ATE425183T1 - P53-bindendes polypeptid - Google Patents

P53-bindendes polypeptid

Info

Publication number
ATE425183T1
ATE425183T1 AT03756559T AT03756559T ATE425183T1 AT E425183 T1 ATE425183 T1 AT E425183T1 AT 03756559 T AT03756559 T AT 03756559T AT 03756559 T AT03756559 T AT 03756559T AT E425183 T1 ATE425183 T1 AT E425183T1
Authority
AT
Austria
Prior art keywords
binding polypeptide
polypeptide
activity
inhibits
interfere
Prior art date
Application number
AT03756559T
Other languages
English (en)
Inventor
Xin Lu
Patricia Kuwabara
David Selwood
Original Assignee
Ludwig Inst For Cancer Res Ltd
Genome Res Ltd
Ucl Cruciform Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0223193A external-priority patent/GB0223193D0/en
Priority claimed from GB0306261A external-priority patent/GB0306261D0/en
Application filed by Ludwig Inst For Cancer Res Ltd, Genome Res Ltd, Ucl Cruciform Ltd filed Critical Ludwig Inst For Cancer Res Ltd
Application granted granted Critical
Publication of ATE425183T1 publication Critical patent/ATE425183T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03756559T 2002-10-07 2003-10-03 P53-bindendes polypeptid ATE425183T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0223193A GB0223193D0 (en) 2002-10-07 2002-10-07 Polypeptide
GB0306261A GB0306261D0 (en) 2003-03-19 2003-03-19 Polypeptide

Publications (1)

Publication Number Publication Date
ATE425183T1 true ATE425183T1 (de) 2009-03-15

Family

ID=32071253

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03756559T ATE425183T1 (de) 2002-10-07 2003-10-03 P53-bindendes polypeptid
AT08153666T ATE537186T1 (de) 2002-10-07 2003-10-03 P53-bindendes polypeptid

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT08153666T ATE537186T1 (de) 2002-10-07 2003-10-03 P53-bindendes polypeptid

Country Status (8)

Country Link
US (2) US20060100143A1 (de)
EP (2) EP1558638B1 (de)
JP (1) JP2006517787A (de)
AT (2) ATE425183T1 (de)
AU (1) AU2003299132A1 (de)
CA (1) CA2487206A1 (de)
DE (1) DE60326623D1 (de)
WO (1) WO2004031229A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0514538D0 (en) * 2005-07-14 2005-08-24 Ludwig Inst Cancer Res Variant polypeptide and screening assay
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CA2682174C (en) 2007-03-28 2021-04-06 President And Fellows Of Harvard College Stitched polypeptides
GB0716322D0 (en) * 2007-08-21 2007-10-03 Cancer Rec Tech Ltd Crystal structure
KR20130099938A (ko) 2010-08-13 2013-09-06 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
CN104039342A (zh) 2011-10-18 2014-09-10 爱勒让治疗公司 拟肽大环化合物
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
WO2013131019A1 (en) 2012-03-02 2013-09-06 Ludwig Institute For Cancer Research Ltd. Iaspp phosphorylation and metastatic potential
SG11201503052RA (en) 2012-11-01 2015-05-28 Aileron Therapeutics Inc Disubstituted amino acids and methods of preparation and use thereof
EP2994476B1 (de) * 2013-05-08 2019-07-31 The Regents of the University of California Strukturbasierte peptidinhibitoren der p53-aggregation als neuer ansatz für krebstherapeutika
MX2017003797A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
MX389354B (es) 2014-09-24 2025-03-20 Aileron Therapeutics Inc Macrociclos peptidomimeticos y formulaciones de los mismos.
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
WO2017059239A1 (en) * 2015-10-02 2017-04-06 Arizona Board Of Regents On Behalf Of Arizona State University Methods for processing biopolymeric arrays
WO2020023502A1 (en) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2345497A1 (en) 1988-10-28 1990-04-28 Genentech, Inc. Growth hormone variants and method for forming growth hormone variants
FI903489A0 (fi) 1988-11-11 1990-07-10 Medical Res Council Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
DE69704206T2 (de) 1996-08-16 2001-08-30 Medical Research Council, London Selbst-replizierende episomale expressionsvektoren, welche gewebespezifische expression vermitteln
KR100272659B1 (ko) 1997-06-28 2000-12-01 김영환 반도체 소자의 금속배선 선폭 측정방법
CA2319089A1 (en) 1998-04-09 1999-10-21 Genset S.A. 5' ests and encoded human proteins
KR20010080647A (ko) * 1998-12-03 2001-08-22 우에노 도시오 ＲｅｌＡ 결합성 저해 인자, 그 제조 방법 및 그 용도
AU3871300A (en) 1999-03-12 2000-10-04 Human Genome Sciences, Inc. 50 human secreted proteins
AU5286999A (en) * 1999-07-23 2001-02-13 Glaxo Group Limited Combination of an anti-ep-cam antibody with a chemotherapeutic agent
EP1313762B1 (de) 2000-08-04 2006-07-05 Ludwig Institute For Cancer Research Suppressor-gen

Also Published As

Publication number Publication date
EP1558638B1 (de) 2009-03-11
JP2006517787A (ja) 2006-08-03
US7745571B2 (en) 2010-06-29
CA2487206A1 (en) 2004-04-15
US20060100143A1 (en) 2006-05-11
US20080260756A1 (en) 2008-10-23
AU2003299132A1 (en) 2004-04-23
DE60326623D1 (de) 2009-04-23
EP1947113A1 (de) 2008-07-23
WO2004031229A2 (en) 2004-04-15
WO2004031229A3 (en) 2004-09-23
HK1083220A1 (en) 2006-06-30
EP1947113B1 (de) 2011-12-14
ATE537186T1 (de) 2011-12-15
EP1558638A2 (de) 2005-08-03

Similar Documents

Publication Publication Date Title
ATE537186T1 (de) P53-bindendes polypeptid
DE60233955D1 (de) Spezifische bindungsmittel von human angiopoietin-2
MX2007001345A (es) Regiones variantes fc.
ATE485303T1 (de) Isoformen von gehirn-natriuretischem peptid
DK1534335T3 (da) FcgammaRIIB-specifikke antistoffer og fremgangsmåder til anvendelse deraf
PT1171465E (pt) Analogos de petido inibidor gastrico e sua utilizacao para o tratamento de diabetes
BRPI0418286A (pt) proteìnas de fusão de il-7
NO20040022L (no) Slitesammenstilling
ATE320344T1 (de) Atmungsaktive und elastische verbundmaterialien und methoden
NO20052771D0 (no) Kamille/Alovera-behandlet hanske.
DE60128701D1 (en) Claudin polypeptide
ATE437185T1 (de) Gegen das gemeinsame epitop von mutierten p53 gerichtete humane synthetische einzelkettenantikörper und anwendungen davon
DE50206480D1 (de) Antimikrobiell wirkendes peptid
ATE527280T1 (de) Fluoreszentprotein und chromoprotein
WO2004017992A3 (en) Ptk7 protein involvement in carcinoma
EA200400392A1 (ru) Связывающий каспазу-8 белок, его получение и применение
EP1359932A4 (de) Tip39 polypeptide
CY1109904T1 (el) Προαγωγεας της il-18bp, η παρασκευη και χρηση του
DE69409961D1 (de) Triarylethylenderivate zur therapeutischen verwendung
ATE485831T1 (de) Behandlung von neurodegeneration
WO2003095484A3 (en) Polypeptides increasing p53 expression
ATE487734T1 (de) Polypeptide, abgeleitet von der amyloid vorläuferprotein (app), und ihre verwendungen
ES1052133Y (es) Urna funeraria.
ES1051236Y (es) Asta portatil para bandera o banderin.
WO2006003427A8 (en) A protein involved in carcinoma

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties