ATE435906T1 - Verfahren zur reinigung von viren - Google Patents
Verfahren zur reinigung von virenInfo
- Publication number
- ATE435906T1 ATE435906T1 AT06126383T AT06126383T ATE435906T1 AT E435906 T1 ATE435906 T1 AT E435906T1 AT 06126383 T AT06126383 T AT 06126383T AT 06126383 T AT06126383 T AT 06126383T AT E435906 T1 ATE435906 T1 AT E435906T1
- Authority
- AT
- Austria
- Prior art keywords
- cleaning viruses
- adenovirus
- viruses
- cleaning
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000005349 anion exchange Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10051—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2004050190 | 2004-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435906T1 true ATE435906T1 (de) | 2009-07-15 |
Family
ID=34878416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06126383T ATE435906T1 (de) | 2004-02-23 | 2005-02-21 | Verfahren zur reinigung von viren |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070207461A1 (de) |
| EP (2) | EP1780269B1 (de) |
| JP (1) | JP2007522814A (de) |
| KR (1) | KR101211329B1 (de) |
| CN (2) | CN101343625A (de) |
| AT (1) | ATE435906T1 (de) |
| AU (1) | AU2005214090B2 (de) |
| CA (1) | CA2555412C (de) |
| DE (1) | DE602005015332D1 (de) |
| DK (1) | DK1780269T3 (de) |
| ES (1) | ES2329607T3 (de) |
| NZ (1) | NZ548495A (de) |
| WO (1) | WO2005080556A2 (de) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL160406A0 (en) | 1995-06-15 | 2004-07-25 | Crucell Holland Bv | A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products |
| US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| US20070207461A1 (en) | 2004-02-23 | 2007-09-06 | Crucell Holland B.V. | Virus Purification Methods |
| CA2602944C (en) | 2005-04-11 | 2015-08-11 | Crucell Holland B.V. | Virus purification using ultrafiltration |
| ES2525518T3 (es) | 2005-11-01 | 2014-12-26 | Novartis Vaccines And Diagnostics Gmbh | Vacunas virales derivadas de células con niveles reducidos de ADN celular residual |
| EP1998804B1 (de) * | 2006-03-27 | 2014-04-16 | Crucell Holland B.V. | Zusammensetzungen, die einen rekombinanten adenovirus und ein adjuvans umfassen |
| US7875446B2 (en) * | 2006-04-20 | 2011-01-25 | Wyeth Llc | Purification processes for isolating purified vesicular stomatitis virus from cell culture |
| EP2195418B1 (de) | 2007-10-02 | 2012-12-12 | PTC Phage Technology Center GmbH | Verfahren und system zur grosstechnischen aufreinigung von für eine bakteriophagentherapie vorgesehenen bakteriophagen |
| CN102257134B (zh) * | 2008-02-12 | 2014-03-05 | 赛诺菲巴斯德有限公司 | 使用离子交换和凝胶过滤色谱进行痘病毒纯化的方法 |
| DK2307551T3 (en) * | 2008-06-18 | 2017-03-20 | Oxford Biomedica (Uk) Ltd | CLEANING RETROVIRAL VECTORS |
| US8785173B2 (en) | 2008-09-24 | 2014-07-22 | Medimmune, Llc | Methods for purification of viruses |
| US10041049B2 (en) | 2008-11-03 | 2018-08-07 | Janssen Vaccines & Prevention B.V. | Method for the production of adenoviral vectors |
| US20110293660A1 (en) * | 2009-02-06 | 2011-12-01 | Bruno Rene Andre | Novel method |
| JP2010207800A (ja) * | 2009-02-16 | 2010-09-24 | Kuraray Co Ltd | ろ過ユニットおよびこれを備えたろ過装置 |
| JP2010193720A (ja) * | 2009-02-23 | 2010-09-09 | Asahi Kasei Chemicals Corp | アニオン交換基が固定された多孔膜を用いたウイルスの分離方法 |
| US8609392B2 (en) * | 2009-05-12 | 2013-12-17 | Transgene S.A. | Method for orthopoxvirus production and purification |
| ES2565335T3 (es) * | 2009-08-17 | 2016-04-04 | Merck Patent Gmbh | Método para aislar virus |
| JP5393896B2 (ja) | 2009-10-15 | 2014-01-22 | クルセル ホランド ベー ヴェー | アデノウイルス粒子の精製方法 |
| CA2777116C (en) | 2009-10-15 | 2020-09-01 | Crucell Holland B.V. | Process for adenovirus purification from high cell density cultures |
| EP2531592A1 (de) | 2010-02-04 | 2012-12-12 | Vivalis | Fed-batch-verfahren mit konzentriertem zellkulturmedium zur effizienten produktion von biologischen wirkstoffen bei eb66-zellen |
| MX2012007936A (es) | 2010-02-15 | 2012-11-22 | Crucell Holland Bv | Metodo para la produccion de vectores adenovirales del serotipo 26 del adenovirus. |
| BR112012026095A2 (pt) | 2010-04-14 | 2015-09-15 | Emd Millipore Corp | métodos de produção de estoques de vírus de alta pureza e altos títulos e métodos de uso dos mesmos. |
| JP5945270B2 (ja) * | 2010-07-20 | 2016-07-05 | バヴァリアン・ノルディック・アクティーゼルスカブ | 発現産物を採取するための方法 |
| WO2012019354A1 (en) | 2010-08-12 | 2012-02-16 | Yisheng Biopharma Holdings Ltd. | Method for reducing dna impurities in viral compositions |
| US8771709B2 (en) | 2010-09-20 | 2014-07-08 | Crucell Holland B.V. | Therapeutic vaccination against active Tuberculosis |
| BR112013004582A2 (pt) | 2010-09-27 | 2016-09-06 | Crucell Holland Bv | método para induzir uma resposta imune em um sujeito contra um antígeno de um parasita que causa a malária |
| DE102010046817A1 (de) * | 2010-09-28 | 2012-03-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium |
| US9273289B2 (en) * | 2010-11-26 | 2016-03-01 | Probiogen Ag | Depletion of host cell components from live vector vaccines |
| KR20140038517A (ko) * | 2011-06-13 | 2014-03-28 | 머크 샤프 앤드 돔 코포레이션 | 천연 또는 돌연변이 형태의 디프테리아 독소의 정제 방법 |
| ES2726975T3 (es) * | 2011-07-27 | 2019-10-11 | Flash Therapeutics | Método para la producción de partículas retrovíricas útiles para transducir células eucariotas |
| US20130122038A1 (en) | 2011-11-14 | 2013-05-16 | The United States Of America As Represented By The Secretary Of The Department | Heterologous prime-boost immunization using measles virus-based vaccines |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| SI2825640T1 (sl) | 2012-03-12 | 2016-08-31 | Crucell Holland B.V. | Šarže rekombinantnega adenovirusa s spremenjenimi konci |
| JP5805908B2 (ja) | 2012-03-22 | 2015-11-10 | クルセル ホランド ベー ヴェー | Rsvに対するワクチン |
| US9119813B2 (en) | 2012-03-22 | 2015-09-01 | Crucell Holland B.V. | Vaccine against RSV |
| CN103571800B (zh) * | 2012-07-27 | 2018-04-24 | 江苏康润生物科技有限公司 | 一种去除疫苗中宿主dna的方法 |
| RU2493872C1 (ru) * | 2012-08-08 | 2013-09-27 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации ( ФГУП "НПО "Микроген" Минздрава России) | Способ очистки вируса гриппа |
| CN103768589B (zh) * | 2012-10-18 | 2016-12-21 | 辽宁成大生物股份有限公司 | 利用中空纤维膜去除人用乙型脑炎疫苗制品中残留dna的方法 |
| BR112015021297A2 (pt) * | 2013-02-28 | 2017-10-10 | Psioxus Therapeutics Ltd | um processo para a produção de adenovírus. |
| KR102236497B1 (ko) | 2013-04-25 | 2021-04-06 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 가용성 예비융합 rsv f 폴리펩타이드 |
| CA2914790C (en) | 2013-06-14 | 2024-02-27 | Psioxus Therapeutics Limited | A dosing regime and formulations for type b adenoviruses |
| CN105408348B (zh) | 2013-06-17 | 2021-07-06 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| EP3172317B1 (de) * | 2014-07-24 | 2019-05-01 | Janssen Vaccines & Prevention B.V. | Verfahren zur reinigung von poliovirus aus zellkulturen |
| GB201417042D0 (en) * | 2014-09-29 | 2014-11-12 | Fkd Therapies Oy | Method |
| RS58080B1 (sr) | 2014-11-04 | 2019-02-28 | Janssen Vaccines & Prevention Bv | Terapeutske vakcine protiv hpv16 |
| JP6735288B2 (ja) | 2015-04-14 | 2020-08-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 双方向性プロモーターを有する2つの導入遺伝子を発現する組換えアデノウイルス |
| US10954492B2 (en) | 2015-06-10 | 2021-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Processes for production and purification of nucleic acid-containing compositions |
| US10457708B2 (en) | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
| EA039065B1 (ru) | 2015-07-07 | 2021-11-29 | Янссен Вэксинс Энд Превеншн Б.В. | Вакцина против rsv |
| JP6470872B2 (ja) | 2015-08-20 | 2019-02-13 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 治療用hpv18ワクチン |
| JP7233928B2 (ja) | 2016-04-05 | 2023-03-07 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Rsvに対するワクチン |
| IL262108B2 (en) | 2016-04-05 | 2023-04-01 | Janssen Vaccines Prevention B V | Soluble pre-fusion rsv f proteins are stabilized |
| JP7053491B2 (ja) | 2016-05-02 | 2022-04-12 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 治療用hpvワクチン組み合わせ |
| CN109154000B (zh) | 2016-05-12 | 2022-07-05 | 扬森疫苗与预防公司 | 有效和平衡的双向启动子 |
| CN109311946A (zh) | 2016-05-30 | 2019-02-05 | 扬森疫苗与预防公司 | 稳定化的融合前rsv f蛋白 |
| RU2745500C2 (ru) | 2016-06-20 | 2021-03-25 | Янссен Вэксинс Энд Превеншн Б.В. | Эффективный и сбалансированный двунаправленный промотор |
| WO2018011196A1 (en) | 2016-07-14 | 2018-01-18 | Janssen Vaccines & Prevention B.V. | Hpv vaccines |
| CN106434571A (zh) * | 2016-10-19 | 2017-02-22 | 深圳源兴基因技术有限公司 | 一种wave无血清培养悬浮细胞制备重组腺病毒的方法 |
| CN108085301B (zh) * | 2016-11-22 | 2021-10-26 | 贺道耀 | 从宿主细胞提取和纯化腺相关病毒和腺病毒的方法及其组分和试剂盒 |
| US10294452B2 (en) | 2016-11-22 | 2019-05-21 | Dao-Yao He | Lysis, extraction and purification of adeno-associated virus and adenovirus from host cells |
| US11034978B2 (en) | 2017-02-09 | 2021-06-15 | Janssen Vaccines & Prevention B.V. | Potent and short promoter for expression of heterologous genes |
| CN106868025B (zh) * | 2017-03-13 | 2020-01-21 | 中国人民解放军军事医学科学院生物工程研究所 | 用酵母制备三聚体埃博拉病毒糖蛋白突变体的方法 |
| AU2018267971A1 (en) | 2017-05-17 | 2019-11-07 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
| CN107603959A (zh) * | 2017-08-30 | 2018-01-19 | 四川大学 | 提高缓冲液盐离子浓度纯化病毒的方法 |
| SG11202001458SA (en) | 2017-09-15 | 2020-03-30 | Janssen Vaccines & Prevention Bv | Method for the safe induction of immunity against rsv |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| US11603527B2 (en) * | 2017-12-27 | 2023-03-14 | Global Life Sciences Solutions Usa Llc | Method and kit for viral vector isolation |
| GB201814590D0 (en) * | 2018-09-07 | 2018-10-24 | Oxford Biomedica Ltd | Viral vector production system |
| CN110317832B (zh) * | 2018-03-28 | 2022-07-05 | 西比曼生物科技(香港)有限公司 | Gmp级规模化制备重组慢病毒载体的纯化制剂的方法 |
| WO2019209632A1 (en) | 2018-04-24 | 2019-10-31 | Merck Sharp & Dohme Corp. | Scalable chromatography process for purification of human cytomegalovirus |
| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| US11529413B2 (en) | 2018-06-12 | 2022-12-20 | Kbio Holdings Limited | Virus and antigen purification and conjugation |
| IL279295B2 (en) | 2018-06-12 | 2026-03-01 | Kentucky Bioprocessing Inc | Purification and cross-linking of virus and antigen |
| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| MX2021005607A (es) | 2018-11-13 | 2021-06-30 | Janssen Vaccines & Prevention Bv | Proteinas f de prefusion del vrs estabilizadas. |
| CA3120129A1 (en) * | 2018-11-21 | 2020-05-28 | Western Oncolytics Ltd. | Manufacture of virus |
| MX2021013950A (es) * | 2019-05-14 | 2022-01-04 | Janssen Biotech Inc | Eliminacion eficaz de impurezas usando un proceso de diafiltracion. |
| GB201909081D0 (en) * | 2019-06-25 | 2019-08-07 | Psioxus Therapeutics Ltd | Method |
| CN114173827B (zh) * | 2019-06-28 | 2025-01-28 | 武田药品工业株式会社 | 腺相关病毒纯化方法 |
| IL295154A (en) * | 2020-01-28 | 2022-09-01 | Lonza Walkersville Inc | Methods for determining viral titer |
| CN111249456A (zh) * | 2020-03-13 | 2020-06-09 | 武汉生物制品研究所有限责任公司 | 一种狂犬病病毒灭活疫苗的纯化方法 |
| CN111394390A (zh) * | 2020-03-26 | 2020-07-10 | 赛诺(深圳)生物医药研究有限公司 | 用于新型冠状病毒基因疫苗的批量生产重组腺病毒的方法 |
| US20230302381A1 (en) * | 2020-08-18 | 2023-09-28 | Sartorius Bia Separations D.O.O. | Metal-affinity extraction of host cell dna |
| US12577540B2 (en) | 2020-12-10 | 2026-03-17 | Sarepta Therapeutics, Inc. | Suspension mode seed train development for adherent cells |
| AU2022279062A1 (en) | 2021-05-17 | 2024-01-04 | Sarepta Therapeutics, Inc. | Production of recombinant aav vectors for treating muscular dystrophy |
| KR20240042648A (ko) * | 2021-08-10 | 2024-04-02 | 바이오콘 리미티드 | 리라글루티드의 정제 |
| CN113817689B (zh) * | 2021-11-22 | 2023-10-03 | 北京艺妙神州医药科技有限公司 | 慢病毒纯化工艺 |
| JP2025510977A (ja) * | 2022-03-30 | 2025-04-15 | シーエスエル・ベーリング・エルエルシー | エンベロープ型ウイルスを精製する方法 |
| CN115807064A (zh) * | 2022-07-20 | 2023-03-17 | 上海泰昶生物技术有限公司 | 重组腺相关病毒载体制品中游离和错误包装dna的检测方法 |
| CN115141813A (zh) * | 2022-07-29 | 2022-10-04 | 深圳源兴基因技术有限公司 | 一种高效去除宿主细胞残留蛋白的腺病毒纯化方法 |
| EP4590838A1 (de) | 2022-09-23 | 2025-07-30 | Sarepta Therapeutics, Inc. | Rekombinante aav-vektoren zur behandlung von muskeldystrophie |
| EP4634371A1 (de) * | 2022-12-16 | 2025-10-22 | Avirmax Biopharma Inc. | Verfahren zur herstellung von viren und viruspartikeln |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434914B (sv) * | 1975-07-07 | 1984-08-27 | Jonsson U R S | Forfarande for att ur en suspension av bakterier och ett vetskeformigt medium genom filtrering avskilja mediet under samtidig anrikning av bakterierna |
| US4435289A (en) * | 1981-12-23 | 1984-03-06 | Romicon, Inc. | Series ultrafiltration with pressurized permeate |
| US5173418A (en) * | 1985-05-10 | 1992-12-22 | Benzon Pharma, A/S | Production in Escherichia coli of extracellular Serratia spp. hydrolases |
| US4808315A (en) * | 1986-04-28 | 1989-02-28 | Asahi Kasei Kogyo Kabushiki Kaisha | Porous hollow fiber membrane and a method for the removal of a virus by using the same |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| FR2716682B1 (fr) * | 1994-01-28 | 1996-04-26 | Centre Nat Rech Scient | Procédé de préparation de virus adéno-associés (AAV) recombinants et utilisations. |
| US5851806A (en) * | 1994-06-10 | 1998-12-22 | Genvec, Inc. | Complementary adenoviral systems and cell lines |
| ATE336587T1 (de) * | 1994-06-10 | 2006-09-15 | Genvec Inc | Adenoviren-vektor systeme und zelllinien |
| SE9500724D0 (sv) | 1994-06-23 | 1995-02-24 | Pharmacia Ab | Filtrering |
| US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5965541A (en) * | 1995-11-28 | 1999-10-12 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US6146873A (en) * | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
| US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US5837520A (en) * | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| IL160406A0 (en) * | 1995-06-15 | 2004-07-25 | Crucell Holland Bv | A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products |
| FR2737730B1 (fr) * | 1995-08-10 | 1997-09-05 | Pasteur Merieux Serums Vacc | Procede de purification de virus par chromatographie |
| US5840565A (en) * | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
| WO1997008298A1 (en) * | 1995-08-30 | 1997-03-06 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
| US5837511A (en) * | 1995-10-02 | 1998-11-17 | Cornell Research Foundation, Inc. | Non-group C adenoviral vectors |
| US5891690A (en) * | 1996-04-26 | 1999-04-06 | Massie; Bernard | Adenovirus E1-complementing cell lines |
| IL127692A0 (en) * | 1996-07-01 | 1999-10-28 | Rhone Poulenc Rorer Sa | Method for producing recombinant adenovirus |
| FR2751343B1 (fr) * | 1996-07-16 | 1998-12-18 | Transgene Sa | Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament |
| WO1998022588A2 (en) * | 1996-11-20 | 1998-05-28 | Introgen Therapeutics, Inc. | An improved method for the production and purification of adenoviral vectors |
| US7732129B1 (en) * | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
| US6261823B1 (en) * | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| US6168944B1 (en) * | 1997-01-31 | 2001-01-02 | Schering Corporation | Methods for cultivating cells and propagating viruses |
| EP0981601B1 (de) | 1997-01-31 | 2006-09-06 | Schering Corporation | Verfahren zur kultivierung von zellen und zur vermehrung von viren |
| CA2283253A1 (en) | 1997-03-04 | 1998-09-11 | Baxter International Inc. | Adenovirus e1-complementing cell lines |
| TW570803B (en) * | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
| US6020191A (en) * | 1997-04-14 | 2000-02-01 | Genzyme Corporation | Adenoviral vectors capable of facilitating increased persistence of transgene expression |
| US5947689A (en) * | 1997-05-07 | 1999-09-07 | Scilog, Inc. | Automated, quantitative, system for filtration of liquids having a pump controller |
| DK1025209T3 (da) * | 1997-08-28 | 2007-06-25 | Cheil Jedang Corp | Et attenueret japansk encephalitis-virus tilpasset til Vero-celle og en japansk encephalitis-vaccine |
| US6210683B1 (en) | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| IL137510A0 (en) | 1998-02-17 | 2001-07-24 | Schering Corp | Compositions comprising viruses and methods for concentrating virus preparations |
| US5981225A (en) * | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
| IL139040A0 (en) * | 1998-04-22 | 2001-11-25 | Genvec Inc | Efficient purification of adenovirus |
| US5994134A (en) * | 1998-05-04 | 1999-11-30 | Canji, Inc. | Viral production process |
| US6113913A (en) * | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
| US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| US6342384B1 (en) * | 1998-08-21 | 2002-01-29 | The University Of Va Patent Foundation | Production of adenoviral vectors using serum-free suspension cell culture in a hollow fiber system |
| DK1133316T3 (da) | 1998-11-16 | 2009-05-25 | Introgen Therapeutics Inc | Adenovirus-formulering til genterapi |
| NZ512504A (en) * | 1998-12-31 | 2004-01-30 | Aventis Pharma Sa | Method for separating viral particles |
| JP4802366B2 (ja) | 1999-02-22 | 2011-10-26 | トランスジェン・ソシエテ・アノニム | 精製ウイルス調製物の取得方法 |
| US6120820A (en) * | 1999-02-22 | 2000-09-19 | Land O'lakes, Inc. | Method of modifying the color of a dairy material |
| ES2372823T3 (es) | 1999-05-17 | 2012-01-26 | Crucell Holland B.V. | Adenovirus recombinante del serotipo ad11. |
| US6492169B1 (en) * | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| WO2003104467A1 (en) | 2002-04-25 | 2003-12-18 | Crucell Holland B.V. | Means and methods for the production of adenovirus vectors |
| DE19955558C2 (de) | 1999-11-18 | 2003-03-20 | Stefan Kochanek | Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren |
| EP1103610A1 (de) | 1999-11-26 | 2001-05-30 | Introgene B.V. | Impfstoffherstellung von immortalisierten Säugetierzellinien |
| JP5118798B2 (ja) | 2000-03-07 | 2013-01-16 | メルク・シャープ・エンド・ドーム・コーポレイション | アデノウイルス製剤 |
| US6168941B1 (en) * | 2000-04-07 | 2001-01-02 | Genvec, Inc. | Method of producing adenoviral vector stocks |
| DE10022258A1 (de) * | 2000-05-08 | 2001-11-15 | Bayer Ag | Reinigung von Proteineinschlusskörpern durch Querstrom-Mikrofiltration |
| JP2004508064A (ja) | 2000-09-15 | 2004-03-18 | メルク エンド カムパニー インコーポレーテッド | コドン最適化hiv1−gag、pol、nefおよび修飾体を発現する増強された第1世代アデノウイルスワクチン |
| US6365395B1 (en) * | 2000-11-03 | 2002-04-02 | Millipore Corporation | Process for removing protein aggregates and virus from a protein solution |
| US20020064860A1 (en) | 2000-11-29 | 2002-05-30 | Schering Corporation | Method for purifying adenoviruses |
| IL152420A0 (en) | 2001-02-23 | 2003-05-29 | Novartis Ag | Novel oncolytic adenoviral vectors |
| ATE496120T1 (de) | 2001-03-01 | 2011-02-15 | Bayer Schering Pharma Ag | Konzentration und lyse von adenovirus-infizierten zellen in derselben prozesseinheit |
| CA2776391C (en) | 2001-10-01 | 2015-03-31 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Development of a preventive vaccine for filovirus infection in primates |
| US6951752B2 (en) | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| CA2469623C (en) | 2001-12-12 | 2012-05-29 | F H Faulding & Co Limited | Composition for the preservation of viruses |
| US20030180936A1 (en) | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
| EP1492890A4 (de) | 2002-03-29 | 2006-10-18 | Merck & Co Inc | Verfahren im grossmassstab zur produktion von adenovirus und adenovirus-stammlösungen zur aussaat |
| EP1497440B1 (de) | 2002-04-25 | 2008-08-20 | Crucell Holland B.V. | Stabile adenovirale vektoren und methoden für deren vermehrung |
| ATE360683T1 (de) * | 2002-05-14 | 2007-05-15 | Merck & Co Inc | Verfahren zur reinigung von adenovirus |
| US20050095705A1 (en) | 2003-04-15 | 2005-05-05 | Michael Kadan | Method for production of oncolytic adenoviruses |
| EP1633321A4 (de) * | 2003-06-18 | 2006-11-02 | Onyx Pharma Inc | Verfahren zur reinigung von virus |
| US20070207461A1 (en) | 2004-02-23 | 2007-09-06 | Crucell Holland B.V. | Virus Purification Methods |
| US20060078628A1 (en) * | 2004-10-09 | 2006-04-13 | Karl Koman | Wound treating agent |
-
2005
- 2005-02-21 US US10/590,427 patent/US20070207461A1/en not_active Abandoned
- 2005-02-21 CN CNA2008101300506A patent/CN101343625A/zh active Pending
- 2005-02-21 WO PCT/EP2005/050739 patent/WO2005080556A2/en not_active Ceased
- 2005-02-21 NZ NZ548495A patent/NZ548495A/en not_active IP Right Cessation
- 2005-02-21 CA CA2555412A patent/CA2555412C/en not_active Expired - Fee Related
- 2005-02-21 CN CNA2005800056824A patent/CN1922308A/zh active Pending
- 2005-02-21 EP EP06126383A patent/EP1780269B1/de not_active Revoked
- 2005-02-21 EP EP05729676A patent/EP1718738A2/de not_active Withdrawn
- 2005-02-21 AT AT06126383T patent/ATE435906T1/de active
- 2005-02-21 JP JP2006553596A patent/JP2007522814A/ja active Pending
- 2005-02-21 DK DK06126383T patent/DK1780269T3/da active
- 2005-02-21 AU AU2005214090A patent/AU2005214090B2/en not_active Ceased
- 2005-02-21 ES ES06126383T patent/ES2329607T3/es not_active Expired - Lifetime
- 2005-02-21 DE DE602005015332T patent/DE602005015332D1/de not_active Expired - Lifetime
-
2006
- 2006-08-30 KR KR1020067017560A patent/KR101211329B1/ko not_active Expired - Fee Related
-
2008
- 2008-07-28 US US12/220,828 patent/US8124106B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005080556A9 (en) | 2006-10-26 |
| DK1780269T3 (da) | 2009-10-12 |
| WO2005080556A3 (en) | 2006-02-23 |
| CA2555412C (en) | 2013-06-25 |
| DE602005015332D1 (de) | 2009-08-20 |
| JP2007522814A (ja) | 2007-08-16 |
| AU2005214090B2 (en) | 2008-09-11 |
| WO2005080556A2 (en) | 2005-09-01 |
| KR101211329B1 (ko) | 2012-12-12 |
| EP1780269A2 (de) | 2007-05-02 |
| ES2329607T3 (es) | 2009-11-27 |
| EP1780269A3 (de) | 2007-07-18 |
| CN101343625A (zh) | 2009-01-14 |
| EP1718738A2 (de) | 2006-11-08 |
| CN1922308A (zh) | 2007-02-28 |
| US20070207461A1 (en) | 2007-09-06 |
| AU2005214090A1 (en) | 2005-09-01 |
| US20090017523A1 (en) | 2009-01-15 |
| EP1780269B1 (de) | 2009-07-08 |
| US8124106B2 (en) | 2012-02-28 |
| NZ548495A (en) | 2009-05-31 |
| CA2555412A1 (en) | 2005-09-01 |
| KR20070001163A (ko) | 2007-01-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE435906T1 (de) | Verfahren zur reinigung von viren | |
| ATE446792T1 (de) | Verfahren zur behandlung von sinuskopfschmerzen | |
| EP1726599A4 (de) | Verfahren zur herstellung von fluorpolymer | |
| ATE431139T1 (de) | Verfahren zur identifizierung von glp-1- sekretionsförderern | |
| DE602004021790D1 (de) | Verfahren zur behandlung von parkinson-krankheit | |
| DE502004009763D1 (de) | Verfahren zur herstellung von 1-buten | |
| DE602004010234D1 (de) | Verfahren zur herstellung von 4-aminodiphenylamin | |
| DE502004009768D1 (de) | Verfahren zur herstellung von dreiwertigen organophosphor-verbindungen | |
| ATE485517T1 (de) | Verfahren zur identifizierung von polypeptid- targets | |
| DE60234952D1 (de) | VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL | |
| ATE435209T1 (de) | Verfahren zur herstellung von montelukast-natrium | |
| DE60217096D1 (de) | Verfahren zur herstellung von (s)-(+)- und (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepin-5-carboxamid | |
| ATE474602T1 (de) | Verfahren zur behandlung von hiv-infektion | |
| DE502005010038D1 (de) | Verfahren zur herstellung von 3-pentennitril | |
| DE60302139D1 (de) | Verfahren zur herstellung von aripiprazole | |
| DE602004018249D1 (de) | Verfahren zur Dearomatisierung von Molkeprotein | |
| ATE514673T1 (de) | Verfahren zur trennung von pentennitril-isomeren | |
| DE502004001216D1 (de) | Verfahren zur aufreinigung von blausäure | |
| DE502005000428D1 (de) | Verfahren zur Herstellung von 1,2-Diaminocyclohexan-Platin(II)-Komplexen | |
| DE502006002510D1 (de) | Verfahren zur herstellung von silikon-haltigen polymerisaten | |
| DE60226310D1 (de) | Verfahren zur herstellung von cycloolefinadditionspolymerisat | |
| DE502005007702D1 (de) | Verfahren zur herstellung von terrylen-3,4:11,12-t | |
| ATE394369T1 (de) | Verfahren zur aufreinigung von mesotrion | |
| DE60233130D1 (de) | Verfahren zur herstellung von imipenem | |
| DE502004002810D1 (de) | Verfahren zur herstellung von copolymerisaten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1780269 Country of ref document: EP |
|
| UEP | Publication of translation of european patent specification |
Ref document number: 1780269 Country of ref document: EP |