ATE432470T1 - Verfahren zur unterscheidung des reizkolons von der entzündlichen darmerkrankung (inflammatory bowel disease, ibd) und zur überwachung von patienten mit ibd unter verwendung von endogenem gesamt-lactoferrin als marker - Google Patents
Verfahren zur unterscheidung des reizkolons von der entzündlichen darmerkrankung (inflammatory bowel disease, ibd) und zur überwachung von patienten mit ibd unter verwendung von endogenem gesamt-lactoferrin als markerInfo
- Publication number
- ATE432470T1 ATE432470T1 AT01996331T AT01996331T ATE432470T1 AT E432470 T1 ATE432470 T1 AT E432470T1 AT 01996331 T AT01996331 T AT 01996331T AT 01996331 T AT01996331 T AT 01996331T AT E432470 T1 ATE432470 T1 AT E432470T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammatory bowel
- bowel disease
- ibd
- lactoferrin
- endogene
- Prior art date
Links
- 208000022559 Inflammatory bowel disease Diseases 0.000 title abstract 7
- 102000010445 Lactoferrin Human genes 0.000 title abstract 7
- 108010063045 Lactoferrin Proteins 0.000 title abstract 7
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 title abstract 7
- 229940078795 lactoferrin Drugs 0.000 title abstract 7
- 235000021242 lactoferrin Nutrition 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 238000012544 monitoring process Methods 0.000 title abstract 2
- 239000003550 marker Substances 0.000 title 1
- 230000002550 fecal effect Effects 0.000 abstract 3
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24828800P | 2000-11-14 | 2000-11-14 | |
| PCT/US2001/045301 WO2002039883A2 (en) | 2000-11-14 | 2001-11-14 | Method for differentiating between irritable bowel syndrome and inflammatory bowel disease using lactoferrin as marker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE432470T1 true ATE432470T1 (de) | 2009-06-15 |
Family
ID=22938469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01996331T ATE432470T1 (de) | 2000-11-14 | 2001-11-14 | Verfahren zur unterscheidung des reizkolons von der entzündlichen darmerkrankung (inflammatory bowel disease, ibd) und zur überwachung von patienten mit ibd unter verwendung von endogenem gesamt-lactoferrin als marker |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7192724B2 (de) |
| EP (2) | EP2071332A1 (de) |
| AT (1) | ATE432470T1 (de) |
| AU (3) | AU2002902A (de) |
| CA (1) | CA2427898C (de) |
| DE (1) | DE60138829D1 (de) |
| ES (1) | ES2325059T3 (de) |
| WO (1) | WO2002039883A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2306902T3 (es) * | 2002-10-25 | 2008-11-16 | Techlab, Inc. | Panel de diagnostico ibd-first chek para la enfermedad inflamatoria del intestino y el sindrome del colon irritable. |
| US7759079B2 (en) * | 2004-05-13 | 2010-07-20 | Prometheus Laboratories Inc. | Methods of diagnosing inflammatory bowel disease |
| US20060154276A1 (en) | 2004-05-13 | 2006-07-13 | Prometheus Laboratories Inc. | Methods of diagnosing inflammatory bowel disease |
| US7943328B1 (en) | 2006-03-03 | 2011-05-17 | Prometheus Laboratories Inc. | Method and system for assisting in diagnosing irritable bowel syndrome |
| US20080085524A1 (en) * | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| US20100094560A1 (en) * | 2006-08-15 | 2010-04-15 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| WO2010056682A2 (en) | 2008-11-11 | 2010-05-20 | Prometheus Laboratories Inc. | Methods for prediction of inflammatory bowel disease (ibd) using serologic markers |
| WO2010120814A1 (en) | 2009-04-14 | 2010-10-21 | Prometheus Laboratories Inc. | Inflammatory bowel disease prognostics |
| EP3309556B1 (de) | 2009-06-25 | 2020-04-08 | Prometheus Biosciences, Inc. | Verfahren zur diagnostizierung des reizdarmsyndroms |
| WO2011060098A1 (en) | 2009-11-10 | 2011-05-19 | Prometheus Laboratories Inc. | Methods for predicting post-surgery risk associated with ileal pouch-anal anastomosis |
| DK3564357T3 (da) | 2010-02-01 | 2022-06-20 | Rebiotix Inc | Bakterieterapi mod clostridium difficile colitis |
| ES2380664B2 (es) | 2010-10-19 | 2012-09-13 | Certest Biotec, S.L. | Método y dispositivo para el diagnóstico rápido de enfermedades en muestras fecales. |
| CA2827609A1 (en) | 2011-02-17 | 2012-11-15 | Nestec S.A. | Assays for detecting autoantibodies to anti-tnf.alpha. drugs |
| US10295535B2 (en) * | 2011-04-29 | 2019-05-21 | Techlab, Inc. | Clostridium difficile dehydrogenase and toxin as a biomarker for monitoring infection in patients with clostridium difficile disease and differentiating carrier state from active disease |
| US20120276059A1 (en) | 2011-04-29 | 2012-11-01 | Techlab, Inc. | Fecal lactoferrin as a biomarker for determining disease severity and for monitoring infection in patients with clostridium difficile disease |
| WO2015067913A1 (en) | 2013-11-07 | 2015-05-14 | Diagnodus Limited | Biomarkers |
| AU2012253422B2 (en) | 2011-05-10 | 2015-08-13 | Société des Produits Nestlé S.A. | Methods of disease activity profiling for personalized therapy management |
| EP2734543B1 (de) * | 2011-07-24 | 2018-10-03 | Carmel-Haifa University Economic Corp. | Lactoferrinfragmente und verwendung davon |
| US20120258477A1 (en) * | 2011-07-25 | 2012-10-11 | Northwestern University | Fecal neopterin concentration measurement as an indicator of disease activity in inflammatory bowel disease |
| JP2015502740A (ja) | 2011-10-21 | 2015-01-29 | ネステク ソシエテ アノニム | 炎症性腸疾患の診断を改善するための方法 |
| WO2013082288A1 (en) * | 2011-11-29 | 2013-06-06 | The Regents Of The University Of California | Glucorticoid receptor gene nr3c1 methylation in irritable bowel syndrome and other stress disorders |
| WO2013132347A2 (en) | 2012-03-06 | 2013-09-12 | Calpro As | Improved elisa immunoassay for calprotectin |
| WO2013132338A2 (en) | 2012-03-06 | 2013-09-12 | Calpro As | Competitive immunoassay for calprotectin |
| CN103575903B (zh) * | 2012-08-07 | 2016-01-20 | 中国检验检疫科学研究院 | 一种人乳铁蛋白夹心elisa检测试剂盒及其应用 |
| RU2504779C1 (ru) * | 2012-10-08 | 2014-01-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Минздравсоцразвития России | Способ оценки эффективности лечения больных язвенным колитом |
| US9511099B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10383901B2 (en) | 2013-06-05 | 2019-08-20 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| KR102099503B1 (ko) | 2013-06-05 | 2020-04-09 | 리바이오틱스, 인코퍼레이티드 | 미생물상 복원 요법(mrt) 조성물 |
| US9782445B2 (en) | 2013-06-05 | 2017-10-10 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9511100B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US9694039B2 (en) | 2013-06-05 | 2017-07-04 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| US10799539B2 (en) | 2015-06-09 | 2020-10-13 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US10828340B2 (en) | 2015-06-09 | 2020-11-10 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| US10905726B2 (en) | 2015-06-09 | 2021-02-02 | Rebiotix, Inc. | Microbiota restoration therapy (MRT) compositions and methods of manufacture |
| ES2889902T3 (es) | 2015-06-09 | 2022-01-14 | Rebiotix Inc | Métodos de fabricación de composiciones para terapia de restauración de la microbiota (TRM) |
| ES2657414T3 (es) * | 2015-11-20 | 2018-03-05 | Geroa Diagnostics, S.L | Uso de la lactoferrina en el diagnóstico o el pronóstico de la enfermedad de Alzheimer |
| CN116973572B (zh) * | 2023-06-02 | 2025-03-07 | 东南大学附属中大医院 | 基于血、粪便铁蛋白检测评估肠屏障损伤严重程度的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US5124252A (en) * | 1989-11-28 | 1992-06-23 | University Of Virginia Alumni Patents Foundation | In vitro test for fecal leukocytes |
| US5552292A (en) * | 1993-01-18 | 1996-09-03 | Ikagaku Co., Ltd. | Method of screening for colorectal cancer |
| US5455160A (en) | 1993-05-27 | 1995-10-03 | Fagerhol; Magne K. | Diagnostic test and kit for disease or disorders in the digestive system |
| US5681699A (en) | 1994-02-11 | 1997-10-28 | Cedars-Sinai Medical Center | Methods of diagnosing ulcerative colitis and Crohn's disease |
| US6174664B1 (en) * | 1997-02-05 | 2001-01-16 | University Of Pittsburgh | Screening method for inflammatory diseases using neutrophil defensins and lactoferrin |
| US6358939B1 (en) * | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
-
2001
- 2001-11-14 AU AU2002902A patent/AU2002902A/xx active Pending
- 2001-11-14 CA CA2427898A patent/CA2427898C/en not_active Expired - Lifetime
- 2001-11-14 WO PCT/US2001/045301 patent/WO2002039883A2/en not_active Ceased
- 2001-11-14 EP EP09002897A patent/EP2071332A1/de not_active Ceased
- 2001-11-14 US US10/002,842 patent/US7192724B2/en not_active Expired - Lifetime
- 2001-11-14 DE DE60138829T patent/DE60138829D1/de not_active Expired - Lifetime
- 2001-11-14 EP EP01996331A patent/EP1340078B1/de not_active Expired - Lifetime
- 2001-11-14 ES ES01996331T patent/ES2325059T3/es not_active Expired - Lifetime
- 2001-11-14 AU AU2002220029A patent/AU2002220029B2/en not_active Expired
- 2001-11-14 AT AT01996331T patent/ATE432470T1/de not_active IP Right Cessation
-
2003
- 2003-07-30 US US10/629,975 patent/US7560240B2/en not_active Expired - Lifetime
-
2007
- 2007-11-15 AU AU2007234504A patent/AU2007234504B2/en not_active Expired
-
2009
- 2009-06-17 US US12/486,727 patent/US7892762B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP2071332A1 (de) | 2009-06-17 |
| DE60138829D1 (de) | 2009-07-09 |
| CA2427898A1 (en) | 2002-05-23 |
| CA2427898C (en) | 2017-08-15 |
| EP1340078A2 (de) | 2003-09-03 |
| AU2002220029B2 (en) | 2007-09-06 |
| EP1340078A4 (de) | 2006-07-05 |
| US20040033537A1 (en) | 2004-02-19 |
| US7560240B2 (en) | 2009-07-14 |
| EP1340078B1 (de) | 2009-05-27 |
| WO2002039883A2 (en) | 2002-05-23 |
| US20090253155A1 (en) | 2009-10-08 |
| AU2007234504A1 (en) | 2007-12-06 |
| US7192724B2 (en) | 2007-03-20 |
| US20020168698A1 (en) | 2002-11-14 |
| US7892762B2 (en) | 2011-02-22 |
| AU2007234504B2 (en) | 2010-11-18 |
| WO2002039883A3 (en) | 2002-08-08 |
| AU2002902A (en) | 2002-05-27 |
| ES2325059T3 (es) | 2009-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |