ATE430198T1 - Antikörperkonstruktion unter verwendung einer mrl/lpr-maus - Google Patents

Antikörperkonstruktion unter verwendung einer mrl/lpr-maus

Info

Publication number
ATE430198T1
ATE430198T1 AT03794237T AT03794237T ATE430198T1 AT E430198 T1 ATE430198 T1 AT E430198T1 AT 03794237 T AT03794237 T AT 03794237T AT 03794237 T AT03794237 T AT 03794237T AT E430198 T1 ATE430198 T1 AT E430198T1
Authority
AT
Austria
Prior art keywords
mrl
lpr mouse
antibodies construction
producing
relates
Prior art date
Application number
AT03794237T
Other languages
English (en)
Inventor
Iwao Ohizumi
Mikiyoshi Saito
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE430198T1 publication Critical patent/ATE430198T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03794237T 2002-09-04 2003-09-04 Antikörperkonstruktion unter verwendung einer mrl/lpr-maus ATE430198T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP2002/008998 WO2004022595A1 (ja) 2002-09-04 2002-09-04 MRL/lprマウスを用いた抗体の作製
PCT/JP2003/011319 WO2004022754A1 (ja) 2002-09-04 2003-09-04 MRL/lprマウスを用いた抗体の作製

Publications (1)

Publication Number Publication Date
ATE430198T1 true ATE430198T1 (de) 2009-05-15

Family

ID=31972305

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03794237T ATE430198T1 (de) 2002-09-04 2003-09-04 Antikörperkonstruktion unter verwendung einer mrl/lpr-maus

Country Status (7)

Country Link
US (1) US20060246550A1 (de)
EP (3) EP1849867A1 (de)
JP (1) JP4571496B2 (de)
AT (1) ATE430198T1 (de)
AU (2) AU2002328429A1 (de)
DE (1) DE60327442D1 (de)
WO (2) WO2004022595A1 (de)

Families Citing this family (29)

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AU2005256113B2 (en) 2004-07-09 2011-02-10 Chugai Seiyaku Kabushiki Kaisha Anti-glypican 3 antibody
KR101300546B1 (ko) 2004-08-24 2013-09-02 추가이 세이야쿠 가부시키가이샤 항 글리피칸 3 항체를 이용한 어쥬번트 요법
KR101296931B1 (ko) 2004-10-26 2013-08-14 추가이 세이야쿠 가부시키가이샤 변형된 당쇄를 갖는 항-글리피칸 3 항체
US20070087005A1 (en) 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
JP2008110943A (ja) * 2006-10-31 2008-05-15 Niigata Univ モノクローナル抗体の作成方法
AU2008275985B2 (en) 2007-07-17 2013-09-19 E. R. Squibb & Sons, L.L.C. Monoclonal antibodies against Glypican-3
TWI654203B (zh) 2010-11-30 2019-03-21 Chugai Seiyaku Kabushiki Kaisha 具有鈣依存性的抗原結合能力之抗體
TWI736437B (zh) 2010-11-30 2021-08-11 日商中外製藥股份有限公司 細胞傷害誘導治療劑
EP2698431B1 (de) 2011-03-30 2020-09-09 Chugai Seiyaku Kabushiki Kaisha Aufrechterhaltung antigenbindender moleküle im blutplasma und verfahren zur modifizierung einer immunogenität
KR102366029B1 (ko) 2011-09-30 2022-02-23 추가이 세이야쿠 가부시키가이샤 표적 항원에 대한 면역응답을 유도하는 항원 결합 분자
KR20250078601A (ko) 2011-09-30 2025-06-02 추가이 세이야쿠 가부시키가이샤 항원의 소실을 촉진시키는 항원 결합 분자
EP2765192A4 (de) 2011-10-05 2015-04-15 Chugai Pharmaceutical Co Ltd Antigenbindendes molekül zur herstellung eines abstands zwischen einem plasma und einem antigen mit einer saccharidkettenrezeptor-bindenden domäne
CA2865158C (en) 2012-02-24 2022-11-01 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for promoting disappearance of antigen via fc.gamma.riib
WO2013180200A1 (ja) 2012-05-30 2013-12-05 中外製薬株式会社 標的組織特異的抗原結合分子
TWI693073B (zh) 2012-12-21 2020-05-11 日商中外製藥股份有限公司 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
US20140273031A1 (en) * 2013-03-15 2014-09-18 The Cleveland Clinic Foundation In-vitro method for monoclonal antibody production
TWI702316B (zh) 2013-12-04 2020-08-21 日商中外製藥股份有限公司 因應化合物濃度使抗原結合能力變化的抗原結合分子及其資料庫
KR102409014B1 (ko) 2014-05-08 2022-06-14 추가이 세이야쿠 가부시키가이샤 Gpc3 표적 치료제 요법이 유효한 환자에게 투여되는 gpc3 표적 치료제
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
US11376326B2 (en) 2015-07-01 2022-07-05 Chugai Seiyaku Kabushiki Kaisha GPC3-targeting therapeutic agent which is administered to patient for whom the GPC3-targeting therapeutic agent is effective
EP3431102A4 (de) 2016-03-14 2019-09-25 Chugai Seiyaku Kabushiki Kaisha Zellschadeninduzierendes therapeutisches arzneimittel zur verwendung in der krebstherapie
AU2017364818C1 (en) 2016-11-28 2025-05-15 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand binding activity
KR20200089312A (ko) 2017-11-28 2020-07-24 추가이 세이야쿠 가부시키가이샤 리간드 결합 활성을 조정 가능한 리간드 결합 분자
EP3816182A4 (de) 2018-05-30 2022-07-13 Chugai Seiyaku Kabushiki Kaisha Ligandbindungsmolekül mit einzeldomänen-antikörper
JP7601758B2 (ja) 2019-03-19 2024-12-17 中外製薬株式会社 Ｍｔａ依存的に抗原に対する結合活性が変化する抗原結合ドメインを含む抗原結合分子及び当該抗原結合ドメイン取得用ライブラリ
EP3981428A4 (de) 2019-06-05 2023-07-12 Chugai Seiyaku Kabushiki Kaisha Proteasesubstrat und polypeptid mit proteasespaltungssequenz
CN113905757B (zh) 2019-06-05 2026-01-13 中外制药株式会社 抗体切割位点结合分子
WO2021100715A1 (ja) * 2019-11-18 2021-05-27 住友化学株式会社 抗体の作製方法
TW202220677A (zh) 2020-07-31 2022-06-01 日商中外製藥股份有限公司 含有表現嵌合受體之細胞的醫藥組成物

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US4965198A (en) * 1985-12-24 1990-10-23 Konica Corporation Monoclonal antibody and method of manufacturing hybridoma producing the same
JPH0787798B2 (ja) * 1987-04-27 1995-09-27 コニカ株式会社 モノクロ−ナル抗体の製造方法
JPH0722518B2 (ja) * 1987-06-04 1995-03-15 コニカ株式会社 モノクローナル抗体
JPH0776600B2 (ja) 1991-01-28 1995-08-16 未来工業株式会社 流体管の二重配管における消音構造及びそれに使用する介在材
US5976835A (en) * 1992-03-19 1999-11-02 The Rockefeller University Nucleic acids encoding receptor recognition factor Stat1α and Stat1β, and methods of use thereof
US5648267A (en) 1992-11-13 1997-07-15 Idec Pharmaceuticals Corporation Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
US5756361A (en) * 1992-12-17 1998-05-26 Metra Biosystems, Inc. Screening method for periodontal disease
US5641488A (en) * 1993-04-01 1997-06-24 National Jewish Center For Immunology And Respiratory Medicine Method for producing an antibody to a chosen antigen
JPH0776600A (ja) * 1993-07-14 1995-03-20 Kao Corp モノクローナル抗体及びこれを産生するハイブリドーマ
ATE340590T1 (de) 1994-07-13 2006-10-15 Chugai Pharmaceutical Co Ltd Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper
CA2215905A1 (en) * 1995-03-20 1996-09-26 Sumitomo Electric Industries, Ltd. Monoclonal antibody reacting specifically with fas ligand and process for producing the same
CZ106299A3 (cs) 1996-09-26 1999-08-11 Chugai Seiyaku Kabushiki Kaisha Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
AU2422999A (en) * 1998-01-27 1999-08-09 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw New members of the glypican gene family
RU2319969C2 (ru) * 2002-05-23 2008-03-20 Саннибрук Энд Вуменз Колледж Хелс Сайнсиз Сентре Способ диагностики гепатоцеллюлярной карциномы

Also Published As

Publication number Publication date
EP1541686B1 (de) 2009-04-29
EP2075257A1 (de) 2009-07-01
EP1541686A1 (de) 2005-06-15
EP1849867A1 (de) 2007-10-31
EP1541686A4 (de) 2005-12-21
EP2075257B1 (de) 2012-08-08
WO2004022595A1 (ja) 2004-03-18
US20060246550A1 (en) 2006-11-02
AU2002328429A1 (en) 2004-03-29
DE60327442D1 (de) 2009-06-10
JPWO2004022754A1 (ja) 2005-12-22
WO2004022754A1 (ja) 2004-03-18
AU2003261942A1 (en) 2004-03-29
JP4571496B2 (ja) 2010-10-27

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