ATE437875T1 - Heterozyklische antivirale verbindungen - Google Patents

Heterozyklische antivirale verbindungen

Info

Publication number
ATE437875T1
ATE437875T1 AT05777382T AT05777382T ATE437875T1 AT E437875 T1 ATE437875 T1 AT E437875T1 AT 05777382 T AT05777382 T AT 05777382T AT 05777382 T AT05777382 T AT 05777382T AT E437875 T1 ATE437875 T1 AT E437875T1
Authority
AT
Austria
Prior art keywords
antiviral compounds
heterocyclic antiviral
heterocyclic
compounds
antiviral
Prior art date
Application number
AT05777382T
Other languages
English (en)
Inventor
James Blake
Jay Fell
John Fischer
John Robinson
Stacey Spencer
Peter Stengel
Robert HENDRICKS
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE437875T1 publication Critical patent/ATE437875T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT05777382T 2004-08-23 2005-08-16 Heterozyklische antivirale verbindungen ATE437875T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60377104P 2004-08-23 2004-08-23
US67771005P 2005-05-04 2005-05-04
PCT/EP2005/008855 WO2006021340A1 (en) 2004-08-23 2005-08-16 Heterocyclic antiviral compounds

Publications (1)

Publication Number Publication Date
ATE437875T1 true ATE437875T1 (de) 2009-08-15

Family

ID=35180855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05777382T ATE437875T1 (de) 2004-08-23 2005-08-16 Heterozyklische antivirale verbindungen

Country Status (19)

Country Link
US (1) US7479489B2 (de)
EP (1) EP1786807B1 (de)
JP (1) JP4624419B2 (de)
KR (1) KR100847181B1 (de)
CN (1) CN101048403B (de)
AR (1) AR050703A1 (de)
AT (1) ATE437875T1 (de)
AU (1) AU2005276648A1 (de)
BR (1) BRPI0514591A (de)
CA (1) CA2577528A1 (de)
DE (1) DE602005015732D1 (de)
ES (1) ES2327764T3 (de)
IL (1) IL181219A0 (de)
MX (1) MX2007002238A (de)
NO (1) NO20071162L (de)
RU (1) RU2007110531A (de)
SG (1) SG137868A1 (de)
TW (1) TWI296626B (de)
WO (1) WO2006021340A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2007004040A0 (en) 2004-12-17 2007-06-30 Anadys Pharmaceuticals Inc Pyridazinone compounds
JP2009526808A (ja) * 2006-02-17 2009-07-23 エフ．ホフマン−ラ ロシュ アーゲー 抗ウイルス性複素環化合物
WO2008051637A2 (en) * 2006-06-22 2008-05-02 Anadys Pharmaceuticals, Inc. Pyridazinone compounds
WO2007150001A1 (en) * 2006-06-22 2007-12-27 Anadys Pharmaceuticals, Inc. Pyrro[1,2-b]pyridazinone compounds
HRP20110193T1 (hr) 2006-10-10 2011-05-31 Medivir Ab Inhibitor hcv nukleozida
WO2008073987A1 (en) * 2006-12-12 2008-06-19 Anadys Pharmaceuticals, Inc. Saturated fused [1,2-b] pyridazinone compounds
TW200840572A (en) 2006-12-12 2008-10-16 Anadys Pharmaceuticals Inc 5,6-dihydro-1H-pyridin-2-one compounds
US20080188466A1 (en) * 2006-12-21 2008-08-07 Anadys Pharmaceuticals, Inc. Pyridazinone compounds
US20080275032A1 (en) * 2006-12-29 2008-11-06 Yuefen Zhou Pyridazinone compounds
US20080227774A1 (en) * 2007-03-15 2008-09-18 Frank Ruebsam 5,5-disubstituted-indolizinone compounds
US7964580B2 (en) * 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
UA100120C2 (en) * 2007-04-03 2012-11-26 Анадис Фармасьютикалз, Инк. 5,6-dihydro-1h-pyridin-2-one compounds
MX2009011930A (es) 2007-05-04 2009-11-18 Vertex Pharma Terapia de combinacion para el tratamiento de infeccion de virus de hepatitis c.
ITMI20071012A1 (it) * 2007-05-18 2008-11-19 St Microelectronics Srl Dispositivo di memoria migliorato a veloce programmazione
US7834009B2 (en) * 2007-08-27 2010-11-16 Anadys Pharmaceuticals, Inc. 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds
US20090060872A1 (en) * 2007-08-31 2009-03-05 Idenix Pharmaceuticals, Inc. Phosphadiazine hcv polymerase inhibitors v
GB0800855D0 (en) 2008-01-17 2008-02-27 Syngenta Ltd Herbicidal compounds
CA2720846A1 (en) * 2008-04-15 2009-11-05 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
TWI438206B (zh) 2008-06-10 2014-05-21 Anadys Pharmaceuticals Inc 〔１，２，４〕噻二１，１二氧化物化合物
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
MX2011002846A (es) * 2008-09-26 2011-04-07 Hoffmann La Roche Derivados de pirina o pirazina para tratar el virus de la hepatitis c.
TW201026675A (en) * 2008-10-09 2010-07-16 Anadys Pharmaceuticals Inc 5,6-dihydro-1H-pyridin-2-one compounds
WO2010042834A1 (en) * 2008-10-09 2010-04-15 Anadys Pharmaceuticals, Inc. A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds
EP2350074B1 (de) * 2008-10-29 2013-03-06 Basf Se Substituierte pyridine mit herbizider wirkung
MX2011004133A (es) * 2008-10-30 2011-05-24 Hoffmann La Roche Derivados de arilpiridona antiviral heterociclica.
KR20110094352A (ko) * 2008-12-22 2011-08-23 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
MX2011006890A (es) 2008-12-23 2011-07-20 Pharmasset Inc Analogos de nucleosidos.
AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
JP2012519661A (ja) 2009-03-06 2012-08-30 エフ．ホフマン−ラ ロシュ アーゲー 抗ウイルス性複素環化合物
WO2010122082A1 (en) 2009-04-25 2010-10-28 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
CN102803212A (zh) 2009-06-24 2012-11-28 弗·哈夫曼-拉罗切有限公司 抗病毒的杂环化合物
CA2768924A1 (en) 2009-09-21 2011-03-24 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
KR20120092142A (ko) 2009-10-28 2012-08-20 애나디스 파마슈티칼스, 인코포레이티드 중수소화 5,6-다이하이드로-1ｈ-파이리딘-2-온 화합물
TW201121968A (en) * 2009-11-09 2011-07-01 Intermune Inc Novel inhibitors of hepatitis C virus replication
WO2011061243A1 (en) 2009-11-21 2011-05-26 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
TW201136945A (en) 2010-03-31 2011-11-01 Pharmasset Inc Purine nucleoside phosphoramidate
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
AP2012006535A0 (en) 2010-03-31 2012-10-31 Gilead Pharmasset Llc Stereoselective synthesis of phosphorous containing actives
ES2716158T3 (es) 2010-11-30 2019-06-10 Gilead Pharmasset Llc 2'-spiro-nucleótidos para el tratamiento de hepatitis C
HRP20180237T4 (hr) 2011-09-16 2020-12-11 Gilead Pharmasset Llc Metode za liječenje hcv-a
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
EP2950786B1 (de) 2013-01-31 2019-11-27 Gilead Pharmasset LLC Kombinationsformulierung zweier antiviraler verbindungen
EA201690473A1 (ru) 2013-08-27 2017-03-31 ГАЙЛИД ФАРМАССЕТ ЭлЭлСи Комбинированный состав двух противовирусных соединений
RU2626239C1 (ru) * 2016-10-11 2017-07-25 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) Фторированные 4-фурфурил-3,4-дигидро-2н-бензо[1,4]тиазин-1,1-диоксиды, обладающие высокой аритмической активностью
RU2627499C1 (ru) * 2016-10-11 2017-08-08 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) 4-арил(гетарил)метил-замещенные 8-циклопентиламино-5,7-дифтор-3,4-дигидро-2н-бензо[1,4]тиазин-1,1-диоксиды, обладающие гипертензивным действием
CN110724102B (zh) * 2019-10-25 2021-06-15 华南农业大学 一种含四氢罂粟碱-3-羧酸甲酯的多酚类化合物及其制备方法和应用
CN112510260B (zh) * 2020-11-27 2022-11-04 珠海市赛纬电子材料股份有限公司 电解液添加剂、非水电解液和锂离子电池

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9108547D0 (en) * 1991-04-22 1991-06-05 Fujisawa Pharmaceutical Co Quinoline derivatives
FR2691459B1 (fr) * 1992-05-25 1995-06-09 Adir Nouveaux derives de la phenothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
AU3147500A (en) * 1999-03-12 2000-10-04 Novo Nordisk A/S Fused 1,4-thiazine-2-carbonitrile derivatives, their preparation and use
AU6062600A (en) * 1999-07-06 2001-01-22 Procter & Gamble Company, The Devices
WO2001085172A1 (en) 2000-05-10 2001-11-15 Smithkline Beecham Corporation Novel anti-infectives
AR036081A1 (es) 2001-06-07 2004-08-11 Smithkline Beecham Corp Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos
WO2003037262A2 (en) * 2001-10-29 2003-05-08 Smithkline Beecham Corporation Novel anit-infectives
WO2003059356A2 (en) * 2001-10-30 2003-07-24 Smithkline Beecham Corporation Novel anti-infectives
WO2003099801A1 (en) * 2002-05-24 2003-12-04 Smithkline Beecham Corporation Novel anti-infectives
US20040097492A1 (en) * 2002-11-01 2004-05-20 Pratt John K Anti-infective agents
US7902203B2 (en) * 2002-11-01 2011-03-08 Abbott Laboratories, Inc. Anti-infective agents
US20040162285A1 (en) * 2002-11-01 2004-08-19 Pratt John K. Anti-infective agents
BR0315897A (pt) 2002-11-01 2008-05-13 Abbott Lab agentes antiinfecciosos
US20050075331A1 (en) * 2003-10-06 2005-04-07 Pratt John K. Anti-infective agents
WO2004052313A2 (en) 2002-12-11 2004-06-24 Smithkline Beecham Corporation Anti-infectives
WO2004052312A2 (en) 2002-12-11 2004-06-24 Smithkline Beecham Corporation Anti-infectives
WO2004058150A2 (en) 2002-12-17 2004-07-15 Smithkline Beecham Corporation Anti-infectives
WO2005019191A2 (en) 2003-08-25 2005-03-03 Abbott Laboratories 1, 1-dioxido-4h-1,2,4-benzothiadiazine derivate und verwandte verbindungen als inhibitoren der hcv polymerase zur behandlung von hepatitis c

Also Published As

Publication number Publication date
WO2006021340A1 (en) 2006-03-02
EP1786807A1 (de) 2007-05-23
KR100847181B1 (ko) 2008-07-17
US20060040927A1 (en) 2006-02-23
ES2327764T3 (es) 2009-11-03
AU2005276648A1 (en) 2006-03-02
CA2577528A1 (en) 2006-03-02
IL181219A0 (en) 2007-07-04
MX2007002238A (es) 2007-04-20
SG137868A1 (en) 2007-12-28
KR20070034637A (ko) 2007-03-28
US7479489B2 (en) 2009-01-20
TW200621761A (en) 2006-07-01
NO20071162L (no) 2007-04-17
CN101048403B (zh) 2010-06-16
BRPI0514591A (pt) 2008-06-17
JP4624419B2 (ja) 2011-02-02
EP1786807B1 (de) 2009-07-29
CN101048403A (zh) 2007-10-03
RU2007110531A (ru) 2008-09-27
JP2008510747A (ja) 2008-04-10
DE602005015732D1 (de) 2009-09-10
AR050703A1 (es) 2006-11-15
TWI296626B (en) 2008-05-11

Similar Documents

Publication Publication Date Title
DE602005015732D1 (de) Heterozyklische antivirale verbindungen
ATE516293T1 (de) Antivirale verbindungen
NO20161521L (no) Antivirale forbindelser
DK1919907T5 (da) Heterocyklisk forbindelse
IL179534A0 (en) Heterocyclic antiviral compounds
IL186661A0 (en) Heterocyclic antiviral compounds
EP1874736A4 (de) Kondensierte heterocyclische verbindungen
DK1745052T3 (da) HIV-intergrase-inhibitorer: cykliske pyrimidinonforbindelser
EP1873153A4 (de) Heterocyclische verbindung
IS8578A (is) 3- karbamoýl - 2- pýridón afleiður
ATE394399T1 (de) Tetrahydropyridoindolderivate
ATE540935T1 (de) Chinazolinderivate
ATE383361T1 (de) Pyrrazolopyrimidinderivate
EP1718903A4 (de) Hybridheizvorrichtung
ATE512960T1 (de) Pyrimidinderivate
ATE512953T1 (de) Heterocyclische verbindungen
ATE417830T1 (de) Sulfonylbenzimidazolderivate
DE602004019555D1 (de) Heterocyclische 7-aminoalkylidenylchinolone und -naphthyridone
NO20070299L (no) Novel heterocyclic compounds
DE602006018341D1 (de) Antihypercholesterinämische verbindungen
ATE404546T1 (de) Substituierte n-sulfonylaminobenzyl-2- phenoxyacetamidverbindungen
ATE430142T1 (de) Phenylpiperazin-methanon-derivate
EP1907393A4 (de) Introvertierte cucurbituril-verbindungen
DK1812448T3 (da) Organiske forbindelser
ATE404542T1 (de) 4-phenylpyrimidin-2-carbonitrilderivate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties