ATE433962T1 - Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors - Google Patents
Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptorsInfo
- Publication number
- ATE433962T1 ATE433962T1 AT01983901T AT01983901T ATE433962T1 AT E433962 T1 ATE433962 T1 AT E433962T1 AT 01983901 T AT01983901 T AT 01983901T AT 01983901 T AT01983901 T AT 01983901T AT E433962 T1 ATE433962 T1 AT E433962T1
- Authority
- AT
- Austria
- Prior art keywords
- serotonin
- receptor
- antagonists
- compounds
- piperazinylpyrazine
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 4
- 229940076279 serotonin Drugs 0.000 title abstract 2
- HCGFLVDMFDHYJD-UHFFFAOYSA-N 2-piperazin-1-ylpyrazine Chemical class C1CNCCN1C1=CN=CC=N1 HCGFLVDMFDHYJD-UHFFFAOYSA-N 0.000 title 1
- 108091005479 5-HT2 receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000006902 5-HT2C Serotonin Receptor Human genes 0.000 abstract 1
- 108010072553 5-HT2C Serotonin Receptor Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004244A SE0004244D0 (sv) | 2000-11-20 | 2000-11-20 | Novel compounds and their use |
| US25370200P | 2000-11-28 | 2000-11-28 | |
| PCT/SE2001/002570 WO2002040457A1 (en) | 2000-11-20 | 2001-11-20 | Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE433962T1 true ATE433962T1 (de) | 2009-07-15 |
Family
ID=26655310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01983901T ATE433962T1 (de) | 2000-11-20 | 2001-11-20 | Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1337518B1 (de) |
| JP (1) | JP4204315B2 (de) |
| KR (1) | KR100831909B1 (de) |
| CN (1) | CN1227237C (de) |
| AT (1) | ATE433962T1 (de) |
| AU (1) | AU1529402A (de) |
| BR (1) | BR0115436A (de) |
| CA (2) | CA2428905A1 (de) |
| DE (1) | DE60139021D1 (de) |
| DK (1) | DK1337518T3 (de) |
| EA (1) | EA005975B1 (de) |
| ES (1) | ES2328671T3 (de) |
| IL (2) | IL155875A0 (de) |
| MX (1) | MXPA03004391A (de) |
| NO (1) | NO325321B1 (de) |
| NZ (1) | NZ525699A (de) |
| PL (1) | PL360982A1 (de) |
| WO (1) | WO2002040457A1 (de) |
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| US6825198B2 (en) | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7226925B2 (en) | 2002-06-19 | 2007-06-05 | Biovitrum Ab | Compounds, their use and preparation |
| JP4460450B2 (ja) * | 2002-06-19 | 2010-05-12 | ビオヴィトルム・アクチボラゲット（プブリクト） | 新規化合物、その使用および製造法 |
| SI1645558T1 (sl) * | 2002-06-19 | 2008-10-31 | Biovitrum Ab Publ | Piperazinilpirazini kot modulatorji serotonin 5-HT2C receptorja |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CL2004000826A1 (es) * | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| ATE547404T1 (de) | 2003-09-22 | 2012-03-15 | Msd Kk | Piperidinderivate |
| EP1734963A4 (de) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | Verfahren zur behandlung von menschen mit metabolischen und anthropometrischen störungen |
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| JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
| CN101094689B (zh) | 2004-11-01 | 2013-06-12 | 安米林药品有限责任公司 | 治疗肥胖以及肥胖相关疾病和病症的方法 |
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| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| BRPI0610580B8 (pt) | 2005-05-30 | 2021-05-25 | Banyu Pharma Co Ltd | composto derivado de piperidina |
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| EP2727585A1 (de) | 2006-05-16 | 2014-05-07 | Takeda Pharmaceutical Company Limited | In-vivo Screening-Methode |
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| ES2660173T3 (es) | 2007-01-16 | 2018-03-21 | Ipintl, Llc | Nueva composición para el tratamiento del síndrome metabólico |
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| GB9902047D0 (en) | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| WO2000076984A2 (en) | 1999-05-21 | 2000-12-21 | Biovitrum Ab | Novel compounds, their use and preparation |
| ATE277048T1 (de) | 1999-06-15 | 2004-10-15 | Bristol Myers Squibb Pharma Co | Substituierte hetercyclisch kondensierte gamma carboline |
| ES2198329T3 (es) | 1999-07-29 | 2004-02-01 | Eli Lilly And Company | Agonistas de la serotonina benzofurilpiperazina. |
| EP1204654B1 (de) | 1999-07-29 | 2003-07-23 | Eli Lilly And Company | Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten |
| ES2231229T3 (es) | 1999-07-29 | 2005-05-16 | Eli Lilly And Company | Benzotiofenos serotoninergicos. |
| DE60006825T2 (de) | 1999-07-29 | 2004-08-12 | Eli Lilly And Co., Indianapolis | Serotonerge benzofurane |
| GB9918962D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
| GB9918965D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
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2001
- 2001-11-20 NZ NZ525699A patent/NZ525699A/en unknown
- 2001-11-20 CN CNB018192416A patent/CN1227237C/zh not_active Expired - Fee Related
- 2001-11-20 DE DE60139021T patent/DE60139021D1/de not_active Expired - Lifetime
- 2001-11-20 DK DK01983901T patent/DK1337518T3/da active
- 2001-11-20 EP EP01983901A patent/EP1337518B1/de not_active Expired - Lifetime
- 2001-11-20 PL PL36098201A patent/PL360982A1/xx unknown
- 2001-11-20 CA CA002428905A patent/CA2428905A1/en active Pending
- 2001-11-20 IL IL15587501A patent/IL155875A0/xx active IP Right Grant
- 2001-11-20 MX MXPA03004391A patent/MXPA03004391A/es active IP Right Grant
- 2001-11-20 KR KR1020037006822A patent/KR100831909B1/ko not_active Expired - Fee Related
- 2001-11-20 EA EA200300595A patent/EA005975B1/ru not_active IP Right Cessation
- 2001-11-20 AT AT01983901T patent/ATE433962T1/de not_active IP Right Cessation
- 2001-11-20 BR BR0115436-2A patent/BR0115436A/pt not_active IP Right Cessation
- 2001-11-20 CA CA2449899A patent/CA2449899C/en not_active Expired - Fee Related
- 2001-11-20 JP JP2002542785A patent/JP4204315B2/ja not_active Expired - Fee Related
- 2001-11-20 WO PCT/SE2001/002570 patent/WO2002040457A1/en not_active Ceased
- 2001-11-20 AU AU1529402A patent/AU1529402A/xx not_active Withdrawn
- 2001-11-20 ES ES01983901T patent/ES2328671T3/es not_active Expired - Lifetime
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2003
- 2003-05-12 IL IL155875A patent/IL155875A/en not_active IP Right Cessation
- 2003-05-19 NO NO20032253A patent/NO325321B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1520404A (zh) | 2004-08-11 |
| NO20032253D0 (no) | 2003-05-19 |
| EA200300595A1 (ru) | 2003-10-30 |
| MXPA03004391A (es) | 2004-05-31 |
| NZ525699A (en) | 2005-03-24 |
| AU1529402A (en) | 2002-05-27 |
| JP4204315B2 (ja) | 2009-01-07 |
| BR0115436A (pt) | 2004-01-06 |
| IL155875A0 (en) | 2003-12-23 |
| CA2449899C (en) | 2010-04-06 |
| JP2004531465A (ja) | 2004-10-14 |
| DE60139021D1 (de) | 2009-07-30 |
| KR100831909B1 (ko) | 2008-05-26 |
| PL360982A1 (en) | 2004-09-20 |
| ES2328671T3 (es) | 2009-11-17 |
| KR20030060946A (ko) | 2003-07-16 |
| EA005975B1 (ru) | 2005-08-25 |
| EP1337518A1 (de) | 2003-08-27 |
| CN1227237C (zh) | 2005-11-16 |
| IL155875A (en) | 2007-06-17 |
| DK1337518T3 (da) | 2009-10-19 |
| WO2002040457A1 (en) | 2002-05-23 |
| NO20032253L (no) | 2003-07-18 |
| CA2449899A1 (en) | 2002-05-23 |
| CA2428905A1 (en) | 2002-05-23 |
| HK1066810A1 (en) | 2005-04-01 |
| NO325321B1 (no) | 2008-03-31 |
| EP1337518B1 (de) | 2009-06-17 |
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