ATE425171T1 - Verbesserter herstellungsprozess von 4-amino- hydroxybutyliden-1,1-bisphosphonischer säure und ihrer salze - Google Patents
Verbesserter herstellungsprozess von 4-amino- hydroxybutyliden-1,1-bisphosphonischer säure und ihrer salzeInfo
- Publication number
- ATE425171T1 ATE425171T1 AT06126565T AT06126565T ATE425171T1 AT E425171 T1 ATE425171 T1 AT E425171T1 AT 06126565 T AT06126565 T AT 06126565T AT 06126565 T AT06126565 T AT 06126565T AT E425171 T1 ATE425171 T1 AT E425171T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxybutylidene
- salts
- amino
- production process
- improved production
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- DCSBSVSZJRSITC-UHFFFAOYSA-M alendronate sodium trihydrate Chemical compound O.O.O.[Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O DCSBSVSZJRSITC-UHFFFAOYSA-M 0.000 abstract 1
- 229960004343 alendronic acid Drugs 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1628MU2005 | 2005-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425171T1 true ATE425171T1 (de) | 2009-03-15 |
Family
ID=37889600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06126565T ATE425171T1 (de) | 2005-12-27 | 2006-12-19 | Verbesserter herstellungsprozess von 4-amino- hydroxybutyliden-1,1-bisphosphonischer säure und ihrer salze |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7414151B2 (de) |
| EP (1) | EP1803727B1 (de) |
| AT (1) | ATE425171T1 (de) |
| DE (1) | DE602006005597D1 (de) |
| ES (1) | ES2323728T3 (de) |
| PT (1) | PT1803727E (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100681282B1 (ko) * | 2002-05-17 | 2007-02-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법 |
| PT103600B (pt) * | 2006-11-06 | 2009-01-30 | Hovione Farmaciencia Sa | Processo para a preparação de ácidos biosfónicos e seus sais farmaceuticamente aceitáveis |
| US8247726B2 (en) * | 2009-07-22 | 2012-08-21 | Eaton Corporation | Electrical switching apparatus and arc chute assembly therefor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| IT1196315B (it) | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
| US4922007A (en) | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| US5039819A (en) | 1990-09-18 | 1991-08-13 | Merck & Co., Inc. | Diphosphonate intermediate for preparing an antihypercalcemic agent |
| CA2197267C (en) | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| AU757104B2 (en) * | 1998-06-24 | 2003-01-30 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| TR200101250A2 (tr) | 2001-05-10 | 2003-04-21 | E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. | 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses |
| CN1325506C (zh) | 2003-05-15 | 2007-07-11 | 中国科学院上海药物研究所 | 骨重吸收抑制剂阿伦膦酸及生理可接受的盐和它的制备 |
-
2006
- 2006-12-19 ES ES06126565T patent/ES2323728T3/es active Active
- 2006-12-19 PT PT06126565T patent/PT1803727E/pt unknown
- 2006-12-19 AT AT06126565T patent/ATE425171T1/de not_active IP Right Cessation
- 2006-12-19 EP EP06126565A patent/EP1803727B1/de not_active Not-in-force
- 2006-12-19 DE DE602006005597T patent/DE602006005597D1/de active Active
- 2006-12-27 US US11/645,757 patent/US7414151B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006005597D1 (de) | 2009-04-23 |
| US20070149486A1 (en) | 2007-06-28 |
| EP1803727B1 (de) | 2009-03-11 |
| US7414151B2 (en) | 2008-08-19 |
| ES2323728T3 (es) | 2009-07-23 |
| EP1803727A1 (de) | 2007-07-04 |
| PT1803727E (pt) | 2009-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |