PL376866A1 - Nowe antagonistyczne pochodne receptora witronektyny, sposób ich przygotowania, ich zastosowanie jako leków i kompozycje farmaceutyczne je zawierające - Google Patents

Nowe antagonistyczne pochodne receptora witronektyny, sposób ich przygotowania, ich zastosowanie jako leków i kompozycje farmaceutyczne je zawierające

Info

Publication number
PL376866A1
PL376866A1 PL376866A PL37686603A PL376866A1 PL 376866 A1 PL376866 A1 PL 376866A1 PL 376866 A PL376866 A PL 376866A PL 37686603 A PL37686603 A PL 37686603A PL 376866 A1 PL376866 A1 PL 376866A1
Authority
PL
Poland
Prior art keywords
same
medicines
pharmaceutical compositions
compositions containing
receptor antagonist
Prior art date
Application number
PL376866A
Other languages
English (en)
Inventor
Jean-Marie Ruxer
Jean-Michel Lefrancois
Bertrand Heckmann
Original Assignee
Proskelia Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proskelia Sas filed Critical Proskelia Sas
Publication of PL376866A1 publication Critical patent/PL376866A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL376866A 2002-11-19 2003-11-12 Nowe antagonistyczne pochodne receptora witronektyny, sposób ich przygotowania, ich zastosowanie jako leków i kompozycje farmaceutyczne je zawierające PL376866A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0214429A FR2847254B1 (fr) 2002-11-19 2002-11-19 Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant

Publications (1)

Publication Number Publication Date
PL376866A1 true PL376866A1 (pl) 2006-01-09

Family

ID=32187700

Family Applications (1)

Application Number Title Priority Date Filing Date
PL376866A PL376866A1 (pl) 2002-11-19 2003-11-12 Nowe antagonistyczne pochodne receptora witronektyny, sposób ich przygotowania, ich zastosowanie jako leków i kompozycje farmaceutyczne je zawierające

Country Status (27)

Country Link
US (2) US7582640B2 (pl)
EP (2) EP2070914B1 (pl)
JP (1) JP4567459B2 (pl)
KR (1) KR101140752B1 (pl)
CN (2) CN1738817B (pl)
AR (2) AR042068A1 (pl)
AT (2) ATE518842T1 (pl)
AU (2) AU2003299330B2 (pl)
BR (1) BR0316307A (pl)
CA (1) CA2506310C (pl)
CO (1) CO5700761A2 (pl)
CY (1) CY1112218T1 (pl)
DE (1) DE60327712D1 (pl)
DK (2) DK2070914T3 (pl)
ES (2) ES2325616T3 (pl)
FR (1) FR2847254B1 (pl)
IL (2) IL168136A (pl)
MA (1) MA27492A1 (pl)
MX (1) MXPA05005340A (pl)
NO (1) NO20052491D0 (pl)
PL (1) PL376866A1 (pl)
PT (2) PT1565467E (pl)
RU (1) RU2412185C2 (pl)
SI (2) SI2070914T1 (pl)
TW (1) TW200412969A (pl)
WO (1) WO2004048375A1 (pl)
ZA (1) ZA200502850B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2847254B1 (fr) 2002-11-19 2005-01-28 Aventis Pharma Sa Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
FR2870541B1 (fr) * 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine
US20110189174A1 (en) 2010-02-01 2011-08-04 Afshin Shafiee Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization
US20110237605A1 (en) 2010-03-26 2011-09-29 Eric Phillips Molecular Crystal of (4-(1,8-Naphthyridin-2-YL)Piperidin-1-YL)Pyrimidine Derivative
ES2836733T3 (es) 2018-08-17 2021-06-28 Oxurion NV Antagonistas de integrina
WO2021165206A1 (en) 2020-02-19 2021-08-26 Oxurion NV Treatment of dry amd with integrin antagonists
EP4171212A4 (en) 2020-06-29 2024-07-24 Ickovic & Bliss, Inc. Systems, methods, and program products for digital pet identification

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217994A (en) 1991-08-09 1993-06-08 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives
US5204350A (en) 1991-08-09 1993-04-20 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives
EP0667773A4 (en) 1992-10-14 1996-09-25 Merck & Co Inc FIBRINOGEN RECEPTOR ANTAGONISTS.
CA2150550A1 (en) 1992-12-01 1994-06-09 Melissa S. Egbertson Fibrinogen receptor antagonists
ATE227567T1 (de) 1994-05-27 2002-11-15 Merck & Co Inc Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption
WO1996000730A1 (en) 1994-06-29 1996-01-11 Smithkline Beecham Corporation Vitronectin receptor antagonists
ZA955391B (en) * 1994-06-29 1996-02-09 Smithkline Beecham Corp Vitronectin receptor antagonists
EP0907637A1 (de) 1996-06-28 1999-04-14 MERCK PATENT GmbH Phenylalanin-derivate als integrin-inhibitoren
DE19629816A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19653646A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
US6723727B1 (en) * 1996-12-20 2004-04-20 Hoechst Aktiengesellschaft Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them
DE19705450A1 (de) * 1997-02-13 1998-08-20 Merck Patent Gmbh Bicyclische aromatische Aminosäuren
EP0933367A1 (en) * 1997-12-19 1999-08-04 Hoechst Marion Roussel Deutschland GmbH Novel acylguanidine derivates as inhibitors of bone resorption and as vitronectin receptor antagonists
BR9907735A (pt) 1998-01-23 2000-10-17 Aventis Pharma Gmbh Derivados de sulfonamida como inibidores da reabsorção óssea e como inibidores da aderência celular
WO1999050249A2 (en) * 1998-04-01 1999-10-07 Du Pont Pharmaceuticals Company Pyrimidines and triazines as integrin antagonists
US6458814B1 (en) * 1998-08-07 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
EP1194151A4 (en) 1999-06-23 2003-01-15 Merck & Co Inc ANTAGONISTS OF THE INTEGRIN RECEPTORS
EP1065208A1 (en) * 1999-07-02 2001-01-03 Aventis Pharma Deutschland GmbH Substituted purine derivatives as inhibitors of cell adhesion
EP1065207A1 (en) 1999-07-02 2001-01-03 Aventis Pharma Deutschland GmbH Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
EP1218095B1 (en) * 1999-10-05 2003-09-03 Element Six (Pty) Ltd Growth of diamond clusters
DE10042655A1 (de) * 2000-08-31 2002-03-14 Aventis Pharma Gmbh Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion
FR2847254B1 (fr) 2002-11-19 2005-01-28 Aventis Pharma Sa Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
FR2870541B1 (fr) * 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine

Also Published As

Publication number Publication date
JP4567459B2 (ja) 2010-10-20
IL205693A (en) 2011-06-30
EP1565467B1 (fr) 2009-05-20
SI2070914T1 (sl) 2012-02-29
US7582640B2 (en) 2009-09-01
FR2847254B1 (fr) 2005-01-28
DK2070914T3 (da) 2011-11-21
SI1565467T1 (sl) 2009-10-31
PT2070914E (pt) 2011-10-12
CA2506310C (fr) 2014-04-08
CN101928287A (zh) 2010-12-29
ES2325616T3 (es) 2009-09-10
EP2070914B1 (fr) 2011-08-03
EP1565467A1 (fr) 2005-08-24
PT1565467E (pt) 2009-07-15
AU2003299330A1 (en) 2004-06-18
ATE431825T1 (de) 2009-06-15
ZA200502850B (en) 2005-10-25
CO5700761A2 (es) 2006-11-30
CY1112218T1 (el) 2015-12-09
EP2070914A1 (fr) 2009-06-17
AU2003299330B2 (en) 2009-09-17
BR0316307A (pt) 2005-09-27
TW200412969A (en) 2004-08-01
NO20052491L (no) 2005-05-23
AR077476A2 (es) 2011-08-31
ES2369561T3 (es) 2011-12-01
CA2506310A1 (fr) 2004-06-10
MA27492A1 (fr) 2005-08-01
US7763621B2 (en) 2010-07-27
DK1565467T3 (da) 2009-09-14
KR20050083926A (ko) 2005-08-26
AR042068A1 (es) 2005-06-08
IL168136A (en) 2012-06-28
WO2004048375A1 (fr) 2004-06-10
DE60327712D1 (de) 2009-07-02
MXPA05005340A (es) 2005-11-17
ATE518842T1 (de) 2011-08-15
CN1738817A (zh) 2006-02-22
AU2009212779A1 (en) 2009-09-17
NO20052491D0 (no) 2005-05-23
HK1076277A1 (en) 2006-01-13
CN1738817B (zh) 2011-12-21
HK1129372A1 (en) 2009-11-27
RU2412185C2 (ru) 2011-02-20
AU2009212779B2 (en) 2011-09-01
FR2847254A1 (fr) 2004-05-21
US20060052398A1 (en) 2006-03-09
US20090149476A1 (en) 2009-06-11
RU2005119163A (ru) 2006-02-27
KR101140752B1 (ko) 2012-05-03
JP2006508999A (ja) 2006-03-16

Similar Documents

Publication Publication Date Title
HUP0400570A3 (en) Phenylethenyl or phenylethinyl heteroaril derivatives as glutamate receptor antagonists, their use, process for their preparation and pharmaceutical compositions containing them
HUP0402588A3 (en) Quinazoline derivatives, pharmaceutical compositions containing them, process for producing them and their use
IL163831A (en) Derivatives of aminoindazoles, pharmaceutical compositions comprising them, process for their preparation and use thereof
HUP0202787A3 (en) Piperazine derivatives as 5-ht1b antagonists, process for their preparation and pharmaceutical compositions containing them
HUP0300138A3 (en) Cyclic amine derivatives as ccr5 antagonists, their production and use and pharmaceutical compositions containing them
HUP0200139A3 (en) 3-phenylpyridine derivatives and their use as nk-1 receptor antagonists, process for their preparation and pharmaceutical compositions containing them
HUP0400989A3 (en) Substituted 2-pyridine-cyclohexane-1,4-diamine derivatives, process for their preparation and pharmaceutical compositions containing them
IL169818A0 (en) Adamantane derivatives, processes for their preparation and pharmaceutical composition containing them
MXPA03006538A (es) Nuevos derivados de urea, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion.
HUP0200438A3 (en) Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
HUP0300052A3 (en) Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists, process for their preparation and pharmaceutical compositions containing them
PL1720544T3 (pl) Nowe pochodne azabicykliczne, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne
HUP0101143A3 (en) Pyridin-carboxylic acid derivatives as vitronectin receptor antagonists, process for producing them and pharmaceutical compositions containing them
HUP0201571A2 (en) Il-8 receptor antagonist phenyl urea derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HUP0003641A3 (en) Dibenzocycloheptene derivatives as vitronectin receptor antagonists, process for producing them and pharmaceutical compositions containing them
HUP0203976A3 (en) Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
AU2003231920A8 (en) Antiinfectve compounds, process for their preparation and pharmaceutical compositions containing them
HUP0201710A3 (en) Biphenyl derivatives as antagonists of the neurokinine-1 receptor, process for producing them and pharmaceutical compositions containing them
HUP0104804A3 (en) Tetrahydro-naphthyridinyl derivative as vitronectin receptor antagonist, process for its preparation and pharmaceutical composition containing the same
SI1565467T1 (sl) Novi derivati antagonista vitronektin receptorja, postopek za pripravo le teh njihova uporaba kot zdravila in farmacevtskega sestavka, ki jih vsebuje
HUP0202706A3 (en) Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4 antagonists, their intermediates, process for their preparation and pharmaceutical compositions containing them
HUP0500958A2 (en) 2-arylimino-2,3-dihydrothiazole derivatives, methods for preparing them, therapeutic use thereof and pharmaceutical compositions containing them
IL158660A0 (en) Novel piperidinecarboxamide derivatives, method for preparing same and pharmaceutical compositions containing same
HUP0202710A3 (en) Vitronectin receptor antagonists, pharmaceutical compositions containing them and their use
HUP0103090A3 (en) Vitronectin receptor antagonist oxazole derivatives, process for their preparation, pharmaceutical compositions containing them and their use

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)