ATE504836T1 - Verfahren zur identifizierung von trpv2- modulatoren - Google Patents

Verfahren zur identifizierung von trpv2- modulatoren

Info

Publication number
ATE504836T1
ATE504836T1 AT06836632T AT06836632T ATE504836T1 AT E504836 T1 ATE504836 T1 AT E504836T1 AT 06836632 T AT06836632 T AT 06836632T AT 06836632 T AT06836632 T AT 06836632T AT E504836 T1 ATE504836 T1 AT E504836T1
Authority
AT
Austria
Prior art keywords
trpv2
identifying
modulators
discovery
discovered
Prior art date
Application number
AT06836632T
Other languages
English (en)
Inventor
Ning Qin
Yi Liu
Christopher Flores
Tasha Hutchinson
Michael Neeper
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE504836T1 publication Critical patent/ATE504836T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/658Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058Neurological cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948Sedatives, e.g. cannabinoids, barbiturates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT06836632T 2005-10-31 2006-10-30 Verfahren zur identifizierung von trpv2- modulatoren ATE504836T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73168605P 2005-10-31 2005-10-31
US78265606P 2006-03-15 2006-03-15
PCT/US2006/042241 WO2007053526A1 (en) 2005-10-31 2006-10-30 Compositions and methods for identifying modulators of trpv2

Publications (1)

Publication Number Publication Date
ATE504836T1 true ATE504836T1 (de) 2011-04-15

Family

ID=37776906

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06836632T ATE504836T1 (de) 2005-10-31 2006-10-30 Verfahren zur identifizierung von trpv2- modulatoren

Country Status (8)

Country Link
US (2) US7575882B2 (de)
EP (1) EP1952160B1 (de)
JP (1) JP2009513159A (de)
CN (1) CN101542288A (de)
AT (1) ATE504836T1 (de)
AU (1) AU2006308914A1 (de)
DE (1) DE602006021223D1 (de)
WO (1) WO2007053526A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007259745A (ja) * 2006-03-28 2007-10-11 Japan Health Science Foundation Trpv2特異的アッセイ方法およびtrpv2特異的薬剤のスクリーニング方法
WO2008109596A2 (en) * 2007-03-07 2008-09-12 Janssen Pharmaceutica N.V. Canine transient receptor potential v2 (ctrpv2) and methods of screening for trpv2 channel modulators
GB2448535A (en) * 2007-04-19 2008-10-22 Gw Pharma Ltd New use for cannabinoid-containing plant extracts
KR100951656B1 (ko) 2008-02-25 2010-04-07 고려대학교 산학협력단 프로베네시드를 포함하는 trpv2 활성제
JP5328190B2 (ja) * 2008-03-24 2013-10-30 株式会社マンダム Trpa1の活性化物質の評価方法
CN102575997B (zh) 2009-06-09 2014-12-17 生物传感器股份有限公司 血液代谢物水平的无创监测
US20130203715A1 (en) * 2010-07-20 2013-08-08 Pulmatrix, Inc. Use of trp channel agonists to treat infections
US20130316008A1 (en) * 2010-08-05 2013-11-28 Agency For Science, Technology And Research Multicompartmentalized vesicular structure and a method for forming the same
JP5877204B2 (ja) 2010-09-29 2016-03-02 パルマトリックス,インコーポレイテッド 吸入用の一価金属カチオン乾燥粉末
CN102154494B (zh) * 2011-03-14 2013-01-02 中国人民解放军军事医学科学院基础医学研究所 一种用于儿童哮喘检测的标志物
WO2014165303A1 (en) 2013-04-01 2014-10-09 Pulmatrix, Inc. Tiotropium dry powders
US10024845B2 (en) * 2013-12-23 2018-07-17 Basf Se Methods for determining modulators of insect transient receptor potential V (TRPV) channel
JP2017521044A (ja) 2014-04-22 2017-08-03 キュー−ステート バイオサイエンシーズ, インコーポレイテッドQ−State Biosciences, Inc. 疼痛及び感覚障害のための化合物の分析
WO2016138383A1 (en) 2015-02-27 2016-09-01 The Feinstein Institute For Medical Research Treatment method, compounds, and method of increasing trpv2 activity
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
JP2020520966A (ja) 2017-05-22 2020-07-16 ジービーエス グローバル バイオファーマ,インコーポレイテッド Trpv1を標的にするミルセン及びカンナビノイド含有組成物
AU2019272849A1 (en) 2018-05-22 2021-01-14 Gbs Global Biopharma, Inc. Cannabinoids and/or terpenes for use in TRPV1 modulation
US10959961B2 (en) 2018-12-14 2021-03-30 Natural Extraction Systems, LLC Methods of administering anionic cannabinoid molecules dissolved in water
US10609944B1 (en) 2018-12-14 2020-04-07 Natural Extraction Systems, LLC Compositions comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate and 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol
BR112021011509A2 (pt) * 2018-12-14 2021-08-31 Natural Extraction Systems, LLC Composições e métodos relativos a moléculas de canabinoide aniônicas
CA3130763A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
JP2022538864A (ja) * 2019-06-28 2022-09-06 ジービーエス グローバル バイオファーマ,インコーポレイテッド Trpv1のアロステリックモジュレータを用いた疼痛の治療
US20230003713A1 (en) * 2019-12-02 2023-01-05 CCG Holding, Inc. Methods of screening compositions for cannabinoids
WO2022026960A1 (en) 2020-07-31 2022-02-03 Natural Extraction Systems, LLC Compositions and methods related to excipients and cannabinoid formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037675A1 (en) * 1998-01-22 1999-07-29 The Regents Of The University Of California Nucleic acid sequences encoding capsaicin receptors
GB9827016D0 (en) 1998-12-08 1999-02-03 Merck Sharp & Dohme Receptor protein
CH695661A5 (de) * 2001-03-06 2006-07-31 Forsch Hiscia Ver Fuer Krebsfo Pharmazeutische Zusammensetzung.
US20070196866A1 (en) * 2004-03-13 2007-08-23 Irm Llc Modulators of ion channel trpa1
WO2006005471A1 (en) 2004-07-15 2006-01-19 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with vanilloid receptor 2 (vr2(vrl-1))
WO2006116773A2 (en) 2005-04-28 2006-11-02 The Regents Of The University Of California Methods, compositions, and compounds for modulation of monoacylglycerol lipase, pain, and stress-related disorders

Also Published As

Publication number Publication date
US7575882B2 (en) 2009-08-18
DE602006021223D1 (de) 2011-05-19
EP1952160B1 (de) 2011-04-06
US20070105086A1 (en) 2007-05-10
EP1952160A1 (de) 2008-08-06
WO2007053526A1 (en) 2007-05-10
JP2009513159A (ja) 2009-04-02
AU2006308914A1 (en) 2007-05-10
US20090275649A1 (en) 2009-11-05
CN101542288A (zh) 2009-09-23

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