ATE437233T1 - Matrix-anheftungsregionen und verfahren zu deren verwendung - Google Patents
Matrix-anheftungsregionen und verfahren zu deren verwendungInfo
- Publication number
- ATE437233T1 ATE437233T1 AT02726395T AT02726395T ATE437233T1 AT E437233 T1 ATE437233 T1 AT E437233T1 AT 02726395 T AT02726395 T AT 02726395T AT 02726395 T AT02726395 T AT 02726395T AT E437233 T1 ATE437233 T1 AT E437233T1
- Authority
- AT
- Austria
- Prior art keywords
- matrix attachment
- attachment regions
- relates
- mar
- compositions
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 238000003153 stable transfection Methods 0.000 abstract 1
- 238000003146 transient transfection Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Local Oxidation Of Silicon (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Electric Connection Of Electric Components To Printed Circuits (AREA)
- Wire Bonding (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26435501P | 2001-01-26 | 2001-01-26 | |
| US28139101P | 2001-04-04 | 2001-04-04 | |
| PCT/IB2002/002137 WO2002074969A2 (en) | 2001-01-26 | 2002-01-28 | Matrix attachment regions and methods for use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE437233T1 true ATE437233T1 (de) | 2009-08-15 |
Family
ID=26950488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02726395T ATE437233T1 (de) | 2001-01-26 | 2002-01-28 | Matrix-anheftungsregionen und verfahren zu deren verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7129062B2 (de) |
| EP (1) | EP1395669B1 (de) |
| JP (1) | JP4307079B2 (de) |
| AT (1) | ATE437233T1 (de) |
| CA (1) | CA2435972C (de) |
| DE (1) | DE60233049D1 (de) |
| DK (1) | DK1395669T3 (de) |
| ES (1) | ES2330201T3 (de) |
| SG (1) | SG141239A1 (de) |
| WO (1) | WO2002074969A2 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100408844B1 (ko) * | 2000-07-29 | 2003-12-06 | 한국산업기술평가원 | 동물세포 발현벡터 |
| NZ536475A (en) * | 2002-05-24 | 2008-06-30 | Schering Corp | Neutralizing human anti-igfr antibody |
| EP2314629B2 (de) | 2002-07-18 | 2022-11-16 | Merus N.V. | Rekombinante Herstellung von Mischungen aus Aantikörpern |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| ATE354645T1 (de) | 2002-12-20 | 2007-03-15 | Chromagenics Bv | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| JP2005031812A (ja) * | 2003-07-08 | 2005-02-03 | Toshiba Corp | 画像形成装置およびその制御方法 |
| PL1959011T3 (pl) | 2003-10-24 | 2012-07-31 | Selexis Sa | Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy |
| ATE514783T1 (de) | 2003-11-12 | 2011-07-15 | Schering Corp | Plasmidsystem zur expression mehrerer gene |
| PE20050928A1 (es) | 2003-11-21 | 2005-11-08 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti-igfr1 |
| GB0327919D0 (en) * | 2003-12-02 | 2004-01-07 | Plant Bioscience Ltd | Enhanced expression |
| AU2005205412B2 (en) | 2004-01-20 | 2011-08-11 | Merus N.V. | Mixtures of binding proteins |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| CN101090968B (zh) | 2004-11-08 | 2011-10-26 | 科罗迈吉尼科斯公司 | 高水平表达蛋白质的宿主细胞的选择 |
| PL1809750T3 (pl) | 2004-11-08 | 2012-08-31 | Chromagenics Bv | Selekcja komórki gospodarza eksprymującej białko na wysokich poziomach |
| DE602005025685D1 (de) * | 2004-12-03 | 2011-02-10 | Schering Corp | Biologische marker zur vorauswahl von patienten für die anti-igf1r-therapie |
| JP2008543283A (ja) * | 2005-06-10 | 2008-12-04 | ジェネンテック・インコーポレーテッド | インスレーターエレメントを含むベクターを使用する抗体発現の改良 |
| JP4958905B2 (ja) * | 2005-08-11 | 2012-06-20 | セントカー・インコーポレーテツド | ペプチド鎖発現を増大させるための物質および方法 |
| US7968700B2 (en) | 2006-03-20 | 2011-06-28 | Chromagenics B.V. | Expression augmenting DNA fragments, use thereof, and methods for finding thereof |
| WO2008085956A2 (en) * | 2007-01-08 | 2008-07-17 | Millipore Corporation | High expression cell line that eliminates gene amplification |
| US8058027B2 (en) * | 2007-01-08 | 2011-11-15 | Millipore Corporation | Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants |
| WO2008121324A2 (en) * | 2007-03-30 | 2008-10-09 | Abbott Laboratories | Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells |
| KR101617895B1 (ko) | 2007-12-24 | 2016-05-03 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 재조합 ｒｓｖ 항원 |
| EP2245145B1 (de) | 2008-01-18 | 2016-12-14 | BioMarin Pharmaceutical Inc. | Herstellung aktiver hochphosphorylierter menschlicher lysosomen-sulfatasen und verwendungen davon |
| AU2009309387A1 (en) * | 2008-10-28 | 2010-05-06 | Avesthagen Limited | An expression vector and processes thereof |
| WO2010081494A1 (en) | 2009-01-19 | 2010-07-22 | King Faisal Specialist Hospital And Research Centre | A method of increasing protein expression in eukaryotic cells |
| ES2539045T3 (es) | 2009-01-19 | 2015-06-25 | Innate Pharma | Anticuerpos anti-KIR3D |
| DK2445526T3 (en) | 2009-06-24 | 2016-06-27 | Glaxosmithkline Biologicals Sa | Recombinant RSV antigens. |
| MX2012000036A (es) | 2009-06-24 | 2012-02-28 | Glaxosmithkline Biolog Sa | Vacuna. |
| TW201116294A (en) | 2009-07-15 | 2011-05-16 | Novartis Ag | RSV F protein compositions and methods for making same |
| WO2011015917A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant tnk-tpa (tenecteplase) |
| WO2011015918A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant cetuximab |
| WO2011015916A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant infliximab |
| WO2011015924A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant trastuzumab |
| CN102575264A (zh) | 2009-09-18 | 2012-07-11 | 瑟莱克斯公司 | 增加的转基因表达和加工的产品和方法 |
| AR082319A1 (es) | 2010-07-22 | 2012-11-28 | Biomarin Pharm Inc | Produccion de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos |
| CA2813903A1 (en) * | 2010-10-08 | 2012-04-12 | Cadila Healthcare Limited | Expression vector for high level expression of recombinant proteins |
| WO2012095514A1 (en) | 2011-01-14 | 2012-07-19 | Vivalis | Recombinant protein production system |
| CN103842374A (zh) | 2011-05-13 | 2014-06-04 | 诺华股份有限公司 | 融合前的rsv f抗原 |
| ES2806146T3 (es) | 2011-09-22 | 2021-02-16 | Amgen Inc | Proteínas de unión al antígeno CD27L |
| DK2838918T3 (da) | 2012-04-20 | 2019-08-12 | Merus Nv | Fremgangsmåder og midler til fremstilling af heterodimere ig-lignende molekyler |
| AR091069A1 (es) | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| HUE043103T2 (hu) | 2013-02-01 | 2019-08-28 | Selexis Sa | Fokozott transzgén expresszió és processzálás |
| US9546203B2 (en) | 2013-03-14 | 2017-01-17 | Amgen Inc. | Aglycosylated Fc-containing polypeptides with cysteine substitutions |
| WO2014144817A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Inhibitory polypeptides specific to wnt inhibitors |
| SG11201508829QA (en) | 2013-05-30 | 2015-12-30 | Biogen Ma Inc | Oncostatin m receptor antigen binding proteins |
| CA2923145C (en) | 2013-09-05 | 2025-09-16 | Amgen Inc. | MOLECULES CONTAINING FCS AND EXHIBITING PREDICTABLE, UNIFORM AND REPRODUCIBLE GLYCOFORM PROFILES |
| WO2015060935A1 (en) * | 2013-10-22 | 2015-04-30 | Lubris, Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
| MX2017012966A (es) | 2015-04-10 | 2018-06-06 | Amgen Inc | Muteinas de interleuquina 2 para la expansion de celulas t regulatorias. |
| EP3286227A2 (de) | 2015-04-24 | 2018-02-28 | F. Hoffmann-La Roche AG | Multispezifische antigenbindende proteine |
| AU2016329001A1 (en) | 2015-09-22 | 2018-03-29 | Genentech, Inc. | Expression of Fc-containing proteins |
| WO2017059551A1 (en) | 2015-10-08 | 2017-04-13 | Zymeworks Inc. | Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof |
| WO2017079165A1 (en) | 2015-11-02 | 2017-05-11 | Genentech, Inc. | Methods of making fucosylated and afucosylated forms of a protein |
| CN115073581A (zh) | 2016-05-04 | 2022-09-20 | 美国安进公司 | 用于扩增t调节性细胞的白细胞介素-2突变蛋白 |
| EP3293263A1 (de) * | 2016-09-07 | 2018-03-14 | Steinbeis Innovation gGmbH | Induzierbare genexpression durch lineare at-reiche dna-fragmente in säugetierzellen und zugehörige verfahren |
| RU2019142330A (ru) | 2017-06-30 | 2021-07-30 | Займворкс, Инк. | Стабилизированные химерные fab |
| CN113348248B (zh) | 2018-10-24 | 2024-12-31 | 思兰克斯有限公司 | 表达系统、重组细胞及其用途 |
| UY38836A (es) | 2019-08-13 | 2021-02-26 | Amgen Inc | Muteínas de interleucina-2 para la expansión de células t reguladoras |
| CN114867749A (zh) | 2019-12-17 | 2022-08-05 | 安进公司 | 用于疗法中的双重白介素-2/tnf受体激动剂 |
| US20230127949A1 (en) | 2020-02-24 | 2023-04-27 | Novartis Ag | Purification of recombinantly produced polypeptides |
| EP4185692A1 (de) * | 2020-07-22 | 2023-05-31 | Deutsches Krebsforschungszentrum | 5' s/mar-anwendungen |
| AU2024307352A1 (en) | 2023-06-27 | 2025-12-11 | Amgen Inc. | Charge pair mutations to enable correct heavy-light chain pairing |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8925590D0 (en) * | 1989-11-13 | 1990-01-04 | Central Blood Lab Authority | Monoclonal antibodies |
| US5968502A (en) * | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6063630A (en) * | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
| DE69331908T2 (de) | 1992-10-05 | 2002-12-12 | North Carolina State University, Raleigh | Verfahren zur erhöhung der expression und zur verminderung der expressionsvariabilität von fremdgenen in pflanzenzellen |
| US5610053A (en) * | 1993-04-07 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells |
| US5888981A (en) * | 1993-06-14 | 1999-03-30 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| US5464758A (en) * | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| WO2000073434A1 (en) * | 1999-05-28 | 2000-12-07 | Sangamo Biosciences, Inc. | Gene switches |
| US5907078A (en) * | 1994-12-09 | 1999-05-25 | Greenberg; Norman M. | Transgenic mouse model for prostate cancer |
| DE19541450C2 (de) * | 1995-11-07 | 1997-10-02 | Gsf Forschungszentrum Umwelt | Genkonstrukt und dessen Verwendung |
| US6596514B2 (en) * | 1996-01-11 | 2003-07-22 | Immunex Corporation | Expression augmenting sequence elements (EASE) for eukaryotic expression systems |
| US5773695A (en) * | 1996-01-26 | 1998-06-30 | North Carolina State University | Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells |
| EP0914421A2 (de) * | 1996-02-29 | 1999-05-12 | Immusol, Inc. | Ribozyme gegen den hepatitis c virus |
| AU718551B2 (en) * | 1996-06-06 | 2000-04-13 | Novartis Ag | Vectors comprising SAR elements |
| CA2689842A1 (en) | 1996-12-02 | 1998-06-11 | Genaera Corporation | Il-9 receptor variants, useful in treating and diagnosing atopic allergies including asthma and related disorders |
| US6245974B1 (en) | 1997-08-06 | 2001-06-12 | North Carolina State University | Matrix attachment regions |
| US6897066B1 (en) * | 1997-09-26 | 2005-05-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| WO1999022773A2 (en) * | 1997-11-05 | 1999-05-14 | Baylor College Of Medicine | Sequences for targeting metastatic cells |
| US6635806B1 (en) * | 1998-05-14 | 2003-10-21 | Dekalb Genetics Corporation | Methods and compositions for expression of transgenes in plants |
| CN100365127C (zh) | 1998-07-21 | 2008-01-30 | 密理博公司 | 具有遍在染色质开放表达元件(ucoe)的聚核苷酸 |
| US6388066B1 (en) * | 1998-09-29 | 2002-05-14 | Pioneer Hi-Bred International, Inc. | MAR/SAR elements flanking RSYN7-driven construct |
| DE19848017A1 (de) * | 1998-10-17 | 2000-04-20 | Multigene Biotech Gmbh | Episomal replizierender Vektor zur Expression eines Transgens in Säugerzellen |
| EP1135512B1 (de) | 1998-12-01 | 2004-10-13 | Dow AgroSciences LLC | Künstliche matrix-anheftungsregion zur erhöhung der expression von in pflanzen eingeführten genen |
| US6225113B1 (en) * | 1998-12-04 | 2001-05-01 | Genvec, Inc. | Use of trans-activation and cis-activation to modulate the persistence of expression of a transgene in an at least E4-deficient adenovirus |
| US6429357B1 (en) * | 1999-05-14 | 2002-08-06 | Dekalb Genetics Corp. | Rice actin 2 promoter and intron and methods for use thereof |
| US6232526B1 (en) * | 1999-05-14 | 2001-05-15 | Dekalb Genetics Corp. | Maize A3 promoter and methods for use thereof |
| US6207879B1 (en) * | 1999-05-14 | 2001-03-27 | Dekalb Genetics Corporation | Maize RS81 promoter and methods for use thereof |
| US6194636B1 (en) * | 1999-05-14 | 2001-02-27 | Dekalb Genetics Corp. | Maize RS324 promoter and methods for use thereof |
| US20050129669A1 (en) * | 1999-06-21 | 2005-06-16 | Transkaryotic Therapies, Inc., A Massachusetts Corporation | DNA construct for effecting homologous recombination and uses thereof |
| US6972349B1 (en) * | 1999-11-12 | 2005-12-06 | University Of South Carolina | Control of post-transcriptional gene silencing in plants |
| JP3507858B2 (ja) * | 1999-11-19 | 2004-03-15 | 奈良先端科学技術大学院大学長 | 植物において外来遺伝子の発現を安定化させるｄｎａ断片、外来遺伝子を植物において安定に発現させる遺伝子導入方法、外来遺伝子を安定に発現させた形質転換植物 |
| WO2001040488A1 (en) | 1999-11-30 | 2001-06-07 | Novartis Ag | Increased transgene expression in retroviral vectors having scaffold attachment region |
| US6864085B2 (en) | 1999-12-14 | 2005-03-08 | Novartis Ag | Bovine immunodeficiency virus (BIV) based vectors |
| US20020127199A1 (en) | 2000-02-03 | 2002-09-12 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| US6821775B1 (en) * | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
| DE10006886A1 (de) | 2000-02-16 | 2001-08-23 | Hepavec Ag Fuer Gentherapie | Nichthumaner helferabhängiger Virusvektor |
| US6569681B1 (en) * | 2000-03-14 | 2003-05-27 | Transkaryotic Therapies, Inc. | Methods of improving homologous recombination |
| US6747189B1 (en) * | 2000-03-21 | 2004-06-08 | Dekalb Genetics Corporation | Maize glycine rich protein promoter compositions and methods for use thereof |
| US6730826B2 (en) * | 2000-03-22 | 2004-05-04 | University Of Kentucky Research Foundation | Plant trichome gland specific promoter sequence |
| US20030157715A1 (en) * | 2000-06-26 | 2003-08-21 | Ulrich Laemmli | Modulation of chromosome function by chromatin remodeling agents |
| CA2409408A1 (en) | 2000-06-26 | 2002-01-03 | Ulrich Laemmli | Modulation of chromosome function by chromatin remodeling agents |
| WO2002009507A1 (de) | 2000-07-27 | 2002-02-07 | Apogene Gmbh & Co. Kg | Somatischer klonierungs-gentransfer zur produktion von rekombinanten proteinen, zellen und organen |
| KR100408844B1 (ko) * | 2000-07-29 | 2003-12-06 | 한국산업기술평가원 | 동물세포 발현벡터 |
| CN1330753C (zh) * | 2000-08-30 | 2007-08-08 | 北卡罗莱纳州立大学 | 含有可改变蛋白含量的分子诱导物的转基因植物 |
| WO2002020811A2 (en) * | 2000-09-09 | 2002-03-14 | Basf Plant Science Gmbh | Modified tet-inducible system for regulation of gene expression in plants |
| GB0022995D0 (en) * | 2000-09-20 | 2000-11-01 | Cobra Therapeutics Ltd | Polynucleotide |
| US6919204B2 (en) * | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| JP2004515233A (ja) * | 2000-11-01 | 2004-05-27 | イルーシス セラポーティクス，インコーポレーテッド | タンパク質トランススプライシングによる二重特異性分子の作製方法 |
| DE10061150A1 (de) * | 2000-12-08 | 2002-06-13 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| WO2002048379A1 (en) * | 2000-12-15 | 2002-06-20 | Pangen Biotech Inc. | Expression vector for animal cell containing nuclear matrix attachment region fo interferon beta |
| US7151204B2 (en) | 2001-01-09 | 2006-12-19 | Monsanto Technology Llc | Maize chloroplast aldolase promoter compositions and methods for use thereof |
| DE10109780A1 (de) | 2001-02-28 | 2002-09-05 | Cardion Ag | Episomale Vektoren enthaltend Matrix-Anheftungsregionen zur zellspezifischen Genexpression |
| WO2002072138A1 (en) | 2001-03-08 | 2002-09-19 | Hyseq, Inc. | Methods and materials relating to fibulin-like polypeptides and polynucleotides |
| JP4817514B2 (ja) * | 2001-03-09 | 2011-11-16 | 協和発酵キリン株式会社 | 新規動物細胞用ベクターおよびその使用 |
| US20040076954A1 (en) * | 2001-03-12 | 2004-04-22 | Irm, Llc | Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters |
| US7070993B2 (en) * | 2001-03-13 | 2006-07-04 | Novartis Ag | Lentiviral packaging constructs |
| AU2002255995A1 (en) * | 2001-03-30 | 2002-10-15 | Avigenics, Inc. | Avian lysozyme promoter |
| DE10129010A1 (de) * | 2001-06-13 | 2002-12-19 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| US20040126189A1 (en) * | 2001-06-27 | 2004-07-01 | Chowdhury Ajit K. | Method for stabilizing chromium-contaminated materials |
| US20030032597A1 (en) * | 2001-07-31 | 2003-02-13 | Sebestyen Magdolna G. | Targeting nucleic acids to a cellular nucleus |
| US7122715B2 (en) * | 2001-09-20 | 2006-10-17 | Monsanto Technology Llc | In vitro method to create circular molecules for use in transformation |
| AU2002341795A1 (en) | 2001-09-21 | 2003-04-01 | Avigenics, Inc. | Production of transgenic avians using sperm-mediated transfection |
| US7138278B2 (en) * | 2001-11-20 | 2006-11-21 | Monsanto Technology, L.L.C. | Maize cytoplasmic glutamine synthetase promoter compositions and methods for use thereof |
| FR2832423B1 (fr) | 2001-11-22 | 2004-10-08 | Vivalis | Systeme d'expression de proteines exogenes dans un systeme aviaire |
| US6875588B2 (en) * | 2001-11-30 | 2005-04-05 | Avigenics, Inc. | Ovomucoid promoter and methods of use |
| CA2427190A1 (en) * | 2002-04-30 | 2003-10-30 | Alberta Research Council Inc. | Production of recombinant epidermal growth factor in plants |
| US20030224477A1 (en) * | 2002-05-31 | 2003-12-04 | Heartlein Michael W. | Optimized promoter constructs |
| EP1513929A4 (de) * | 2002-06-18 | 2006-04-19 | Zymogenetics Inc | Hybridvektor mit einem cytomegalovirus-enhancer und promotor des myeloproliferativen sarkom-virus |
| US20040016015A1 (en) * | 2002-07-17 | 2004-01-22 | Nguyen Thanh-Tuyen T. | High efficiency germline transformation system |
| US6933136B2 (en) * | 2002-09-20 | 2005-08-23 | Novo Nordisk A/S | Method for making recombinant proteins |
| CN1263860C (zh) * | 2002-09-30 | 2006-07-12 | 华南农业大学 | 多基因载体的构建方法与应用 |
| WO2004053106A2 (en) | 2002-12-05 | 2004-06-24 | Regulome Corporation | Profiled regulatory sites useful for gene control |
| WO2004053137A2 (en) | 2002-12-11 | 2004-06-24 | Cytos Biotechnology Ag | Method for protein production |
| AU2002953381A0 (en) | 2002-12-18 | 2003-01-09 | Diatech Pty Ltd | In vivo affinity maturation scheme |
| EP1445320A1 (de) | 2003-02-05 | 2004-08-11 | ARTEMIS Pharmaceuticals GmbH | Automatisches Gen-Targeting mittels nicht toxisischer nachweissbarer Marker |
| JP2006523438A (ja) | 2003-04-15 | 2006-10-19 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | ニワトリ卵白アルブミン遺伝子領域を用いたトリ遺伝子組換え |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| WO2005005644A1 (en) * | 2003-07-11 | 2005-01-20 | Cytos Biotechnology Ag | Gene expression system |
| US20070143872A1 (en) | 2003-08-27 | 2007-06-21 | Orf Liftaekni Hf. | Enhancing accumulation of heterologous polypeptides in plant seeds through targeted suppression of endogenous storage proteins |
| ATE484591T1 (de) | 2003-10-21 | 2010-10-15 | Merck Serono Sa | Minimale dna sequenz, die als chromatin-isolator wirkt, und deren verwendung für die protein- expression |
-
2002
- 2002-01-28 EP EP02726395A patent/EP1395669B1/de not_active Expired - Lifetime
- 2002-01-28 SG SG200504635-4A patent/SG141239A1/en unknown
- 2002-01-28 ES ES02726395T patent/ES2330201T3/es not_active Expired - Lifetime
- 2002-01-28 DK DK02726395T patent/DK1395669T3/da active
- 2002-01-28 JP JP2002574359A patent/JP4307079B2/ja not_active Expired - Lifetime
- 2002-01-28 DE DE60233049T patent/DE60233049D1/de not_active Expired - Lifetime
- 2002-01-28 CA CA2435972A patent/CA2435972C/en not_active Expired - Lifetime
- 2002-01-28 AT AT02726395T patent/ATE437233T1/de active
- 2002-01-28 US US10/059,561 patent/US7129062B2/en not_active Expired - Lifetime
- 2002-01-28 WO PCT/IB2002/002137 patent/WO2002074969A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2435972A1 (en) | 2002-09-26 |
| WO2002074969A3 (en) | 2003-12-24 |
| DK1395669T3 (da) | 2009-11-16 |
| CA2435972C (en) | 2011-09-13 |
| JP2004519246A (ja) | 2004-07-02 |
| EP1395669A2 (de) | 2004-03-10 |
| US20030087342A1 (en) | 2003-05-08 |
| ES2330201T3 (es) | 2009-12-07 |
| EP1395669B1 (de) | 2009-07-22 |
| JP4307079B2 (ja) | 2009-08-05 |
| US7129062B2 (en) | 2006-10-31 |
| WO2002074969A2 (en) | 2002-09-26 |
| SG141239A1 (en) | 2008-04-28 |
| DE60233049D1 (de) | 2009-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60233049D1 (de) | Matrix-anheftungsregionen und verfahren zu deren verwendung | |
| BR0209989A (pt) | Plataformas baseadas em cromossomas | |
| ATE549395T1 (de) | Medium und kultur von embryonalen stammzellen | |
| DE69942459D1 (de) | Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung | |
| DK1546174T3 (da) | Fremgangsmåder og sammensætninger til RNA-interferens | |
| WO2001090345A3 (en) | Methods and compositions for enhancing the delivery of a nucleic acid to a cell | |
| BR0112633A (pt) | Método para substituir, translocar e empilhar dna em genomas eucarióticos | |
| ATE311363T1 (de) | Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren | |
| DK1137798T3 (da) | Fremgangsmåde til isolering af stamceller | |
| HUP0105052A2 (hu) | Eljárások nukleinsav amplifikálására és szekvenálására | |
| ATE388237T1 (de) | Dendritische zellhybride | |
| DE60327471D1 (de) | Verfahren und zusammensetzungen zur reinigung von nukleinsäure aus einer wirtszelle | |
| ATE335086T1 (de) | Künstliche chromosomen, die die genetische information für die bildung von rekombinantem virus enthalten | |
| DK1321477T3 (da) | Fremgangsmåde til frembringelsen af genetisk modificerede vertebrate precursor-lymfocytter og anvendelse deraf til fremstillingen af heterologe bindende proteiner | |
| DK1141358T3 (da) | Stabilt transfekterede celler til identificering af forbindelser, der påvirker stabiliteten af mRNA | |
| DE60239729D1 (de) | Männliche fertilitätvermittelnde nukleotidsequenzen und deren verwendung | |
| DK1025245T3 (da) | Hurtig etablering af stabile pattedyrscelelinjer, der producerer höje koncentrationer af rekombinante proteiner | |
| PT942999E (pt) | Construcao armadilha de genes para a identificacao e isolamento de genes | |
| AR017368A1 (es) | Un procedimiento para la insercion de adn foraneo en una celula hospedante, un vector recombinante utilizado en dicho procedimiento y el uso del mismo | |
| WO2004022782A3 (en) | Compositions and methods for tissue specific or inducible inhibition of gene expression | |
| DE60228822D1 (de) | Stress-resistenz als selektierbarer marker in transgenen pflanzen | |
| DE60323267D1 (en) | Rna-bioassay | |
| DE60130465D1 (de) | Mutierte muskelspezifische enhancer | |
| SG146623A1 (en) | Rodent expression systems utilising polyoma virus and epstein barr virus sequences | |
| DK0643719T3 (da) | Nukleinsyresekvenser, som koder for eller er komplementære til nukleinsyresekvenser, som koder for interleukin 9-receptor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1395669 Country of ref document: EP |