ATE423975T1 - Nanopartikelabbildungssystem und -verfahren - Google Patents

Nanopartikelabbildungssystem und -verfahren

Info

Publication number
ATE423975T1
ATE423975T1 AT02805501T AT02805501T ATE423975T1 AT E423975 T1 ATE423975 T1 AT E423975T1 AT 02805501 T AT02805501 T AT 02805501T AT 02805501 T AT02805501 T AT 02805501T AT E423975 T1 ATE423975 T1 AT E423975T1
Authority
AT
Austria
Prior art keywords
substrate
module
spots
imaging
automatic
Prior art date
Application number
AT02805501T
Other languages
English (en)
Inventor
William Cork
Tim Patno
Mark Weber
Dave Morrow
Wesley Buckingham
Original Assignee
Nanosphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosphere Inc filed Critical Nanosphere Inc
Application granted granted Critical
Publication of ATE423975T1 publication Critical patent/ATE423975T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Colloid Chemistry (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measurement Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02805501T 2001-08-03 2002-08-02 Nanopartikelabbildungssystem und -verfahren ATE423975T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31010201P 2001-08-03 2001-08-03
US36673202P 2002-03-22 2002-03-22

Publications (1)

Publication Number Publication Date
ATE423975T1 true ATE423975T1 (de) 2009-03-15

Family

ID=26977210

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02805501T ATE423975T1 (de) 2001-08-03 2002-08-02 Nanopartikelabbildungssystem und -verfahren

Country Status (9)

Country Link
US (4) US7110585B2 (de)
EP (1) EP1412536B1 (de)
JP (1) JP4347053B2 (de)
AT (1) ATE423975T1 (de)
AU (1) AU2002365247B2 (de)
CA (1) CA2455118C (de)
DE (1) DE60231309D1 (de)
NZ (1) NZ531212A (de)
WO (1) WO2003053535A2 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) * 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
AU768535B2 (en) 1998-11-30 2003-12-18 Nanosphere, Inc. Nanoparticles with polymer shells
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
CA2396113C (en) * 2000-01-13 2009-04-07 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AU2001276870B2 (en) * 2000-07-11 2006-07-20 Northwestern University Method of detection by enhancement of silver staining
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
AU2002239726A1 (en) * 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
ATE423975T1 (de) 2001-08-03 2009-03-15 Nanosphere Inc Nanopartikelabbildungssystem und -verfahren
ATE437216T1 (de) 2001-09-06 2009-08-15 Genomic Profiling Systems Inc Schnellnachweis replizierender zellen
CA2466656C (en) 2001-11-09 2013-07-02 Nanosphere, Inc. Bioconjugate-nanoparticle probes
US7361310B1 (en) 2001-11-30 2008-04-22 Northwestern University Direct write nanolithographic deposition of nucleic acids from nanoscopic tips
CA2468743A1 (en) * 2001-11-30 2003-06-12 Northwestern University Direct write nanolithographic deposition of nucleic acids from nanoscopic tips
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US7227988B2 (en) * 2002-07-01 2007-06-05 Xerox Corporation Prioritized PDL segmentation producing two bit selector
JP2005532456A (ja) * 2002-07-02 2005-10-27 ナノスフェアー　インコーポレイテッド ナノ粒子ポリアニオン複合物ならびに分析物の検出における同複合物の用途
EP1597399A2 (de) * 2003-02-27 2005-11-23 Nanosphere, Inc. Markierungsfreie erstellung von genexpressionsprofilen mittels universeller nanopartikelsonden im mikroarray-testformat
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
CA2834041C (en) * 2003-12-31 2017-05-16 President And Fellows Of Harvard College Assay device and method
US7555154B2 (en) * 2004-03-10 2009-06-30 Biomedical Photometrics Inc. Fully automated segmentation of genetic micro-array images
DE102004013052A1 (de) * 2004-03-10 2005-09-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Charakterisierung von technischen Oberflächen
JP2008507296A (ja) * 2004-07-26 2008-03-13 ナノスフェアー　インコーポレイテッド 混合培養物中でメチシリン耐性黄色ブドウ球菌とメチシリン感受性黄色ブドウ球菌とを区別する方法
US7612769B2 (en) * 2004-09-14 2009-11-03 E.I. Du Pont De Nemours And Company Computer-implemented methods for organizing image data produced by resonant Mie scattering of light from microparticles and resulting data structures
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
EP1748030B1 (de) * 2005-07-07 2016-04-20 Fei Company Verfahren und Apparat zur statistischen Charakterisierung von Nano-Partikeln
EP1915466B1 (de) * 2005-08-19 2010-11-24 Nanosphere, Inc. Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon
US20070105125A1 (en) * 2005-11-08 2007-05-10 Tsai George P Chemical array housing having a gas delivery element and methods of using the same
JP4991252B2 (ja) * 2006-11-10 2012-08-01 株式会社日立ハイテクノロジーズ 電気泳動装置、及び電気泳動分析方法
US8040959B2 (en) * 2006-12-11 2011-10-18 Texas Instruments Incorporated Dynamic resource allocation to improve MIMO detection performance
US8194920B2 (en) * 2007-02-16 2012-06-05 Ford Global Technologies, Llc Method and system for detecting objects using far infrared images
US7692785B2 (en) * 2007-03-29 2010-04-06 General Electric Company System and method for optical power management
US20090116696A1 (en) * 2007-05-29 2009-05-07 Mckernan Steffen System, method and machine-readable medium for characterizing nanotube materials
TWI384214B (zh) * 2008-01-18 2013-02-01 國立中正大學 Biological sensing device and its system
KR101435522B1 (ko) 2008-01-23 2014-09-02 삼성전자 주식회사 바이오 칩
US20110045481A1 (en) 2008-01-25 2011-02-24 Patrick Gladding Methods and compositions for the assessment of drug response
JP2009229103A (ja) * 2008-03-19 2009-10-08 Toshiba Corp 金属コロイドの定量方法
CN102224410B (zh) 2008-09-24 2017-02-08 施特劳斯控股公司 用于测试分析物的成像分析仪
GB2464747B (en) * 2008-10-10 2013-05-15 Hai Kang Life Corp Ltd Method for detection of analyte in microarray of samples and apparatus for performing such method
US8306780B2 (en) * 2009-01-26 2012-11-06 Exelis Inc. Data quality and ancillary data checking for Raman sensor
WO2010111656A2 (en) 2009-03-27 2010-09-30 Life Technologies Corporation Systems and methods for assessing images
JP5288634B2 (ja) 2010-03-31 2013-09-11 富士フイルム株式会社 呈色測定装置および方法
EP2603450B1 (de) 2010-08-14 2016-11-02 University of Massachusetts Wandpartikel aus hefezellen für rezeptorengerichtete nanopartikelfreisetzung
CN102297965A (zh) * 2011-05-23 2011-12-28 无锡安迪生物工程有限公司 一种氯吡脲快速检测卡及其检测方法
JP5914992B2 (ja) * 2011-06-02 2016-05-11 ソニー株式会社 表示制御装置、表示制御方法、およびプログラム
US20140072959A1 (en) 2012-09-12 2014-03-13 Force Diagnostics, Inc. Rapid tests for insurance underwriting
WO2014062885A1 (en) 2012-10-17 2014-04-24 Bio-Rad Laboratories, Inc. Image capture for large analyte arrays
US10254279B2 (en) 2013-03-29 2019-04-09 Nima Labs, Inc. System and method for detection of target substances
US10466236B2 (en) 2013-03-29 2019-11-05 Nima Labs, Inc. System and method for detecting target substances
CN105209912B (zh) 2013-03-29 2018-04-17 第6感传感器实验室公司 用于有害物质的检测的便携式装置
US8736685B1 (en) * 2013-12-11 2014-05-27 Anritsu Company Systems and methods for measuring brightness response of a camera operating in automatic exposure mode
WO2017059103A1 (en) * 2015-09-30 2017-04-06 Nima Labs, Inc. System and method for detecting target substances
US9835842B2 (en) * 2015-12-04 2017-12-05 Omnivision Technologies, Inc. Microscope attachment
EP3387617B1 (de) * 2015-12-10 2020-05-27 Qiagen GmbH Verfahren zur bestimmung der gesamthelligkeit von mindestens einem objekt in einem digitalen bild
CN105738294B (zh) * 2016-03-01 2018-11-06 江苏大学 基于单目多视成像的穗状水果自动检测装置及方法
CN106442238B (zh) * 2016-07-22 2023-06-23 华北电力大学 一种检测空气中颗粒浓度的装置
JP6317003B2 (ja) * 2017-02-27 2018-04-25 株式会社Ｓｃｒｅｅｎホールディングス 撮像装置および撮像方法
CN107167478A (zh) * 2017-04-25 2017-09-15 明基材料有限公司 片材面内标记检测方法及装置
CN109061797B (zh) * 2017-06-13 2020-03-27 京东方科技集团股份有限公司 导光结构、显示装置及视角调节方法
US12031985B2 (en) 2018-04-19 2024-07-09 First Light Diagnostics, Inc. Detection of targets
CN112423883A (zh) 2018-07-12 2021-02-26 卢米耐克斯公司 用于进行可变样品制备和分析过程的系统和方法
CA3115279A1 (en) 2018-10-04 2020-04-09 First Light Diagnostics, Inc. Analysis instrument
CN113227342A (zh) * 2019-01-09 2021-08-06 株式会社日立高新技术 核酸分析用基板、核酸分析用流动池以及图像分析方法
CN110177280A (zh) * 2019-04-02 2019-08-27 苏州摩比信通智能系统有限公司 二维解码器的曝光调节方法
WO2021011944A2 (en) * 2019-07-18 2021-01-21 Essenlix Corporation Imaging based homogeneous assay
CN117563517A (zh) * 2023-11-07 2024-02-20 合肥工业大学 一种超高密度球形核酸及制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202037A (en) * 1977-04-22 1980-05-06 Der Loos Hendrik Van Computer microscope apparatus and method for superimposing an electronically-produced image from the computer memory upon the image in the microscope's field of view
GB2196219A (en) * 1986-10-11 1988-04-20 Astromed Ltd Imaging of light-opaque specimens by transmission of radiation therethrough
JPH07104943B2 (ja) * 1988-02-29 1995-11-13 株式会社日立製作所 物体認識装置
US5428690A (en) * 1991-09-23 1995-06-27 Becton Dickinson And Company Method and apparatus for automated assay of biological specimens
US5820879A (en) * 1993-02-12 1998-10-13 Access Pharmaceuticals, Inc. Method of delivering a lipid-coated condensed-phase microparticle composition
US5654006A (en) * 1993-02-12 1997-08-05 Mayo Foundation For Medical Education And Research Condensed-phase microparticle composition and method
US5753261A (en) * 1993-02-12 1998-05-19 Access Pharmaceuticals, Inc. Lipid-coated condensed-phase microparticle composition
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
IL126544A (en) * 1996-04-25 2004-08-31 Genicon Sciences Inc Analyte assay using scattered-light detectable particles
US6036920A (en) 1996-05-09 2000-03-14 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
US6361944B1 (en) * 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6396941B1 (en) * 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
AU5895898A (en) * 1996-12-20 1998-07-17 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
US6587581B1 (en) * 1997-01-10 2003-07-01 Hitachi, Ltd. Visual inspection method and apparatus therefor
WO1998037417A1 (en) * 1997-02-20 1998-08-27 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
JPH10241625A (ja) 1997-02-24 1998-09-11 Hitachi Ltd プラズマイオン源質量分析装置及び方法
US5909276A (en) * 1997-03-31 1999-06-01 Microtherm, Llc Optical inspection module and method for detecting particles and defects on substrates in integrated process tools
US6294327B1 (en) 1997-09-08 2001-09-25 Affymetrix, Inc. Apparatus and method for detecting samples labeled with material having strong light scattering properties, using reflection mode light and diffuse scattering
US6294223B1 (en) * 1997-12-23 2001-09-25 Georgia Tech Research Corp. Method for ion implantation induced embedded particle formation via reduction
US6248988B1 (en) 1998-05-05 2001-06-19 Kla-Tencor Corporation Conventional and confocal multi-spot scanning optical microscope
US6212292B1 (en) * 1998-07-08 2001-04-03 California Institute Of Technology Creating an image of an object with an optical microscope
US6219137B1 (en) * 1998-12-03 2001-04-17 Lockheed Martin Energy Research Corporation Nanoprobe for surface-enhanced Raman spectroscopy in medical diagnostic and drug screening
US6221579B1 (en) * 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
JP2000241120A (ja) * 1999-02-23 2000-09-08 Fanuc Ltd 計測装置
AU779752B2 (en) * 1999-05-19 2005-02-10 Eppendorf Array Technologies S.A. Method for the identification and/or the quantification of a target compound
US6286763B1 (en) 1999-09-21 2001-09-11 Intermac Ip Corp. Method and apparatus to automatically search data carriers, such as RFID tags and machine-readable symbols
JP2001168159A (ja) * 1999-12-03 2001-06-22 Sony Corp 検査装置及び検査方法
AU2001247195A1 (en) * 2000-01-31 2001-08-07 Board Of Regents, The University Of Texas System Method and system for collecting and transmitting chemical information
US20020107640A1 (en) * 2000-11-14 2002-08-08 Ideker Trey E. Methods for determining the true signal of an analyte
EP1390719A4 (de) 2001-04-19 2007-08-29 Maven Technologies Llc Abbildungsvorrichtung und -verfahren
ATE423975T1 (de) 2001-08-03 2009-03-15 Nanosphere Inc Nanopartikelabbildungssystem und -verfahren
US6707958B2 (en) 2001-11-20 2004-03-16 Agilent Technologies, Inc. Biochemical assay device using frustrated total internal reflection modulator with an imaging optical waveguide
AU2003202980A1 (en) 2002-01-12 2003-07-30 Maven Technologies, Llc Apparatus and method for imaging
US7163823B2 (en) 2002-01-28 2007-01-16 Nanosphere, Inc. DNA hybridization device and method
WO2004042070A2 (en) 2002-05-14 2004-05-21 Nanosphere, Inc. Electrical detection of dna hybridization and specific binding events

Also Published As

Publication number Publication date
US20030068638A1 (en) 2003-04-10
US7773790B2 (en) 2010-08-10
JP4347053B2 (ja) 2009-10-21
CA2455118C (en) 2012-01-17
CA2455118A1 (en) 2003-07-03
US20070148665A1 (en) 2007-06-28
WO2003053535B1 (en) 2003-11-06
WO2003053535A3 (en) 2003-09-12
WO2003053535A9 (en) 2003-12-24
US20070041624A1 (en) 2007-02-22
US20120063653A1 (en) 2012-03-15
NZ531212A (en) 2006-01-27
WO2003053535A2 (en) 2003-07-03
AU2002365247A1 (en) 2003-07-09
EP1412536A2 (de) 2004-04-28
US7110585B2 (en) 2006-09-19
EP1412536A4 (de) 2005-12-28
EP1412536B1 (de) 2009-02-25
DE60231309D1 (de) 2009-04-09
AU2002365247B2 (en) 2006-06-08
JP2005521033A (ja) 2005-07-14

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