ATE427951T1 - Diazinopyrimidine und ihre verwendung als proteinkinaseinhibitoren - Google Patents

Diazinopyrimidine und ihre verwendung als proteinkinaseinhibitoren

Info

Publication number: ATE427951T1
Authority: AT; Austria
Prior art keywords: sup; alkyl; hydrogen; cycloalkyl; haloalkyl
Prior art date: 2002-11-18

Application number

AT03775346T

Other languages

English (en)

Inventor

Jian Chen

Kin-Chun Luk

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-18

Filing date

2003-11-12

Publication date

2009-04-15

2003-11-12 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2009-04-15 Application granted granted Critical

2009-04-15 Publication of ATE427951T1 publication Critical patent/ATE427951T1/de

Links

229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
239000003909 protein kinase inhibitor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
125000001188 haloalkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000004966 cyanoalkyl group Chemical group 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
125000004404 heteroalkyl group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
239000012826 P38 inhibitor Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Tropical Medicine & Parasitology (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
AIDS & HIV (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)

AT03775346T 2002-11-18 2003-11-12 Diazinopyrimidine und ihre verwendung als proteinkinaseinhibitoren ATE427951T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US42765202P	2002-11-18	2002-11-18

Publications (1)

Publication Number	Publication Date
ATE427951T1 true ATE427951T1 (de)	2009-04-15

Family

ID=32326577

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03775346T ATE427951T1 (de)	2002-11-18	2003-11-12	Diazinopyrimidine und ihre verwendung als proteinkinaseinhibitoren

Country Status (14)

Country	Link
US (2)	US6943158B2 (de)
EP (1)	EP1565475B1 (de)
JP (1)	JP2006514624A (de)
KR (1)	KR20050075028A (de)
CN (1)	CN100357293C (de)
AT (1)	ATE427951T1 (de)
AU (1)	AU2003283393A1 (de)
BR (1)	BR0316375A (de)
CA (1)	CA2506565A1 (de)
DE (1)	DE60327097D1 (de)
MX (1)	MXPA05005028A (de)
PL (1)	PL377620A1 (de)
RU (1)	RU2340618C2 (de)
WO (1)	WO2004046152A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7846915B2 (en) *	2004-10-20	2010-12-07	Resverlogix Corporation	Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
WO2007016525A2 (en)	2005-07-29	2007-02-08	Resverlogix Corp.	Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US20090192164A1 (en) *	2006-06-28	2009-07-30	Aska Pharmaceutical Co., Ltd.	Treating agent of inflammatory bowel disease
EP1918284A1 (de) *	2006-10-30	2008-05-07	Glaxo Group	Hydrazinopyrimidine als Cysteine Protease Inhibitoren
PT2118074E (pt)	2007-02-01	2014-03-20	Resverlogix Corp	Compostos para a prevenção e tratamento de doenças cardiovasculares
US8114995B2 (en)	2008-06-26	2012-02-14	Resverlogix Corp.	Methods of preparing quinazolinone derivatives
DE102008063561A1 (de) *	2008-12-18	2010-08-19	Bayer Cropscience Ag	Hydrazide, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Insektizide
ES2542835T3 (es)	2009-01-08	2015-08-12	Resverlogix Corporation	Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
US20120189641A1 (en)	2009-02-25	2012-07-26	OSI Pharmaceuticals, LLC	Combination anti-cancer therapy
WO2010099138A2 (en)	2009-02-27	2010-09-02	Osi Pharmaceuticals, Inc.	Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US8642834B2 (en)	2009-02-27	2014-02-04	OSI Pharmaceuticals, LLC	Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
JP2012519282A (ja)	2009-02-27	2012-08-23	オーエスアイ・ファーマシューティカルズ，エルエルシー	間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
NZ617779A (en)	2009-03-18	2015-08-28	Resverlogix Corp	Novel anti-inflammatory agents
US9757368B2 (en)	2009-04-22	2017-09-12	Resverlogix Corp.	Anti-inflammatory agents
WO2012088266A2 (en)	2010-12-22	2012-06-28	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
JP2014519813A (ja)	2011-04-25	2014-08-21	オーエスアイ・ファーマシューティカルズ，エルエルシー	癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用
PT2773354T (pt)	2011-11-01	2019-07-17	Resverlogix Corp	Formulações orais de libertação imediata para quinazolinonas substituídas
WO2013152252A1 (en)	2012-04-06	2013-10-10	OSI Pharmaceuticals, LLC	Combination anti-cancer therapy
CA2876689C (en)	2012-06-13	2022-04-26	Incyte Corporation	Substituted tricyclic compounds as fgfr inhibitors
US9388185B2 (en)	2012-08-10	2016-07-12	Incyte Holdings Corporation	Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9765039B2 (en)	2012-11-21	2017-09-19	Zenith Epigenetics Ltd.	Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en)	2012-11-21	2015-07-07	Zenith Epigenetics Corp.	Cyclic amines as bromodomain inhibitors
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
JP2016507496A (ja)	2012-12-21	2016-03-10	ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈＥｐｉｇｅｎｅｔｉｃｓＣｏｒｐ．	ブロモドメイン阻害剤としての新規複素環式化合物
PH12015502383B1 (en) *	2013-04-19	2023-02-03	Incyte Holdings Corp	Bicyclic heterocycles as fgfr inhibitors
CN103757026B (zh)	2013-12-20	2017-04-05	广州圣露生物技术有限公司	FGFR2b胞外段的基因序列、多肽及其应用
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
CA2976790C (en)	2015-02-20	2024-02-27	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US9580423B2 (en)	2015-02-20	2017-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
CN114984016A (zh)	2015-03-13	2022-09-02	雷斯韦洛吉克斯公司	用于治疗补体相关疾病之组合物及治疗方法
US20190060286A1 (en)	2016-02-29	2019-02-28	University Of Florida Research Foundation, Incorpo	Chemotherapeutic Methods
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
ES2927715T3 (es)	2017-10-05	2022-11-10	Fulcrum Therapeutics Inc	Inhibidores de la quinasa p38 reducen la expresión de dux4 y de los genes que le siguen para el tratamiento de la FSHD
RS66310B1 (sr)	2018-05-04	2025-01-31	Incyte Corp	Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu
KR102956194B1 (ko)	2018-05-04	2026-04-23	인사이트 코포레이션	Fgfr 억제제의 염
WO2020185532A1 (en)	2019-03-08	2020-09-17	Incyte Corporation	Methods of treating cancer with an fgfr inhibitor
WO2021007269A1 (en)	2019-07-09	2021-01-14	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
US12122767B2 (en)	2019-10-01	2024-10-22	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
GEP20247679B (en)	2019-10-14	2024-10-10	Incyte Corp	Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en)	2019-10-16	2023-01-31	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
MX2022006691A (es)	2019-12-04	2022-09-19	Incyte Corp	Derivados de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr).
WO2021113479A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en)	2020-01-15	2024-06-18	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
EP4323405A1 (de)	2021-04-12	2024-02-21	Incyte Corporation	Kombinationstherapie mit einem fgfr-inhibitor und einem auf nectin-4 abzielenden mittel
CA3220274A1 (en)	2021-06-09	2022-12-15	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
TW202313610A (zh)	2021-06-09	2023-04-01	美商英塞特公司	作為ｆｇｆｒ抑制劑之三環雜環

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1353534A (en)	1971-07-13	1974-05-22	Roche Products Ltd	Pyrimidotriazines and a process for the manufacture thereof
US4025510A (en) *	1975-12-01	1977-05-24	E. I. Du Pont De Nemours And Company	2,4-Diaryl[1,3,4H]thiadiazines fused to quinoxalines
DE60033307T2 (de) *	1999-10-21	2007-07-12	F. Hoffmann-La Roche Ag	Heteroalkylamino-substituierte bicyclische stickstoffheterocyclen als p38-proteinkinase-inhibitoren
KR100571339B1 (ko) *	2000-08-31	2006-04-17	에프. 호프만-라 로슈 아게	세포증식 억제제로서의 7-옥소 피리도피리미딘
US6642381B2 (en) *	2001-12-27	2003-11-04	Hoffman-La Roche Inc.	Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors

2003
- 2003-11-12 PL PL377620A patent/PL377620A1/pl not_active Application Discontinuation
- 2003-11-12 BR BR0316375-0A patent/BR0316375A/pt not_active IP Right Cessation
- 2003-11-12 DE DE60327097T patent/DE60327097D1/de not_active Expired - Fee Related
- 2003-11-12 KR KR1020057008919A patent/KR20050075028A/ko not_active Ceased
- 2003-11-12 CA CA002506565A patent/CA2506565A1/en not_active Abandoned
- 2003-11-12 CN CNB2003801035760A patent/CN100357293C/zh not_active Expired - Fee Related
- 2003-11-12 EP EP03775346A patent/EP1565475B1/de not_active Expired - Lifetime
- 2003-11-12 WO PCT/EP2003/012652 patent/WO2004046152A1/en not_active Ceased
- 2003-11-12 RU RU2005119281/04A patent/RU2340618C2/ru not_active IP Right Cessation
- 2003-11-12 MX MXPA05005028A patent/MXPA05005028A/es active IP Right Grant
- 2003-11-12 AU AU2003283393A patent/AU2003283393A1/en not_active Abandoned
- 2003-11-12 AT AT03775346T patent/ATE427951T1/de not_active IP Right Cessation
- 2003-11-12 JP JP2004552580A patent/JP2006514624A/ja active Pending
- 2003-11-18 US US10/715,666 patent/US6943158B2/en not_active Expired - Fee Related
2005
- 2005-07-27 US US11/190,292 patent/US20050261284A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20040097493A1 (en)	2004-05-20
CN100357293C (zh)	2007-12-26
EP1565475B1 (de)	2009-04-08
DE60327097D1 (de)	2009-05-20
RU2340618C2 (ru)	2008-12-10
US6943158B2 (en)	2005-09-13
AU2003283393A1 (en)	2004-06-15
WO2004046152A1 (en)	2004-06-03
CN1714093A (zh)	2005-12-28
BR0316375A (pt)	2005-10-04
KR20050075028A (ko)	2005-07-19
RU2005119281A (ru)	2006-03-20
MXPA05005028A (es)	2005-08-03
PL377620A1 (pl)	2006-02-06
US20050261284A1 (en)	2005-11-24
JP2006514624A (ja)	2006-05-11
CA2506565A1 (en)	2004-06-03
EP1565475A1 (de)	2005-08-24

Legal Events

Date	Code	Title	Description
2009-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60327097D1 (de)	2009-05-20	Diazinopyrimidine und ihre verwendung als proteinkinaseinhibitoren
AR040787A1 (es)	2005-04-20	6-alcoxi-piridopirimidinas
ATE265432T1 (de)	2004-05-15	3-amino-5-carboxy-substituierte piperidine und 3- amino-4-carboxy-substituierte pyrrolidine als tachykinin-antagonisten
DE60023318D1 (de)	2006-03-02	Heteropolycyclische verbindungen und ihre verwendung als antagonisten von metabotropen glutamatrezeptoren
NZ509939A (en)	2002-08-28	1H-imidazopyridine derivatives useful as TNF or IL-1 inhibitors
PT1022272E (pt)	2004-08-31	Compostos heterociclicos fundidos substituidos
NZ509045A (en)	2002-09-27	Intermediates in the formation of antivirally active heterocyclic azahexane derivatives
EA200600509A1 (ru)	2006-08-25	Соединения пиримидотиофена
DK0873123T3 (da)	2003-08-04	Inhibitorer af protein-isoprenyltransferaser
DE60129806D1 (de)	2007-09-20	Neue bizyklische verbindungen
ATE206412T1 (de)	2001-10-15	Heterocyclische verbindungen als bradykinin antagonisten
PE20010306A1 (es)	2001-03-29	Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
RU2010154425A (ru)	2012-07-20	Новое урациловое соединение или его соль, обладающие ингибирующей активностью относительно дезоксиуридинтрифосфатазы человека
DK0976748T3 (da)	2004-03-22	Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet
KR970705545A (ko)	1997-10-09	복소환 유도체 및 의약(heterocyclic derivative and medicine)
KR960702444A (ko)	1996-04-27	3-아미노아제핀 화합물 및 그 의약 용도(3-aminoazepine compound and pharmaceutical use thereof)
ATE291018T1 (de)	2005-04-15	Pyrazol verbindungen und ihre verwendung
ATE307812T1 (de)	2005-11-15	Imidazopyridinverbindungen als 5-ht4- rezeptormodulatoren
KR900004693A (ko)	1990-04-12	피리딘 화합물 및 그의 약제학적 용도
YU69699A (sh)	2001-12-26	Derivati aril karbonske kiseline i tetrazola
AU2003268526A8 (en)	2004-03-29	Adenosine a3 receptor agonists
EP0889034A4 (de)	2001-06-06	Aminopyridin-derivate
MY134226A (en)	2007-11-30	1,2-dihydropyrazol-3-ones which control inflammatory cyctokines
SE8602449D0 (sv)	1986-05-29	11-beta substituted steroids and process for their preparation
ATE278678T1 (de)	2004-10-15	Substituierte 1-aza-2-imino-heterocyclen und ihre verwendung als aktivatoren der nikotinergen acetylcholinrezeptoren