ATE437233T1 - Matrix-anheftungsregionen und verfahren zu deren verwendung - Google Patents
Matrix-anheftungsregionen und verfahren zu deren verwendungInfo
- Publication number
- ATE437233T1 ATE437233T1 AT02726395T AT02726395T ATE437233T1 AT E437233 T1 ATE437233 T1 AT E437233T1 AT 02726395 T AT02726395 T AT 02726395T AT 02726395 T AT02726395 T AT 02726395T AT E437233 T1 ATE437233 T1 AT E437233T1
- Authority
- AT
- Austria
- Prior art keywords
- matrix attachment
- attachment regions
- relates
- mar
- compositions
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 238000003153 stable transfection Methods 0.000 abstract 1
- 238000003146 transient transfection Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Local Oxidation Of Silicon (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Wire Bonding (AREA)
- Electric Connection Of Electric Components To Printed Circuits (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26435501P | 2001-01-26 | 2001-01-26 | |
| US28139101P | 2001-04-04 | 2001-04-04 | |
| PCT/IB2002/002137 WO2002074969A2 (en) | 2001-01-26 | 2002-01-28 | Matrix attachment regions and methods for use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE437233T1 true ATE437233T1 (de) | 2009-08-15 |
Family
ID=26950488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02726395T ATE437233T1 (de) | 2001-01-26 | 2002-01-28 | Matrix-anheftungsregionen und verfahren zu deren verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7129062B2 (de) |
| EP (1) | EP1395669B1 (de) |
| JP (1) | JP4307079B2 (de) |
| AT (1) | ATE437233T1 (de) |
| CA (1) | CA2435972C (de) |
| DE (1) | DE60233049D1 (de) |
| DK (1) | DK1395669T3 (de) |
| ES (1) | ES2330201T3 (de) |
| SG (1) | SG141239A1 (de) |
| WO (1) | WO2002074969A2 (de) |
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| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| ATE354645T1 (de) | 2002-12-20 | 2007-03-15 | Chromagenics Bv | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
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| EP1737971B1 (de) | 2004-01-20 | 2017-08-16 | Merus N.V. | Gemische bindender proteine |
| ES2384391T3 (es) | 2004-11-08 | 2012-07-04 | Chromagenics B.V. | Selección de células hospedantes que expresan proteína a altos niveles |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| KR101271884B1 (ko) | 2004-11-08 | 2013-06-05 | 크로마제닉스 비.브이. | 고수준으로 단백질을 발현하는 숙주세포의 선택 |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
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-
2002
- 2002-01-28 DK DK02726395T patent/DK1395669T3/da active
- 2002-01-28 DE DE60233049T patent/DE60233049D1/de not_active Expired - Lifetime
- 2002-01-28 US US10/059,561 patent/US7129062B2/en not_active Expired - Lifetime
- 2002-01-28 ES ES02726395T patent/ES2330201T3/es not_active Expired - Lifetime
- 2002-01-28 WO PCT/IB2002/002137 patent/WO2002074969A2/en not_active Ceased
- 2002-01-28 AT AT02726395T patent/ATE437233T1/de active
- 2002-01-28 SG SG200504635-4A patent/SG141239A1/en unknown
- 2002-01-28 EP EP02726395A patent/EP1395669B1/de not_active Expired - Lifetime
- 2002-01-28 CA CA2435972A patent/CA2435972C/en not_active Expired - Lifetime
- 2002-01-28 JP JP2002574359A patent/JP4307079B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2330201T3 (es) | 2009-12-07 |
| WO2002074969A2 (en) | 2002-09-26 |
| US20030087342A1 (en) | 2003-05-08 |
| JP4307079B2 (ja) | 2009-08-05 |
| CA2435972A1 (en) | 2002-09-26 |
| WO2002074969A3 (en) | 2003-12-24 |
| DK1395669T3 (da) | 2009-11-16 |
| US7129062B2 (en) | 2006-10-31 |
| EP1395669A2 (de) | 2004-03-10 |
| CA2435972C (en) | 2011-09-13 |
| DE60233049D1 (de) | 2009-09-03 |
| EP1395669B1 (de) | 2009-07-22 |
| SG141239A1 (en) | 2008-04-28 |
| JP2004519246A (ja) | 2004-07-02 |
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