ATE431825T1 - Neue antagonisten für den vitronectinrezeptor, verfahren zu deren herstellung, deren verwendung als arzneimittel und pharmazeutische zusammensetzung, die diese enthalten - Google Patents
Neue antagonisten für den vitronectinrezeptor, verfahren zu deren herstellung, deren verwendung als arzneimittel und pharmazeutische zusammensetzung, die diese enthaltenInfo
- Publication number
- ATE431825T1 ATE431825T1 AT03799611T AT03799611T ATE431825T1 AT E431825 T1 ATE431825 T1 AT E431825T1 AT 03799611 T AT03799611 T AT 03799611T AT 03799611 T AT03799611 T AT 03799611T AT E431825 T1 ATE431825 T1 AT E431825T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- pharmaceutical compositions
- compositions containing
- medicinal products
- vitronectin receptor
- Prior art date
Links
- 102100022337 Integrin alpha-V Human genes 0.000 title 1
- 108010048673 Vitronectin Receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0214429A FR2847254B1 (fr) | 2002-11-19 | 2002-11-19 | Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant |
| PCT/FR2003/003349 WO2004048375A1 (fr) | 2002-11-19 | 2003-11-12 | Nouveaux derives antagonistes du recepteur de la vitronectine leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE431825T1 true ATE431825T1 (de) | 2009-06-15 |
Family
ID=32187700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03799611T ATE431825T1 (de) | 2002-11-19 | 2003-11-12 | Neue antagonisten für den vitronectinrezeptor, verfahren zu deren herstellung, deren verwendung als arzneimittel und pharmazeutische zusammensetzung, die diese enthalten |
| AT09003174T ATE518842T1 (de) | 2002-11-19 | 2003-11-12 | Neue antagonistische derivate des vitronektinrezeptors, ihr herstellungsverfahren, ihre anwendung als arzneimittel und die pharmazeutischen zusammensetzungen, die sie enthalten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09003174T ATE518842T1 (de) | 2002-11-19 | 2003-11-12 | Neue antagonistische derivate des vitronektinrezeptors, ihr herstellungsverfahren, ihre anwendung als arzneimittel und die pharmazeutischen zusammensetzungen, die sie enthalten |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7582640B2 (de) |
| EP (2) | EP2070914B1 (de) |
| JP (1) | JP4567459B2 (de) |
| KR (1) | KR101140752B1 (de) |
| CN (2) | CN101928287A (de) |
| AR (2) | AR042068A1 (de) |
| AT (2) | ATE431825T1 (de) |
| AU (2) | AU2003299330B2 (de) |
| BR (1) | BR0316307A (de) |
| CA (1) | CA2506310C (de) |
| CO (1) | CO5700761A2 (de) |
| CY (1) | CY1112218T1 (de) |
| DE (1) | DE60327712D1 (de) |
| DK (2) | DK2070914T3 (de) |
| ES (2) | ES2369561T3 (de) |
| FR (1) | FR2847254B1 (de) |
| IL (2) | IL168136A (de) |
| MA (1) | MA27492A1 (de) |
| MX (1) | MXPA05005340A (de) |
| NO (1) | NO20052491L (de) |
| PL (1) | PL376866A1 (de) |
| PT (2) | PT2070914E (de) |
| RU (1) | RU2412185C2 (de) |
| SI (2) | SI2070914T1 (de) |
| TW (1) | TW200412969A (de) |
| WO (1) | WO2004048375A1 (de) |
| ZA (1) | ZA200502850B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2847254B1 (fr) | 2002-11-19 | 2005-01-28 | Aventis Pharma Sa | Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant |
| FR2870541B1 (fr) | 2004-05-18 | 2006-07-14 | Proskelia Sas | Derives de pyrimidines antigonistes du recepteur de la vitronectine |
| US20110189174A1 (en) * | 2010-02-01 | 2011-08-04 | Afshin Shafiee | Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization |
| US20110237605A1 (en) * | 2010-03-26 | 2011-09-29 | Eric Phillips | Molecular Crystal of (4-(1,8-Naphthyridin-2-YL)Piperidin-1-YL)Pyrimidine Derivative |
| WO2020043533A1 (en) | 2018-08-17 | 2020-03-05 | Oxurion NV | Integrin antagonists |
| WO2021165206A1 (en) | 2020-02-19 | 2021-08-26 | Oxurion NV | Treatment of dry amd with integrin antagonists |
| US11778420B2 (en) | 2020-06-29 | 2023-10-03 | Ickovic & Bliss, Inc. | Systems, methods, and program products for digital PET identification |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5217994A (en) | 1991-08-09 | 1993-06-08 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives |
| US5204350A (en) | 1991-08-09 | 1993-04-20 | Merck & Co., Inc. | Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives |
| AU674553B2 (en) | 1992-10-14 | 1997-01-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| JPH08504194A (ja) | 1992-12-01 | 1996-05-07 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲンレセプターアンタゴニスト |
| JPH10501222A (ja) | 1994-05-27 | 1998-02-03 | メルク エンド カンパニー インコーポレーテッド | 破骨細胞仲介骨吸収を抑制するための化合物 |
| EP0767792A4 (de) | 1994-06-29 | 2002-11-20 | Smithkline Beecham Corp | Vitronectin-rezeptor antagonisten |
| EP0762882A4 (de) * | 1994-06-29 | 2002-09-11 | Smithkline Beecham Corp | Vibronectin-rezeptor-antagonisten |
| KR20000022190A (ko) | 1996-06-28 | 2000-04-25 | 플레믹 크리스티안 | 인테그린 저해제로서의 페닐알라닌 유도체 |
| DE19629816A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
| DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
| US6723727B1 (en) | 1996-12-20 | 2004-04-20 | Hoechst Aktiengesellschaft | Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them |
| DE19705450A1 (de) * | 1997-02-13 | 1998-08-20 | Merck Patent Gmbh | Bicyclische aromatische Aminosäuren |
| EP0933367A1 (de) | 1997-12-19 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Acylguanidin Derivate als Inhibitoren von Knochenaufsauge und als Vitronectin Rezeptor Antagonisten |
| IL137423A0 (en) | 1998-01-23 | 2001-07-24 | Aventis Pharma Gmbh | Novel sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
| CA2333927A1 (en) * | 1998-04-01 | 1999-10-07 | Dupont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| CN1322133A (zh) * | 1998-08-07 | 2001-11-14 | 史密丝克莱恩比彻姆公司 | 玻璃体结合蛋白受体拮抗剂 |
| JP2003502373A (ja) | 1999-06-23 | 2003-01-21 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体アンタゴニスト |
| EP1065207A1 (de) | 1999-07-02 | 2001-01-03 | Aventis Pharma Deutschland GmbH | Naphthyridin derivate, Verfahren zu ihrer Herstellung, ihre Anwendung und sie enthaltende pharmazeutische Zusammenfassungen |
| EP1065208A1 (de) * | 1999-07-02 | 2001-01-03 | Aventis Pharma Deutschland GmbH | Substituierte Purin Derivate als Inhibitoren der Zell-Adhäsion |
| EP1218095B1 (de) * | 1999-10-05 | 2003-09-03 | Element Six (Pty) Ltd | Wachstum von diamantclustern |
| DE10042655A1 (de) | 2000-08-31 | 2002-03-14 | Aventis Pharma Gmbh | Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion |
| FR2847254B1 (fr) | 2002-11-19 | 2005-01-28 | Aventis Pharma Sa | Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant |
| FR2870541B1 (fr) * | 2004-05-18 | 2006-07-14 | Proskelia Sas | Derives de pyrimidines antigonistes du recepteur de la vitronectine |
-
2002
- 2002-11-19 FR FR0214429A patent/FR2847254B1/fr not_active Expired - Fee Related
-
2003
- 2003-11-12 DK DK09003174.1T patent/DK2070914T3/da active
- 2003-11-12 MX MXPA05005340A patent/MXPA05005340A/es active IP Right Grant
- 2003-11-12 WO PCT/FR2003/003349 patent/WO2004048375A1/fr not_active Ceased
- 2003-11-12 DE DE60327712T patent/DE60327712D1/de not_active Expired - Lifetime
- 2003-11-12 AU AU2003299330A patent/AU2003299330B2/en not_active Ceased
- 2003-11-12 US US10/536,028 patent/US7582640B2/en active Active
- 2003-11-12 SI SI200332048T patent/SI2070914T1/sl unknown
- 2003-11-12 JP JP2004554592A patent/JP4567459B2/ja not_active Expired - Fee Related
- 2003-11-12 AT AT03799611T patent/ATE431825T1/de active
- 2003-11-12 KR KR1020057009101A patent/KR101140752B1/ko not_active Expired - Fee Related
- 2003-11-12 EP EP09003174A patent/EP2070914B1/de not_active Expired - Lifetime
- 2003-11-12 AT AT09003174T patent/ATE518842T1/de active
- 2003-11-12 CN CN2009101705723A patent/CN101928287A/zh active Pending
- 2003-11-12 RU RU2005119163/04A patent/RU2412185C2/ru not_active Application Discontinuation
- 2003-11-12 EP EP03799611A patent/EP1565467B1/de not_active Expired - Lifetime
- 2003-11-12 ES ES09003174T patent/ES2369561T3/es not_active Expired - Lifetime
- 2003-11-12 PT PT09003174T patent/PT2070914E/pt unknown
- 2003-11-12 PT PT03799611T patent/PT1565467E/pt unknown
- 2003-11-12 CA CA2506310A patent/CA2506310C/fr not_active Expired - Lifetime
- 2003-11-12 BR BR0316307-5A patent/BR0316307A/pt not_active IP Right Cessation
- 2003-11-12 CN CN2003801088984A patent/CN1738817B/zh not_active Expired - Fee Related
- 2003-11-12 SI SI200331636T patent/SI1565467T1/sl unknown
- 2003-11-12 ES ES03799611T patent/ES2325616T3/es not_active Expired - Lifetime
- 2003-11-12 DK DK03799611T patent/DK1565467T3/da active
- 2003-11-12 PL PL376866A patent/PL376866A1/pl not_active Application Discontinuation
- 2003-11-13 TW TW092131850A patent/TW200412969A/zh unknown
- 2003-11-18 AR ARP030104254A patent/AR042068A1/es unknown
-
2005
- 2005-04-07 ZA ZA200502850A patent/ZA200502850B/en unknown
- 2005-04-19 IL IL168136A patent/IL168136A/en active IP Right Grant
- 2005-05-12 MA MA28281A patent/MA27492A1/fr unknown
- 2005-05-16 CO CO05046617A patent/CO5700761A2/es not_active Application Discontinuation
- 2005-05-23 NO NO20052491A patent/NO20052491L/no not_active Application Discontinuation
-
2008
- 2008-10-03 US US12/245,622 patent/US7763621B2/en not_active Expired - Fee Related
-
2009
- 2009-08-24 AU AU2009212779A patent/AU2009212779B2/en not_active Ceased
-
2010
- 2010-05-11 IL IL205693A patent/IL205693A/en active IP Right Grant
- 2010-07-15 AR ARP100102568A patent/AR077476A2/es not_active Application Discontinuation
-
2011
- 2011-11-02 CY CY20111101051T patent/CY1112218T1/el unknown
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