ATE429511T1 - Verfahren zur entwicklung von gensätzen zu diagnostischen und therapeutischen zwecken auf grundlage des expressions- und methylierungsstatus der gene - Google Patents

Verfahren zur entwicklung von gensätzen zu diagnostischen und therapeutischen zwecken auf grundlage des expressions- und methylierungsstatus der gene

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Publication number
ATE429511T1
ATE429511T1 AT02724190T AT02724190T ATE429511T1 AT E429511 T1 ATE429511 T1 AT E429511T1 AT 02724190 T AT02724190 T AT 02724190T AT 02724190 T AT02724190 T AT 02724190T AT E429511 T1 ATE429511 T1 AT E429511T1
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Prior art keywords
gene
diagnostic
therapeutic purposes
genes
knowledge base
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AT02724190T
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English (en)
Inventor
Alexander Olek
Kurt Berlin
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Epigenomics Ag
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Publication of ATE429511T1 publication Critical patent/ATE429511T1/de

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
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AT02724190T 2001-03-01 2002-03-01 Verfahren zur entwicklung von gensätzen zu diagnostischen und therapeutischen zwecken auf grundlage des expressions- und methylierungsstatus der gene ATE429511T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27254901P 2001-03-01 2001-03-01
PCT/EP2002/002255 WO2002070742A1 (en) 2001-03-01 2002-03-01 Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes

Publications (1)

Publication Number Publication Date
ATE429511T1 true ATE429511T1 (de) 2009-05-15

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AT02724190T ATE429511T1 (de) 2001-03-01 2002-03-01 Verfahren zur entwicklung von gensätzen zu diagnostischen und therapeutischen zwecken auf grundlage des expressions- und methylierungsstatus der gene

Country Status (7)

Country Link
US (1) US20020137086A1 (de)
EP (1) EP1364069B1 (de)
JP (1) JP2004529630A (de)
AT (1) ATE429511T1 (de)
CA (1) CA2439854A1 (de)
DE (1) DE60232059D1 (de)
WO (1) WO2002070742A1 (de)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
AU2002329000A1 (en) * 2001-09-24 2003-04-07 University Of Aarhus Methods for diagnosis and treatment of diseases associated with altered expression of pik3r1
US20110151438A9 (en) * 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
WO2003064700A2 (en) * 2002-01-30 2003-08-07 Epigenomics Ag Identification of cell differentiation states based on methylation patterns
WO2004020662A2 (en) * 2002-08-27 2004-03-11 Epigenomics Ag Method and nucleic acids for the analysis of breast cell proliferative disorders
DE60331852D1 (de) * 2002-12-02 2010-05-06 Illumina Cambridge Ltd Bestimmung der methylierung von nukleinsäuresequenzen
WO2004071267A2 (en) * 2003-02-11 2004-08-26 Roche Diagnostics Gmbh Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample
WO2004087957A2 (en) * 2003-04-03 2004-10-14 Oncomethylome Sciences S.A. Hypermethylated genes and cervical cancer
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
WO2004108960A2 (en) * 2003-06-09 2004-12-16 Decode Genetics Ehf. Methods for predicting drug efficacy in patients afflicted with hypertension
EP1664336A2 (de) * 2003-09-11 2006-06-07 University College Cork-National University of Ireland, Cork Erkennungsverfahren für autismus und verwandte krankheiten
WO2005038046A1 (en) * 2003-10-14 2005-04-28 Bionomics Limited Methylation-based diagnostic method
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
EP1756311A2 (de) * 2004-05-17 2007-02-28 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Silencing von tumorsuppressorgenen durch cpg-methylierung bei prostatakrebs
US8399241B2 (en) * 2004-12-01 2013-03-19 Whitehead Institute For Biomedical Research Modulators of alpha-synuclein toxicity
JP5745202B2 (ja) * 2004-12-02 2015-07-08 エピゲノミックス アクチェンゲゼルシャフト 前立腺細胞増殖障害の予後に関連する遺伝子発現分析のための方法および核酸
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
EP2272984B1 (de) * 2005-02-01 2012-06-20 John Wayne Cancer Institute Verwendung von ID4 zur Diagnose und Behandlung von Krebs
WO2006124892A2 (en) 2005-05-13 2006-11-23 Whitehead Institute For Biomedical Research Modulators of alpha-synuclein toxicity
US20070015183A1 (en) * 2005-06-03 2007-01-18 The General Hospital Corporation Biomarkers for huntington's disease
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2007003397A2 (en) * 2005-07-01 2007-01-11 Epigenomics Ag Method and nucleic acids for the improved treatment of cancers
WO2007039291A2 (en) * 2005-10-03 2007-04-12 Epigenomics Ag Methods, apparatus and nomograms to determine prostate cancer progression
WO2007039290A2 (en) * 2005-10-03 2007-04-12 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the prognosis of cell proliferative disorders
US20070207467A1 (en) * 2006-03-01 2007-09-06 Ming Xu Detection of lymph node metastasis from gastric carcinoma
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
GB0609498D0 (en) * 2006-05-12 2006-06-21 Oncomethylome Sciences S A Novel methylation marker
US20070281305A1 (en) * 2006-06-05 2007-12-06 Sean Wuxiong Cao Detection of lymph node metastasis from gastric carcinoma
WO2007146229A2 (en) 2006-06-07 2007-12-21 Tethys Bioscience, Inc. Markers associated with arteriovascular events and methods of use thereof
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
WO2008096146A1 (en) * 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
EP2474627B1 (de) * 2007-02-21 2015-05-20 Oslo Universitetssykehus HF Neue Krebsmarker
US7844609B2 (en) * 2007-03-16 2010-11-30 Expanse Networks, Inc. Attribute combination discovery
WO2008124428A1 (en) * 2007-04-03 2008-10-16 Indiana University Research And Technology Corporation Blood biomarkers for mood disorders
US20090155788A1 (en) * 2007-05-22 2009-06-18 Abbas Alexander R Gene expression markers for inflammatory bowel disease
KR101035007B1 (ko) 2007-06-20 2011-05-17 가톨릭대학교 산학협력단 총량 감지 유전자군을 이용하여 위암 발생, 진행 여부 및 소인 추정에 필요한 데이터를 수집하는 방법, 그 프라이머 및 키트
US20090043752A1 (en) * 2007-08-08 2009-02-12 Expanse Networks, Inc. Predicting Side Effect Attributes
RU2492243C2 (ru) * 2007-09-17 2013-09-10 Конинклейке Филипс Электроникс Н.В. Способ анализа онкологических заболеваний молочной железы
US9783857B2 (en) * 2007-11-30 2017-10-10 Genomictree, Inc. Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
US9670551B2 (en) 2007-11-30 2017-06-06 Genomictree, Inc. Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
US10113203B2 (en) 2007-11-30 2018-10-30 Genomictree, Inc. Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
US9670552B2 (en) 2007-11-30 2017-06-06 Genomictree, Inc. Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
EP2390371A1 (de) 2007-11-30 2011-11-30 Genomictree, Inc. Diagnosekit und Chip für Blasenkrebs mit blasenkrebsspezifischem Methylierungsmarkergen
US9797017B2 (en) * 2007-11-30 2017-10-24 Genomictree, Inc. Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
WO2009071920A2 (en) * 2007-12-07 2009-06-11 Oncomethylome Sciences Sa Methods for identifying epigenetically silenced genes and novel tumour suppressor genes
WO2009079208A2 (en) * 2007-12-17 2009-06-25 Siemens Healthcare Diagnostics Inc. Methylation markers for cancer
WO2009086306A1 (en) 2007-12-21 2009-07-09 Whitehead Institute For Biomedical Research Modulators of alpha-synuclein toxicity
US8242243B2 (en) 2008-05-15 2012-08-14 Ribomed Biotechnologies, Inc. Methods and reagents for detecting CpG methylation with a methyl CpG binding protein (MBP)
US20100063835A1 (en) * 2008-09-10 2010-03-11 Expanse Networks, Inc. Method for Secure Mobile Healthcare Selection
US20100076950A1 (en) * 2008-09-10 2010-03-25 Expanse Networks, Inc. Masked Data Service Selection
US8200509B2 (en) * 2008-09-10 2012-06-12 Expanse Networks, Inc. Masked data record access
US20100063865A1 (en) * 2008-09-10 2010-03-11 Expanse Networks, Inc. Masked Data Provider Profiling
US20100076988A1 (en) * 2008-09-10 2010-03-25 Expanse Networks, Inc. Masked Data Service Profiling
US7917438B2 (en) 2008-09-10 2011-03-29 Expanse Networks, Inc. System for secure mobile healthcare selection
US20100070292A1 (en) * 2008-09-10 2010-03-18 Expanse Networks, Inc. Masked Data Transaction Database
US20100063830A1 (en) * 2008-09-10 2010-03-11 Expanse Networks, Inc. Masked Data Provider Selection
US8541207B2 (en) * 2008-10-22 2013-09-24 Illumina, Inc. Preservation of information related to genomic DNA methylation
US20110318738A1 (en) * 2008-12-23 2011-12-29 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
US8108406B2 (en) 2008-12-30 2012-01-31 Expanse Networks, Inc. Pangenetic web user behavior prediction system
US8386519B2 (en) 2008-12-30 2013-02-26 Expanse Networks, Inc. Pangenetic web item recommendation system
EP3276526B8 (de) 2008-12-31 2025-01-15 23andMe, Inc. Suche nach verwandten in einer datenbank
EP2391735A2 (de) * 2009-01-30 2011-12-07 Koninklijke Philips Electronics N.V. Verfahren zur subklassifizierung von mammakarzinomen
WO2010107716A2 (en) 2009-03-15 2010-09-23 Ribomed Biotechnologies, Inc. Abscription based molecular detection
US20100303795A1 (en) * 2009-05-27 2010-12-02 Soerensen Karina Dalsgaard Marker of prostate cancer
EP2558594A2 (de) * 2010-04-16 2013-02-20 Koninklijke Philips Electronics N.V. Verfahren zur analyse von brustkrebserkrankungen
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
JP5838557B2 (ja) 2010-07-05 2016-01-06 ソニー株式会社 生体情報処理方法および装置、並びに記録媒体
JP6222202B2 (ja) * 2010-07-05 2017-11-01 ソニー株式会社 生体情報処理方法および装置、並びに記録媒体
JP6242388B2 (ja) * 2012-06-14 2017-12-06 オーフス ユニバーシテットＡａｒｈｕｓ Ｕｎｉｖｅｒｓｉｔｅｔ 前立腺ガンのバイオマーカー
EA201492284A1 (ru) * 2012-06-27 2015-11-30 Берг Ллк Применение маркеров в диагностике и лечении рака предстательной железы
KR101557183B1 (ko) * 2012-08-14 2015-10-02 충북대학교 산학협력단 방광암 예후 진단 마커
CA3210007A1 (en) * 2013-03-15 2014-09-18 Sera Prognostics, Inc Biomarkers and methods for predicting preeclampsia
US20140287948A1 (en) * 2013-03-15 2014-09-25 Sera Prognostics, Inc. Biomarkers and methods for predicting preterm birth
KR101553870B1 (ko) 2013-10-11 2015-09-17 서울대학교산학협력단 Dna 탈메틸효소를 이용한 pcr 기반의 dna 메틸화 분석 방법
WO2015109107A1 (en) * 2014-01-15 2015-07-23 Cal Poly Pomona Foundation, Inc. Treatment and diagnosis of huntington's disease
EP2915883A1 (de) * 2014-03-07 2015-09-09 Ruprecht-Karls-Universität Heidelberg Nichtinvasives Assay-Verfahren zur Früherkennung von Krebs
JP6413163B2 (ja) * 2014-07-17 2018-10-31 国立大学法人 東京大学 クリティカルコロナイゼーション創傷又は感染創傷の判定用キット、判定方法及び試験方法
EP4242329A3 (de) 2014-12-08 2023-10-25 Berg LLC Verwendung von markern einschliesslich filamin a bei der diagnose und behandlung von prostatakrebs
EP3274440B1 (de) 2015-03-27 2026-03-04 Exact Sciences Corporation Nachweis von erkrankungen der speiseröhre
PL3311158T3 (pl) 2015-06-19 2023-11-27 Sera Prognostics, Inc. Pary biomarkerów do przewidywania przedwczesnego porodu
JP7481804B2 (ja) * 2016-04-14 2024-05-13 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 高度膵異形成の検出
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
CA3064275A1 (en) * 2017-05-19 2018-11-22 The Board Of Trustees Of The Leland Stanford Junior University Enzastaurin and fragile histidine triad (fhit)-increasing agents for the treatment of pulmonary hypertension
EP3668996A4 (de) 2017-08-18 2021-04-21 Sera Prognostics, Inc. Clock-schwangerschaftsprotein zur vorhersage des entbindungstermins und der zeit bis zur entbindung
JP7320345B2 (ja) * 2017-10-27 2023-08-03 シスメックス株式会社 遺伝子解析方法、遺伝子解析装置、遺伝子解析システム、プログラム、および記録媒体
KR102129066B1 (ko) * 2018-04-11 2020-07-15 한국과학기술연구원 항암 보조치료법의 선택을 위한 혈액 마커 및 이를 이용한 치료법 선택의 방법
CN108676888B (zh) * 2018-07-12 2022-01-28 吉林大学 一种肺部恶性肿瘤易感性预测试剂盒及系统
CN108841959B (zh) * 2018-07-12 2022-03-01 吉林大学 一种口腔及头颈部恶性肿瘤易感性预测试剂盒及系统
CN108866189B (zh) * 2018-07-12 2022-03-01 吉林大学 一种喉鳞状细胞癌易感性预测试剂盒及系统
AU2019371238B2 (en) * 2018-10-30 2026-02-05 Somalogic Operating Co., Inc. Methods for sample quality assessment
KR102039529B1 (ko) * 2019-01-31 2019-11-01 주식회사 에스씨엘헬스케어 대사증후군의 위험인자 예측용 단일염기다형성 및 이의 용도
RU2698453C1 (ru) * 2019-04-02 2019-08-27 Федеральное государственное бюджетное учреждение науки "Кировский научно-исследовательский институт гематологии и переливания крови Федерального медико-биологического агентства" Способ прогнозирования клинического течения гемофилии с уровнем активности факторов VIII, IX
CN110317871B (zh) * 2019-07-11 2022-06-07 广州康立明生物科技股份有限公司 一种基因标志物组合及其应用
CN117169534A (zh) 2019-08-05 2023-12-05 禧尔公司 用于样品制备、数据生成和蛋白质冠分析的系统和方法
CN110951873A (zh) * 2019-12-03 2020-04-03 中山大学 一种骨肉瘤标志物及其应用、试剂盒
WO2022064163A1 (en) * 2020-09-22 2022-03-31 The Secretary Of State For Defence Apparatus, kits and methods for predicting the development of sepsis
CN116710574A (zh) * 2020-12-04 2023-09-05 赢创运营有限公司 用于对禽类肠道炎症状态进行分类的方法
CN116536279B (zh) * 2022-01-25 2023-11-14 杭州馨海酶源生物科技有限公司 一种基因工程菌及在制备去氢表雄酮上的应用
CN115631857B (zh) * 2022-04-01 2023-06-23 洛兮医疗科技(杭州)有限公司 甲状腺癌cd8+t细胞免疫相关基因预后预测模型
CN116004795B (zh) * 2022-11-02 2025-11-28 南京鼓楼医院 一种基于cyp51a1基因表达检测辅助诊断系统性红斑狼疮的试剂盒
CN117418013A (zh) * 2023-12-19 2024-01-19 四川省肿瘤医院 用于检测卵巢癌细胞MyD88基因5'URR CpG岛甲基化水平的引物、方法及其应用
CN118441052B (zh) * 2024-02-02 2025-04-22 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 早期检测子宫内膜癌的甲基化基因标志物组合、多重pcr检测试剂盒及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525300A (en) * 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
WO2000039347A1 (en) * 1998-12-31 2000-07-06 St. Jude Children's Research Hospital A tumor suppressor protein involved in death signaling, and diagnostics, therapeutics, and screening based on this protein
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
CA2381987A1 (en) * 1999-08-22 2001-03-15 Dot Diagnostics B.V. Improved method for nucleotide detection and devices used therein

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