ATE431426T1 - Verfahren zur identifizierung von lrrk2 interagierenden molekülen und zur reinigung von lrrk2 - Google Patents
Verfahren zur identifizierung von lrrk2 interagierenden molekülen und zur reinigung von lrrk2Info
- Publication number
- ATE431426T1 ATE431426T1 AT07717962T AT07717962T ATE431426T1 AT E431426 T1 ATE431426 T1 AT E431426T1 AT 07717962 T AT07717962 T AT 07717962T AT 07717962 T AT07717962 T AT 07717962T AT E431426 T1 ATE431426 T1 AT E431426T1
- Authority
- AT
- Austria
- Prior art keywords
- lrrk2
- purifying
- identifying
- interacting molecules
- indol ligand
- Prior art date
Links
- 102000009784 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Human genes 0.000 title abstract 4
- 108010020246 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Proteins 0.000 title abstract 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78211906P | 2006-03-14 | 2006-03-14 | |
| PCT/EP2007/052357 WO2007104763A1 (en) | 2006-03-14 | 2007-03-13 | Methods for the identification of lrrk2 interacting molecules and for the purification of lrrk2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE431426T1 true ATE431426T1 (de) | 2009-05-15 |
Family
ID=38093568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07717962T ATE431426T1 (de) | 2006-03-14 | 2007-03-13 | Verfahren zur identifizierung von lrrk2 interagierenden molekülen und zur reinigung von lrrk2 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8163511B2 (de) |
| EP (1) | EP1866433B1 (de) |
| JP (1) | JP2009529860A (de) |
| CN (1) | CN101426927B (de) |
| AT (1) | ATE431426T1 (de) |
| AU (1) | AU2007224411B2 (de) |
| CA (1) | CA2645214A1 (de) |
| DE (1) | DE602007001103D1 (de) |
| DK (1) | DK1866433T3 (de) |
| ES (1) | ES2325797T3 (de) |
| WO (1) | WO2007104763A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0706709D0 (en) | 2007-04-05 | 2007-05-16 | Medical Res Council | Methods |
| US8206942B2 (en) | 2007-04-05 | 2012-06-26 | Medical Research Council | Methods of identifying LRRK2 inhibitors |
| ES2348187T3 (es) | 2007-10-05 | 2010-12-01 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Amplificacion proteomica de pequeñas moleculas que se unen a proteinas celulares diana. |
| EP2410062A1 (de) * | 2008-02-04 | 2012-01-25 | Cellzome Ag | Selektive Profilierung von PI3K-Interaktionsmolekülen gegen mehrere Ziele |
| GB2463656B (en) * | 2008-09-18 | 2010-10-13 | Medical Res Council | Substrate of LRRK2 and methods of assessing LRRK2 activity |
| US8367349B2 (en) * | 2010-04-19 | 2013-02-05 | Medical Research Council | Methods for identifying modulators of LRRK2 |
| EP2710041A4 (de) * | 2011-05-18 | 2014-11-05 | Parkinson S Inst | Assay zur bestimmung der lrrk2-aktivität bei morbus parkinson |
| EA025186B1 (ru) | 2012-06-29 | 2016-11-30 | Пфайзер Инк. | НОВЫЕ 4-(ЗАМЕЩЕННЫЙ АМИНО)-7Н-ПИРРОЛО[2,3-d]ПИРИМИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ LRRK2 |
| EP3083618B1 (de) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Neuartige 3,4-disubstituierte-1h-pyrrolo[2,3-b]pyridine und 4,5-disubstituierte 7h-pyrrolo[2,3-c]pyridazine als lrrk2-hemmer |
| RU2722149C1 (ru) | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
| CN111566081B (zh) * | 2017-11-20 | 2021-04-06 | 天津安百胜医疗科技有限公司 | 一种双酰胺复合物及其制备方法和用途 |
| CN112505328B (zh) * | 2020-11-02 | 2024-02-13 | 武汉金开瑞生物工程有限公司 | 一种同位素标记试剂盒和标记方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6797725B2 (en) * | 2001-04-09 | 2004-09-28 | Sugen, Inc. | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| WO2004006838A2 (en) * | 2002-07-15 | 2004-01-22 | Sugen, Inc. | Novel kinases |
| PL1891446T3 (pl) | 2005-06-14 | 2013-08-30 | Cellzome Gmbh | Sposób identyfikacji nowych związków oddziałujących z enzymami |
-
2007
- 2007-03-13 CN CN2007800142956A patent/CN101426927B/zh not_active Expired - Fee Related
- 2007-03-13 AU AU2007224411A patent/AU2007224411B2/en not_active Ceased
- 2007-03-13 JP JP2008558809A patent/JP2009529860A/ja active Pending
- 2007-03-13 DE DE602007001103T patent/DE602007001103D1/de active Active
- 2007-03-13 US US12/282,851 patent/US8163511B2/en not_active Expired - Fee Related
- 2007-03-13 WO PCT/EP2007/052357 patent/WO2007104763A1/en not_active Ceased
- 2007-03-13 ES ES07717962T patent/ES2325797T3/es active Active
- 2007-03-13 DK DK07717962T patent/DK1866433T3/da active
- 2007-03-13 AT AT07717962T patent/ATE431426T1/de active
- 2007-03-13 EP EP07717962A patent/EP1866433B1/de not_active Not-in-force
- 2007-03-13 CA CA002645214A patent/CA2645214A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101426927B (zh) | 2012-05-23 |
| DK1866433T3 (da) | 2009-08-17 |
| US8163511B2 (en) | 2012-04-24 |
| EP1866433A1 (de) | 2007-12-19 |
| EP1866433B1 (de) | 2009-05-13 |
| DE602007001103D1 (de) | 2009-06-25 |
| AU2007224411B2 (en) | 2012-11-01 |
| CA2645214A1 (en) | 2007-09-20 |
| JP2009529860A (ja) | 2009-08-27 |
| WO2007104763A1 (en) | 2007-09-20 |
| WO2007104763A9 (en) | 2007-11-15 |
| ES2325797T3 (es) | 2009-09-17 |
| US20090220992A1 (en) | 2009-09-03 |
| AU2007224411A1 (en) | 2007-09-20 |
| CN101426927A (zh) | 2009-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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