ATE426605T1 - Inhibitoren von mitotischem kinesin - Google Patents

Inhibitoren von mitotischem kinesin

Info

Publication number: ATE426605T1
Authority: AT; Austria
Prior art keywords: inhibitors; mitotic kinesin; compounds; ksp kinesin; treating
Prior art date: 2003-06-12

Application number

AT04776354T

Other languages

English (en)

Inventor

Paul Coleman

Lou Anne Neilson

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-12

Filing date

2004-06-08

Publication date

2009-04-15

2004-06-08 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2009-04-15 Application granted granted Critical

2009-04-15 Publication of ATE426605T1 publication Critical patent/ATE426605T1/de

Links

102000010638 Kinesin Human genes 0.000 title abstract 3
108010063296 Kinesin Proteins 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title 1
230000000394 mitotic effect Effects 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
-1 bicyclic dihydropyrrole compounds Chemical class 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT04776354T 2003-06-12 2004-06-08 Inhibitoren von mitotischem kinesin ATE426605T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US47797503P	2003-06-12	2003-06-12

Publications (1)

Publication Number	Publication Date
ATE426605T1 true ATE426605T1 (de)	2009-04-15

Family

ID=33539075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04776354T ATE426605T1 (de)	2003-06-12	2004-06-08	Inhibitoren von mitotischem kinesin

Country Status (9)

Country	Link
US (1)	US7427637B2 (de)
EP (1)	EP1635641B1 (de)
JP (1)	JP2007501863A (de)
CN (1)	CN100403900C (de)
AT (1)	ATE426605T1 (de)
AU (1)	AU2004249138B2 (de)
CA (1)	CA2527533A1 (de)
DE (1)	DE602004020221D1 (de)
WO (1)	WO2004112699A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7465746B2 (en) *	2003-08-15	2008-12-16	Merck & Co., Inc.	Fluorinated 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP
AR064106A1 (es) *	2006-12-05	2009-03-11	Bayer Schering Pharma Ag	Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis
WO2009052288A1 (en) *	2007-10-19	2009-04-23	Schering Corporation	Spiro-condensed 1, 3, 4-thiadiazole derivatives for inhibiting ksp kinesin activity
EP2507234B1 (de)	2009-11-30	2014-03-12	Novartis AG	Imidazolderivate als aldosteron-synthasehemmer
CN103068980B (zh)	2010-08-02	2017-04-05	瑟纳治疗公司	使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
JO3210B1 (ar)	2011-10-28	2018-03-08	Merck Sharp & Dohme	مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة
SMT201700595T1 (it)	2012-11-28	2018-03-08	Merck Sharp & Dohme	Composizioni e metodi per trattare il cancro
CA2990398A1 (en) *	2015-06-23	2016-12-29	Bayer Pharma Aktiengesellschaft	Antibody drug conjugates of kinesin spindel protein (ksp) inhibitors with anti-cd123-antibodies
JP7160833B2 (ja)	2017-04-13	2022-10-25	サイロパビー．ブイ．	抗ｓｉｒｐアルファ抗体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW224974B (de) *	1991-07-02	1994-06-11	Hoffmann La Roche
DE10004157A1 (de) *	2000-02-01	2001-08-02	Merckle Gmbh Chem Pharm Fabrik	4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
IL165624A0 (en)	2002-06-14	2006-01-15	Merck & Co Inc	Mitotic kinesin inhibitors

2004
- 2004-06-08 JP JP2006533604A patent/JP2007501863A/ja active Pending
- 2004-06-08 AU AU2004249138A patent/AU2004249138B2/en not_active Ceased
- 2004-06-08 DE DE602004020221T patent/DE602004020221D1/de not_active Expired - Lifetime
- 2004-06-08 US US10/559,855 patent/US7427637B2/en not_active Expired - Fee Related
- 2004-06-08 AT AT04776354T patent/ATE426605T1/de not_active IP Right Cessation
- 2004-06-08 CN CNB2004800164453A patent/CN100403900C/zh not_active Expired - Fee Related
- 2004-06-08 CA CA002527533A patent/CA2527533A1/en not_active Abandoned
- 2004-06-08 EP EP04776354A patent/EP1635641B1/de not_active Expired - Lifetime
- 2004-06-08 WO PCT/US2004/018137 patent/WO2004112699A2/en not_active Ceased

Also Published As

Publication number	Publication date
EP1635641A4 (de)	2006-12-20
WO2004112699A2 (en)	2004-12-29
EP1635641B1 (de)	2009-03-25
JP2007501863A (ja)	2007-02-01
US20060142278A1 (en)	2006-06-29
AU2004249138B2 (en)	2008-07-17
CN1805686A (zh)	2006-07-19
EP1635641A2 (de)	2006-03-22
WO2004112699A3 (en)	2005-04-14
US7427637B2 (en)	2008-09-23
AU2004249138A1 (en)	2004-12-29
CA2527533A1 (en)	2004-12-29
DE602004020221D1 (de)	2009-05-07
CN100403900C (zh)	2008-07-23

Legal Events

Date	Code	Title	Description
2009-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE446094T1 (de)	2009-11-15	Mitotische kinesin-hemmer
ATE421512T1 (de)	2009-02-15	Inhibitoren von mitotischem kinesin
ATE356804T1 (de)	2007-04-15	Inhibitoren von mitotischem kinesin
DE60222302D1 (de)	2007-10-18	Inhibitoren von mitotischem kinesin
ATE424388T1 (de)	2009-03-15	Mitotische kinesinhemmer
ATE447577T1 (de)	2009-11-15	Mitotische kinesin-hemmer
ATE448207T1 (de)	2009-11-15	Mitotische kinesin-hemmer
WO2005017190A3 (en)	2005-12-15	Mitotic kinesin inhibitors
WO2005018547A3 (en)	2005-09-15	Mitotic kinesin inhibitors
WO2004037171A3 (en)	2004-07-08	Mitotic kinesin inhibitors
WO2004039774A3 (en)	2004-07-01	Mitotic kinesin inhibitors
WO2003099211A3 (en)	2004-02-26	Mitotic kinesin inhibitors
WO2004058700A3 (en)	2004-10-14	Mitotic kinesin inhibitors
WO2004058148A3 (en)	2004-09-16	Mitotic kinesin inhibitors
WO2005060654A3 (en)	2005-12-08	Mitotic kinesin inhibitors
WO2005065183A3 (en)	2005-09-29	Mitotic kinesin inhibitors
PT2332940E (pt)	2013-01-30	Azaindoles úteis como inibidores de jak e outras proteínas quinases
NO20070589L (no)	2007-03-22	Mitotiske kinesin-inhibitorer.
DE602004020221D1 (de)	2009-05-07	Inhibitoren von mitotischem kinesin
WO2006007496A3 (en)	2006-10-05	Mitotic kinesin inhibitors
WO2006007501A3 (en)	2006-07-27	Mitotic kinesin inhibitors
WO2006023440A3 (en)	2007-03-15	Mitotic kinesin inhibitors
WO2004087050A3 (en)	2005-03-24	Mitotic kinesin inhibitors