ATE431835T1 - Verfahren zum schutz von thiolgruppen in antikörpern - Google Patents
Verfahren zum schutz von thiolgruppen in antikörpernInfo
- Publication number
- ATE431835T1 ATE431835T1 AT03780938T AT03780938T ATE431835T1 AT E431835 T1 ATE431835 T1 AT E431835T1 AT 03780938 T AT03780938 T AT 03780938T AT 03780938 T AT03780938 T AT 03780938T AT E431835 T1 ATE431835 T1 AT E431835T1
- Authority
- AT
- Austria
- Prior art keywords
- antibodies
- thiol groups
- protecting thiol
- protecting
- protein
- Prior art date
Links
- 150000003573 thiols Chemical group 0.000 title 1
- 235000018102 proteins Nutrition 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical group SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/066—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amido functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002370822 | 2002-12-20 | ||
| PCT/JP2003/016362 WO2004056872A1 (ja) | 2002-12-20 | 2003-12-19 | タンパク質のチオール基を保護する方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE431835T1 true ATE431835T1 (de) | 2009-06-15 |
Family
ID=32677181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03780938T ATE431835T1 (de) | 2002-12-20 | 2003-12-19 | Verfahren zum schutz von thiolgruppen in antikörpern |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060257393A1 (de) |
| EP (1) | EP1574521B1 (de) |
| JP (1) | JPWO2004056872A1 (de) |
| AT (1) | ATE431835T1 (de) |
| AU (1) | AU2003289455A1 (de) |
| CA (1) | CA2511228A1 (de) |
| DE (1) | DE60327715D1 (de) |
| ES (1) | ES2326076T3 (de) |
| WO (1) | WO2004056872A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR103172A1 (es) | 2014-12-22 | 2017-04-19 | Novartis Ag | Reducción selectiva de residuos de cisteina en anticuerpos il-17 |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734362A (en) * | 1986-02-03 | 1988-03-29 | Cambridge Bioscience Corporation | Process for purifying recombinant proteins, and products thereof |
| ES2064336T3 (es) * | 1987-10-13 | 1995-02-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de proteinas. |
| US5130418A (en) * | 1989-05-02 | 1992-07-14 | California Biotechnology Inc. | Method to stabilize basic fibroblast growth factor |
| AU660001B2 (en) * | 1990-10-25 | 1995-06-08 | Trustees Of Columbia University In The City Of New York, The | Development of DNA probes and immunological reagents of human tumor associated antigens |
| US5284830A (en) * | 1991-02-13 | 1994-02-08 | The Board Of Trustees Of The Leland Stanford Junior University | Thyroid-derived chondrocyte-stimulating factor |
| JP3220180B2 (ja) * | 1991-05-23 | 2001-10-22 | 三菱化学株式会社 | 薬剤含有タンパク質結合リポソーム |
| CA2072249C (en) * | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
| JP3236667B2 (ja) * | 1991-06-28 | 2001-12-10 | 三菱化学株式会社 | ヒト型モノクローナル抗体およびそれをコードする遺伝子、ハイブリドーマ並びに抗腫瘍剤 |
| FI950062A7 (fi) * | 1992-07-06 | 1995-01-05 | Biomira Inc | Proteiinien foroaktivaatio konjugaatiotarkoituksia varten |
| EP0943690B1 (de) * | 1995-12-21 | 2006-11-29 | Ajinomoto Co., Inc. | Verfahren zur rückfaltung von menschlichem activin a |
| AU714318B2 (en) * | 1996-06-11 | 2000-01-06 | Roche Diagnostics Gmbh | Process for the activation of denatured protein |
| WO2001075095A1 (fr) * | 2000-03-30 | 2001-10-11 | Takeda Chemical Industries, Ltd. | Procede de production de proteine de recombinaison |
| WO2003048357A1 (fr) * | 2001-12-04 | 2003-06-12 | Mitsubishi Pharma Corporation | Procede d'activation de proteine |
-
2003
- 2003-12-19 EP EP03780938A patent/EP1574521B1/de not_active Expired - Lifetime
- 2003-12-19 WO PCT/JP2003/016362 patent/WO2004056872A1/ja not_active Ceased
- 2003-12-19 AU AU2003289455A patent/AU2003289455A1/en not_active Abandoned
- 2003-12-19 US US10/539,756 patent/US20060257393A1/en not_active Abandoned
- 2003-12-19 CA CA002511228A patent/CA2511228A1/en not_active Abandoned
- 2003-12-19 DE DE60327715T patent/DE60327715D1/de not_active Expired - Fee Related
- 2003-12-19 JP JP2004562060A patent/JPWO2004056872A1/ja not_active Withdrawn
- 2003-12-19 AT AT03780938T patent/ATE431835T1/de not_active IP Right Cessation
- 2003-12-19 ES ES03780938T patent/ES2326076T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060257393A1 (en) | 2006-11-16 |
| EP1574521A4 (de) | 2006-04-12 |
| AU2003289455A1 (en) | 2004-07-14 |
| EP1574521A1 (de) | 2005-09-14 |
| JPWO2004056872A1 (ja) | 2006-04-20 |
| ES2326076T3 (es) | 2009-09-30 |
| DE60327715D1 (de) | 2009-07-02 |
| EP1574521B1 (de) | 2009-05-20 |
| WO2004056872A1 (ja) | 2004-07-08 |
| CA2511228A1 (en) | 2004-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |