ATE432270T1 - Verfahren zu herstellung von lovastatin. - Google Patents

Verfahren zu herstellung von lovastatin.

Info

Publication number: ATE432270T1
Authority: AT; Austria
Prior art keywords: lovastatin; impure; producing lovastatin; producing; lactonisation
Prior art date: 2003-10-14

Application number

AT03782759T

Other languages

English (en)

Inventor

Sanjay Kumar Vaishnav

Bhupendra Harishchandra Thakur

Subhash Rajaram Kadam

Original Assignee

Lupin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-14

Filing date

2003-10-14

Publication date

2009-06-15

2003-10-14 Application filed by Lupin Ltd filed Critical Lupin Ltd

2009-06-15 Application granted granted Critical

2009-06-15 Publication of ATE432270T1 publication Critical patent/ATE432270T1/de

Links

QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title abstract 6
PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 title abstract 5
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title abstract 5
229960004844 lovastatin Drugs 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 2
QLJODMDSTUBWDW-BXMDZJJMSA-N mevinolinic acid Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@@H](C)C=C21 QLJODMDSTUBWDW-BXMDZJJMSA-N 0.000 abstract 2
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrane Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03782759T 2003-10-14 2003-10-14 Verfahren zu herstellung von lovastatin. ATE432270T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IN2003/000333 WO2005035515A1 (en)	2003-10-14	2003-10-14	A method for the manufacture of lovastatin

Publications (1)

Publication Number	Publication Date
ATE432270T1 true ATE432270T1 (de)	2009-06-15

Family

ID=34430672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03782759T ATE432270T1 (de)	2003-10-14	2003-10-14	Verfahren zu herstellung von lovastatin.

Country Status (9)

Country	Link
US (1)	US7566792B2 (de)
EP (1)	EP1673361B1 (de)
AT (1)	ATE432270T1 (de)
AU (1)	AU2003290396A1 (de)
CA (1)	CA2540068C (de)
DE (1)	DE60327813D1 (de)
ES (1)	ES2325498T3 (de)
PT (1)	PT1673361E (de)
WO (1)	WO2005035515A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102993145B (zh) *	2011-09-19	2015-06-03	北大方正集团有限公司	一种提取纯化洛伐他汀的方法
EP2597092A1 (de) *	2011-11-24	2013-05-29	Sterling Biotech Limited	Verfahren zum Reinigen von Lovastatin
CN111718317A (zh) *	2019-03-21	2020-09-29	福安药业集团烟台只楚药业有限公司	一种洛伐他汀的提炼方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7271696A (en)	1995-12-06	1997-06-27	Antibiotic Co	Method of production of lovastatin
SI20527A (sl) *	1999-06-29	2001-10-31	Kaneka Corporation	Postopek za selektivno laktonizacijo
AU8030900A (en) *	1999-10-27	2001-05-08	Merck & Co., Inc.	Lactonization process
IN192861B (de) *	2000-06-30	2004-05-22	Ranbaxy Lab Ltd

2003
- 2003-10-14 US US10/571,192 patent/US7566792B2/en not_active Expired - Fee Related
- 2003-10-14 DE DE60327813T patent/DE60327813D1/de not_active Expired - Lifetime
- 2003-10-14 EP EP03782759A patent/EP1673361B1/de not_active Expired - Lifetime
- 2003-10-14 CA CA2540068A patent/CA2540068C/en not_active Expired - Fee Related
- 2003-10-14 AU AU2003290396A patent/AU2003290396A1/en not_active Abandoned
- 2003-10-14 WO PCT/IN2003/000333 patent/WO2005035515A1/en not_active Ceased
- 2003-10-14 ES ES03782759T patent/ES2325498T3/es not_active Expired - Lifetime
- 2003-10-14 AT AT03782759T patent/ATE432270T1/de not_active IP Right Cessation
- 2003-10-14 PT PT03782759T patent/PT1673361E/pt unknown

Also Published As

Publication number	Publication date
EP1673361B1 (de)	2009-05-27
ES2325498T3 (es)	2009-09-07
CA2540068C (en)	2012-05-29
EP1673361A1 (de)	2006-06-28
DE60327813D1 (de)	2009-07-09
WO2005035515A1 (en)	2005-04-21
CA2540068A1 (en)	2003-10-14
AU2003290396A1 (en)	2005-04-27
US20070238885A1 (en)	2007-10-11
PT1673361E (pt)	2009-07-13
US7566792B2 (en)	2009-07-28

Similar Documents

Publication	Publication Date	Title
DE60009910D1 (de)	2004-05-19	Verfahren zur herstellung von zsm-5 und zsm-11
ATE332304T1 (de)	2006-07-15	Cefdinir salze als zwischenprodukte
ATE407127T1 (de)	2008-09-15	Verfahren zur herstellung von beraprost und dessen salzen
ATE323777T1 (de)	2006-05-15	Verfahren zur herstellung von lysophosphatidyl- ethanolamin
ATE425121T1 (de)	2009-03-15	Verfahren zur umwandlung von polysulfanen
DK1644389T3 (da)	2011-05-09	Pyrinidinforbindelser med phosphonatgrupper som antivirale nukleotidanaloger
ATE457972T1 (de)	2010-03-15	Verfahren zur herstellung von 7-amino-syn-3,5- dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung
ATE359272T1 (de)	2007-05-15	Verfahren zur herstellung von 3-hydroxy-n-1,6-
ATE432270T1 (de)	2009-06-15	Verfahren zu herstellung von lovastatin.
DE69908909D1 (de)	2003-07-24	Verfahren zur herstellung von simvastatin und ihren derivaten
DE60015563D1 (de)	2004-12-09	Verfahren zur herstellung von benzoperhydroisoindolen
ATE455087T1 (de)	2010-01-15	Verfahren zur herstellung von 2,5- dimethylphenylessigsäure
ATE415404T1 (de)	2008-12-15	Lösungsmittelfreies verfahren zur herstellung von diketopyrrolopyrrol-derivaten
ATE496038T1 (de)	2011-02-15	Verfahren zur herstellung von quetiapin
ATE445601T1 (de)	2009-10-15	Verfahren zur herstellung von carvedilol und seinen enantiomeren
EA200001084A1 (ru)	2001-06-25	Новые производные аналогов камптотецина, способ их получения и содержащие их фармацевтические композиции
DE60107292D1 (de)	2004-12-23	Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin
DE602004008486D1 (de)	2007-10-04	Verfahren zur herstellung von (1s,4r)-cis-4-ä2-amino-6-chlor-9h-purin-9-ylü-2-cyclopenten-1-methanol
ATE399757T1 (de)	2008-07-15	Neues verfahren zur herstellung von nitrooxyderivaten von paracetamol
ATE417826T1 (de)	2009-01-15	Verfahren zur herstellung von zwischenprodukten
ATE363460T1 (de)	2007-06-15	Verfahren zur herstellung von fluorhalogenalkanen
ATE457304T1 (de)	2010-02-15	Verfahren zur herstellung von 1,2-dichlorethan freien kristallen von zonisamid und hochreinezonisamidkristalle
ATE300534T1 (de)	2005-08-15	Verfahren und zwischenverbindungen zur herstellung von imidazopyridinen
ATE375355T1 (de)	2007-10-15	Verfahren zur herstellung von cefpodoxim-proxetil
DE50214080D1 (de)	2010-01-21	N-methyl-homocysteine und ihre verwendung sowie verfahren zu ihrer herstellung

Legal Events

Date	Code	Title	Description
2009-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties