ATE426662T1 - Feedback resistante mevalonate kinase - Google Patents

Feedback resistante mevalonate kinase

Info

Publication number: ATE426662T1
Authority: AT; Austria
Prior art keywords: mevalonate kinase; feedback resistant; resistant mevalonate; vectors; producing
Prior art date: 2003-06-12

Application number

AT04736497T

Other languages

English (en)

Inventor

Renyunan Bai

Mbelin Markus H

Martin Lehmann

Rual Lopez-Ulibarri

Markus Wyss

Original Assignee

Dsm Ip Assets Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-12

Filing date

2004-06-10

Publication date

2009-04-15

2004-06-10 Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv

2009-04-15 Application granted granted Critical

2009-04-15 Publication of ATE426662T1 publication Critical patent/ATE426662T1/de

Links

108700040132 Mevalonate kinases Proteins 0.000 title abstract 2
102000002678 mevalonate kinase Human genes 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
102000040430 polynucleotide Human genes 0.000 abstract 2
108091033319 polynucleotide Proteins 0.000 abstract 2
239000002157 polynucleotide Substances 0.000 abstract 2
239000013598 vector Substances 0.000 abstract 2
KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical class OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
-1 isoprenoid compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT04736497T 2003-06-12 2004-06-10 Feedback resistante mevalonate kinase ATE426662T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03012294		2003-06-12

Publications (1)

Publication Number	Publication Date
ATE426662T1 true ATE426662T1 (de)	2009-04-15

Family

ID=33547583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04736497T ATE426662T1 (de)	2003-06-12	2004-06-10	Feedback resistante mevalonate kinase

Country Status (9)

Country	Link
US (1)	US7422884B2 (de)
EP (1)	EP1631664B1 (de)
JP (1)	JP4643569B2 (de)
KR (1)	KR101190897B1 (de)
CN (1)	CN1806042B (de)
AT (1)	ATE426662T1 (de)
DE (1)	DE602004020218D1 (de)
ES (1)	ES2323175T3 (de)
WO (1)	WO2004111214A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1824969B1 (de) *	2004-12-14	2011-03-02	DSM IP Assets B.V.	Verbesserte mevalonatkinase
CN103589650A (zh)	2005-03-18	2014-02-19	米克罗比亚公司	产油酵母和真菌中类胡萝卜素的产生
DK2066778T3 (en)	2006-09-26	2016-04-18	Amyris Biotechnologies Inc	PREPARATION OF ISOPRENOIDS AND ISOPRENOID PRECURSORS
WO2008042338A2 (en)	2006-09-28	2008-04-10	Microbia, Inc.	Production of carotenoids in oleaginous yeast and fungi
JP2009000046A (ja) *	2007-06-21	2009-01-08	Hitachi Zosen Corp	トチュウのメバロン酸経路の酵素をコードする遺伝子
AU2008334945C1 (en)	2007-12-13	2013-09-05	Danisco Us Inc.	Compositions and methods for producing isoprene
AU2009240505B2 (en)	2008-04-23	2013-09-05	Danisco Us Inc.	Isoprene synthase variants for improved microbial production of isoprene
EP2157174A1 (de)	2008-08-12	2010-02-24	DSM IP Assets B.V.	Erhöhte Produktion von Pantothenate (Vitamin B5)
CA2737158A1 (en)	2008-09-15	2010-03-18	Danisco Us Inc.	Increased isoprene production using the archaeal lower mevalonate pathway
AU2010238770A1 (en)	2009-04-23	2011-11-03	Danisco Us Inc.	Three-dimensional structure of isoprene synthase and its use thereof for generating variants
EP2336310A1 (de)	2009-12-16	2011-06-22	Isobionics B.V.	Valencensynthase
CN105671108A (zh)	2010-06-02	2016-06-15	沃维公司	甜菊糖苷的重组生产
WO2012014228A1 (en)	2010-07-28	2012-02-02	Abhishek Narain Singh	A method to by-pass allosteric domain activity of an enzyme so as to alter its feedback or feed-forward inhibition or activation
WO2012019169A1 (en) *	2010-08-06	2012-02-09	Danisco Us Inc.	Production of isoprene under neutral ph conditions
CA2816306A1 (en)	2010-10-27	2012-05-03	Danisco Us Inc.	Isoprene synthase variants for improved production of isoprene
EP2537926A1 (de)	2011-06-21	2012-12-26	Isobionics B.V.	Valencensynthase
WO2012175574A1 (en)	2011-06-21	2012-12-27	Dsm Ip Assets B.V.	Increased pantothenate (vitamin b5) production
WO2012175575A2 (en)	2011-06-21	2012-12-27	Dsm Ip Assets B.V.	Increased vitamin b5 production
US8951764B2 (en)	2011-08-05	2015-02-10	Danisco Us Inc.	Production of isoprenoids under neutral pH conditions
CN108396044A (zh)	2011-08-08	2018-08-14	埃沃尔瓦公司	甜菊醇糖苷类的重组生产
CN103205432B (zh) *	2012-01-11	2015-06-10	安徽医科大学第一附属医院	弥散型浅表性光线性汗孔角化症(dsap)相关基因
US9163263B2 (en)	2012-05-02	2015-10-20	The Goodyear Tire & Rubber Company	Identification of isoprene synthase variants with improved properties for the production of isoprene
SG11201505597SA (en)	2013-02-06	2015-08-28	Evolva Sa	Methods for improved production of rebaudioside d and rebaudioside m
CA2900882A1 (en)	2013-02-11	2014-08-14	Evolva Sa	Efficient production of steviol glycosides in recombinants hosts
RU2014112066A (ru)	2014-03-28	2015-10-10	Адзиномото Ко., Инк.	Способ получения мономерного изопрена
AU2015303294A1 (en)	2014-08-11	2017-02-02	Evolva Sa.	Production of steviol glycosides in recombinant hosts
AU2015314251A1 (en)	2014-09-09	2017-03-16	Evolva Sa	Production of steviol glycosides in recombinant hosts
SG11201705606PA (en)	2015-01-30	2017-08-30	Evolva Sa	Production of steviol glycosides in recombinant hosts
CA2979931A1 (en)	2015-03-16	2016-09-22	Dsm Ip Assets B.V.	Udp-glycosyltransferases
AU2016307066A1 (en)	2015-08-07	2018-02-08	Evolva Sa	Production of steviol glycosides in recombinant hosts
US10982249B2 (en)	2016-04-13	2021-04-20	Evolva Sa	Production of steviol glycosides in recombinant hosts
WO2017198682A1 (en)	2016-05-16	2017-11-23	Evolva Sa	Production of steviol glycosides in recombinant hosts
US11396669B2 (en)	2016-11-07	2022-07-26	Evolva Sa	Production of steviol glycosides in recombinant hosts
NL2018457B1 (en)	2017-03-02	2018-09-21	Isobionics B V	Santalene Synthase
NL2019473B1 (en)	2017-09-01	2019-03-11	Isobionics B V	Terpene Synthase producing patchoulol and elemol, and preferably also pogostol
KR102092075B1 (ko) *	2017-10-27	2020-03-23	경상대학교산학협력단	MmMVK-메발론산 복합체의 3차원 결정 구조 및 기질저해 저항성 돌연변이 메발론산 인산화효소
CA3084263A1 (en)	2017-12-07	2019-06-13	Zymergen Inc.	Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
BR112020012704A8 (pt)	2017-12-21	2022-03-03	Zymergen Inc	Nepetalactol oxidorredutases, nepetalactol sintases, e micróbios capazes de produzir nepetalactona

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI250210B (en) *	1998-05-06	2006-03-01	Dsm Ip Assets Bv	An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
DE60228439D1 (de) *	2001-06-06	2008-10-02	Dsm Ip Assets Bv	Verbesserte isoprenoid herstellung

2004
- 2004-06-10 DE DE602004020218T patent/DE602004020218D1/de not_active Expired - Lifetime
- 2004-06-10 EP EP04736497A patent/EP1631664B1/de not_active Expired - Lifetime
- 2004-06-10 KR KR1020057023857A patent/KR101190897B1/ko not_active Expired - Fee Related
- 2004-06-10 ES ES04736497T patent/ES2323175T3/es not_active Expired - Lifetime
- 2004-06-10 WO PCT/CH2004/000353 patent/WO2004111214A1/en not_active Ceased
- 2004-06-10 JP JP2006515622A patent/JP4643569B2/ja not_active Expired - Fee Related
- 2004-06-10 AT AT04736497T patent/ATE426662T1/de not_active IP Right Cessation
- 2004-06-10 CN CN2004800163840A patent/CN1806042B/zh not_active Expired - Fee Related
- 2004-06-10 US US10/560,726 patent/US7422884B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2323175T3 (es)	2009-07-08
KR101190897B1 (ko)	2012-10-12
DE602004020218D1 (de)	2009-05-07
CN1806042B (zh)	2012-07-04
EP1631664B1 (de)	2009-03-25
KR20060022692A (ko)	2006-03-10
JP2007523612A (ja)	2007-08-23
CN1806042A (zh)	2006-07-19
US7422884B2 (en)	2008-09-09
US20070141685A1 (en)	2007-06-21
JP4643569B2 (ja)	2011-03-02
EP1631664A1 (de)	2006-03-08
WO2004111214A1 (en)	2004-12-23

Legal Events

Date	Code	Title	Description
2009-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE426662T1 (de)	2009-04-15	Feedback resistante mevalonate kinase
ATE500321T1 (de)	2011-03-15	Verbesserte mevalonatkinase
WO2003081210A3 (en)	2007-07-26	Identification of kinase inhibitors
WO2008033408A3 (en)	2008-12-11	Methods for identifying compounds that modulate cell signaling and methods employing such compounds
AU2003255779A1 (en)	2004-02-25	1h-indazole-3-carboxamide compounds as cyclin dependent kinases (cdk) inhibitors
NO20066050L (no)	2007-02-05	Substituerte indazoler, sammensetninger inneholdende disse samt fremstilling og anvendelse derav
CY1118330T1 (el)	2017-06-28	Δι-αρυλ μετα-πυριμιδινο αναστολεις κινασων
WO2002044331A3 (en)	2003-09-04	Dap-kinase and hoxa9, two human genes associated with genesis, progression, and aggressiveness of non-small cell lung cancer
IS7504A (is)	2004-10-14	Arýl keton pýrróló-tríazín efnasambönd gagnleg sem kínasatálmar
TW200720257A (en)	2007-06-01	Pyrimidine compounds and methods of use
ATE354573T1 (de)	2007-03-15	ßPYRAZOLVERBINDUNGEN, DIE SICH ALS PROTEINKINASEINHIBITOREN EIGNENß
BR0315233A (pt)	2005-08-23	Derivados de azaindol como inibidores de p38 cinase
NO20052887D0 (no)	2005-06-14	Pyridazinonderivater som GSK-3Beta inhibitorer.
TW200731094A (en)	2007-08-16	Extensible meta-data
DE60323749D1 (de)	2008-11-06	Substituierte pyrroline als kinase inhibitoren
PH12012502411A1 (en)	2019-07-17	Method of modulating stress-activated protein kinase system
PL1648905T3 (pl)	2009-07-31	Tienopirydynowe i furopirydynowe inhibitory kinazy
CY1108092T1 (el)	2014-02-12	Ενωσεις και μεθοδοι για την αναστολη της μιτωτικης προοδου με την αναστολη της κινασης aurora
MXPA06003297A (es)	2006-06-08	Metodo de servicio de certificacion segura.
PL1682530T3 (pl)	2007-09-28	Podstawione pirolo-indole jako inhibitory PAI-1
ATE404574T1 (de)	2008-08-15	Verfahren zur inhibierung der proliferation von tumorzellen, bei dem platinkomplexe eingesetzt werden
EP1560120A4 (de)	2008-10-29	Zugriffsverfahren
WO2009054939A3 (en)	2009-06-25	Cancer classification and methods of use
WO2001096606A3 (en)	2003-12-04	Identification of genes and compounds for treatment of cancer
BRPI0512547A (pt)	2008-03-25	pirimidinas