ATE437886T1 - Verfahren und reagentien zum nachweis von endotoxin - Google Patents

Verfahren und reagentien zum nachweis von endotoxin

Info

Publication number
ATE437886T1
ATE437886T1 AT02768293T AT02768293T ATE437886T1 AT E437886 T1 ATE437886 T1 AT E437886T1 AT 02768293 T AT02768293 T AT 02768293T AT 02768293 T AT02768293 T AT 02768293T AT E437886 T1 ATE437886 T1 AT E437886T1
Authority
AT
Austria
Prior art keywords
reagents
methods
detecting endotoxin
endotoxin
factor
Prior art date
Application number
AT02768293T
Other languages
English (en)
Inventor
Lin Chen
Michael Pepe
Original Assignee
Lonza Walkersville Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23162060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE437886(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lonza Walkersville Inc filed Critical Lonza Walkersville Inc
Application granted granted Critical
Publication of ATE437886T1 publication Critical patent/ATE437886T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT02768293T 2001-06-28 2002-06-28 Verfahren und reagentien zum nachweis von endotoxin ATE437886T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30112501P 2001-06-28 2001-06-28
PCT/US2002/020395 WO2003002976A2 (en) 2001-06-28 2002-06-28 Methods and reagents for detecting endotoxin

Publications (1)

Publication Number Publication Date
ATE437886T1 true ATE437886T1 (de) 2009-08-15

Family

ID=23162060

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02768293T ATE437886T1 (de) 2001-06-28 2002-06-28 Verfahren und reagentien zum nachweis von endotoxin

Country Status (14)

Country Link
US (2) US6849426B2 (de)
EP (1) EP1409984B2 (de)
JP (2) JP2005500520A (de)
CN (1) CN100390193C (de)
AT (1) ATE437886T1 (de)
AU (1) AU2002330860C1 (de)
BR (1) BRPI0210681B8 (de)
CY (1) CY1109554T1 (de)
DE (1) DE60233142D1 (de)
DK (1) DK1409984T4 (de)
ES (1) ES2329664T5 (de)
MX (1) MXPA03012032A (de)
PT (1) PT1409984E (de)
WO (1) WO2003002976A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1318848C (zh) * 2003-11-26 2007-05-30 中国科学院大连化学物理研究所 一种用于细菌内毒素鲎试验检测法的缓冲液及其制备方法
MXPA06012864A (es) * 2004-05-07 2007-07-18 Peptimmune Inc Metodo de tratamiento de enfermedades con copolimeros aleatorios.
US20060101539A1 (en) * 2004-11-05 2006-05-11 Ainley William M Cryopreservation of cells
US20060223074A1 (en) * 2005-04-05 2006-10-05 Bunch Thomas A Spotting compositions and methods of use thereof
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
WO2007047498A2 (en) * 2005-10-14 2007-04-26 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
EP2050820A4 (de) * 2006-07-07 2009-12-16 Seikagaku Kogyo Co Ltd Progerinnungsenzym und verfahren zum nachweis von endotoxin oder (1 3)- -d-glucan unter verwendung davon
ATE539102T1 (de) 2006-10-31 2012-01-15 Surmodics Pharmaceuticals Inc Kugelförmige polymer-partikel
WO2009064442A1 (en) * 2007-11-13 2009-05-22 Brookwood Pharmaceuticals, Inc. Viscous terpolymers as drug delivery platform
US8772041B2 (en) * 2008-05-22 2014-07-08 The Regents Of The University Of California Membrane precursors and membranes formed therefrom
US7846678B2 (en) * 2008-08-18 2010-12-07 BioDtech, Inc. Enhancing endotoxin detection
JP5926958B2 (ja) 2008-10-29 2016-05-25 ティー２ バイオシステムズ，インコーポレーテッド 凝固時間のｎｍｒ検出
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
EP2446018B1 (de) 2009-06-26 2017-01-18 Charles River Laboratories, Inc. Wärmebehandelte limulus-amebocyt-lysaten
EP2521650A4 (de) 2010-01-05 2013-05-15 Univ California Tröpfchendoppelschichtbildung durch behandlungsverfahren für geleitete flüssigkeiten
WO2011146463A2 (en) * 2010-05-17 2011-11-24 BioDtech, Inc. Enhancing endotoxin detection
WO2012030821A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Terpolymer blends and their use as pressure-sensitive adhesives
EP3517962A1 (de) * 2011-02-28 2019-07-31 Seikagaku Corporation Mittel zur messung von endotoxin
WO2012118800A2 (en) * 2011-02-28 2012-09-07 BioDtech, Inc. Enhancing endotoxin detection
EP2732046B1 (de) 2011-07-13 2017-09-06 T2 Biosystems, Inc. Kernspinresonanzverfahren zur überwachung der bildung von blutgerinnseln
US10620205B2 (en) 2011-09-21 2020-04-14 T2 Biosystems, Inc. NMR methods for endotoxin analysis
EP2578207A3 (de) 2011-10-05 2015-10-07 Jacob J. Schmidt Maskierungsvorrichtung, die Automatisierung und Lösungsaustausch in sessilen Fetttröpfchen-Doppelschichten ermöglicht
CU24073B1 (es) 2011-12-27 2015-01-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem COMPOSICIÓN A PARTIR DE EXTRACTO DE HEMOCITOS DE LANGOSTA PARA LA DETECCIÓN DE LIPOPOLISACÁRIDOS, PEPTIDOGLICANOS Y 1,3-ß-D-GLUCANOS
CN103290042A (zh) * 2012-02-27 2013-09-11 上海拜生生物科技有限公司 内毒素检测及去除关键分子中国鲎c因子克隆和序列分析
CN103290041A (zh) * 2012-02-27 2013-09-11 上海拜生生物科技有限公司 中国鲎c因子原核及昆虫杆状病毒重组表达载体的构建
CN103290054A (zh) * 2012-02-27 2013-09-11 上海拜生生物科技有限公司 应用昆虫细胞表达重组的中国鲎c因子
EP2740791A1 (de) 2012-12-05 2014-06-11 MicroCoat Biotechnologie GmbH Verfahren für die rekombinante Herstellung von Pfeilschwanzkrebs-Faktor-C-Protein in Protozoen
US9739733B2 (en) 2012-12-07 2017-08-22 T2 Biosystems, Inc. Methods for monitoring tight clot formation
US10144923B2 (en) 2012-12-10 2018-12-04 Seikagaku Corporation Recombinant Factor C and method for producing the same, and method for measuring endotoxin
CN104356211B (zh) * 2014-09-22 2017-08-29 山东信得科技股份有限公司 一种应用Triton X‑114和尿囊素去除重组蛋白质溶液中内毒素的方法
JP6927993B2 (ja) 2016-10-18 2021-09-01 生化学工業株式会社 リムルス属由来の組換え蛋白質及びこれをコードするｄｎａ
CN111077307B (zh) * 2018-10-21 2022-08-23 厦门鲎试剂生物科技股份有限公司 一种用革兰氏阴性细菌感染快速检测脓毒病的新方法
JP7349104B2 (ja) * 2019-11-13 2023-09-22 株式会社島津製作所 ベロ毒素の検出方法
WO2021210669A1 (ja) 2020-04-16 2021-10-21 キッコーマン株式会社 加水分解酵素を利用した微量物質の測定方法
EP4692354A1 (de) 2023-03-30 2026-02-11 Kikkoman Corporation Rekombinantes protein
JPWO2024204497A1 (de) 2023-03-30 2024-10-03
CN119881319B (zh) * 2024-12-04 2025-11-28 苏州鲎源生物科技有限公司 一种重组鲎三因子试剂及试剂盒

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322217A (en) * 1980-06-27 1982-03-30 Mallinckrodt, Inc. Process for preparing Limulus lysate
BE889407A (fr) * 1980-06-27 1981-10-16 Mallinckrodt Inc Amelioration du procede de preparation d'un lysat de limule
JPH03187378A (ja) * 1989-12-16 1991-08-15 Taiyo Fishery Co Ltd 酵素前駆体ファクターｃの調整方法及びその調整試薬
JP3524120B2 (ja) * 1992-05-08 2004-05-10 生化学工業株式会社 前処理剤、前処理方法、前処理された試料による測定法、測定用キット及び試料の判定方法
JP3402476B2 (ja) * 1992-08-24 2003-05-06 生化学工業株式会社 リポ多糖結合性タンパク質及びその製造法
JP3429036B2 (ja) * 1993-09-30 2003-07-22 生化学工業株式会社 エンドトキシンの特異的測定剤
US5716834A (en) 1994-08-19 1998-02-10 National University Of Singapore Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme
US6168924B1 (en) * 1996-10-21 2001-01-02 Seikagaku Kogyo Kabushiki Kaisha Limulus reaction-activating substance, method for inactivating the substance and measuring its amount, and method for measuring limulus reaction
JP3869094B2 (ja) * 1996-10-21 2007-01-17 生化学工業株式会社 エンドトキシンの測定方法
DE69826013T2 (de) * 1997-09-19 2005-09-15 National University Of Singapore Eine neue generation des rekombinanten faktor c der hufeisenkrabbe zur erkennung und entfernung von endotoxin
JP3957386B2 (ja) * 1998-01-08 2007-08-15 生化学工業株式会社 昆虫体液反応性物質の特異的測定剤及び測定方法
WO2001027289A2 (en) * 1999-10-15 2001-04-19 National University Of Singapore Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics

Also Published As

Publication number Publication date
JP2009150903A (ja) 2009-07-09
EP1409984A2 (de) 2004-04-21
DK1409984T3 (da) 2009-11-16
BRPI0210681B1 (pt) 2016-03-29
JP2005500520A (ja) 2005-01-06
US6849426B2 (en) 2005-02-01
CN1529711A (zh) 2004-09-15
EP1409984B2 (de) 2013-04-10
DE60233142D1 (de) 2009-09-10
US20040235080A1 (en) 2004-11-25
DK1409984T4 (da) 2013-07-08
AU2002330860C1 (en) 2009-05-14
WO2003002976A2 (en) 2003-01-09
MXPA03012032A (es) 2005-07-01
JP5039729B2 (ja) 2012-10-03
PT1409984E (pt) 2009-10-29
ES2329664T5 (es) 2013-08-28
CY1109554T1 (el) 2014-08-13
ES2329664T3 (es) 2009-11-30
BRPI0210681B8 (pt) 2021-07-27
WO2003002976A3 (en) 2003-05-15
EP1409984B1 (de) 2009-07-29
EP1409984A4 (de) 2006-07-19
US20030054432A1 (en) 2003-03-20
CN100390193C (zh) 2008-05-28
AU2002330860B2 (en) 2008-12-04
BR0210681A (pt) 2004-09-21

Similar Documents

Publication Publication Date Title
ATE437886T1 (de) Verfahren und reagentien zum nachweis von endotoxin
DE60223635D1 (de) Reagenzien, Verfahren und Vorrichtungen zum Nachweis von Analyten
ATE385259T1 (de) Verfahren zum nachweis von influenza a/b-viren in speichel
DE69522831D1 (de) Assays und vorrichtungen zum nachweis von extrahepatischer biliäreratresie
DE69521104D1 (de) Spezifische Bindungstests und Reagenzien dafür
ATE423972T1 (de) Vorrichtung und verfahren um gleichzeitig verschiedene antikörper und antigene nachzuweisen in klinischen, nahrungsmittel- und umwelt-proben
ATE269977T1 (de) Bindungsbeschleunigungsverfahren zum nachweis von analyten
ATE206211T1 (de) Linker-system zum aktivieren von oberflächen für die biokonjugation und verfahren zu ihrer verwendung
EP1329717A4 (de) Reagenzien und verfahren zum nachweis von substanzen
DE69717840D1 (de) Nachweis und identifizierung von nicht-polio enteroviren
ATE394507T1 (de) Verfahren zum nachweis von polynukleotiden
DE60310012D1 (de) Verfahren, Assay und Kit zur Quantifizierung von HIV-Proteasehemmer
ATE184055T1 (de) Verfahren zum sensitiven nachweis von reverser transcriptase
ATE513058T1 (de) Verdrängungsassay zur detektion von nukleinsäureoligomer-hybridisierungsereignissen
ATE359512T1 (de) Biochemisches verfahren und vorrichtung zur bestimmung von eigenschaften von proteinen
DE59907982D1 (de) Verfahren zum Nachweis einer bei Apoptose aktivierten Protease
ATE437243T1 (de) Verfahren zum nachweis von norwalk-ähnlichem virus (gii)
DK1190245T3 (da) Allergenpåvisning
ATE466961T1 (de) Verfahren zum nachweis von norwalk-ähnlichem virus (gi)
DE59811247D1 (de) Nachweis von adenosin in kleinen proben
DE60127941D1 (de) Versuchsaufbau zum messen von kobalamin und folsäure
DE60330877D1 (de) Verfahren zum nachweis und zur quantifizierung von hepatitis-c-virus
DE60216482D1 (de) Zusammensetzungen und verfahren zum bestimmen von aa4rp
ATE274183T1 (de) Diffusionskontrollierende sensorschicht
DE10393898D2 (de) Verfahren zum Nachweis von Analyten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1409984

Country of ref document: EP