ATE452899T1 - Herstellung von bisphosphonsaüren und salzen davon - Google Patents
Herstellung von bisphosphonsaüren und salzen davonInfo
- Publication number
- ATE452899T1 ATE452899T1 AT02807339T AT02807339T ATE452899T1 AT E452899 T1 ATE452899 T1 AT E452899T1 AT 02807339 T AT02807339 T AT 02807339T AT 02807339 T AT02807339 T AT 02807339T AT E452899 T1 ATE452899 T1 AT E452899T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- production
- bisphosphonic acids
- reaction
- acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title 1
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 229960004343 alendronic acid Drugs 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000908A ITMI20020908A1 (it) | 2002-04-29 | 2002-04-29 | Processo di preparazione di sodio alendronato |
| PCT/IB2002/004941 WO2003093282A1 (en) | 2002-04-29 | 2002-11-25 | Preparation of biphosphonic acids and salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE452899T1 true ATE452899T1 (de) | 2010-01-15 |
Family
ID=11449800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02807339T ATE452899T1 (de) | 2002-04-29 | 2002-11-25 | Herstellung von bisphosphonsaüren und salzen davon |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7332603B2 (de) |
| EP (1) | EP1504012B9 (de) |
| JP (1) | JP2005523938A (de) |
| KR (1) | KR20050025162A (de) |
| AT (1) | ATE452899T1 (de) |
| AU (1) | AU2002367897A1 (de) |
| DE (1) | DE60234870D1 (de) |
| ES (1) | ES2338540T3 (de) |
| IT (1) | ITMI20020908A1 (de) |
| WO (1) | WO2003093282A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA006053B1 (ru) * | 2001-12-24 | 2005-08-25 | Тева Фармасьютикал Индастриес Лтд. | Твёрдая лекарственная форма, способ её изготовления и устройство |
| US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
| ATE461205T1 (de) * | 2002-05-17 | 2010-04-15 | Teva Pharma | Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren |
| EP1525207A2 (de) * | 2003-02-27 | 2005-04-27 | Teva Pharmaceutical Industries Limited | Verfahren zur reinigung von zoledronischer säure |
| ES2322592T3 (es) * | 2003-07-03 | 2009-06-23 | Teva Pharmaceutical Industries Ltd. | Formas cristalinas de acido zoledronico, formas cristlinas de la sal sodica de zoledronato, sal sodica de zoledronato amorfa y procedimientos para su preparacion. |
| WO2005063717A1 (en) * | 2003-12-26 | 2005-07-14 | Natco Pharma Limited | An improved process for the preparation of zoledronic acid |
| ES2289650T3 (es) * | 2004-03-03 | 2008-02-01 | Chemi S.P.A. | Sal monosodica del acido 3-piridil-1-hidroxietiliden-1,1-bifosfonico amorfa y procedimiento para la preparacion de la misma. |
| ES2358269T3 (es) | 2004-08-23 | 2011-05-09 | Teva Pharmaceutical Industries Ltd | Forma cristalina del ibandronato sódico y procedimientos para su preparación. |
| PL199215B1 (pl) * | 2004-12-28 | 2008-08-29 | Politechnika Gdanska | Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej |
| US8071574B2 (en) | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| AR054673A1 (es) * | 2005-07-28 | 2007-07-11 | Gador Sa | Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende |
| WO2007032808A1 (en) * | 2005-09-12 | 2007-03-22 | Dr. Reddy's Laboratories Ltd. | Crystalline trihydrate of zoledronic acid |
| WO2007083240A2 (en) * | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| WO2007125521A2 (en) * | 2006-05-02 | 2007-11-08 | Ranbaxy Laboratories Limited | Polymorphic form of zoledronic acid and processes for their preparation |
| JP5354858B2 (ja) * | 2006-05-09 | 2013-11-27 | 株式会社Ａｄｅｋａ | スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物 |
| EP2016084A2 (de) | 2006-05-11 | 2009-01-21 | Ind-Swift Laboratories Limited | Verfahren zur herstellung von reiner risedronsäure oder -salzen |
| EP1923394A1 (de) * | 2006-11-16 | 2008-05-21 | Sandoz A/S | Reagenz und dessen Verwendung in der Herstellung von Bisphosphonaten |
| WO2008152518A2 (en) * | 2007-05-16 | 2008-12-18 | Actavis Group Ptc Ehf | Process for the preparation of risedronic acid or risedronate sodium |
| WO2009050731A2 (en) * | 2007-06-20 | 2009-04-23 | Alkem Laboratories Ltd | Novel process for preparing risedronic acid |
| US8080323B2 (en) * | 2007-06-28 | 2011-12-20 | Kennametal Inc. | Cutting insert with a wear-resistant coating scheme exhibiting wear indication and method of making the same |
| KR100877667B1 (ko) * | 2007-06-28 | 2009-01-08 | 보령제약 주식회사 | 리세드로네이트의 제조 방법 |
| JP5258370B2 (ja) * | 2008-05-08 | 2013-08-07 | ダイト株式会社 | リセドロン酸の工業的製造方法 |
| PL213599B1 (pl) | 2008-10-31 | 2013-03-29 | Politechnika Gdanska | Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego |
| US20100130746A1 (en) * | 2008-11-26 | 2010-05-27 | Martin Kas | Process for Making Zoledronic Acid |
| EP2192126B1 (de) | 2008-11-26 | 2013-03-27 | Synthon B.V. | Verfahren zur Herstellung von Zoledronsäure |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| KR101813728B1 (ko) * | 2009-07-31 | 2017-12-29 | 그뤼넨탈 게엠베하 | 결정화 방법 및 생체이용률 |
| WO2011016738A1 (en) | 2009-08-05 | 2011-02-10 | Zaklady Farmaceutyczne Polpharma Sa | A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate |
| US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
| CN106632483B (zh) * | 2016-12-20 | 2018-11-16 | 隋妍蕾 | 一种替诺福韦二吡呋酯的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3262971A (en) * | 1962-10-12 | 1966-07-26 | Monsanto Res Corp | Phosphorus compounds |
| DE1250439B (de) | 1965-03-30 | 1967-09-21 | The Procter & Gamble Company, Cincinnati, Ohio (V. St. A.) | Verfahren zur Herstellung von Äthan - 1 - hydroxy - 1,1-diphosphonsäure |
| DE2534391C2 (de) | 1975-08-01 | 1983-01-13 | Henkel KGaA, 4000 Düsseldorf | 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren |
| DE2745083C2 (de) | 1977-10-07 | 1985-05-02 | Henkel KGaA, 4000 Düsseldorf | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung |
| DE2943498C2 (de) | 1979-10-27 | 1983-01-27 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure |
| DE3016289A1 (de) | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| US4304734A (en) | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
| IT1201087B (it) | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| SU1719405A1 (ru) | 1985-07-02 | 1992-03-15 | Институт Химической Кинетики И Горения Со Ан Ссср | Способ получени высших 1-оксиалкилиден-1,1-дифосфоновых кислот или их смесей, или солей |
| DE3700772A1 (de) * | 1987-01-13 | 1988-07-21 | Inst Khim Kinetiki I Gorenija | Verfahren zur herstellung von i-funktionellsubstituierten alkyliden-i,i-diphosphonsaeuren und deren gemischen |
| US4922007A (en) | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| US5510517A (en) | 1993-08-25 | 1996-04-23 | Merck & Co., Inc. | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
| KR100192215B1 (ko) | 1996-09-03 | 1999-06-15 | 강재헌 | 3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법 |
| CA2197267C (en) | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| YU59401A (sh) | 1999-02-17 | 2004-05-12 | Teva Pharmaceutical Industries Ltd. | Postupak za proizvodnju alendronske kiseline |
| ES2153794B1 (es) | 1999-08-06 | 2001-10-16 | Medichem Sa | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
| US6562974B2 (en) * | 2000-02-01 | 2003-05-13 | The Procter & Gamble Company | Process for making geminal bisphosphonates |
| GB0115824D0 (en) | 2001-06-28 | 2001-08-22 | Rhodia Cons Spec Ltd | Improved solvent systems |
-
2002
- 2002-04-29 IT IT2002MI000908A patent/ITMI20020908A1/it unknown
- 2002-11-25 EP EP02807339A patent/EP1504012B9/de not_active Expired - Lifetime
- 2002-11-25 AU AU2002367897A patent/AU2002367897A1/en not_active Abandoned
- 2002-11-25 WO PCT/IB2002/004941 patent/WO2003093282A1/en not_active Ceased
- 2002-11-25 JP JP2004501421A patent/JP2005523938A/ja active Pending
- 2002-11-25 KR KR1020047017332A patent/KR20050025162A/ko not_active Withdrawn
- 2002-11-25 US US10/512,930 patent/US7332603B2/en not_active Expired - Lifetime
- 2002-11-25 AT AT02807339T patent/ATE452899T1/de not_active IP Right Cessation
- 2002-11-25 ES ES02807339T patent/ES2338540T3/es not_active Expired - Lifetime
- 2002-11-25 DE DE60234870T patent/DE60234870D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1504012B9 (de) | 2010-04-28 |
| EP1504012B1 (de) | 2009-12-23 |
| WO2003093282A1 (en) | 2003-11-13 |
| AU2002367897A8 (en) | 2003-11-17 |
| JP2005523938A (ja) | 2005-08-11 |
| WO2003093282A8 (en) | 2007-09-07 |
| US20050288509A1 (en) | 2005-12-29 |
| AU2002367897A1 (en) | 2003-11-17 |
| KR20050025162A (ko) | 2005-03-11 |
| ITMI20020908A0 (it) | 2002-04-29 |
| EP1504012A1 (de) | 2005-02-09 |
| US7332603B2 (en) | 2008-02-19 |
| ITMI20020908A1 (it) | 2003-10-29 |
| ES2338540T3 (es) | 2010-05-10 |
| DE60234870D1 (de) | 2010-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |