ATE361922T1 - Pyrrol-substituierte indole als inhibitoren von pai-1 - Google Patents
Pyrrol-substituierte indole als inhibitoren von pai-1Info
- Publication number
- ATE361922T1 ATE361922T1 AT04784989T AT04784989T ATE361922T1 AT E361922 T1 ATE361922 T1 AT E361922T1 AT 04784989 T AT04784989 T AT 04784989T AT 04784989 T AT04784989 T AT 04784989T AT E361922 T1 ATE361922 T1 AT E361922T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrole
- pai
- inhibitors
- substituted indoles
- indoles
- Prior art date
Links
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 title 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- UVVVFGSFGDHACP-UHFFFAOYSA-N 1h-indole;1h-pyrrole Chemical class C=1C=CNC=1.C1=CC=C2NC=CC2=C1 UVVVFGSFGDHACP-UHFFFAOYSA-N 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50582103P | 2003-09-25 | 2003-09-25 | |
| US10/947,727 US7265148B2 (en) | 2003-09-25 | 2004-09-23 | Substituted pyrrole-indoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE361922T1 true ATE361922T1 (de) | 2007-06-15 |
Family
ID=34396270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04784989T ATE361922T1 (de) | 2003-09-25 | 2004-09-24 | Pyrrol-substituierte indole als inhibitoren von pai-1 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7265148B2 (de) |
| EP (1) | EP1682530B1 (de) |
| JP (1) | JP2007506762A (de) |
| AT (1) | ATE361922T1 (de) |
| AU (1) | AU2004276311A1 (de) |
| BR (1) | BRPI0414599A (de) |
| CA (1) | CA2538355A1 (de) |
| DE (1) | DE602004006433T2 (de) |
| DK (1) | DK1682530T3 (de) |
| ES (1) | ES2285523T3 (de) |
| MX (1) | MXPA06003245A (de) |
| PL (1) | PL1682530T3 (de) |
| WO (1) | WO2005030756A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60221391T2 (de) | 2001-06-20 | 2008-04-17 | Wyeth | Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) |
| TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| CA2509191A1 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| BR0316574A (pt) * | 2002-12-10 | 2005-10-04 | Wyeth Corp | Derivados de ácido acético 3-carbonil-1h-indol-1-il substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1) |
| DK1569899T3 (da) * | 2002-12-10 | 2006-10-23 | Wyeth Corp | Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1) |
| US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7268159B2 (en) * | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| JP2008510814A (ja) * | 2004-08-23 | 2008-04-10 | ワイス | Ｐａｉ−１阻害剤としてのピロロ−ナフチル酸 |
| CA2577846A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
| US7754747B2 (en) * | 2004-08-23 | 2010-07-13 | Wyeth Llc | Oxazolo-naphthyl acids |
| US20060211754A1 (en) * | 2005-03-16 | 2006-09-21 | Yu Ruey J | Compositions comprising N-propanoyl derivatives of amino acids, aminocarbohydrates and derivatives thereof |
| MX2007016541A (es) * | 2005-06-30 | 2008-03-07 | Smithkline Beecham Corp | Compuestos quimicos. |
| EP1919866A2 (de) * | 2005-08-17 | 2008-05-14 | Wyeth a Corporation of the State of Delaware | Substituierte indole und deren verwendung |
| UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
| EP2010171A2 (de) * | 2006-02-27 | 2009-01-07 | Wyeth a Corporation of the State of Delaware | Pai-1-hemmer zur behandlung von muskelerkrankungen |
| WO2008044729A1 (fr) | 2006-10-12 | 2008-04-17 | Institute Of Medicinal Molecular Design. Inc. | Dérivé d'acide carboxylique |
| AU2007307599A1 (en) | 2006-10-12 | 2008-04-17 | Institute Of Medicinal Molecular Design. Inc. | N-phenyloxamic acid derivatives |
| RU2010120675A (ru) | 2007-10-23 | 2011-11-27 | Инститьют Оф Медисинал Молекьюлар Дизайн, Инк. (Jp) | Ингибитор продуцирования pai-1 |
| US8633245B2 (en) * | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
| CN102766083B (zh) * | 2011-05-03 | 2014-10-22 | 中国科学院上海有机化学研究所 | 2-氨基-3-全氟乙酰吲哚类化合物及其衍生物、制备方法和应用 |
| KR102261104B1 (ko) * | 2012-12-26 | 2021-06-04 | 에스에프씨 주식회사 | 유기발광 화합물 및 이를 포함하는 유기전계발광소자 |
| WO2014143125A1 (en) | 2013-03-13 | 2014-09-18 | Alevere Medical Corporation | Use of indole compounds for fat reduction and skin and soft tissue tightening |
| WO2015061280A1 (en) | 2013-10-21 | 2015-04-30 | Alevere Medical Corporation | Fused heterocyclic organic compounds, pharmaceutical compositions, and medical uses thereof |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
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| TW591020B (en) | 2001-06-20 | 2004-06-11 | Wyeth Corp | 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| DE60221391T2 (de) | 2001-06-20 | 2008-04-17 | Wyeth | Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) |
| TWI240723B (en) | 2001-06-20 | 2005-10-01 | Wyeth Corp | Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
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| KR100810468B1 (ko) | 2001-10-10 | 2008-03-07 | 씨제이제일제당 (주) | 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난1ｈ-인돌 유도체 |
| CN1915991B (zh) | 2002-02-12 | 2010-05-26 | 威斯康星校友研究基金会 | 用于ah受体作为配体的吲哚噻唑化合物的合成 |
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| CA2509191A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
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| BR0316574A (pt) | 2002-12-10 | 2005-10-04 | Wyeth Corp | Derivados de ácido acético 3-carbonil-1h-indol-1-il substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1) |
| DK1569899T3 (da) | 2002-12-10 | 2006-10-23 | Wyeth Corp | Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1) |
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| US20050215626A1 (en) | 2003-09-25 | 2005-09-29 | Wyeth | Substituted benzofuran oximes |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
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| US7411083B2 (en) * | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
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-
2004
- 2004-09-23 US US10/947,727 patent/US7265148B2/en not_active Expired - Fee Related
- 2004-09-24 DE DE602004006433T patent/DE602004006433T2/de not_active Expired - Fee Related
- 2004-09-24 EP EP04784989A patent/EP1682530B1/de not_active Expired - Lifetime
- 2004-09-24 BR BRPI0414599-2A patent/BRPI0414599A/pt not_active IP Right Cessation
- 2004-09-24 AT AT04784989T patent/ATE361922T1/de not_active IP Right Cessation
- 2004-09-24 JP JP2006528219A patent/JP2007506762A/ja active Pending
- 2004-09-24 CA CA002538355A patent/CA2538355A1/en not_active Abandoned
- 2004-09-24 DK DK04784989T patent/DK1682530T3/da active
- 2004-09-24 ES ES04784989T patent/ES2285523T3/es not_active Expired - Lifetime
- 2004-09-24 MX MXPA06003245A patent/MXPA06003245A/es not_active Application Discontinuation
- 2004-09-24 AU AU2004276311A patent/AU2004276311A1/en not_active Abandoned
- 2004-09-24 WO PCT/US2004/031395 patent/WO2005030756A1/en not_active Ceased
- 2004-09-24 PL PL04784989T patent/PL1682530T3/pl unknown
-
2007
- 2007-07-27 US US11/881,514 patent/US20070299126A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050113439A1 (en) | 2005-05-26 |
| PL1682530T3 (pl) | 2007-09-28 |
| JP2007506762A (ja) | 2007-03-22 |
| WO2005030756A1 (en) | 2005-04-07 |
| ES2285523T3 (es) | 2007-11-16 |
| BRPI0414599A (pt) | 2006-11-07 |
| DK1682530T3 (da) | 2007-07-16 |
| US7265148B2 (en) | 2007-09-04 |
| CA2538355A1 (en) | 2005-04-07 |
| AU2004276311A1 (en) | 2005-04-07 |
| DE602004006433T2 (de) | 2008-01-10 |
| DE602004006433D1 (de) | 2007-06-21 |
| EP1682530B1 (de) | 2007-05-09 |
| MXPA06003245A (es) | 2006-05-22 |
| EP1682530A1 (de) | 2006-07-26 |
| US20070299126A1 (en) | 2007-12-27 |
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