatomide Drugs 0.000 abstract 1
BAINIUMDFURPJM-UHFFFAOYSA-N oxatomide Chemical compound O=C1NC2=CC=CC=C2N1CCCN(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 BAINIUMDFURPJM-UHFFFAOYSA-N 0.000 abstract 1
229960003045 oxomemazine Drugs 0.000 abstract 1
CHOBRHHOYQKCOU-UHFFFAOYSA-N phenbenzamine Chemical compound C=1C=CC=CC=1N(CCN(C)C)CC1=CC=CC=C1 CHOBRHHOYQKCOU-UHFFFAOYSA-N 0.000 abstract 1
229950003863 phenbenzamine Drugs 0.000 abstract 1
229960001190 pheniramine Drugs 0.000 abstract 1
229950010674 picumast Drugs 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
229960003910 promethazine Drugs 0.000 abstract 1
229960000620 ranitidine Drugs 0.000 abstract 1
VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 abstract 1
JUQLTPCYUFPYKE-UHFFFAOYSA-N ritanserin Chemical compound CC=1N=C2SC=CN2C(=O)C=1CCN(CC1)CCC1=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 JUQLTPCYUFPYKE-UHFFFAOYSA-N 0.000 abstract 1
229950005829 temelastine Drugs 0.000 abstract 1
229960000351 terfenadine Drugs 0.000 abstract 1
229950011533 tiotidine Drugs 0.000 abstract 1
230000009529 traumatic brain injury Effects 0.000 abstract 1
230000000472 traumatic effect Effects 0.000 abstract 1
229960003223 tripelennamine Drugs 0.000 abstract 1
229960001128 triprolidine Drugs 0.000 abstract 1
CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Transplantation (AREA)
Nutrition Science (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT07107669T 2001-11-23 2002-11-22 Verwendung von histaminrezeptorantagonisten für die senkung des intrakranialen druckes ATE423599T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01204574		2001-11-23

Publications (1)

Publication Number	Publication Date
ATE423599T1 true ATE423599T1 (de)	2009-03-15

Family

ID=8181317

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT02803410T ATE370149T1 (de)	2001-11-23	2002-11-22	Verwendung von substituierten tetrazyclischen imidazolderivaten als antihistaminika
AT07107669T ATE423599T1 (de)	2001-11-23	2002-11-22	Verwendung von histaminrezeptorantagonisten für die senkung des intrakranialen druckes

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT02803410T ATE370149T1 (de)	2001-11-23	2002-11-22	Verwendung von substituierten tetrazyclischen imidazolderivaten als antihistaminika

Country Status (25)

Country	Link
US (1)	US7732437B2 (de)
EP (2)	EP1832287B1 (de)
JP (2)	JP4505226B2 (de)
KR (1)	KR100967601B1 (de)
CN (2)	CN100379744C (de)
AT (2)	ATE370149T1 (de)
AU (1)	AU2002356715B2 (de)
CA (2)	CA2690483C (de)
CY (2)	CY1107472T1 (de)
DE (2)	DE60221891T2 (de)
DK (2)	DK1451196T3 (de)
ES (2)	ES2290364T3 (de)
HR (1)	HRP20040427B1 (de)
HU (1)	HU229118B1 (de)
IL (4)	IL162109A0 (de)
MX (1)	MXPA04004867A (de)
NO (1)	NO333656B1 (de)
NZ (2)	NZ532718A (de)
PL (1)	PL209953B1 (de)
PT (2)	PT1451196E (de)
RU (1)	RU2311418C2 (de)
SI (2)	SI1451196T1 (de)
UA (1)	UA76803C2 (de)
WO (1)	WO2003044023A1 (de)
ZA (1)	ZA200403923B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2690483C (en)	2001-11-23	2012-07-24	Janssen Pharmaceutica N.V.	The use of anti-histaminics for acute reduction of elevated intracranial pressure
TWI290140B (en)	2003-08-25	2007-11-21	Schering Corp	2-Substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for thr treatment of obesity and related disorders
CN103987932A (zh) *	2011-12-20	2014-08-13	丰田自动车株式会社	电加热式催化剂的故障检测装置
US9717726B2 (en) *	2013-03-14	2017-08-01	Maregade Rx, LLC	Product and method for treating diarrhea
EP3558296B1 (de)	2016-12-23	2023-06-28	Maregade RX, LLC	Niedrigdosisprodukt und verfahren zur behandlung von durchfall
US10947253B2 (en)	2019-08-05	2021-03-16	Ankh Life Sciences Limited	Fused polycyclic dimers
US12129265B2 (en)	2020-07-21	2024-10-29	Ankh Life Sciences Limited	Therapeutic agents and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU223465B1 (hu) *	1992-12-04	2004-07-28	Janssen Pharmaceutica N.V.	Allergia elleni triazolo(pirrolo, tieno vagy furán)-azepin-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
TW429256B (en)	1995-12-27	2001-04-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
TW382017B (en) *	1995-12-27	2000-02-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en)	1996-03-19	2003-04-11	Janssen Pharmaceutica Nv	Fused imidazole derivatives as multidrug resistance modulators
US6544979B1 (en) *	1997-09-18	2003-04-08	Janssen Pharmaceuticals, N.V.	Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents
US7476662B2 (en) *	2001-06-12	2009-01-13	Janssen Pharmaceutica N.V.	Substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
CA2690483C (en)	2001-11-23	2012-07-24	Janssen Pharmaceutica N.V.	The use of anti-histaminics for acute reduction of elevated intracranial pressure

2002
- 2002-11-22 CA CA2690483A patent/CA2690483C/en not_active Expired - Fee Related
- 2002-11-22 MX MXPA04004867A patent/MXPA04004867A/es active IP Right Grant
- 2002-11-22 CN CNB028230140A patent/CN100379744C/zh not_active Expired - Fee Related
- 2002-11-22 DK DK02803410T patent/DK1451196T3/da active
- 2002-11-22 US US10/494,006 patent/US7732437B2/en not_active Expired - Lifetime
- 2002-11-22 UA UA20040604966A patent/UA76803C2/uk unknown
- 2002-11-22 PL PL369864A patent/PL209953B1/pl unknown
- 2002-11-22 PT PT02803410T patent/PT1451196E/pt unknown
- 2002-11-22 DE DE60221891T patent/DE60221891T2/de not_active Expired - Lifetime
- 2002-11-22 KR KR1020047005513A patent/KR100967601B1/ko not_active Expired - Fee Related
- 2002-11-22 DK DK07107669T patent/DK1832287T3/da active
- 2002-11-22 AT AT02803410T patent/ATE370149T1/de active
- 2002-11-22 CN CNB2006100841411A patent/CN100478031C/zh not_active Expired - Fee Related
- 2002-11-22 EP EP07107669A patent/EP1832287B1/de not_active Expired - Lifetime
- 2002-11-22 IL IL16210902A patent/IL162109A0/xx unknown
- 2002-11-22 SI SI200230617T patent/SI1451196T1/sl unknown
- 2002-11-22 NZ NZ532718A patent/NZ532718A/en not_active IP Right Cessation
- 2002-11-22 HR HRP20040427AA patent/HRP20040427B1/xx not_active IP Right Cessation
- 2002-11-22 AT AT07107669T patent/ATE423599T1/de active
- 2002-11-22 SI SI200230813T patent/SI1832287T1/sl unknown
- 2002-11-22 PT PT07107669T patent/PT1832287E/pt unknown
- 2002-11-22 ES ES02803410T patent/ES2290364T3/es not_active Expired - Lifetime
- 2002-11-22 HU HU0402357A patent/HU229118B1/hu not_active IP Right Cessation
- 2002-11-22 WO PCT/EP2002/013180 patent/WO2003044023A1/en not_active Ceased
- 2002-11-22 JP JP2003545660A patent/JP4505226B2/ja not_active Expired - Lifetime
- 2002-11-22 AU AU2002356715A patent/AU2002356715B2/en not_active Ceased
- 2002-11-22 EP EP02803410A patent/EP1451196B1/de not_active Expired - Lifetime
- 2002-11-22 DE DE60231351T patent/DE60231351D1/de not_active Expired - Lifetime
- 2002-11-22 NZ NZ550723A patent/NZ550723A/en not_active IP Right Cessation
- 2002-11-22 RU RU2004118838/04A patent/RU2311418C2/ru not_active IP Right Cessation
- 2002-11-22 ES ES07107669T patent/ES2321987T3/es not_active Expired - Lifetime
- 2002-11-22 CA CA2467097A patent/CA2467097C/en not_active Expired - Fee Related
2004
- 2004-05-20 ZA ZA2004/03923A patent/ZA200403923B/en unknown
- 2004-05-20 IL IL162109A patent/IL162109A/en not_active IP Right Cessation
- 2004-06-22 NO NO20042618A patent/NO333656B1/no not_active IP Right Cessation
2007
- 2007-11-14 CY CY20071101471T patent/CY1107472T1/el unknown
- 2007-12-27 IL IL188457A patent/IL188457A/en not_active IP Right Cessation
2008
- 2008-10-30 IL IL194992A patent/IL194992A/en not_active IP Right Cessation
2009
- 2009-02-04 JP JP2009023575A patent/JP4991770B2/ja not_active Expired - Lifetime
- 2009-05-25 CY CY20091100559T patent/CY1109108T1/el unknown

Also Published As

Publication number	Publication date
PT1451196E (pt)	2007-10-25
CN100379744C (zh)	2008-04-09
MXPA04004867A (es)	2004-07-30
DK1832287T3 (da)	2009-06-08
PL209953B1 (pl)	2011-11-30
IL162109A0 (en)	2005-11-20
US7732437B2 (en)	2010-06-08
ZA200403923B (en)	2005-10-26
IL194992A0 (en)	2009-08-03
JP4991770B2 (ja)	2012-08-01
AU2002356715B2 (en)	2008-05-15
US20050070525A1 (en)	2005-03-31
PT1832287E (pt)	2009-05-05
NZ532718A (en)	2007-01-26
IL188457A (en)	2010-11-30
KR20050044328A (ko)	2005-05-12
RU2311418C2 (ru)	2007-11-27
HK1073309A1 (en)	2005-09-30
WO2003044023A1 (en)	2003-05-30
HRP20040427A2 (en)	2005-06-30
HU229118B1 (en)	2013-08-28
CA2467097A1 (en)	2003-05-30
DE60221891D1 (de)	2007-09-27
NO333656B1 (no)	2013-08-05
HRP20040427B1 (hr)	2012-09-30
JP2005509680A (ja)	2005-04-14
EP1832287A3 (de)	2007-12-26
ES2290364T3 (es)	2008-02-16
ATE370149T1 (de)	2007-09-15
AU2002356715A1 (en)	2003-06-10
EP1832287B1 (de)	2009-02-25
KR100967601B1 (ko)	2010-07-05
JP2009102417A (ja)	2009-05-14
DE60221891T2 (de)	2008-05-08
HUP0402357A3 (en)	2009-10-28
NZ550723A (en)	2008-06-30
DK1451196T3 (da)	2007-11-12
HUP0402357A2 (hu)	2005-02-28
SI1832287T1 (sl)	2009-06-30
CN1589273A (zh)	2005-03-02
HK1101672A1 (zh)	2007-10-26
CY1107472T1 (el)	2012-12-19
RU2004118838A (ru)	2005-04-10
ES2321987T3 (es)	2009-06-15
CN1895673A (zh)	2007-01-17
IL162109A (en)	2010-04-29
IL188457A0 (en)	2008-03-20
CY1109108T1 (el)	2014-07-02
JP4505226B2 (ja)	2010-07-21
UA76803C2 (uk)	2006-09-15
CA2690483A1 (en)	2003-05-30
IL194992A (en)	2010-12-30
EP1832287A2 (de)	2007-09-12
EP1451196A1 (de)	2004-09-01
EP1451196B1 (de)	2007-08-15
CA2467097C (en)	2011-02-01
SI1451196T1 (sl)	2007-12-31
DE60231351D1 (de)	2009-04-09
NO20042618L (no)	2004-06-22
CA2690483C (en)	2012-07-24
PL369864A1 (en)	2005-05-02
CN100478031C (zh)	2009-04-15

Legal Events

Date

Code

Title

Description

2009-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1832287

Country of ref document: EP

Publication	Publication Date	Title
IL194992A0 (en)	2009-08-03	The use of anti-histaminics for acute reduction of elevated intracranial pressure
Grodzinsky	1983	Electromechanical and physicochemical properties of connective tissue.
RU2004133764A (ru)	2005-07-20	Производные бензимидазола в качестве н3-гистаминовых антагонистов
CY1109579T1 (el)	2014-08-13	Μιμητοσωματα του πυρηνα αρθρωσης μιμητικα της ανθρωπινης ερο, συνθεσεις, μεθοδοι και χρησεις
CA2330469A1 (fr)	2001-07-13	Compositions cosmetiques contenant un amidon amphotere et un agent conditionneur cationique et leurs utilisations
EP1034778A3 (de)	2001-08-16	Verwendung von Octocrylen zur Solubilisierung von 2,4-Bis- [4-(2-Ethyl-hexyloxy)-2-hydroxy]-phenyl -6-(4-methoxyphenyl)-1,3,5-triazin in kosmetischen oder dermatologischen Lichtschutzmitteln
ES2636253T3 (es)	2017-10-05	Preparación cosmética estable
ATE454403T1 (de)	2010-01-15	Menschliche koagulationsfaktor vii polypeptide
DK0920498T3 (da)	2006-07-10	Hamster EF-1alfa transskriptionelt, regulatorisk DNA
CY1107214T1 (el)	2012-11-21	Αγωνιστες και ανταγωνιστες υποδοχεων λυσοφωσφατιδικου οξεος (lpa) kai τροποι χρησης
ES2110858T3 (es)	1998-02-16	Composicion siliconada que contiene un agente activo sensible al agua.
DE60001232D1 (de)	2003-02-20	Hautreinigungsmittel
White et al.	2004	Effects of Crest Whitestrips bleaching on subsurface microhardness and ultrastructure of tooth enamel and coronal dentin.
ATE423186T1 (de)	2009-03-15	Emulsion
ATE457384T1 (de)	2010-02-15	Von weichmachender lotion durchdrungenes tissuepapier
ATE521329T1 (de)	2011-09-15	Säuregepufferte körperpflege zusammensetzungen
ATE465173T1 (de)	2010-05-15	Verändertes vp-1capsidprotein von parvovirus b19
Nelson et al.	1991	Identification and isolation of Cryptosporidium parvum genes encoding microtubule and microfilament proteins.
Frost	2003	On the strength-safety factor (SSF) for load-bearing skeletal organs.
Rousselle et al.	2022	Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved
ES2320104T3 (es)	2009-05-19	Metodo para la deformacion duradera de fibras que contienen queratina y producto correspondiente.
ATE415421T1 (de)	2008-12-15	Deamidiertes interferon-beta
Banita	2025	Navigating roots and routes: the topos of return in contemporary Nigerian and Nigerian diaspora literature
CO5410173A1 (es)	2004-06-30	Composicion para peinar el cabello que no requiere enjuague e imparte levedad al mismo
Korte et al.	2004	S 2-42: Expression of CAP1 and CAP2 in developing and adult mouse tissues