ATE428692T1 - 24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen - Google Patents

24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen

Info

Publication number: ATE428692T1
Authority: AT; Austria
Prior art keywords: alpha; dihydroxy vitamin; analogue; compounds; sulfur substituted
Prior art date: 2001-08-22

Application number

AT02752924T

Other languages

English (en)

Inventor

Gary Posner

Kenneth Crawford

Hong Yang

Jay White

Glenville Jones

Byung-Chul Suh

Heungbae Jeon

Mark Hatcher

Original Assignee

Univ Johns Hopkins

Cytochroma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-22

Filing date

2002-08-22

Publication date

2009-05-15

2002-08-22 Application filed by Univ Johns Hopkins, Cytochroma Inc filed Critical Univ Johns Hopkins

2009-05-15 Application granted granted Critical

2009-05-15 Publication of ATE428692T1 publication Critical patent/ATE428692T1/de

Links

GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 title abstract 3
229910052717 sulfur Inorganic materials 0.000 title 1
239000011593 sulfur Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 2
235000020964 calcitriol Nutrition 0.000 abstract 2
239000011612 calcitriol Substances 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
102100027518 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Human genes 0.000 abstract 1
101000861278 Homo sapiens 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Proteins 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02752924T 2001-08-22 2002-08-22 24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen ATE428692T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US31376901P	2001-08-22	2001-08-22
US32842901P	2001-10-12	2001-10-12
US38793102P	2002-06-13	2002-06-13
PCT/CA2002/001294 WO2003018545A1 (en)	2001-08-22	2002-08-22	24-sulfur-substituted analogs of 1α,25-dihydroxy vitamin d¿3?

Publications (1)

Publication Number	Publication Date
ATE428692T1 true ATE428692T1 (de)	2009-05-15

Family

ID=27405675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02752924T ATE428692T1 (de)	2001-08-22	2002-08-22	24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen

Country Status (6)

Country	Link
EP (1)	EP1419143B1 (de)
JP (1)	JP2005500402A (de)
AT (1)	ATE428692T1 (de)
CA (1)	CA2458415C (de)
DE (1)	DE60231987D1 (de)
WO (1)	WO2003018545A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1781302A4 (de) *	2004-07-28	2010-02-17	Lipopeptide Ab	Neue verwendung
WO2006037023A2 (en) *	2004-09-24	2006-04-06	Sapphire Therapeutics, Inc.	Use of inhibitors of 24-hydroxylase in the treatment of cancer
US20060078494A1 (en) *	2004-09-24	2006-04-13	Sapphire Therapeutics, Inc.	Use of inhibitors of 24-hydroxylase in the treatment of cancer
US9481646B2 (en) *	2007-04-18	2016-11-01	The Johns Hopkins University	Low calcemic, highly antiproliferative, analogs of calcitriol
WO2025094144A1 (en)	2023-11-02	2025-05-08	Eirgen Pharma Ltd.	Controlling loss of kidney function

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4973584A (en) *	1989-03-09	1990-11-27	Deluca Hector F	Novel 1α-hydroxyvitamin D2 epimer and derivatives
GB9007236D0 (en) *	1990-03-30	1990-05-30	Leo Pharm Prod Ltd	Chemical compounds
GB9223061D0 (en) *	1992-11-04	1992-12-16	Leo Pharm Prod Ltd	Chemical compounds
GB9226877D0 (en) *	1992-12-23	1993-02-17	Leo Pharm Prod Ltd	Chemical compounds
ATE344039T1 (de) *	1999-04-01	2006-11-15	Univ Johns Hopkins	Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung

2002
- 2002-08-22 WO PCT/CA2002/001294 patent/WO2003018545A1/en not_active Ceased
- 2002-08-22 EP EP02752924A patent/EP1419143B1/de not_active Expired - Lifetime
- 2002-08-22 JP JP2003523209A patent/JP2005500402A/ja active Pending
- 2002-08-22 CA CA2458415A patent/CA2458415C/en not_active Expired - Fee Related
- 2002-08-22 DE DE60231987T patent/DE60231987D1/de not_active Expired - Lifetime
- 2002-08-22 AT AT02752924T patent/ATE428692T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2003018545A1 (en)	2003-03-06
EP1419143B1 (de)	2009-04-15
DE60231987D1 (de)	2009-05-28
WO2003018545B1 (en)	2003-07-31
CA2458415A1 (en)	2003-03-06
CA2458415C (en)	2010-09-21
EP1419143A1 (de)	2004-05-19
JP2005500402A (ja)	2005-01-06

Legal Events

Date	Code	Title	Description
2009-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60219655D1 (de)	2007-05-31	Oxim-analoga von 1-alpha,25-dihydroxy-vitamin-d3 mit geringer calcemischer wirkung
BR9804437A (pt)	2001-05-02	Compostos para a osteoporose
SE0201635D0 (sv)	2002-05-30	Novel compounds
SE0303180D0 (sv)	2003-11-26	Novel compounds
DK1625126T3 (da)	2008-03-31	Imidazo- og thiazolopyridiner som JAK3-kinaseinhibitorer
SE0302232D0 (sv)	2003-08-18	Novel Compounds
PL363168A1 (pl)	2004-11-15	Cyklopentanole, kompozycje zawierające takie związki i sposoby leczenia
CY1110555T1 (el)	2015-04-29	4-((φαινοξυαλκυλ)θειο)-φαινοξυοξεικα οξεα και αναλογα
NO20052595L (no)	2005-06-27	Sammensetninger anvendelige som inhibitorer av ROCK- og andre proteinkinaser.
MY137040A (en)	2008-12-31	Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment
MXPA03011484A (es)	2004-03-18	Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades.
ATE232873T1 (de)	2003-03-15	Phosphonsaürederivate als ptp-1b-inhibitoren
ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
NO20051008L (no)	2005-06-07	Nye imidazolforbindelser som transformerende vekst faktor (TGF) inhibitorer
BR0307833A (pt)	2004-12-07	Sìntese controlada de ziprasidona e suas composições
MY143390A (en)	2011-05-13	Sulfonamide derivatives for the treatment of diseases.
ATE543796T1 (de)	2012-02-15	24-sulfoximine vitamin d3 derivate
DK1448562T3 (da)	2007-09-24	Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer
NO20014241D0 (no)	2001-08-31	C16-umettede FP-selektive prostaglandinanaloger
ATE432278T1 (de)	2009-06-15	Verbindungen zur behandlung von krankheiten
ATE443044T1 (de)	2009-10-15	Tace inhibitoren
ATE372114T1 (de)	2007-09-15	Verfahren zur erhöhung des testosteronspiegels
WO2004054968A3 (en)	2004-10-21	25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol)
ATE428692T1 (de)	2009-05-15	24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen
NO20050612L (no)	2005-02-03	Pyrrolidinderivater som oksytocinantagonister