ATE425978T1 - Durch c-verbundene imidazole substituierte 1,8- annellierten chinolon-derivate als farnesyl transferase inhibitoren - Google Patents

Durch c-verbundene imidazole substituierte 1,8- annellierten chinolon-derivate als farnesyl transferase inhibitoren

Info

Publication number: ATE425978T1
Authority: AT; Austria
Prior art keywords: sup; annellated; farnesyl transferase; transferase inhibitors; derivatives substituted
Prior art date: 2001-12-19

Application number

AT02792974T

Other languages

English (en)

Inventor

Patrick Angibaud

Marc Venet

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-19

Filing date

2002-12-11

Publication date

2009-04-15

2002-12-11 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2009-04-15 Application granted granted Critical

2009-04-15 Publication of ATE425978T1 publication Critical patent/ATE425978T1/de

Links

150000002460 imidazoles Chemical class 0.000 title 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical group C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
102000007317 Farnesyltranstransferase Human genes 0.000 abstract 1
108010007508 Farnesyltranstransferase Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Epoxy Resins (AREA)

AT02792974T 2001-12-19 2002-12-11 Durch c-verbundene imidazole substituierte 1,8- annellierten chinolon-derivate als farnesyl transferase inhibitoren ATE425978T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01204989		2001-12-19

Publications (1)

Publication Number	Publication Date
ATE425978T1 true ATE425978T1 (de)	2009-04-15

Family

ID=8181465

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02792974T ATE425978T1 (de)	2001-12-19	2002-12-11	Durch c-verbundene imidazole substituierte 1,8- annellierten chinolon-derivate als farnesyl transferase inhibitoren

Country Status (9)

Country	Link
US (1)	US7408063B2 (de)
EP (1)	EP1458720B1 (de)
JP (1)	JP4537710B2 (de)
AT (1)	ATE425978T1 (de)
AU (1)	AU2002358677B2 (de)
CA (1)	CA2469275C (de)
DE (1)	DE60231646D1 (de)
ES (1)	ES2323265T3 (de)
WO (1)	WO2003051880A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102574843B (zh) *	2009-10-22	2015-06-17	法博太科制药有限公司	抗纤维化剂的稠环类似物
US9975906B2 (en) *	2014-05-16	2018-05-22	Shionogi & Co., Ltd.	Tricyclic heterocycle derivatives having HIV replication inhibitory effect

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW349948B (en)	1995-10-31	1999-01-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 2-quinolone derivatives
SK283335B6 (sk)	1995-12-08	2003-06-03	Janssen Pharmaceutica N. V.	(Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze
TW591030B (en) *	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
RU2205831C2 (ru) *	1997-04-25	2003-06-10	Янссен Фармацевтика Н.В.	Хиназолиноны, ингибирующие фарнезилтрансферазу
AU740603B2 (en)	1997-06-02	2001-11-08	Janssen Pharmaceutica N.V.	(imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation
HRP20000904A2 (en)	1998-07-06	2001-12-31	Janssen Pharmaceutica Nv	Farnesyl protein transferase inhibitors for treating arthropathies
ID26987A (id)	1998-07-06	2001-02-22	Janssen Pharmaceutica Nv	Inhibitor-inhibitor transferase protein farnesil dengan sifat-sifat peka terhadap sinar radiasi in vivo
ES2237125T3 (es)	1998-08-27	2005-07-16	Pfizer Products Inc.	Derivados de quinolin-2-ona utiles como agentes anticancerigenos.
ID27562A (id)	1998-08-27	2001-04-12	Pfizer Prod Inc	Turunan-turunan kinolin-2-ona tersubstitusi alkunil yang berguna sebagai zat anti kanker
ID29241A (id)	1998-12-23	2001-08-16	Janssen Pharmaceutica Nv	Turunan-turunan kinolin teranelasi-1,2
PL349839A1 (en)	1999-02-11	2002-09-23	Pfizer Prod Inc	Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
HN2000000266A (es)	2000-01-21	2001-05-21	Pfizer Prod Inc	Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
WO2001081316A2 (en) *	2000-04-27	2001-11-01	Abbott Laboratories	Substituted phenyl farnesyltransferase inhibitors

2002
- 2002-12-11 AT AT02792974T patent/ATE425978T1/de active
- 2002-12-11 JP JP2003552764A patent/JP4537710B2/ja not_active Expired - Fee Related
- 2002-12-11 CA CA2469275A patent/CA2469275C/en not_active Expired - Fee Related
- 2002-12-11 ES ES02792974T patent/ES2323265T3/es not_active Expired - Lifetime
- 2002-12-11 EP EP02792974A patent/EP1458720B1/de not_active Expired - Lifetime
- 2002-12-11 US US10/498,535 patent/US7408063B2/en not_active Expired - Lifetime
- 2002-12-11 WO PCT/EP2002/014089 patent/WO2003051880A1/en not_active Ceased
- 2002-12-11 AU AU2002358677A patent/AU2002358677B2/en not_active Ceased
- 2002-12-11 DE DE60231646T patent/DE60231646D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1458720A1 (de)	2004-09-22
JP4537710B2 (ja)	2010-09-08
JP2005511790A (ja)	2005-04-28
ES2323265T3 (es)	2009-07-10
WO2003051880A1 (en)	2003-06-26
CA2469275C (en)	2011-09-06
CA2469275A1 (en)	2003-06-26
EP1458720B1 (de)	2009-03-18
US20050176702A1 (en)	2005-08-11
US7408063B2 (en)	2008-08-05
AU2002358677A1 (en)	2003-06-30
AU2002358677B2 (en)	2008-02-07
DE60231646D1 (de)	2009-04-30

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2009-11-15

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