ATE537186T1 - P53-bindendes polypeptid - Google Patents

P53-bindendes polypeptid

Info

Publication number: ATE537186T1
Authority: AT; Austria
Prior art keywords: binding polypeptide; polypeptide; activity; inhibits; interfere
Prior art date: 2002-10-07

Application number

AT08153666T

Other languages

English (en)

Inventor

Xin Ludwig Lu

Patricia Kuwabara

David Selwood

Original Assignee

Ludwig Inst For Cancer Res Ltd

Genome Res Ltd

Ucl Cruciform Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-07

Filing date

2003-10-03

Publication date

2011-12-15

2002-10-07 Priority claimed from GB0223193A external-priority patent/GB0223193D0/en

2003-03-19 Priority claimed from GB0306261A external-priority patent/GB0306261D0/en

2003-10-03 Application filed by Ludwig Inst For Cancer Res Ltd, Genome Res Ltd, Ucl Cruciform Ltd filed Critical Ludwig Inst For Cancer Res Ltd

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE537186T1 publication Critical patent/ATE537186T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 abstract 1
230000001640 apoptogenic effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Marine Sciences & Fisheries (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Materials For Medical Uses (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT08153666T 2002-10-07 2003-10-03 P53-bindendes polypeptid ATE537186T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0223193A GB0223193D0 (en)	2002-10-07	2002-10-07	Polypeptide
GB0306261A GB0306261D0 (en)	2003-03-19	2003-03-19	Polypeptide

Publications (1)

Publication Number	Publication Date
ATE537186T1 true ATE537186T1 (de)	2011-12-15

Family

ID=32071253

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT08153666T ATE537186T1 (de)	2002-10-07	2003-10-03	P53-bindendes polypeptid
AT03756559T ATE425183T1 (de)	2002-10-07	2003-10-03	P53-bindendes polypeptid

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT03756559T ATE425183T1 (de)	2002-10-07	2003-10-03	P53-bindendes polypeptid

Country Status (8)

Country	Link
US (2)	US20060100143A1 (de)
EP (2)	EP1558638B1 (de)
JP (1)	JP2006517787A (de)
AT (2)	ATE537186T1 (de)
AU (1)	AU2003299132A1 (de)
CA (1)	CA2487206A1 (de)
DE (1)	DE60326623D1 (de)
WO (1)	WO2004031229A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0514538D0 (en) *	2005-07-14	2005-08-24	Ludwig Inst Cancer Res	Variant polypeptide and screening assay
PL2118123T3 (pl) *	2007-01-31	2016-06-30	Dana Farber Cancer Inst Inc	Stabilizowane peptydy p53 i ich zastosowania
JP5631201B2 (ja)	2007-03-28	2014-11-26	プレジデントアンドフェローズオブハーバードカレッジ	ステッチングされたポリペプチド
GB0716322D0 (en) *	2007-08-21	2007-10-03	Cancer Rec Tech Ltd	Crystal structure
KR102104762B1 (ko)	2010-08-13	2020-04-24	에일러론 테라퓨틱스 인코포레이티드	펩티도미메틱 거대고리
EP2768518A4 (de)	2011-10-18	2015-05-27	Aileron Therapeutics Inc	Peptidomimetische makrozyklen
CA2864120A1 (en)	2012-02-15	2013-08-22	Aileron Therapeutics, Inc.	Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
RU2642299C2 (ru)	2012-02-15	2018-01-24	Эйлерон Терапьютикс, Инк.	P53 пептидомиметические макроциклы
WO2013131019A1 (en)	2012-03-02	2013-09-06	Ludwig Institute For Cancer Research Ltd.	Iaspp phosphorylation and metastatic potential
BR112015009470A2 (pt)	2012-11-01	2019-12-17	Aileron Therapeutics Inc	aminoácidos dissubstituídos e seus métodos de preparação e uso
US9873718B2 (en)	2013-05-08	2018-01-23	The Regents Of The University Of California	Structure-based peptide inhibitors of P53 aggregation as a new approach to cancer therapeutics
CN107106642B (zh)	2014-09-24	2021-02-26	艾瑞朗医疗公司	拟肽大环化合物及其制剂
EP3197478A4 (de)	2014-09-24	2018-05-30	Aileron Therapeutics, Inc.	Peptidomimetische makrozyklen und verwendungen davon
JP2018516844A (ja)	2015-03-20	2018-06-28	エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	ペプチド模倣大環状分子およびその使用
EP3347372A4 (de)	2015-09-10	2019-09-04	Aileron Therapeutics, Inc.	Peptidomimetische makrocyclen als modulatoren von mcl-1
US20180284114A1 (en) *	2015-10-02	2018-10-04	Arizona Board Of Regents On Behalf Of Arizona State University	Methods for processing biopolymeric arrays
WO2020023502A1 (en)	2018-07-23	2020-01-30	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0397834B1 (de)	1988-10-28	2000-02-02	Genentech, Inc.	Verfahren zum nachweis von aktiven domänen und aminosäureresten in polypeptiden und hormonvarianten
ES2052027T5 (es)	1988-11-11	2005-04-16	Medical Research Council	Clonacion de secuencias de dominio variable de inmunoglobulina.
US6291158B1 (en)	1989-05-16	2001-09-18	Scripps Research Institute	Method for tapping the immunological repertoire
DE69704206T2 (de)	1996-08-16	2001-08-30	Medical Research Council, London	Selbst-replizierende episomale expressionsvektoren, welche gewebespezifische expression vermitteln
KR100272659B1 (ko)	1997-06-28	2000-12-01	김영환	반도체 소자의 금속배선 선폭 측정방법
JP2002511259A (ja)	1998-04-09	2002-04-16	ジェンセット	５’ｅｓｔおよびコードされるヒトタンパク質
WO2000032628A1 (en) *	1998-12-03	2000-06-08	Ono Pharmaceutical Co., Ltd.	ReL1A BINDING INHIBITOR, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF
JP2002538810A (ja)	1999-03-12	2002-11-19	ヒューマンジノームサイエンシーズ，インコーポレイテッド	５０個のヒト分泌タンパク質
AU5286999A (en) *	1999-07-23	2001-02-13	Glaxo Group Limited	Combination of an anti-ep-cam antibody with a chemotherapeutic agent
DK1313762T3 (da)	2000-08-04	2006-10-30	Ludwig Inst Cancer Res	Suppressor-gen

2003
- 2003-10-03 CA CA002487206A patent/CA2487206A1/en not_active Abandoned
- 2003-10-03 AT AT08153666T patent/ATE537186T1/de active
- 2003-10-03 EP EP03756559A patent/EP1558638B1/de not_active Expired - Lifetime
- 2003-10-03 WO PCT/GB2003/004296 patent/WO2004031229A2/en not_active Ceased
- 2003-10-03 EP EP08153666A patent/EP1947113B1/de not_active Expired - Lifetime
- 2003-10-03 DE DE60326623T patent/DE60326623D1/de not_active Expired - Lifetime
- 2003-10-03 US US10/522,043 patent/US20060100143A1/en not_active Abandoned
- 2003-10-03 AU AU2003299132A patent/AU2003299132A1/en not_active Abandoned
- 2003-10-03 AT AT03756559T patent/ATE425183T1/de not_active IP Right Cessation
- 2003-10-03 JP JP2005500064A patent/JP2006517787A/ja active Pending
2008
- 2008-03-05 US US12/043,058 patent/US7745571B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2006517787A (ja)	2006-08-03
HK1083220A1 (en)	2006-06-30
US20080260756A1 (en)	2008-10-23
US20060100143A1 (en)	2006-05-11
EP1947113B1 (de)	2011-12-14
WO2004031229A2 (en)	2004-04-15
DE60326623D1 (de)	2009-04-23
EP1558638A2 (de)	2005-08-03
CA2487206A1 (en)	2004-04-15
WO2004031229A3 (en)	2004-09-23
AU2003299132A1 (en)	2004-04-23
EP1558638B1 (de)	2009-03-11
EP1947113A1 (de)	2008-07-23
ATE425183T1 (de)	2009-03-15
US7745571B2 (en)	2010-06-29

Publication	Publication Date	Title
ATE425183T1 (de)	2009-03-15	P53-bindendes polypeptid
DE60233955D1 (de)	2009-11-19	Spezifische bindungsmittel von human angiopoietin-2
DK1353941T3 (da)	2013-06-17	Modificerede zinkfingerbindingsproteiner
MX2007001345A (es)	2008-03-11	Regiones variantes fc.
ATE485303T1 (de)	2010-11-15	Isoformen von gehirn-natriuretischem peptid
DK1534335T3 (da)	2012-02-13	FcgammaRIIB-specifikke antistoffer og fremgangsmåder til anvendelse deraf
PT1171465E (pt)	2004-12-31	Analogos de petido inibidor gastrico e sua utilizacao para o tratamento de diabetes
BRPI0418286A (pt)	2007-05-02	proteìnas de fusão de il-7
ATE542920T1 (de)	2012-02-15	Modifiziertes menschliches wachstumshormon
SG158141A1 (en)	2010-01-29	Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
ATE363531T1 (de)	2007-06-15	Claudin polypeptide
DE60332711D1 (de)	2010-07-08	Neue insektizide proteine von bazillus thuringiensis
CY1112875T1 (el)	2016-04-13	Sfrp και πεπτιδικα μοτιβα που διαντιδρουν με την sfrp και μεθοδοι χρησης τους
BR0308483B1 (pt)	2013-04-02	composto fenàlico e material de gravaÇço usando o mesmo.
DE602006007967D1 (de)	2009-09-03	Gegen das gemeinsame epitop von mutierten p53 gerichtete humane synthetische einzelkettenantikörper und anwendungen davon
ATE527280T1 (de)	2011-10-15	Fluoreszentprotein und chromoprotein
WO2004017992A3 (en)	2004-04-08	Ptk7 protein involvement in carcinoma
EA200400392A1 (ru)	2004-10-28	Связывающий каспазу-8 белок, его получение и применение
ATE325873T1 (de)	2006-06-15	Androgenrezeptor-komplex assoziiertes protein
ATE485831T1 (de)	2010-11-15	Behandlung von neurodegeneration
EA200500624A1 (ru)	2005-10-27	Промотор для il-18bp, его получение и применение
WO2003095484A3 (en)	2004-01-08	Polypeptides increasing p53 expression
WO2006003427A8 (en)	2006-03-09	A protein involved in carcinoma
DE60045078D1 (de)	2010-11-18	POLYNUKLEOTIDE, WELCHE FüR MITGLIEDER DER HUMANEN B LYMPHOZYTEN-AKTIVIERENDES ANTIGEN FAMILIE KODIEREN, UND VON DIESEN KODIERTE POLYPEPTIDE
ES1048858Y (es)	2002-02-16	Urna funeraria mejorada.