ATE424394T1 - 1h-indol-3-carbonsäurederivate und deren verwendung als ppar-agonisten - Google Patents

1h-indol-3-carbonsäurederivate und deren verwendung als ppar-agonisten

Info

Publication number
ATE424394T1
ATE424394T1 AT05817577T AT05817577T ATE424394T1 AT E424394 T1 ATE424394 T1 AT E424394T1 AT 05817577 T AT05817577 T AT 05817577T AT 05817577 T AT05817577 T AT 05817577T AT E424394 T1 ATE424394 T1 AT E424394T1
Authority
AT
Austria
Prior art keywords
indole
acid derivatives
carbonic acid
ppar agonists
compounds
Prior art date
Application number
AT05817577T
Other languages
English (en)
Inventor
Nathalie Adje
Didier Roche
Stephane Yvon
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE424394T1 publication Critical patent/ATE424394T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT05817577T 2005-01-14 2005-12-17 1h-indol-3-carbonsäurederivate und deren verwendung als ppar-agonisten ATE424394T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0500422A FR2880889B1 (fr) 2005-01-14 2005-01-14 Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique

Publications (1)

Publication Number Publication Date
ATE424394T1 true ATE424394T1 (de) 2009-03-15

Family

ID=34953245

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05817577T ATE424394T1 (de) 2005-01-14 2005-12-17 1h-indol-3-carbonsäurederivate und deren verwendung als ppar-agonisten

Country Status (15)

Country Link
US (1) US7754740B2 (de)
EP (1) EP1836187B1 (de)
JP (1) JP5042855B2 (de)
KR (1) KR20070104353A (de)
CN (1) CN101098865A (de)
AT (1) ATE424394T1 (de)
AU (1) AU2005324895B2 (de)
BR (1) BRPI0519839A2 (de)
CA (1) CA2594377C (de)
DE (1) DE602005013118D1 (de)
ES (1) ES2321745T3 (de)
FR (1) FR2880889B1 (de)
MX (1) MX2007008350A (de)
WO (1) WO2006074789A1 (de)
ZA (1) ZA200706707B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2614544C (en) 2005-07-13 2013-09-10 Banyu Pharmaceutical Co., Ltd. Heterocycle-substituted benzimidazole derivative
CN103880730A (zh) * 2014-02-26 2014-06-25 南通大学 一种7-硝基吲哚-3-甲酸叔丁酯的化学合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL154981A0 (en) * 2000-10-10 2003-10-31 Smithkline Beecham Corp Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppay-y-binding agents
JPWO2002046154A1 (ja) * 2000-12-05 2004-04-08 日本ケミファ株式会社 ペルオキシソーム増殖剤応答性受容体δの活性化剤
WO2005042497A2 (en) * 2003-10-28 2005-05-12 Vertex Pharmaceuticals, Incorporated Benzimidazoles useful as modulators of ion channels

Also Published As

Publication number Publication date
CN101098865A (zh) 2008-01-02
CA2594377A1 (en) 2006-07-20
FR2880889A1 (fr) 2006-07-21
DE602005013118D1 (de) 2009-04-16
WO2006074789A1 (en) 2006-07-20
EP1836187A1 (de) 2007-09-26
US20080114034A1 (en) 2008-05-15
CA2594377C (en) 2014-02-18
ZA200706707B (en) 2008-09-25
JP2008526902A (ja) 2008-07-24
EP1836187B1 (de) 2009-03-04
ES2321745T3 (es) 2009-06-10
FR2880889B1 (fr) 2007-04-06
KR20070104353A (ko) 2007-10-25
US7754740B2 (en) 2010-07-13
JP5042855B2 (ja) 2012-10-03
AU2005324895B2 (en) 2011-08-04
AU2005324895A1 (en) 2006-07-20
BRPI0519839A2 (pt) 2009-03-17
MX2007008350A (es) 2007-07-25

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